超液态碘化油联合药物洗脱微球经肝动脉化疗栓塞术治疗巴塞罗那B/C期肝细胞癌的效果分析

目的研究超液态碘化油联合药物洗脱微球经动脉化疗栓塞术 (TACE) 治疗巴塞罗那 (BCLC) B/C期肝细胞癌 (HCC) 的有效性和安全性。方法回顾性分析2016年5月-2018年9月苏州大学附属第一医院接受超液态碘化油联合药物洗脱微球栓塞治疗的51例BCLC B/C期HCC患者,比较治疗前和治疗后3 d、7 d、1个月的肝功能变化,详细记录不良反应及并发症发生情况,采用改良实体瘤疗效评价标准 (mRECIST) 评价术后1、3个月临床疗效。计量资料组间比较采用t检验。结果 51例患者均完成超选择栓塞,治疗病灶术后1个月疾病缓解率为70. 6%,疾病控制率为96. 1%; 3个月疾病缓解率...

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Published inLinchuang gandanbing zazhi Vol. 35; no. 7; pp. 1509 - 1513
Main Authors 唐浩桓, 朱晓黎, 王万胜, 李婉慈, 周林峰, 杜航
Format Journal Article
LanguageChinese
Published Changchun Journal of Clinical Hepatology 01.07.2019
苏州大学附属第一医院介入科,江苏苏州,215006
Subjects
Chemoembolization
Disease control
Liver cancer
Liver failure
Remission (Medicine)
Surgery
化学栓塞,治疗性
微球体
碘化油
癌,肝细胞
Online AccessGet full text
ISSN1001-5256
2097-3497
DOI10.3969/j.issn.1001-5256.2019.07.018

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Abstract 目的研究超液态碘化油联合药物洗脱微球经动脉化疗栓塞术 (TACE) 治疗巴塞罗那 (BCLC) B/C期肝细胞癌 (HCC) 的有效性和安全性。方法回顾性分析2016年5月-2018年9月苏州大学附属第一医院接受超液态碘化油联合药物洗脱微球栓塞治疗的51例BCLC B/C期HCC患者,比较治疗前和治疗后3 d、7 d、1个月的肝功能变化,详细记录不良反应及并发症发生情况,采用改良实体瘤疗效评价标准 (mRECIST) 评价术后1、3个月临床疗效。计量资料组间比较采用t检验。结果 51例患者均完成超选择栓塞,治疗病灶术后1个月疾病缓解率为70. 6%,疾病控制率为96. 1%; 3个月疾病缓解率为64. 0%,疾病控制率为88. 0%。术后3 d急性肝损伤发生率9. 8% (5/51) ,ALT、AST、TBil、Alb变化较术前有明显差异 (t值分别为-5. 454、-3. 997、-5. 346、7. 212,P值均<0. 001) ,术后1周ALT、TBil、Alb变化较术前有明显差异 (t值分别为-3. 177、-3. 665、3. 194,P值均<0. 05) 。术后1个月1级和2级不良反应...
AbstractList 目的研究超液态碘化油联合药物洗脱微球经动脉化疗栓塞术 (TACE) 治疗巴塞罗那 (BCLC) B/C期肝细胞癌 (HCC) 的有效性和安全性。方法回顾性分析2016年5月-2018年9月苏州大学附属第一医院接受超液态碘化油联合药物洗脱微球栓塞治疗的51例BCLC B/C期HCC患者,比较治疗前和治疗后3 d、7 d、1个月的肝功能变化,详细记录不良反应及并发症发生情况,采用改良实体瘤疗效评价标准 (mRECIST) 评价术后1、3个月临床疗效。计量资料组间比较采用t检验。结果 51例患者均完成超选择栓塞,治疗病灶术后1个月疾病缓解率为70. 6%,疾病控制率为96. 1%; 3个月疾病缓解率为64. 0%,疾病控制率为88. 0%。术后3 d急性肝损伤发生率9. 8% (5/51) ,ALT、AST、TBil、Alb变化较术前有明显差异 (t值分别为-5. 454、-3. 997、-5. 346、7. 212,P值均<0. 001) ,术后1周ALT、TBil、Alb变化较术前有明显差异 (t值分别为-3. 177、-3. 665、3. 194,P值均<0. 05) 。术后1个月1级和2级不良反应...
R735.7; 目的 研究超液态碘化油联合药物洗脱微球经动脉化疗栓塞术(TACE)治疗巴塞罗那(BCLC)B/C期肝细胞癌(HCC)的有效性和安全性.方法 回顾性分析2016年5月-2018年9月苏州大学附属第一医院接受超液态碘化油联合药物洗脱微球栓塞治疗的51例BCLC B/C期HCC患者,比较治疗前和治疗后3 d、7 d、1个月的肝功能变化,详细记录不良反应及并发症发生情况,采用改良实体瘤疗效评价标准(mRECIST)评价术后1、3个月临床疗效.计量资料组间比较采用t检验.结果 51例患者均完成超选择栓塞,治疗病灶术后1个月疾病缓解率为70.6％,疾病控制率为96.1％;3个月疾病缓解率为64.0％,疾病控制率为88.0％.术后3 d急性肝损伤发生率9.8％(5/51),ALT、AST、TBil、Alb变化较术前有明显差异(t值分别为-5.454、-3.997、-5.346、7.212,P值均<0.001),术后1周ALT、TBil、Alb变化较术前有明显差异(t值分别为-3.177、-3.665、3.194,P值均<0.05).术后1个月1级和2级不良反应发生率为68.6％(35/51),未出现肝衰竭、肝脓肿、胆汁瘤、消化道出血等并发症,1例患者术后61 d因肿瘤进展死于多脏器功能衰竭.结论 超液态碘化油联合药物洗脱微球TACE治疗BCLC B/C期HCC是安全有效的,远期疗效及生存获益有待于进一步观察.
Author 周林峰
李婉慈
杜航
王万胜
朱晓黎
唐浩桓
AuthorAffiliation 苏州大学附属第一医院介入科,江苏苏州,215006
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Keywords 化学栓塞,治疗性
微球体
碘化油
癌,肝细胞
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PublicationTitle_FL Journal of Clinical Hepatology
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苏州大学附属第一医院介入科,江苏苏州,215006
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Snippet 目的研究超液态碘化油联合药物洗脱微球经动脉化疗栓塞术 (TACE) 治疗巴塞罗那 (BCLC) B/C期肝细胞癌 (HCC) 的有效性和安全性。方法回顾性分析2016年5月-2018年9月苏州大学...
R735.7; 目的 研究超液态碘化油联合药物洗脱微球经动脉化疗栓塞术(TACE)治疗巴塞罗那(BCLC)B/C期肝细胞癌(HCC)的有效性和安全性.方法 回顾性分析2016年5月-2018年9月苏州...
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SubjectTerms Chemoembolization
Disease control
Liver cancer
Liver failure
Remission (Medicine)
Surgery
Title 超液态碘化油联合药物洗脱微球经肝动脉化疗栓塞术治疗巴塞罗那B/C期肝细胞癌的效果分析
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