흑삼추출물(BGE)과 금산흑삼표준화소재(GBG05-FF)의 In Vitro와 In Vivo상에서의 항당뇨효과

• Published in: 생약학회지 Vol. 46; no. 4; pp. 321 - 326
• Main Authors: 서윤수(Yun Soo Seo), 손미례(Mi Yae Shon), 공룡(Ryong Kong), 강옥화(Ok Hwa Kang), 주전(Tian Zhou), 김도연(Do Yeon Kim), 박종대(Jong Dae Park), 권동렬(Dong Yeul Kwon)
• Format: Journal Article
• Language: Korean
• Published: 한국생약학회 2015
• Subjects: 약학; C₂C< Fasting blood glucose; 12< sub> Glycated hemoglobin; Black ginseng; Type 1 diabetes mellitus; C_2C_{12}
• ISSN: 0253-3073; 2288-9299

The prevalence of diabetes mellitus continues to rise alarmingly because of industrialization of society. The aim of this study was to investigate the antidiabetic effects of black ginseng extract (BGE) which was performed panax ginseng. First we examined the inhibitory effects of BGE on ${\alpha}$-glucosidase. But there was no practical effects in our observations. We, also, investigate the effects of BGE on glucose uptake of skeletal muscle using 2-NBDG in $C_2C_{12}$ myotube. BGE significantly improved the glucose uptake considered as a lowered blood glucose level. Effects of GBG05-FF on fasting blood glucose and glycated hemoglobin (HbA1c) were investigated in streptozotocin (STZ)-induced diabetic mouse. After injection of STZ, fasting blood glucose and glycated hemoglobin rapidly increased. But STZ-induced diabetic mouse treated with GBG05-FF significantly reduced the level of fasting blood glucose and HbA1c. This results showed that supplementation of BGE improve the diabetic parameters and BGE have a potentiality as a functional food for Diabetes mellitus.