肝脏微环境中各种细胞对肝星状细胞活化的影响
肝纤维化是以肝脏细胞外基质过度沉积或疤痕组织过度增生为特点的动态病理过程。肝星状细胞(HSC)的活化被普遍认为是形成肝纤维化的中心环节。HSC的活化受到肝脏微环境中各种复杂因素的调控,包括理化刺激和细胞间交互作用等。肝脏内固有细胞及免疫细胞与HSC共同构建了一个复杂的调控系统,调控HSC的活化过程及其转归。主要介绍了肝脏微环境中各种细胞对HSC活化的调控作用,旨在为新型的抗纤维化诊疗手段的研究拓展思路。...
Saved in:
| Published in | Linchuang gandanbing zazhi Vol. 35; no. 2; pp. 424 - 430 |
|---|---|
| Main Authors | , , , , |
| Format | Journal Article |
| Language | Chinese |
| Published |
Changchun
Journal of Clinical Hepatology
01.02.2019
上海中医药大学附属曙光医院,上海中医药大学肝病研究所,肝肾疾病病证教育部重点实验室,上海市中医临床重点实验室,上海201203%上海中医药大学附属曙光医院,上海中医药大学肝病研究所,肝肾疾病病证教育部重点实验室,上海市中医临床重点实验室,上海201203 上海中医药大学上海高校中医内科学E-研究院,上海201203 |
| Subjects | |
| Online Access | Get full text |
| ISSN | 1001-5256 2097-3497 |
| DOI | 10.3969/j.issn.1001-5256.2019.02.042 |
Cover
| Abstract | 肝纤维化是以肝脏细胞外基质过度沉积或疤痕组织过度增生为特点的动态病理过程。肝星状细胞(HSC)的活化被普遍认为是形成肝纤维化的中心环节。HSC的活化受到肝脏微环境中各种复杂因素的调控,包括理化刺激和细胞间交互作用等。肝脏内固有细胞及免疫细胞与HSC共同构建了一个复杂的调控系统,调控HSC的活化过程及其转归。主要介绍了肝脏微环境中各种细胞对HSC活化的调控作用,旨在为新型的抗纤维化诊疗手段的研究拓展思路。 |
|---|---|
| AbstractList | 肝纤维化是以肝脏细胞外基质过度沉积或疤痕组织过度增生为特点的动态病理过程。肝星状细胞(HSC)的活化被普遍认为是形成肝纤维化的中心环节。HSC的活化受到肝脏微环境中各种复杂因素的调控,包括理化刺激和细胞间交互作用等。肝脏内固有细胞及免疫细胞与HSC共同构建了一个复杂的调控系统,调控HSC的活化过程及其转归。主要介绍了肝脏微环境中各种细胞对HSC活化的调控作用,旨在为新型的抗纤维化诊疗手段的研究拓展思路。 R575.2; 肝纤维化是以肝脏细胞外基质过度沉积或疤痕组织过度增生为特点的动态病理过程.肝星状细胞(HSC)的活化被普遍认为是形成肝纤维化的中心环节.HSC的活化受到肝脏微环境中各种复杂因素的调控,包括理化刺激和细胞间交互作用等.肝脏内固有细胞及免疫细胞与HSC共同构建了一个复杂的调控系统,调控HSC的活化过程及其转归.主要介绍了肝脏微环境中各种细胞对HSC活化的调控作用,旨在为新型的抗纤维化诊疗手段的研究拓展思路. |
| Author | 张定棋 刘平 徐莹 陈佳美 刘伟 |
| AuthorAffiliation | 上海中医药大学附属曙光医院,上海中医药大学肝病研究所,肝肾疾病病证教育部重点实验室,上海市中医临床重点实验室,上海201203%上海中医药大学附属曙光医院,上海中医药大学肝病研究所,肝肾疾病病证教育部重点实验室,上海市中医临床重点实验室,上海201203;上海中医药大学上海高校中医内科学E-研究院,上海201203 |
| AuthorAffiliation_xml | – name: 上海中医药大学附属曙光医院,上海中医药大学肝病研究所,肝肾疾病病证教育部重点实验室,上海市中医临床重点实验室,上海201203%上海中医药大学附属曙光医院,上海中医药大学肝病研究所,肝肾疾病病证教育部重点实验室,上海市中医临床重点实验室,上海201203;上海中医药大学上海高校中医内科学E-研究院,上海201203 |
| Author_xml | – sequence: 1 fullname: 徐莹 – sequence: 2 fullname: 张定棋 – sequence: 3 fullname: 陈佳美 – sequence: 4 fullname: 刘伟 – sequence: 5 fullname: 刘平 |
| BookMark | eNpFz01LAlEUBuBLGGTmr6hFm5nO_Z67ipC-QGhTa5k7zhVFRnOSwGVKi8gKgoiggjatSoKIQurXdJ35GSlGrQ68PLwvZx5lokYUIrSEwaVKqJWaW43jyMUA2OGEC5cAVi4QFxiZQVkCSjqUKZlB2T8zh_JxXNXAMRWKcZFFq-nRbdo7t1_PydnAPnS_35_sRS957CfD47R7ZwcfYzC6vk9O3qbJ6HVoT6-Sm579fLGX_QU0a_x6HOZ_bw7tbazvFrac4s7mdmGt6DQxxdSRwpSVDAiVIvS5ZgoC43nAOKFADCVCchoQkMYIibWvuCah1kCxkB6RXkhzaHnae-hHxo8qpVqj3YrGi6V6UCnrTmfyPRBgdEwXp7TZauy3w_jg31LCJpseZ_QHCaNyMQ |
| ClassificationCodes | R575.2 |
| ContentType | Journal Article |
| Copyright | 2019. This work is published under https://creativecommons.org/licenses/by-nc-nd/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. Copyright © Wanfang Data Co. Ltd. All Rights Reserved. |
