(11)C-MK-8278 PET as a tool for pharmacodynamic brain occupancy of histamine 3 receptor inverse agonists - Van Laere, Koenraad J; Sanabria-Bohórquez, Sandra M; Mozley, David P; Burns, Donald H; Hamill, Terence G; Van Hecken, Anne; De Lepeleire, Inge; Koole, Michel; Bormans, Guy; de Hoon, Jan; Depré, Marleen; Cerchio, Kristine; et al. (The Journal of nuclear medicine (1978), 2014)
Keywords: Administration, Oral; Adult; Animals; Benzofurans - pharmacology; Brain - diagnostic imaging; Carbon Radioisotopes - pharmacology; Histamine Agonists - chemistry; Humans; Imaging, Three-Dimensional; Ligands; Macaca mulatta; Male; Positron-Emission Tomography; Radiometry; Radiopharmaceuticals - pharmacology; Receptors, Histamine H3 - chemistry; Reproducibility of Results; Spiro Compounds - pharmacology; Young Adult; receptor occupancy; H3 receptor; 11C-MK-8278; inverse agonist; PET; kinetic modeling