변이형 협심증 환자에 대한 한약병용치료의 효과 : 체계적 문헌고찰과 메타분석

• Published in: 대한한방내과학회지 Vol. 45; no. 6; pp. 1071 - 1099
• Main Authors: 권성은, 전현영, 권정남, Seong-eun Kwon, Hyeon-yeong Jeon, Jung-nam Kwon
• Format: Journal Article
• Language: Korean
• Published: 대한한방내과학회 01.12.2024
• Subjects: 한의학; Korean medicine; meta-analysis; variant angina; systemic review; herbal medicine
• ISSN: 1226-9174
• DOI: 10.22246/jikm.2024.45.6.1071

Objective: The aim was to compare the effectiveness of traditional Korean herbal medicine versus conventional management in patients with variant angina. Methods: We searched several databases, including five international databases and five domestic electronic databases, for relevant studies. A search was conducted using keywords such as "Korean medicine", "Chinese medicine", and "variant angina pectoris" on February 28, 2024. Two review authors independently extracted the data. We assessed the risk of systemic errors by evaluating risk domains using the Cochrane risk of bias tool. When appropriate, meta-analyses were performed. Results: Twenty-nine trials were included in the review. For these reports, a meta-analysis was performed using RevMan 5.3. The meta-analysis showed that the treatment group (herbal medicine combined with Western medicine) had a significantly higher clinical effective rate and ECG effective rate than the control group (Western medicine only) (OR 4.56 95% CI 3.43 to 6.07, P<0.00001, I2=0%) (OR 3.20 95% CI 2.07 to 4.93, P<0.00001, I2=0%). The treatment group also showed a significantly reduced frequency and duration of angina (MD -1.77 95% CI -2.08 to -1.46, P=0.006, I2=50%) (MD -1.51 95% CI -2.24 to -0.78, P<0.00001, I2=0%). Conclusion: This systematic review and meta-analysis suggests that the combined treatment of herbal medicine and Western medicine can be effective in treating variant angina. However, the results might be somewhat biased because of the unknown or high risk of bias in the included trials and the insufficiency of subgroup studies. Therefore, further studies should consider a large number of high-quality clinical studies.