| Copyright_xml | – notice: 2019. This work is published under https://creativecommons.org/licenses/by-nc-nd/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. – notice: Copyright © Wanfang Data Co. Ltd. All Rights Reserved. |
| DBID | 3V. 7X7 7XB 88E 8FI 8FJ 8FK ABUWG AFKRA AZQEC BENPR CCPQU DWQXO FYUFA GHDGH K9. M0S M1P PHGZM PHGZT PIMPY PJZUB PKEHL PPXIY PQEST PQQKQ PQUKI 2B. 4A8 92I 93N PSX TCJ |
| DOI | 10.3969/j.issn.1001-5256.2019.02.042 |
| DatabaseName | ProQuest Central (Corporate) ProQuest Health & Medical Collection ProQuest Central (purchase pre-March 2016) Medical Database (Alumni Edition) Hospital Premium Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) ProQuest Central (Alumni) ProQuest Central UK/Ireland ProQuest Central Essentials ProQuest Central ProQuest One Community College ProQuest Central Korea Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Health & Medical Complete (Alumni) Health & Medical Collection (Alumni Edition) PML(ProQuest Medical Library) ProQuest Central Premium ProQuest One Academic (New) Publicly Available Content Database ProQuest Health & Medical Research Collection ProQuest One Academic Middle East (New) ProQuest One Health & Nursing ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Academic ProQuest One Academic UKI Edition Wanfang Data Journals - Hong Kong WANFANG Data Centre Wanfang Data Journals 万方数据期刊 - 香港版 China Online Journals (COJ) China Online Journals (COJ) |
| DatabaseTitle | Publicly Available Content Database ProQuest One Academic Middle East (New) ProQuest Central Essentials ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) ProQuest One Community College ProQuest One Health & Nursing ProQuest Central ProQuest Health & Medical Research Collection Health Research Premium Collection Health and Medicine Complete (Alumni Edition) ProQuest Central Korea Health & Medical Research Collection ProQuest Central (New) ProQuest Medical Library (Alumni) ProQuest One Academic Eastern Edition ProQuest Hospital Collection Health Research Premium Collection (Alumni) ProQuest Hospital Collection (Alumni) ProQuest Health & Medical Complete ProQuest Medical Library ProQuest One Academic UKI Edition ProQuest One Academic ProQuest One Academic (New) ProQuest Central (Alumni) |
| DatabaseTitleList | Publicly Available Content Database |
| Database_xml | – sequence: 1 dbid: BENPR name: ProQuest Central url: http://www.proquest.com/pqcentral?accountid=15518 sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine |
| DocumentTitle_FL | Effect of various cells on the activation of hepatic stellate cells in liver microenvironment |
| EISSN | 2097-3497 |
| EndPage | 430 |
| ExternalDocumentID | lcgdbzz201902043 |
| GrantInformation_xml | – fundername: 国家自然科学基金重点项目; 国家自然科学基金项目; 上海市青年科技英才扬帆计划资助项目; 中固博士后科学基金资助项目 funderid: (81530101); (81703681); (17YF1419800); (2016M601643) |
