细胞因子在慢性乙型肝炎治疗中的研究进展
目前，全球范围内仍有约2.5亿人慢性感染HBV，严重威胁人类的生命健康。慢性乙型肝炎(CHB)可进一步发展为肝纤维化、肝硬化和肝细胞癌等肝脏疾病，而现有的临床抗病毒治疗药物有限，治愈率很低，急需研发新型抗病毒药物。HBV具有强嗜肝性，自然情况下只感染人、黑猩猩等少数灵长类动物。免疫反应(固有免疫与适应性免疫)能否有效识别并清除或抑制HBV是导致病毒感染后不同结局的重要因素。其中，细胞因子发挥了重要的免疫调节作用。本文就一些关键细胞因子在CHB感染及治疗中的研究进展进行了总结与讨论。...
Saved in:
| Published in | Linchuang gandanbing zazhi Vol. 38; no. 8; pp. 1710 - 1715 |
|---|---|
| Main Authors | , , , |
| Format | Journal Article |
| Language | Chinese |
| Published |
Changchun
Journal of Clinical Hepatology
01.08.2022
上海市重大传染病和生物安全研究院,上海200032 复旦大学教育部/卫健委/医科院医学分子病毒学重点实验室,上海医学院基础医学院病原生物学系,上海200032%复旦大学教育部/卫健委/医科院医学分子病毒学重点实验室,上海医学院基础医学院病原生物学系,上海200032 复旦大学附属华山医院感染科,上海市传染病与生物安全应急响应重点实验室,国家传染病医学中心,上海200040%复旦大学教育部/卫健委/医科院医学分子病毒学重点实验室,上海医学院基础医学院病原生物学系,上海200032 复旦大学生物医学研究院,上海200032%复旦大学教育部/卫健委/医科院医学分子病毒学重点实验室,上海医学院基础医学院病原生物学系,上海200032 |
| Subjects | |
| Online Access | Get full text |
| ISSN | 1001-5256 2097-3497 |
| DOI | 10.3969/j.issn.1001-5256.2022.08.002 |
Cover
| Abstract | 目前，全球范围内仍有约2.5亿人慢性感染HBV，严重威胁人类的生命健康。慢性乙型肝炎(CHB)可进一步发展为肝纤维化、肝硬化和肝细胞癌等肝脏疾病，而现有的临床抗病毒治疗药物有限，治愈率很低，急需研发新型抗病毒药物。HBV具有强嗜肝性，自然情况下只感染人、黑猩猩等少数灵长类动物。免疫反应(固有免疫与适应性免疫)能否有效识别并清除或抑制HBV是导致病毒感染后不同结局的重要因素。其中，细胞因子发挥了重要的免疫调节作用。本文就一些关键细胞因子在CHB感染及治疗中的研究进展进行了总结与讨论。 |
|---|---|
| AbstractList | 目前，全球范围内仍有约2.5亿人慢性感染HBV，严重威胁人类的生命健康。慢性乙型肝炎(CHB)可进一步发展为肝纤维化、肝硬化和肝细胞癌等肝脏疾病，而现有的临床抗病毒治疗药物有限，治愈率很低，急需研发新型抗病毒药物。HBV具有强嗜肝性，自然情况下只感染人、黑猩猩等少数灵长类动物。免疫反应(固有免疫与适应性免疫)能否有效识别并清除或抑制HBV是导致病毒感染后不同结局的重要因素。其中，细胞因子发挥了重要的免疫调节作用。本文就一些关键细胞因子在CHB感染及治疗中的研究进展进行了总结与讨论。 目前,全球范围内仍有约2.5亿人慢性感染HBV,严重威胁人类的生命健康.慢性乙型肝炎(CHB)可进一步发展为肝纤维化、肝硬化和肝细胞癌等肝脏疾病,而现有的临床抗病毒治疗药物有限,治愈率很低,急需研发新型抗病毒药物.HBV具有强嗜肝性,自然情况下只感染人、黑猩猩等少数灵长类动物.免疫反应(固有免疫与适应性免疫)能否有效识别并清除或抑制HBV是导致病毒感染后不同结局的重要因素.其中,细胞因子发挥了重要的免疫调节作用.本文就一些关键细胞因子在CHB感染及治疗中的研究进展进行了总结与讨论. |
| Author | 沈忠良 刘晶 高子翔 谢幼华 |
| AuthorAffiliation | 复旦大学教育部/卫健委/医科院医学分子病毒学重点实验室,上海医学院基础医学院病原生物学系,上海200032%复旦大学教育部/卫健委/医科院医学分子病毒学重点实验室,上海医学院基础医学院病原生物学系,上海200032;复旦大学附属华山医院感染科,上海市传染病与生物安全应急响应重点实验室,国家传染病医学中心,上海200040%复旦大学教育部/卫健委/医科院医学分子病毒学重点实验室,上海医学院基础医学院病原生物学系,上海200032;复旦大学生物医学研究院,上海200032%复旦大学教育部/卫健委/医科院医学分子病毒学重点实验室,上海医学院基础医学院病原生物学系,上海200032;上海市重大传染病和生物安全研究院,上海200032 |
| AuthorAffiliation_xml | – name: 复旦大学教育部/卫健委/医科院医学分子病毒学重点实验室,上海医学院基础医学院病原生物学系,上海200032%复旦大学教育部/卫健委/医科院医学分子病毒学重点实验室,上海医学院基础医学院病原生物学系,上海200032;复旦大学附属华山医院感染科,上海市传染病与生物安全应急响应重点实验室,国家传染病医学中心,上海200040%复旦大学教育部/卫健委/医科院医学分子病毒学重点实验室,上海医学院基础医学院病原生物学系,上海200032;复旦大学生物医学研究院,上海200032%复旦大学教育部/卫健委/医科院医学分子病毒学重点实验室,上海医学院基础医学院病原生物学系,上海200032;上海市重大传染病和生物安全研究院,上海200032 |
| Author_FL | LIU Jing XIE Youhua SHEN Zhongliang GAO Zixiang |
| Author_FL_xml | – sequence: 1 fullname: GAO Zixiang – sequence: 2 fullname: SHEN Zhongliang – sequence: 3 fullname: LIU Jing – sequence: 4 fullname: XIE Youhua |
