Sprayable powder of hyaluronate embedded in mildly cross-linked alginate as a post-surgical tissue adhesion barrier

• Published in: Macromolecular research Vol. 21; no. 11; pp. 1263 - 1269
• Main Authors: Oh, Se Heang, Na, Seung Yeon, Song, Kyu Sang, Lee, Jin Ho
• Format: Journal Article
• Language: English
• Published: Dordrecht Springer Netherlands 01.11.2013; 한국고분자학회
• Subjects: Characterization and Evaluation of Materials; Chemistry; Chemistry and Materials Science; Complex Fluids and Microfluidics; Nanochemistry; Nanotechnology; Physical Chemistry; Polymer Sciences; Soft and Granular Matter; 고분자공학; alginate; tissue adhesion; tissue adhesion barrier; sprayable powder; hyaluronate
• ISSN: 1598-5032; 2092-7673
• DOI: 10.1007/s13233-013-1163-x

Hyaluronate (HA) powder was embedded in mildly cross-linked alginate (mcALG) for the preperation of the sprayable tissue adhesion barrier. The HA/mcALG powder could easily cover a peritoneal tissue defect site without spatial restriction (by air spraying) and effectively conceal the injured tissues without migration (by muco-adhesiveness of HA). It also remained at the applied area during wound healing (by HA embedding in the network structure of cross-linked ALG). The tissue adhesion prevention ability of HA/mcALG was evaluated and compared with each HA or mcALG powder through an animal study using a rat model. The HA/mcALG powder was highly effective in preventing peritoneal tissue adhesion and did not show abnormal tissue responses during wound healing. Based on these observations, the HA/mcALG powder is expected to be a good candidate for sprayable tissue adhesion barriers in clinical applications.