자극성 섬유종, 구강백반증 및 구강편평세포암종에서 MMP-2 및 MMP-9 발현에 대한 면역조직화학적 연구

• Published in: Journal of the Korean Association of Oral and Maxillofacial Surgeons Vol. 32; no. 4; pp. 352 - 359
• Main Authors: 김문기(Moon-Key Kim), 이은하(Eun-Ha Lee), 김진(Jin Kim), 이의웅(Eui-Woong Lee), 차인호(In-Ho Cha)
• Format: Journal Article
• Language: Korean
• Published: 대한구강악안면외과학회 30.08.2006; Korean Association Of Oral And Maxillofacial Surgeons
• Subjects: 치의학
• ISSN: 2234-7550; 2234-5930

MMP-2 and MMP-9, type IV collagenases which degrade basement membrane, have been known to play important roles in invasion and metastasis of tumor cells, In addition, they seem to be involved in cell differentiation, apoptosis, angiogenesis and immunity, etc. We immunohistochemically examined epithelial and stromal expressions of MMP-2 and MMP-9 in irritation fibroma, oral leukoplakia, and oral squamous cell carcinoma (OSCC) and have some results as follows: 1. Irritation fibromas, oral leukoplakias and OSCCs mostly showed increased expression of MMP-2 and MMP-9 in the epithelium and connective tissue compared with normal mucosa. 2. There was a significant difference in the epithelial expression of MMP-2 and MMP-9 between irritation fibroma and oral leukoplakia. 3. There was a significant difference in the epithelial and stromal expression of MMP-2 and MMP-9 between irritation fibroma and OSCC. 4. There was a significant difference in the stromal expression of MMP-9 between oral leukoplakia and OSCC. We concluded that rritation fibroma, oral leukoplakia and OSCC have somewhat different characteristics of MMP-2 and MMP-9 expressions, which perhaps result from different pathogenesis. KCI Citation Count: 1