CCR5 deficiency in aged mice causes a decrease in bone mass

The CC chemokine receptor 5 (CCR5) is a G protein-coupled receptor that regulates chemotaxis and effector functions of immune cells. It also serves as the major co-receptor for the entry of human immunodeficiency virus (HIV). Recently, CCR5 inhibitors have been developed and used for the treatment o...

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Bibliographic Details
Published inInternational journal of oral biology Vol. 44; no. 4; pp. 173 - 181
Main Authors Oh, Eun-Ji, Zang, Yaran, Kim, Jung-Woo, Lee, Mi Nam, Song, Ju Han, Oh, Sin-Hye, Kwon, Seung Hee, Yang, Jin-Woo, Koh, Jeong-Tae
Format Journal Article
LanguageKorean
Published 대한구강생물학회 31.12.2019
Subjects
치의학
Aging
Osteoporosis
Receptors
CCR5
Online AccessGet full text
ISSN1226-7155
2287-6618

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Table of Contents:
  • Introduction Materials and Methods 1. 실험 동물 2. 마이크로전산화단층촬영(microCT) 3. 골지표 분석 및 3차원 이미지 재구성 4. 조직학적 관찰 5. 통계 분석 Results 1. 12개월령 CCR5 결핍 마우스에서 대퇴골 및 경골의 변화 2. 18개월령 CCR5 결핍 마우스에서 대퇴골 및 경골의 변화 Discussion References