星香正氣散加蒲公英과 單味들이Hypoxia-reoxygenation 에 의해 손상받은 Mouse Neuroblastoma 2a Cells에 미치는 影響

• Published in: 동의신경정신과학회지, 16(1) pp. 19 - 41
• Main Authors: 황의완, 강철훈, 김종우, 유진석
• Format: Journal Article
• Language: Korean
• Published: 대한한방신경정신과학회 01.06.2005
• Subjects: 한의학
• ISSN: 1226-6396; 2234-4942

Object : This study was designed to asses the effect of Sunghyangjungkisan-ga-pogongng and herbs on Mouse neuroblastoma 2a cells damaged by hypoxia-reoxygenation.Method : Mouse neuroblastoma 2a (N2a) cells were measured by MTT assay and LDH assay after 48h hypoxia and 6h reoxygenation. Mouse neuroblastoma 2a (N2a) cells were treated by SHJG+P and herbs.Result : 1. SHJG+P was effective on LDH assay of hypoxia and reoxygenation.2. The herbs were generally effective on LDH assay of hypoxia and reoxygenation. In MTT assay of hypoxia JP and GC were effecctive.In LDH assay of hypoxia all of herbs were effective. DMH, BC, SY, NS were more effective than other herbs. In LDH assay of reoxygenation KH, BH, BBR, DMH were especially effective.In MTT assay of reoxygenation most of herbs were not effective. But GC, SY, BH, JP were effective.Conclusion : The results imply that SHJG+P and all of berbs may have protective effect on dementia and GC, SY, BH, JP may have protective effect. KCI Citation Count: 2