안정된 만성 폐쇄성 폐질환환자와 급성 악화상태의 혈중 Osteopontin 농도 비교

• Published in: Tuberculosis and respiratory diseases Vol. 71; no. 3; pp. 195 - 201
• Main Authors: 마정은, Jeong Eun Ma, 이승훈, Seung Hun Lee, 김유은, Yu Eun Kim, 임수진, Su Jin Lim, 이승준, Seung Jun Lee, 정이영, Yi Yeong Jeong, 김호철, Ho Cheol Kim, 이종덕, Jong Deog Lee, 황영실, Young Sil Hwang, 조유지, Yu Ji Cho
• Format: Journal Article
• Language: Korean
• Published: 대한결핵 및 호흡기학회 30.09.2011; 대한결핵및호흡기학회
• Subjects: Chronic Obstructive; Disease Exacerbation; Biological Markers; Osteopontin; Pulmonary Disease; 내과학; Osteopontin; Disease Exacerbation; Biological Markers; Pulmonary Disease, Chronic Obstructive
• ISSN: 1738-3536; 2005-6184

Background: Osteopontin (Opn) is recognized as an important adhesive bone matrix protein and a key cytokine involved in immune cell recruitment and tissue repair and remolding. However, serum levels of osteopontin have not been evaluated in patients with chronic obstructive pulmonary disease (COPD). Thus, the aim of this study was to evaluate and compare the serum levels of osteopontin in patients experiencing COPD exacerbations and in patients with stable COPD. Methods: Serum samples were obtained from 22 healthy control subjects, 18 stable COPD patients, and 15 COPD with exacerbation patients. Serum concentrations of osteopontin were measured by the ELISA method. Results: Serum levels of osteopontin were higher in patients with acute exacerbation than with stable COPD and in healthy control subjects (62.4±51.9 ng/mL, 36.9±11.1 ng/mL, 30±11 ng/mL, test for trend p=0.003). In the patients with COPD exacerbation, the osteopontin levels when the patient was discharged from the hospital tended to decrease compared to those at admission (45±52.1 ng/mL, 62.4±51.9 ng/mL, p=0.160). Osteopontin levels significantly increased according to patient factors, including never-smoker, ex-smoker and current smoker (23±5.7 ng/mL, 35.5±17.6 ng/mL, 58.6±47.8 ng/mL, test for trend p=0.006). Also, osteopontin levels showed a significantly negative correlation with forced expiratory volume in one second (FEV1%) predicted in healthy controls and stable COPD patients (r=?0.389; p=0.013). C-reactive protein (CRP) was positively correlated with osteopontin levels in patients with COPD exacerbation (r=0.775; p=0.002). Conclusion: The serum levels of osteopontin increased in patients with COPD exacerbation and tended to decrease after clinical improvement. These results suggest the possible role of osteopontin as a biomarker of acute exacerbation of COPD.