| Author_xml | – sequence: 1 fullname: 高子翔 – sequence: 2 fullname: 沈忠良 – sequence: 3 fullname: 刘晶 – sequence: 4 fullname: 谢幼华 |
| BookMark | eNpFj7tKA0EYhQeJ4BrzFFrY7Doz_8zsTinBGwRstA47u5OQEDYxaxBSSbw0glh4QaMh2KhFCi1ESeHLZC-P4UpE4cBpPs7hm0e5oBlohJYItkAKuVK3amEYWARjYnLKhUUxpRZ2LIzpDDIolrYJTNo5ZPwxc6gQhjWFOQEhGRcGksn4ND0aRP1hNLqI7p_jk8f48GnyeRsNztLeQ9I7j9_GyfXN5GOU3B0nw8vk5T396kevVwtotuI2Ql347TzaXV_bKW6ape2NreJqyWwRINTURDJbYwVMU61slsXTrqOF9jgIQYhPlABXa6YoZ75HbM_xbQXcV64HCkMeLU93D9yg4gbVcr3ZaQfZY7nhVX3V7f54YyezztDFKdpqN_c6Otz_Z4GCBM6BEPgGWj5vyQ |
| ContentType | Journal Article |
| Copyright | 2022. This work is published under https://creativecommons.org/licenses/by-nc-nd/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. Copyright © Wanfang Data Co. Ltd. All Rights Reserved. |
| Copyright_xml | – notice: 2022. This work is published under https://creativecommons.org/licenses/by-nc-nd/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. – notice: Copyright © Wanfang Data Co. Ltd. All Rights Reserved. |
| DBID | 3V. 7X7 7XB 88E 8FI 8FJ 8FK ABUWG AFKRA AZQEC BENPR CCPQU DWQXO FYUFA GHDGH K9. M0S M1P PHGZM PHGZT PIMPY PJZUB PKEHL PPXIY PQEST PQQKQ PQUKI 2B. 4A8 92I 93N PSX TCJ |
| DOI | 10.3969/j.issn.1001-5256.2022.08.002 |
| DatabaseName | ProQuest Central (Corporate) Health & Medical Collection ProQuest Central (purchase pre-March 2016) Medical Database (Alumni Edition) Hospital Premium Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) ProQuest Central (Alumni) ProQuest Central UK/Ireland ProQuest Central Essentials ProQuest Central ProQuest One Community College ProQuest Central Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Health & Medical Complete (Alumni) Health & Medical Collection (Alumni Edition) Proquest Medical Database ProQuest Central Premium ProQuest One Academic Publicly Available Content Database ProQuest Health & Medical Research Collection ProQuest One Academic Middle East (New) ProQuest One Health & Nursing ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Academic ProQuest One Academic UKI Edition Wanfang Data Journals - Hong Kong WANFANG Data Centre Wanfang Data Journals 万方数据期刊 - 香港版 China Online Journals (COJ) China Online Journals (COJ) |