| GroupedDBID | -05 3V. 5XA 5XF 7X7 7XB 88E 8FI 8FJ 8FK 92F 92I ABDBF ABJNI ABUWG ACGFS ACUHS AFKRA ALMA_UNASSIGNED_HOLDINGS AZQEC BENPR CCEZO CCPQU CIEJG CW9 DWQXO EAD EAP EOJEC ESX FYUFA K9. M1P OBODZ OK1 PHGZM PHGZT PIMPY PJZUB PKEHL PPXIY PQEST PQQKQ PQUKI RNS TCJ TGQ U1G U5O 2B. 4A8 93N IPNFZ PSX RIG |
| ID | FETCH-LOGICAL-p1313-76fd97c2376ea5b490cf880452302f326753c207ff671ba95b2ebb031678278e3 |
| IEDL.DBID | 7X7 |
| ISSN | 1001-5256 |
| IngestDate | Thu May 29 03:59:50 EDT 2025 Tue Sep 02 12:23:04 EDT 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 2 |
| Keywords | 综述 肝硬化 脂细胞 细胞因子类 |
| Language | Chinese |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-p1313-76fd97c2376ea5b490cf880452302f326753c207ff671ba95b2ebb031678278e3 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 |
| OpenAccessLink | https://www.proquest.com/docview/3240452854?pq-origsite=%requestingapplication% |
| PQID | 3240452854 |
| PQPubID | 7350069 |
| PageCount | 7 |
| ParticipantIDs | wanfang_journals_lcgdbzz201902043 proquest_journals_3240452854 |
| PublicationCentury | 2000 |
| PublicationDate | 2019-02-01 |
| PublicationDateYYYYMMDD | 2019-02-01 |
| PublicationDate_xml | – month: 02 year: 2019 text: 2019-02-01 day: 01 |
| PublicationDecade | 2010 |
| PublicationPlace | Changchun |
| PublicationPlace_xml | – name: Changchun |
| PublicationTitle | Linchuang gandanbing zazhi |
| PublicationTitle_FL | Journal of Clinical Hepatology |
| PublicationYear | 2019 |
| Publisher | Journal of Clinical Hepatology 上海中医药大学附属曙光医院,上海中医药大学肝病研究所,肝肾疾病病证教育部重点实验室,上海市中医临床重点实验室,上海201203%上海中医药大学附属曙光医院,上海中医药大学肝病研究所,肝肾疾病病证教育部重点实验室,上海市中医临床重点实验室,上海201203 上海中医药大学上海高校中医内科学E-研究院,上海201203 |
| Publisher_xml | – name: Journal of Clinical Hepatology – name: 上海中医药大学上海高校中医内科学E-研究院,上海201203 – name: 上海中医药大学附属曙光医院,上海中医药大学肝病研究所,肝肾疾病病证教育部重点实验室,上海市中医临床重点实验室,上海201203%上海中医药大学附属曙光医院,上海中医药大学肝病研究所,肝肾疾病病证教育部重点实验室,上海市中医临床重点实验室,上海201203 |
| SSID | ssib051369456 ssib061082477 ssj0041983 ssib001103858 ssib053243598 ssib002264326 ssib038074677 |
| Score | 2.1831145 |
| Snippet | 肝纤维化是以肝脏细胞外基质过度沉积或疤痕组织过度增生为特点的动态病理过程。肝星状细胞(HSC)的活化被普遍认为是形成肝纤维化的中心环节。HSC的活化受到肝脏微环境中各种... R575.2; 肝纤维化是以肝脏细胞外基质过度沉积或疤痕组织过度增生为特点的动态病理过程.肝星状细胞(HSC)的活化被普遍认为是形成肝纤维化的中心环节.HSC的活化受到肝脏微环... |
| SourceID | wanfang proquest |
| SourceType | Aggregation Database |
| StartPage | 424 |
| Title | 肝脏微环境中各种细胞对肝星状细胞活化的影响 |
| URI | https://www.proquest.com/docview/3240452854 https://d.wanfangdata.com.cn/periodical/lcgdbzz201902043 |
