산양삼이 Cyclophosphamide의 독성에 미치는 영향

• Published in: 동의생리병리학회지 Vol. 25; no. 5; pp. 849 - 856
• Main Authors: 이성우(Sung Woo Lee), 김기태(Ki Tae Kim), 고흥(Heung Ko)
• Format: Journal Article
• Language: Korean
• Published: 한의병리학회 2011
• Subjects: 한의학; organic toxicity; testicular toxicity; cyclophosphamide; Cultivated Wild Ginseng; protective effect
• ISSN: 1738-7698; 2288-2529; 2283-2529

This study was investigated the protective effect of Cultivated Wild Ginseng(WG) on the toxicities induced by cyclophosphamide(CP) in mice. Twenty-four male BALB/c mice were divided into non-treated normal group(n=6), CP treated control group(n=6), CP+WG treated CP+WG group(n=6), WG treated WG group(n=6). CP(100 mg/kg of b.w., i.p) was injected at 0, 7 th, 14 th, 21 th, and 28 th day of the experiment respectively. WG(4.4 g/kg, i.p.) was administrated for 35days. Body and organ(heart, liver, kidney, testis) weight were measured. Histopathological examination on the organ(heart, liver, kidney, testis), morphometric analysis, and BrdU immunohistochemistry on the testis were performed. Body weight was decreased following CP administration. In contrast, such a decrease was significantly attenuated by WG administration. CPK and AST of CP+WG group were significantly decreased compared with CP group. Histopathologically, cross sectional area of testis and diameter of seminiferous tubule were significantly increased in CP+WG group compared with CP group. BrdU labelled cells in the seminiferous tubules were remarkably decreased in CP group. Whereas the number of seminiferous tubules labelled with BrdU in spermatogonia was increased by CP+WG administration. The obtained results suggest that WG has protective effect on CP-induced toxicity. This effect might be mediated through the supplementation of vital energy.