| DatabaseTitle | Publicly Available Content Database ProQuest One Academic Middle East (New) ProQuest Central Essentials ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) ProQuest One Community College ProQuest One Health & Nursing ProQuest Central ProQuest Health & Medical Research Collection Health Research Premium Collection Health and Medicine Complete (Alumni Edition) ProQuest Central Korea Health & Medical Research Collection ProQuest Central (New) ProQuest Medical Library (Alumni) ProQuest One Academic Eastern Edition ProQuest Hospital Collection Health Research Premium Collection (Alumni) ProQuest Hospital Collection (Alumni) ProQuest Health & Medical Complete ProQuest Medical Library ProQuest One Academic UKI Edition ProQuest One Academic ProQuest One Academic (New) ProQuest Central (Alumni) |
| DatabaseTitleList | Publicly Available Content Database |
| Database_xml | – sequence: 1 dbid: BENPR name: ProQuest Central (subscription) url: http://www.proquest.com/pqcentral?accountid=15518 sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine |
| DocumentTitle_FL | Research advances in cytokines in the treatment of chronic hepatitis B |
| EISSN | 2097-3497 |
| EndPage | 1715 |
| ExternalDocumentID | lcgdbzz202208002 |
| GrantInformation_xml | – fundername: 国家自然科学基金 funderid: (81971921) |
| GroupedDBID | -05 3V. 5XA 5XF 7X7 7XB 88E 8FI 8FJ 8FK 92F 92I ABDBF ABJNI ABUWG ACGFS ACUHS AFKRA ALMA_UNASSIGNED_HOLDINGS AZQEC BENPR CCEZO CCPQU CIEJG CW9 DWQXO EAD EAP EOJEC ESX FYUFA K9. M1P OBODZ OK1 PHGZM PHGZT PIMPY PJZUB PKEHL PPXIY PQEST PQQKQ PQUKI RNS TCJ TGQ U1G U5O 2B. 4A8 93N IPNFZ PSX RIG |
| ID | FETCH-LOGICAL-p1312-e1947e0b34e2eb74b74cea8e6ec536611d1b63aee4b254dc17c8d7b35dbac3b03 |
| IEDL.DBID | BENPR |
| ISSN | 1001-5256 |
| IngestDate | Thu May 29 04:06:10 EDT 2025 Tue Oct 07 07:26:05 EDT 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 8 |
| Keywords | 治疗学 乙型肝炎,慢性 细胞因子类 乙型肝炎病毒 |
| Language | Chinese |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-p1312-e1947e0b34e2eb74b74cea8e6ec536611d1b63aee4b254dc17c8d7b35dbac3b03 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 |
| OpenAccessLink | https://www.proquest.com/docview/3239355311?pq-origsite=%requestingapplication%&accountid=15518 |
| PQID | 3239355311 |
| PQPubID | 7350069 |
| PageCount | 6 |
| ParticipantIDs | wanfang_journals_lcgdbzz202208002 proquest_journals_3239355311 |
| PublicationCentury | 2000 |
| PublicationDate | 2022-08-01 |
| PublicationDateYYYYMMDD | 2022-08-01 |
| PublicationDate_xml | – month: 08 year: 2022 text: 2022-08-01 day: 01 |
| PublicationDecade | 2020 |
| PublicationPlace | Changchun |
| PublicationPlace_xml | – name: Changchun |
| PublicationTitle | Linchuang gandanbing zazhi |
| PublicationTitle_FL | Journal of Clinical Hepatology |
| PublicationYear | 2022 |
