基于肝脏病理学对慢性乙型肝炎肝硬化患者FibroTouch测量值的影响因素分析
摘要:目的分析慢性乙型肝炎患者中CD34、CK7、CK19免疫组化阳性染色量以及纤维胶原沉积量的变化特点,阐述影响FibroTouch测量值的病理基础。方法收集2015年1月-2017年12月于上海中医药大学附属曙光医院肝硬化科就诊的72例慢性乙型肝炎患者的一般资料,计算CD34、CK7、CK19免疫组化染色的阳性染色量,Masson三色染色的纤维胶原沉积量,FibroTouch所测定的肝脏硬度值。符合正态分布的计量资料两组间比较采用t检验;不符合正态分布或方差不齐的计量资料两组间比较用Wilcoxon秩和检验;计数资料组间比较采用χ2检验;等级资料多组间比较采用Kruskal-Wallis...
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| Published in | Linchuang gandanbing zazhi Vol. 35; no. 2; pp. 338 - 344 |
|---|---|
| Main Authors | , , , , , |
| Format | Journal Article |
| Language | Chinese |
| Published |
Changchun
Journal of Clinical Hepatology
01.02.2019
上海中医药大学附属曙光医院肝硬化科,上海201203 上海中医药大学附属曙光医院肝病研究所,上海,201203%上海中医药大学附属曙光医院肝病研究所,上海201203 |
| Subjects | |
| Online Access | Get full text |
| ISSN | 1001-5256 2097-3497 |
| DOI | 10.3969/j.issn.1001-5256.2019.02.019 |
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| Abstract | 摘要:目的分析慢性乙型肝炎患者中CD34、CK7、CK19免疫组化阳性染色量以及纤维胶原沉积量的变化特点,阐述影响FibroTouch测量值的病理基础。方法收集2015年1月-2017年12月于上海中医药大学附属曙光医院肝硬化科就诊的72例慢性乙型肝炎患者的一般资料,计算CD34、CK7、CK19免疫组化染色的阳性染色量,Masson三色染色的纤维胶原沉积量,FibroTouch所测定的肝脏硬度值。符合正态分布的计量资料两组间比较采用t检验;不符合正态分布或方差不齐的计量资料两组间比较用Wilcoxon秩和检验;计数资料组间比较采用χ2检验;等级资料多组间比较采用Kruskal-Wallis H检验。利用受试者工作特征曲线分析肝脏硬度值对乙型肝炎肝硬化的诊断价值。采用logistic回归进行多因素分析。结果随着炎症程度的增加,CD34阳性染色量无明显变化 (P> 0. 05) ,CK19阳性染色量、纤维胶原沉积量呈现升高趋势 (H值分别为9. 02、14. 12,P值分别为0. 011、0. 001) 。随着纤维化分期的进展,CD34阳性染色量、CK7阳性染色量、纤维胶原沉积量呈现逐渐升高的趋... |
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| AbstractList | 摘要:目的分析慢性乙型肝炎患者中CD34、CK7、CK19免疫组化阳性染色量以及纤维胶原沉积量的变化特点,阐述影响FibroTouch测量值的病理基础。方法收集2015年1月-2017年12月于上海中医药大学附属曙光医院肝硬化科就诊的72例慢性乙型肝炎患者的一般资料,计算CD34、CK7、CK19免疫组化染色的阳性染色量,Masson三色染色的纤维胶原沉积量,FibroTouch所测定的肝脏硬度值。符合正态分布的计量资料两组间比较采用t检验;不符合正态分布或方差不齐的计量资料两组间比较用Wilcoxon秩和检验;计数资料组间比较采用χ2检验;等级资料多组间比较采用Kruskal-Wallis H检验。利用受试者工作特征曲线分析肝脏硬度值对乙型肝炎肝硬化的诊断价值。采用logistic回归进行多因素分析。结果随着炎症程度的增加,CD34阳性染色量无明显变化 (P> 0. 05) ,CK19阳性染色量、纤维胶原沉积量呈现升高趋势 (H值分别为9. 02、14. 12,P值分别为0. 011、0. 001) 。随着纤维化分期的进展,CD34阳性染色量、CK7阳性染色量、纤维胶原沉积量呈现逐渐升高的趋... R512.62%R575.2; 目的 分析慢性乙型肝炎患者中CD34、CK7、CK19免疫组化阳性染色量以及纤维胶原沉积量的变化特点,阐述影响Fib-roTouch测量值的病理基础.方法 收集2015年1月-2017年12月于上海中医药大学附属曙光医院肝硬化科就诊的72例慢性乙型肝炎患者的一般资料,计算CD34、CK7、CK19免疫组化染色的阳性染色量,Masson三色染色的纤维胶原沉积量,FibroTouch所测定的肝脏硬度值.符合正态分布的计量资料两组间比较采用t检验;不符合正态分布或方差不齐的计量资料两组间比较用Wilcox-on秩和检验;计数资料组间比较采用x2检验;等级资料多组间比较采用Kruskal-Wallis H检验.利用受试者工作特征曲线分析肝脏硬度值对乙型肝炎肝硬化的诊断价值.采用logistic回归进行多因素分析.结果 随着炎症程度的增加,CD34阳性染色量无明显变化(P＞0.05),CK19阳性染色量、纤维胶原沉积量呈现升高趋势(H值分别为9.02、14.12,P值分别为0.011、0.001).随着纤维化分期的进展,CD34阳性染色量、CK7阳性染色量、纤维胶原沉积量呈现逐渐升高的趋势(H值分别为10.26、16.29、22.97,P值分别为0.016、0.001、＜0.001).logistic回归分析显示,CK7阳性染色量、纤维胶原沉积量均是FibroTouch测量值的独立影响因素(Wald值分别为4.756、4.757,P值分别为0.029、0.029).结论 纤维胶原沉积量和CK7阳性染色量的增加可能会提高Fibro-Touch的测量值. |
| Author | 赵志敏 吕靖 陈洋溢 李正鑫 陈高峰 刘成海 |
| AuthorAffiliation | 上海中医药大学附属曙光医院肝病研究所,上海,201203%上海中医药大学附属曙光医院肝病研究所,上海201203;上海中医药大学附属曙光医院肝硬化科,上海201203 |
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| Publisher | Journal of Clinical Hepatology 上海中医药大学附属曙光医院肝硬化科,上海201203 上海中医药大学附属曙光医院肝病研究所,上海,201203%上海中医药大学附属曙光医院肝病研究所,上海201203 |
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| Snippet | 摘要:目的分析慢性乙型肝炎患者中CD34、CK7、CK19免疫组化阳性染色量以及纤维胶原沉积量的变化特点,阐述影响FibroTouch测量值的病理基础。方法收集2015年1月-2017年12月于上... R512.62%R575.2; 目的 分析慢性乙型肝炎患者中CD34、CK7、CK19免疫组化阳性染色量以及纤维胶原沉积量的变化特点,阐述影响Fib-roTouch测量值的病理基础.方法 收集2015年1... |
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| Title | 基于肝脏病理学对慢性乙型肝炎肝硬化患者FibroTouch测量值的影响因素分析 |
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