外周血清5-羟色胺与血小板水平对肝细胞癌患者预后的影响

摘要:目的探究血小板及其内源性5-羟色胺 (5-HT) 与肝细胞癌患者预后的关系。方法回顾性分析西安交通大学第一附属医院2004年1月-2012年12月治疗的210例肝细胞癌患者资料,并根据血小板计数高低分为低血小板组 (n=129) 与高血小板组 (n=81) ,对比组间差异因素并进行预后分析。收集20例住院复发/转移肝癌患者及32例非复发/转移肝癌患者外周血标本,用ELISA法检测患者外周血清5-HT水平,血小板聚集仪检测血小板聚集率。血小板计数与肝癌临床病理因素之间的关系分析采用χ2检验;不同肝癌分组患者的外周血小板计数、聚集率及外周血5-HT水平比较采用Mann-Whitney U检验...

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Published inLinchuang gandanbing zazhi Vol. 36; no. 7; pp. 1534 - 1539
Main Authors 王志鑫, 李姚, 周留馨, 任利, 曲凯, 苗润, 侯立朝, 王海久, 刘昌, 樊海宁
Format Journal Article
LanguageChinese
Published Changchun Journal of Clinical Hepatology 01.07.2020
青海省包虫病重点实验室,西宁810000%西安交通大学第一附属医院肝胆外科,西安710006
青海大学附属医院肝胆胰外科,西宁810000
Subjects
Blood platelets
Liver cancer
Medical prognosis
Metastasis
Regression analysis
Survival analysis
预后
血小板
血清素
癌,肝细胞
Online AccessGet full text
ISSN1001-5256
2097-3497
DOI10.3969/j.issn.1001-5256.2020.07.017

