肿瘤坏死因子α在肝细胞癌发生发展中的作用

肿瘤坏死因子α (TNF-α) 通过TNF受体介导的信号通路，参与调节肝细胞癌 (HCC) 细胞的增殖、侵袭、迁移乃至化疗耐药等多个生物学过程。同时，TNF-α还可发挥诱导HCC细胞凋亡的作用。部分TNF-α抑制剂已被证实可抑制HCC进展，延长生存时间。目前，TNF-α在HCC中的潜在作用机制尚未完全阐明，探究TNF-α与HCC的相互作用有益于更好地确定HCC的潜在治疗靶点。本文总结TNF-α在HCC中作用机制的最新研究进展，并介绍以TNF-α为靶点治疗HCC的可能性，以期为HCC的防治和药物研发提供理论依据及参考。...

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Published inLinchuang gandanbing zazhi Vol. 40; no. 11; pp. 2320 - 2325
Main Authors 朱玲玲, 张亚妮, 史婷婷, 伍杨, 高春, 于晓辉, 何昱静, 张久聪
Format Journal Article
LanguageChinese
Published Changchun Journal of Clinical Hepatology 01.11.2024
中国人民解放军联勤保障部队第九四〇医院消化内科,兰州 730050
甘肃中医药大学第一临床医学院,兰州 730000%中国人民解放军联勤保障部队第九四〇医院消化内科,兰州 730050
Subjects
肿瘤坏死因子α
Carcinoma,Hepatocellular
分子靶向治疗
Signal Transduction
信号传导
Molecular Targeted Therapy
Tumor Necrosis Factor-alpha
癌,肝细胞
Online AccessGet full text
ISSN1001-5256
2097-3497
DOI10.12449/JCH241129

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Abstract 肿瘤坏死因子α (TNF-α) 通过TNF受体介导的信号通路，参与调节肝细胞癌 (HCC) 细胞的增殖、侵袭、迁移乃至化疗耐药等多个生物学过程。同时，TNF-α还可发挥诱导HCC细胞凋亡的作用。部分TNF-α抑制剂已被证实可抑制HCC进展，延长生存时间。目前，TNF-α在HCC中的潜在作用机制尚未完全阐明，探究TNF-α与HCC的相互作用有益于更好地确定HCC的潜在治疗靶点。本文总结TNF-α在HCC中作用机制的最新研究进展，并介绍以TNF-α为靶点治疗HCC的可能性，以期为HCC的防治和药物研发提供理论依据及参考。
AbstractList 肿瘤坏死因子α(TNF-α)通过TNF受体介导的信号通路,参与调节肝细胞癌(HCC)细胞的增殖、侵袭、迁移乃至化疗耐药等多个生物学过程.同时,TNF-α还可发挥诱导HCC细胞凋亡的作用.部分TNF-α抑制剂已被证实可抑制HCC进展,延长生存时间.目前,TNF-α在HCC中的潜在作用机制尚未完全阐明,探究TNF-α与HCC的相互作用有益于更好地确定HCC的潜在治疗靶点.本文总结TNF-α在HCC中作用机制的最新研究进展,并介绍以TNF-α为靶点治疗HCC的可能性,以期为HCC的防治和药物研发提供理论依据及参考.
肿瘤坏死因子α (TNF-α) 通过TNF受体介导的信号通路，参与调节肝细胞癌 (HCC) 细胞的增殖、侵袭、迁移乃至化疗耐药等多个生物学过程。同时，TNF-α还可发挥诱导HCC细胞凋亡的作用。部分TNF-α抑制剂已被证实可抑制HCC进展，延长生存时间。目前，TNF-α在HCC中的潜在作用机制尚未完全阐明，探究TNF-α与HCC的相互作用有益于更好地确定HCC的潜在治疗靶点。本文总结TNF-α在HCC中作用机制的最新研究进展，并介绍以TNF-α为靶点治疗HCC的可能性，以期为HCC的防治和药物研发提供理论依据及参考。
Abstract_FL Tumor necrosis factor-α(TNF-α)is involved in the regulation of multiple biological processes such as the proliferation,invasion,migration,and chemotherapy resistance of hepatocellular carcinoma(HCC)cells through TNF receptor-mediated signaling pathways.At the same time,TNF-α also plays a role in inducing the apoptosis of HCC cells.Some TNF-α inhibitors have been shown to inhibit the progression of HCC and prolong survival time.At present,the potential mechanism of action of TNF-α in HCC remains unclear,and exploration of the interaction between TNF-α and HCC can help to determine the potential therapeutic targets for HCC.This article summarizes the latest research advances in the mechanism of action of TNF-α in HCC and introduces the possibility of targeting TNF-α as a treatment method for HCC,in order to provide a theoretical basis for the prevention and treatment of liver cancer and drug research and development.
Author 朱玲玲
伍杨
史婷婷
于晓辉
张亚妮
张久聪
何昱静
高春
AuthorAffiliation 中国人民解放军联勤保障部队第九四〇医院消化内科,兰州 730050;甘肃中医药大学第一临床医学院,兰州 730000%中国人民解放军联勤保障部队第九四〇医院消化内科,兰州 730050
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Author_FL GAO Chun
ZHU Lingling
WU Yang
ZHANG Jiucong
SHI Tingting
YU Xiaohui
HE Yujing
ZHANG Yani
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Issue 11
Keywords 肿瘤坏死因子α
Carcinoma,Hepatocellular
分子靶向治疗
Signal Transduction
信号传导
Molecular Targeted Therapy
Tumor Necrosis Factor-alpha
癌,肝细胞
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PublicationTitle_FL Journal of Clinical Hepatology
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Publisher Journal of Clinical Hepatology
中国人民解放军联勤保障部队第九四〇医院消化内科,兰州 730050
甘肃中医药大学第一临床医学院,兰州 730000%中国人民解放军联勤保障部队第九四〇医院消化内科,兰州 730050
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Snippet 肿瘤坏死因子α (TNF-α) 通过TNF受体介导的信号通路，参与调节肝细胞癌 (HCC) 细胞的增殖、侵袭、迁移乃至化疗耐药等多个生物学过程。同时，TNF-α还可发挥诱导HCC细胞凋亡的作...
肿瘤坏死因子α(TNF-α)通过TNF受体介导的信号通路,参与调节肝细胞癌(HCC)细胞的增殖、侵袭、迁移乃至化疗耐药等多个生物学过程.同时,TNF-α还可发挥诱导HCC细胞凋亡的作用.部...
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