| Volume | 35 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| journalDatabaseRights | – providerCode: PRVEBS databaseName: EBSCOhost Academic Search Ultimate customDbUrl: https://search.ebscohost.com/login.aspx?authtype=ip,shib&custid=s3936755&profile=ehost&defaultdb=asn eissn: 2097-3497 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0041983 issn: 1001-5256 databaseCode: ABDBF dateStart: 20130401 isFulltext: true titleUrlDefault: https://search.ebscohost.com/direct.asp?db=asn providerName: EBSCOhost – providerCode: PRVHPJ databaseName: ROAD: Directory of Open Access Scholarly Resources customDbUrl: eissn: 2097-3497 dateEnd: 99991231 omitProxy: true ssIdentifier: ssib053243598 issn: 1001-5256 databaseCode: M~E dateStart: 19850101 isFulltext: true titleUrlDefault: https://road.issn.org providerName: ISSN International Centre |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1LS8NAEF58YPEiPvGNgtfYbLKbx0msWkRQRBR6K7tJtiLS-kToUYsH8QWCiKCCF08qgogi-muM6c9wNkltvXgKyS4JTHZnvpmd-QahEY6Zh4nDFYNSVyFccMXizFOIxQAkAYa1QpKk2TljeonMZGgmDrhtxmmVFZ0YKmq34MgYeVISxxEq6_3G1tYV2TVKnq7GLTTqUSMGqCJXtZmpmlOM1T9cLbJotAauSK51UkPnRrFu2KTKLUPhm5LgrnIPSMPSwrrNSNMTcNijBH5wySlghwQakV6wbdjJlXAPj_4OySQyO2QHlU3ha8Bs0w7LC5bP1Vi1dCtqieHo0Hi0ftpQXXG5HSVm4wP3DjRW3r0ql078z4fg-NG_3ft6vfdPS8HdUfC-X9679h_fYML3xU1w8BI9-X5-9w_Pg8uS__Hknx11oqX01OLEtBL3XFDWsI51xTSEa5uOzJXxGOXEVh0BW5zI4LEmQHjg3jiaagphmJgzm3LN4yBKDEZPMy1P70IN-ULe60ZDLnV1ZjNXw0IQ1TKZoauOC4hLJ5RxTntQf0UM2XjjbGarv7kHDceiqY6uOjmXF4tSlmFRb-__r-hDzXJqlGTdjxq2Nra9AcAQW3wwXCiDqHE8NZlKwzU1NTe_8AP0pdBB |
| linkProvider | ProQuest |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV3NS9xAFH9YpdqL9Etqa9st2GM0k8wkmYOItMpaXU8Ke1tnkoyllPUbcY-69CB-gSBFsIVePKkIUlqk_Wsas39G5-Wju71485hMMpCZl3m_N_N-vwfQL4kICfWl4TAWGFQqaXhShAb1hAZJGsN6iUhSacopztB3ZVZug7OcC4NplfmamCzUwbyPe-SDKBxHGfL9hhcWDawahaereQmN1CwmwvU1HbItD42_1fP72rLGRqffFI2sqoCxQGxiG66jAu76mA0SCiYpN32ljZji9qilNJrRAN63TFcpxyVScCatUEoTGeOe5Xqhrfu9Ax3UNilq9bvlpvsmxPxPGwZJqi3wCLXdaYt8HCO2w2lTy4bpb0RBvfxaIxvPSniiqWehhHspYcAkOoBkTif0Y9TNHT74IVkzBv41YdIaT9RIsQh9C3i-uyaqSlTnWrzo2H3ozuBvYSS11wfQVnv_EDpL2QH_IxhubBw36nvR77N49zz6tvnnx2m0X49PduKrT43NL9H5T_3A9eev8db39M715VW0fRgf1aNfF9HBzmOYuZXZ6IH26nw1fAKFgAW24CKwiFLU9Fzh2KYfaIRnUyakZL3Qlw9DJftRlytNs-qFV9nQNFs_-nOBrNVwLBMS8dObu3gJXcXp0mRlcnxq4hncw9fSBO8-aF9ZWg2fa_yyIl8kRlOA2du20r9-HAeq |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=%E8%82%9D%E8%84%8F%E5%BE%AE%E7%8E%AF%E5%A2%83%E4%B8%AD%E5%90%84%E7%A7%8D%E7%BB%86%E8%83%9E%E5%AF%B9%E8%82%9D%E6%98%9F%E7%8A%B6%E7%BB%86%E8%83%9E%E6%B4%BB%E5%8C%96%E7%9A%84%E5%BD%B1%E5%93%8D&rft.jtitle=Linchuang+gandanbing+zazhi&rft.au=%E5%BE%90%E8%8E%B9&rft.au=%E5%BC%A0%E5%AE%9A%E6%A3%8B&rft.au=%E9%99%88%E4%BD%B3%E7%BE%8E&rft.au=%E5%88%98%E4%BC%9F&rft.date=2019-02-01&rft.pub=Journal+of+Clinical+Hepatology&rft.issn=1001-5256&rft.eissn=2097-3497&rft.volume=35&rft.issue=2&rft.spage=424&rft_id=info:doi/10.3969%2Fj.issn.1001-5256.2019.02.042 |
| thumbnail_s | http://utb.summon.serialssolutions.com/2.0.0/image/custom?url=http%3A%2F%2Fwww.wanfangdata.com.cn%2Fimages%2FPeriodicalImages%2Flcgdbzz%2Flcgdbzz.jpg |