滤泡辅助性T淋巴细胞在自身免疫性肝炎中的作用机制
自身免疫性肝炎 (AIH) 是由自身免疫系统攻击肝细胞导致的慢性肝炎，随着病程的延长，可逐渐发展为肝硬化，甚至肝癌。尽管目前对于AIH的认识和治疗已取得很大进展，但其病因和发病机制仍不明确。T淋巴细胞在AIH的发生、发展过程中发挥至关重要的作用，本文聚焦于滤泡辅助性T淋巴细胞，阐述其在AIH机制中的研究进展，以期为AIH的临床治疗提供新的思路和策略。...
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| Published in | Linchuang gandanbing zazhi Vol. 40; no. 7; pp. 1466 - 1469 |
|---|---|
| Main Authors | , , , , , , , , , |
| Format | Journal Article |
| Language | Chinese |
| Published |
Changchun
Journal of Clinical Hepatology
01.07.2024
宁夏医科大学总医院消化内科,银川 750001%中国人民解放军联勤保障部队第九四〇医院 消化内科,兰州 730050%中国人民解放军联勤保障部队第九四〇医院 基础医学实验室,甘肃省干细胞与基因药物重点实验室,兰州 730050 甘肃中医药大学第一临床医学院,兰州 730000%中国人民解放军联勤保障部队第九四〇医院 消化内科,兰州 730050 中国人民解放军联勤保障部队第九四〇医院 消化内科,兰州 730050 |
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| Online Access | Get full text |
| ISSN | 1001-5256 2097-3497 |
| DOI | 10.12449/JCH240727 |
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| Abstract | 自身免疫性肝炎 (AIH) 是由自身免疫系统攻击肝细胞导致的慢性肝炎，随着病程的延长，可逐渐发展为肝硬化，甚至肝癌。尽管目前对于AIH的认识和治疗已取得很大进展，但其病因和发病机制仍不明确。T淋巴细胞在AIH的发生、发展过程中发挥至关重要的作用，本文聚焦于滤泡辅助性T淋巴细胞，阐述其在AIH机制中的研究进展，以期为AIH的临床治疗提供新的思路和策略。 |
|---|---|
| AbstractList | 自身免疫性肝炎 (AIH) 是由自身免疫系统攻击肝细胞导致的慢性肝炎，随着病程的延长，可逐渐发展为肝硬化，甚至肝癌。尽管目前对于AIH的认识和治疗已取得很大进展，但其病因和发病机制仍不明确。T淋巴细胞在AIH的发生、发展过程中发挥至关重要的作用，本文聚焦于滤泡辅助性T淋巴细胞，阐述其在AIH机制中的研究进展，以期为AIH的临床治疗提供新的思路和策略。 自身免疫性肝炎(AIH)是由自身免疫系统攻击肝细胞导致的慢性肝炎,随着病程的延长,可逐渐发展为肝硬化,甚至肝癌.尽管目前对于AIH的认识和治疗已取得很大进展,但其病因和发病机制仍不明确.T淋巴细胞在AIH的发生、发展过程中发挥至关重要的作用,本文聚焦于滤泡辅助性T淋巴细胞,阐述其在AIH机制中的研究进展,以期为AIH的临床治疗提供新的思路和策略. |
| Abstract_FL | Autoimmune hepatitis(AIH)is a type of chronic hepatitis caused by the attack of hepatocytes by the autoimmune system,and with the prolongation of disease course,it may gradually progress to liver cirrhosis and even hepatocellular carcinoma.Although great achievements have been made in the understanding and treatment of AIH,its etiology and pathogenesis still remain unclear.T cells play a crucial role in the development and progression of AIH,and by focusing on follicular helper T cells,this article elaborates on the research advances in follicular helper T cells in AIH,in order to provide new ideas and strategies for the clinical treatment of AIH. |
| Author | 郑英 李斌 邢国静 卢利霞 李初谊 罗龙龙 于晓辉 张久聪 王丽菲 马俊 |
| AuthorAffiliation | 中国人民解放军联勤保障部队第九四〇医院 消化内科,兰州 730050;甘肃中医药大学第一临床医学院,兰州 730000%中国人民解放军联勤保障部队第九四〇医院 消化内科,兰州 730050;宁夏医科大学总医院消化内科,银川 750001%中国人民解放军联勤保障部队第九四〇医院 消化内科,兰州 730050%中国人民解放军联勤保障部队第九四〇医院 基础医学实验室,甘肃省干细胞与基因药物重点实验室,兰州 730050 |
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| Author_FL | LI Bin LI Chuyi ZHENG Ying ZHANG Jiucong LUO Longlong WANG Lifei LU Lixia XING Guojing YU Xiaohui MA Jun |
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| Keywords | T Follicular Helper Cells 滤泡性辅助性T细胞 Hepatitis,Autoimmune B-Lymphocytes T淋巴细胞,调节性 T-Lymphocytes,Regulatory 肝炎,自身免疫性 B-淋巴细胞 |
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| Snippet | 自身免疫性肝炎 (AIH) 是由自身免疫系统攻击肝细胞导致的慢性肝炎，随着病程的延长，可逐渐发展为肝硬化，甚至肝癌。尽管目前对于AIH的认识和治疗已取得很大进展，但其病因... 自身免疫性肝炎(AIH)是由自身免疫系统攻击肝细胞导致的慢性肝炎,随着病程的延长,可逐渐发展为肝硬化,甚至肝癌.尽管目前对于AIH的认识和治疗已取得很大进展,但其病因和发病... |
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| Title | 滤泡辅助性T淋巴细胞在自身免疫性肝炎中的作用机制 |
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