内质网应激在肝衰竭发病机制中的作用
肝衰竭的病理过程复杂,病情进展迅速,病死率高,需对其发病机制进行深入研究。早期的,轻度的内质网应激(ERS)可以通过未折叠蛋白反应维持细胞内环境稳定,而持续的、严重的ERS会促进炎症反应及细胞凋亡引起细胞死亡,因此ERS在疾病的发生发展过程中发挥关键作用。主要阐述ERS及其相关信号通路在肝衰竭发病机制中的作用,为肝衰竭的治疗提供新思路。...
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| Published in | Linchuang gandanbing zazhi Vol. 35; no. 9; pp. 1920 - 1923 |
|---|---|
| Main Authors | , |
| Format | Journal Article |
| Language | Chinese |
| Published |
Changchun
Journal of Clinical Hepatology
01.09.2019
首都医科大学附属北京佑安医院肝病研究所,北京,100069 |
| Subjects | |
| Online Access | Get full text |
| ISSN | 1001-5256 2097-3497 |
| DOI | 10.3969/j.issn.1001-5256.2019.09.006 |
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| Abstract | 肝衰竭的病理过程复杂,病情进展迅速,病死率高,需对其发病机制进行深入研究。早期的,轻度的内质网应激(ERS)可以通过未折叠蛋白反应维持细胞内环境稳定,而持续的、严重的ERS会促进炎症反应及细胞凋亡引起细胞死亡,因此ERS在疾病的发生发展过程中发挥关键作用。主要阐述ERS及其相关信号通路在肝衰竭发病机制中的作用,为肝衰竭的治疗提供新思路。 |
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| AbstractList | 肝衰竭的病理过程复杂,病情进展迅速,病死率高,需对其发病机制进行深入研究。早期的,轻度的内质网应激(ERS)可以通过未折叠蛋白反应维持细胞内环境稳定,而持续的、严重的ERS会促进炎症反应及细胞凋亡引起细胞死亡,因此ERS在疾病的发生发展过程中发挥关键作用。主要阐述ERS及其相关信号通路在肝衰竭发病机制中的作用,为肝衰竭的治疗提供新思路。 R575.3; 肝衰竭的病理过程复杂,病情进展迅速,病死率高,需对其发病机制进行深入研究.早期的,轻度的内质网应激(ERS)可以通过未折叠蛋白反应维持细胞内环境稳定,而持续的、严重的ERS会促进炎症反应及细胞凋亡引起细胞死亡,因此ERS在疾病的发生发展过程中发挥关键作用.主要阐述ERS及其相关信号通路在肝衰竭发病机制中的作用,为肝衰竭的治疗提供新思路. |
| Author | 张向颖 任锋 |
| AuthorAffiliation | 首都医科大学附属北京佑安医院肝病研究所,北京,100069 |
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| Author_FL | REN Feng ZHANG Xiangying |
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| Author_xml | – sequence: 1 fullname: 张向颖 – sequence: 2 fullname: 任锋 |
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| Keywords | 肝功能衰竭 细胞凋亡 未折叠蛋白反应 内质网应激 炎症 |
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| Snippet | 肝衰竭的病理过程复杂,病情进展迅速,病死率高,需对其发病机制进行深入研究。早期的,轻度的内质网应激(ERS)可以通过未折叠蛋白反应维持细胞内环境稳定,而持续的、严重的ERS会... R575.3; 肝衰竭的病理过程复杂,病情进展迅速,病死率高,需对其发病机制进行深入研究.早期的,轻度的内质网应激(ERS)可以通过未折叠蛋白反应维持细胞内环境稳定,而持续的、严... |
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| Title | 内质网应激在肝衰竭发病机制中的作用 |
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