| Publisher | Journal of Clinical Hepatology 上海市重大传染病和生物安全研究院,上海200032 复旦大学教育部/卫健委/医科院医学分子病毒学重点实验室,上海医学院基础医学院病原生物学系,上海200032%复旦大学教育部/卫健委/医科院医学分子病毒学重点实验室,上海医学院基础医学院病原生物学系,上海200032 复旦大学附属华山医院感染科,上海市传染病与生物安全应急响应重点实验室,国家传染病医学中心,上海200040%复旦大学教育部/卫健委/医科院医学分子病毒学重点实验室,上海医学院基础医学院病原生物学系,上海200032 复旦大学生物医学研究院,上海200032%复旦大学教育部/卫健委/医科院医学分子病毒学重点实验室,上海医学院基础医学院病原生物学系,上海200032 |
| Publisher_xml | – name: Journal of Clinical Hepatology – name: 上海市重大传染病和生物安全研究院,上海200032 – name: 复旦大学教育部/卫健委/医科院医学分子病毒学重点实验室,上海医学院基础医学院病原生物学系,上海200032%复旦大学教育部/卫健委/医科院医学分子病毒学重点实验室,上海医学院基础医学院病原生物学系,上海200032 – name: 复旦大学生物医学研究院,上海200032%复旦大学教育部/卫健委/医科院医学分子病毒学重点实验室,上海医学院基础医学院病原生物学系,上海200032 – name: 复旦大学附属华山医院感染科,上海市传染病与生物安全应急响应重点实验室,国家传染病医学中心,上海200040%复旦大学教育部/卫健委/医科院医学分子病毒学重点实验室,上海医学院基础医学院病原生物学系,上海200032 |
| SSID | ssib051369456 ssib061082477 ssj0041983 ssib001103858 ssib053243598 ssib002264326 ssib038074677 |
| Score | 2.3219323 |
| Snippet | 目前，全球范围内仍有约2.5亿人慢性感染HBV，严重威胁人类的生命健康。慢性乙型肝炎(CHB)可进一步发展为肝纤维化、肝硬化和肝细胞癌等肝脏疾病，而现有的临床抗病毒治疗药物... 目前,全球范围内仍有约2.5亿人慢性感染HBV,严重威胁人类的生命健康.慢性乙型肝炎(CHB)可进一步发展为肝纤维化、肝硬化和肝细胞癌等肝脏疾病,而现有的临床抗病毒治疗药物有... |
| SourceID | wanfang proquest |
| SourceType | Aggregation Database |
| StartPage | 1710 |
| Title | 细胞因子在慢性乙型肝炎治疗中的研究进展 |
| URI | https://www.proquest.com/docview/3239355311 https://d.wanfangdata.com.cn/periodical/lcgdbzz202208002 |
| Volume | 38 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| journalDatabaseRights | – providerCode: PRVEBS databaseName: EBSCOhost Academic Search Ultimate customDbUrl: https://search.ebscohost.com/login.aspx?authtype=ip,shib&custid=s3936755&profile=ehost&defaultdb=asn eissn: 2097-3497 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0041983 issn: 1001-5256 databaseCode: ABDBF dateStart: 20130401 isFulltext: true titleUrlDefault: https://search.ebscohost.com/direct.asp?db=asn providerName: EBSCOhost – providerCode: PRVHPJ databaseName: ROAD: Directory of Open Access Scholarly Resources customDbUrl: eissn: 2097-3497 dateEnd: 99991231 omitProxy: true ssIdentifier: ssib053243598 issn: 1001-5256 databaseCode: M~E dateStart: 19850101 isFulltext: true titleUrlDefault: https://road.issn.org providerName: ISSN International Centre – providerCode: PRVPQU databaseName: Health & Medical Collection customDbUrl: eissn: 2097-3497 dateEnd: 99991231 omitProxy: true ssIdentifier: ssib061082477 issn: 1001-5256 databaseCode: 7X7 dateStart: 20190101 isFulltext: true titleUrlDefault: https://search.proquest.com/healthcomplete providerName: ProQuest – providerCode: PRVPQU databaseName: ProQuest Central (subscription) customDbUrl: http://www.proquest.com/pqcentral?accountid=15518 eissn: 2097-3497 dateEnd: 99991231 omitProxy: true ssIdentifier: ssib061082477 issn: 1001-5256 databaseCode: