Profils métabolique et clinique avant, pendant et après la période du ramadan chez des Maliens atteints de diabète de type 2

• Published in: Nutrition clinique et métabolisme Vol. 28; no. 2 p.83-89; pp. 83 - 89
• Main Authors: Traoré, Modibo, Lemieux, Simone, Galibois, Isabelle
• Format: Journal Article
• Language: English; French
• Published: 01.05.2014
• Subjects: adverse effects; blood glucose; blood lipids; drug therapy; fasting; glycemic control; glycosylation; hemoglobin; low density lipoprotein cholesterol; noninsulin-dependent diabetes mellitus; patients; systolic blood pressure; weight loss
• ISSN: 0985-0562
• DOI: 10.1016/j.nupar.2013.12.006

To document the effects of fasting on metabolic and clinical parameters among Malians with type 2 diabetes during Ramadan in Mali.This study was conducted with 25 subjects attending the Centre national de lutte contre le diabète in Bamako. Only those that intended to observe the Ramadan fasting in 2010 were selected. Biological and clinical parameters were measured in 25 participants at three different periods: before Ramadan (T0), during the fourth week of Ramadan (T1) and one month after Ramadan (T2).Compared to T0, an increase was noted at T1 in fasting blood glucose (P<0.05) and systolic blood pressure (P<0.01), although not maintained at T2. Glycosylated haemoglobin was also higher at T2 compared to T0 (P<0.02). Degradation of glycemic control was more marked among patients who had stopped or reduced their doses of medication at T1 (P<0.01). Also, a decrease in LDL-cholesterol (P<0.03), total cholesterol (P<0.05) and total cholesterol/HDL-cholesterol ratio (P<0.01) were observed at T1, along with a slight weight loss (P<0.01). Reductions in weight, levels of LDL-cholesterol and total cholesterol/HDL-cholesterol ratio were maintained at T2.This study showed an adverse effect of fasting on glycemic control among the participants, likely related to the non-observance of oral medication during Ramadan. However, blood lipids sharply improved during Ramadan, and even after.