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Abstract 摘要:目的探究血小板及其内源性5-羟色胺 (5-HT) 与肝细胞癌患者预后的关系。方法回顾性分析西安交通大学第一附属医院2004年1月-2012年12月治疗的210例肝细胞癌患者资料,并根据血小板计数高低分为低血小板组 (n=129) 与高血小板组 (n=81) ,对比组间差异因素并进行预后分析。收集20例住院复发/转移肝癌患者及32例非复发/转移肝癌患者外周血标本,用ELISA法检测患者外周血清5-HT水平,血小板聚集仪检测血小板聚集率。血小板计数与肝癌临床病理因素之间的关系分析采用χ2检验;不同肝癌分组患者的外周血小板计数、聚集率及外周血5-HT水平比较采用Mann-Whitney U检验。血小板计数与生存期相关性以及5-HT水平与血小板计数、聚集率相关性分析采用一元线性回归。生存率及复发率分析采用Kaplan-Meier法,组间比较采用log-rank检验,影响肝癌患者预后因素分析使用Cox回归分析。结果不同血小板水平患者的年龄 (χ2=32. 304,P=0. 044) 、肿瘤大小 (χ2=35. 201,P=0. 001) 、肿瘤数目 (χ2=31. 304,P=0. 032) 、Child分级 (χ2=3...
AbstractList 摘要:目的探究血小板及其内源性5-羟色胺 (5-HT) 与肝细胞癌患者预后的关系。方法回顾性分析西安交通大学第一附属医院2004年1月-2012年12月治疗的210例肝细胞癌患者资料,并根据血小板计数高低分为低血小板组 (n=129) 与高血小板组 (n=81) ,对比组间差异因素并进行预后分析。收集20例住院复发/转移肝癌患者及32例非复发/转移肝癌患者外周血标本,用ELISA法检测患者外周血清5-HT水平,血小板聚集仪检测血小板聚集率。血小板计数与肝癌临床病理因素之间的关系分析采用χ2检验;不同肝癌分组患者的外周血小板计数、聚集率及外周血5-HT水平比较采用Mann-Whitney U检验。血小板计数与生存期相关性以及5-HT水平与血小板计数、聚集率相关性分析采用一元线性回归。生存率及复发率分析采用Kaplan-Meier法,组间比较采用log-rank检验,影响肝癌患者预后因素分析使用Cox回归分析。结果不同血小板水平患者的年龄 (χ2=32. 304,P=0. 044) 、肿瘤大小 (χ2=35. 201,P=0. 001) 、肿瘤数目 (χ2=31. 304,P=0. 032) 、Child分级 (χ2=3...
R735.7; 目的 探究血小板及其内源性5-羟色胺(5-HT)与肝细胞癌患者预后的关系.方法 回顾性分析西安交通大学第一附属医院2004年1月-2012年12月治疗的210例肝细胞癌患者资料,并根据血小板计数高低分为低血小板组(n=129)与高血小板组(n=81),对比组间差异因素并进行预后分析.收集20例住院复发/转移肝癌患者及32例非复发/转移肝癌患者外周血标本,用ELISA法检测患者外周血清5-HT水平,血小板聚集仪检测血小板聚集率.血小板计数与肝癌临床病理因素之间的关系分析采用χ2检验;不同肝癌分组患者的外周血小板计数、聚集率及外周血5-HT水平比较采用Mann-Whitney U检验.血小板计数与生存期相关性以及5-HT水平与血小板计数、聚集率相关性分析采用一元线性回归.生存率及复发率分析采用Kaplan-Meier法,组间比较采用log-rank检验,影响肝癌患者预后因素分析使用Cox回归分析.结果 不同血小板水平患者的年龄(χ2=32.304,P=0.044)、肿瘤大小(χ2=35.201,P=0.001)、肿瘤数目(χ2=31.304,P=0.032)、Child分级(χ2=31.250,P=0.036)及TNM分期(χ2=35.201,P=0.001)等指标差异均有统计学意义.多因素Cox分析显示,与患者整体生存相关的独立危险因素有年龄、入院AFP水平、入院血小板计数、治疗方式(P值均<0.05),而与无复发生存相关的危险因素包括年龄、入院AFP水平、肿瘤大小、入院血小板计数、治疗方式(P值均<0.05).生存分析发现,高血小板组相对低血小板组具有更低的整体生存率和更高的复发率(χ2值分别为34.060和31.030,P值均<0.001).随着血小板计数的增加,患者整体和无复发生存期均呈现下降趋势(R2OS=0.034,POS=0.007;R2DFS=0.045,PDFS=0.002).肝癌复发/转移组血小板计数、血小板聚集率、血清游离5-HT水平显著高于非复发/转移组,差异均有统计学意义(U值分别为2.950、2.363、3.082,P值分别为0.041、0.043、0.048).进一步相关性分析发现,血清5-HT水平与外周血小板计数及最大聚集率均呈正相关(P值均<0.05).结论 血小板计数是肝细胞癌患者整体生存及复发/转移的独立危险因素;外周血5-HT水平与血小板计数、血小板聚集率正相关
Author 李姚
曲凯
王志鑫
王海久
任利
侯立朝
周留馨
刘昌
苗润
樊海宁
AuthorAffiliation 青海大学附属医院肝胆胰外科,西宁810000;青海省包虫病重点实验室,西宁810000%西安交通大学第一附属医院肝胆外科,西安710006
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Author_FL LI Yao
MIAO Run
QU Kai
ZHOU Liuxin
FAN Haining
HOU Lizhao
LIU Chang
WANG Haijiu
WANG Zhixin
REN Li
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血小板
血清素
癌,肝细胞
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PublicationTitle_FL Journal of Clinical Hepatology
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青海省包虫病重点实验室,西宁810000%西安交通大学第一附属医院肝胆外科,西安710006
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Snippet 摘要:目的探究血小板及其内源性5-羟色胺 (5-HT) 与肝细胞癌患者预后的关系。方法回顾性分析西安交通大学第一附属医院2004年1月-2012年12月治疗的210例肝细胞癌患者资料,并...
R735.7; 目的 探究血小板及其内源性5-羟色胺(5-HT)与肝细胞癌患者预后的关系.方法 回顾性分析西安交通大学第一附属医院2004年1月-2012年12月治疗的210例肝细胞癌患者资料,...
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SubjectTerms Blood platelets
Liver cancer
Medical prognosis
Metastasis
Regression analysis
Survival analysis
Title 外周血清5-羟色胺与血小板水平对肝细胞癌患者预后的影响
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