BENPR dateStart: 20190101 isFulltext: true titleUrlDefault: https://www.proquest.com/central providerName: ProQuest |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfZ1LSxxBEMcL3SXiJRg1aGIWBa-j24-ZnjmE4CYuEnCREGFv0q9VRNY3gT0Fk3gRQg5qSExEcokePOhBEjz4ZZyd_Rjpnoe7XgJzGXqYQ01196-mq_4FMK6wErWiRI7LNXYoc5UTYCYczWnAMVVFpWzt8GzFm5mnr6tutQsqWS2MTavM1sR4oVar0v4jnySxVpfxGPRibd2xXaPs6WrWQoOnrRXU81hirBvy2Cpj5SBfmq7MvWkDAireU2-xZaQdAGPV12mHwJuLiBfQttqMa_DDSt5l94Y9fBxXciZrPzUhfJLSb4J019BED4zbuDjwgsnleFZP3A2Z2BTjiSSV8x7ePnjH6zVeX-zY58p98DAF1NGpxKMeQVdjqR96ZtMj-AEIouvd1ofj8OgkPP8S_jhtfvrVfP_79u-38HivtfMz2vncvLyODr_e_jmPvn-MTvajs6vWzVF4cTAI8-Xpty9nnLT_grOGCMKORgFluigI1VgLRs0lNfe1p6VLzL6OFBIe4VpTYcJMJRGTvmKCuEpwSYw1H0OuvlrXQzAqhdQ1TxicopIGVlDHZ8KQJCK-byBODMNIZoCFdBJtLrQ_-TCMpUZpj67IRSUaDWvFmHqf_P8VT6HXPprk7o1AbmtjWz8zPLElCtDNqqwA-anSq1K5kLrMPyFT01U |
| linkProvider | ProQuest |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1JTxRBFH5BiOjFuEYEdUzw2NC19FIHYlwggzATYyDhNnYtgzFmQMEQ5mRwuZgYDy5RlBAvyoEDHoyGRP8MPT0_w1e9MMPFG0lfOpWuw6tXr76v673vAQxrqmXdVcTxIkMdHnjaETSQjom4iCjXrta2drhS9cuz_PacN9cDf4paGJtWWcTENFDrBWX_kY-yVKsLPYZcW3zk2K5R9na1aKER5a0V9FgqMZYXdkyZ1RWkcEtjk7dwva9SOjE-c7Ps5F0GnEXCCHUM0vjAuJJxQ40MOD7KRKHxjfIYnl5EE-mzyBgukUxpRQIV6kAyT8tIMekynPcI9HHGBZK_vhvj1Tt3O4CEuAfUYmzZahdgsmrvvEtQziPMF7yjbuMh3LESe8U7Yp2QppWj2VnDiQizEgIXrY3opR-GLQ8Xvhh9kEaRkf0h5MKUjmSpowfg9NGVqFGPGvNd5-rESTiRA-LS9cyDT0FP8_5p6K_kV_5nQCS7L9vPNuL1zXj7Tfz5e-vF19bTb3u_P8Ybr9prX5K1160fu8n7D3u_tpNPz5PNt8nWz_bf9Xjn3VmYPZSVOAe9jYWGOQ8lJZWp-xLhG1dcWAGfMJCIXAkLQwSNcgCGCgPU8k27VOu42ABcyY3SGX2o5rVsNq0VU5R94f9TXIZj5ZnKdG16sjo1CMftZ1ne4BD0Lj9-Yi4illmWl3KHKcG9w_bRfz0XDws |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=%E7%BB%86%E8%83%9E%E5%9B%A0%E5%AD%90%E5%9C%A8%E6%85%A2%E6%80%A7%E4%B9%99%E5%9E%8B%E8%82%9D%E7%82%8E%E6%B2%BB%E7%96%97%E4%B8%AD%E7%9A%84%E7%A0%94%E7%A9%B6%E8%BF%9B%E5%B1%95&rft.jtitle=%E4%B8%B4%E5%BA%8A%E8%82%9D%E8%83%86%E7%97%85%E6%9D%82%E5%BF%97&rft.au=%E9%AB%98%E5%AD%90%E7%BF%94&rft.au=%E6%B2%88%E5%BF%A0%E8%89%AF&rft.au=%E5%88%98%E6%99%B6&rft.au=%E8%B0%A2%E5%B9%BC%E5%8D%8E&rft.date=2022-08-01&rft.pub=%E4%B8%8A%E6%B5%B7%E5%B8%82%E9%87%8D%E5%A4%A7%E4%BC%A0%E6%9F%93%E7%97%85%E5%92%8C%E7%94%9F%E7%89%A9%E5%AE%89%E5%85%A8%E7%A0%94%E7%A9%B6%E9%99%A2%2C%E4%B8%8A%E6%B5%B7200032&rft.issn=1001-5256&rft.volume=38&rft.issue=8&rft.spage=1710&rft.epage=1715&rft_id=info:doi/10.3969%2Fj.issn.1001-5256.2022.08.002&rft.externalDocID=lcgdbzz202208002 |
| thumbnail_s | http://utb.summon.serialssolutions.com/2.0.0/image/custom?url=http%3A%2F%2Fwww.wanfangdata.com.cn%2Fimages%2FPeriodicalImages%2Flcgdbzz%2Flcgdbzz.jpg |