합환피 추출물의 지방세포 분화 억제 효과

• Published in: 동의생리병리학회지 Vol. 30; no. 6; pp. 447 - 451
• Main Authors: 이수호(Su Ho Lee), 이영래(Young Rae Lee), 류도곤(Do Gon Ryu), 김하림(Ha Rim Kim), 김미성(Mi Seong Kim), 김병숙(Byung Sook Kim), 권강범(Kang Beom Kwon)
• Format: Journal Article
• Language: Korean
• Published: 한의병리학회 2016
• Subjects: 한의학; Albizziae Cortex; Lypolysis; Adipocyte differentiation; OP9 cells
• ISSN: 1738-7698; 2288-2529; 2283-2529
• DOI: 10.15188/kjopp.2016.12.30.6.447

In this study, Albizziae Cortex extracts (ACE) have potent effects on adipogenesis and on lipolysis in OP9 cells. There was no cytotoxicity while cells were treated with ACE in designated time intervals, unaffected by various concentrations. In the cells with ACE-treated, increases in fat storage were inhibited, and also confirmed by Oil red O. To understand the underlying mechanism at the molecular level, the effects of ACE were examined on the expression of the genes involved in adipogenesis by using real-time PCR. In this cell model, the mRNA level of adipogenic genes such as peroxisome-proliferator-activated receptors gamma ($PPAR{\gamma}$) and CAAAT/enhancer binding protein alpha ($C/EBP{\alpha}$) were decreased by ACE treatment, comparing with those of control group. Collectively, our data suggest that ACE may have great potential as a novel anti-obesity agent.