肝星状细胞的活化机制—探寻肝纤维化新的诊断指标和治疗靶点
肝纤维化的形成机制复杂,目前主流研究依然围绕肝星状细胞(HSC)开展,并发现许多促进HSC活化的刺激因子和调节通路。对影响HSC的几种主要细胞因子和过氧化物酶体增殖物激活受体γ相关近期研究结果以及近年的研究热点——小RNA、长非编码RNA、外泌体等与HSC活化的关系进行综述,旨在介绍治疗肝纤维化的潜在新靶点和非侵入性肝病诊断的新检测指标,提出将作用于HSC活化的不同靶点的化学药物或中药成分合理组成复方,以期在肝纤维化治疗学上有所突破的观点。...
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| Published in | Linchuang gandanbing zazhi Vol. 35; no. 3; pp. 640 - 643 |
|---|---|
| Main Authors | , , |
| Format | Journal Article |
| Language | Chinese |
| Published |
Changchun
Journal of Clinical Hepatology
01.03.2019
上海市中医临床重点实验室,上海201203 上海中医药大学肝病研究所,上海201203%上海中医药大学附属曙光医院,上海201203 国家中医药管理局重点研究室(慢性肝病虚损),上海201203 肝肾疾病病证教育部重点实验室,上海201203 上海中医药大学附属曙光医院,上海201203 上海中医药大学肝病研究所,上海201203 国家中医药管理局重点研究室(慢性肝病虚损),上海201203%上海中医药大学附属曙光医院,上海201203 |
| Subjects | |
| Online Access | Get full text |
| ISSN | 1001-5256 2097-3497 |
| DOI | 10.3969/j.issn.1001-5256.2019.03.042 |
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| Abstract | 肝纤维化的形成机制复杂,目前主流研究依然围绕肝星状细胞(HSC)开展,并发现许多促进HSC活化的刺激因子和调节通路。对影响HSC的几种主要细胞因子和过氧化物酶体增殖物激活受体γ相关近期研究结果以及近年的研究热点——小RNA、长非编码RNA、外泌体等与HSC活化的关系进行综述,旨在介绍治疗肝纤维化的潜在新靶点和非侵入性肝病诊断的新检测指标,提出将作用于HSC活化的不同靶点的化学药物或中药成分合理组成复方,以期在肝纤维化治疗学上有所突破的观点。 |
|---|---|
| AbstractList | 肝纤维化的形成机制复杂,目前主流研究依然围绕肝星状细胞(HSC)开展,并发现许多促进HSC活化的刺激因子和调节通路。对影响HSC的几种主要细胞因子和过氧化物酶体增殖物激活受体γ相关近期研究结果以及近年的研究热点——小RNA、长非编码RNA、外泌体等与HSC活化的关系进行综述,旨在介绍治疗肝纤维化的潜在新靶点和非侵入性肝病诊断的新检测指标,提出将作用于HSC活化的不同靶点的化学药物或中药成分合理组成复方,以期在肝纤维化治疗学上有所突破的观点。 R575.2; 肝纤维化的形成机制复杂,目前主流研究依然围绕肝星状细胞(HSC)开展,并发现许多促进HSC活化的刺激因子和调节通路.对影响HSC的几种主要细胞因子和过氧化物酶体增殖物激活受体γ相关近期研究结果以及近年的研究热点——小RNA、长非编码RNA、外泌体等与HSC活化的关系进行综述,旨在介绍治疗肝纤维化的潜在新靶点和非侵入性肝病诊断的新检测指标,提出将作用于HSC活化的不同靶点的化学药物或中药成分合理组成复方,以期在肝纤维化治疗学上有所突破的观点. |
| Author | 徐列明 平键 姜娜 |
| AuthorAffiliation | 上海中医药大学附属曙光医院,上海201203;上海中医药大学肝病研究所,上海201203%上海中医药大学附属曙光医院,上海201203;肝肾疾病病证教育部重点实验室,上海201203;上海市中医临床重点实验室,上海201203;国家中医药管理局重点研究室(慢性肝病虚损),上海201203%上海中医药大学附属曙光医院,上海201203;上海中医药大学肝病研究所,上海201203;肝肾疾病病证教育部重点实验室,上海201203;上海市中医临床重点实验室,上海201203;国家中医药管理局重点研究室(慢性肝病虚损),上海201203 |
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| Author_FL | JIANG Na XU Lieming PING Jian |
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| Keywords | 过氧化物酶体增殖物激活受体 肝星状细胞 综述 细胞因子类 微RNAs |
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| Snippet | 肝纤维化的形成机制复杂,目前主流研究依然围绕肝星状细胞(HSC)开展,并发现许多促进HSC活化的刺激因子和调节通路。对影响HSC的几种主要细胞因子和过氧化物酶体增殖物激活受... R575.2; 肝纤维化的形成机制复杂,目前主流研究依然围绕肝星状细胞(HSC)开展,并发现许多促进HSC活化的刺激因子和调节通路.对影响HSC的几种主要细胞因子和过氧化物酶体增殖... |
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