방사모드에 따른 레이저 치료 효과

• Published in: Journal of biomedical engineering research Vol. 37; no. 4; pp. 134 - 139
• Main Authors: 최덕수, 임현수, 이병구, 네클라 커나르, Choi, Deog Su, Lim, Hyun Soo, Lee, Byung Koo, Kenar, Necla
• Format: Journal Article
• Language: Korean
• Published: 대한의용생체공학회 01.09.2016
• Subjects: 의공학; 5-aminolevulinic acid hydrochloride (ALA-5); Burst pulse mode; Photo Dynamic Therapy (PDT); Continuous Wave mode (CW); Pulse mode
• ISSN: 1229-0807; 2288-9396

US Food and Drug Administration (FDA) approved as a innovative cure for cancer, 1996. The effect is death of cancer cells through necrosis, apoptosis. Mainly the Continuous Wave mode (CW) use for PDT Laser. It sting, the question including itch, and etc. Reportedly, the increase of temperature with the perforated edema, ulcer, necrosis. The Thermal relaxation time and Oxygen recovery time is necessary. To give a normal oxygen recovery time of the cell, used Pulse mode. Progress, it was Burst Pulse mode when easing the thermal wake, the simplicity was secured, the PDT effect is good. Excepted in control group CW, Pulse, Burst pulse mode were incubated with various concentrations of 5-aminolevulinic acid hydrochloride (ALA-5). The tumor size reduction CW mode (44%), Pulse mode (48%), Burst pulse mode (53%) at 4 week after PDT with 0.3, 0.3, 0.3 mg/ml of ALA-5. After 4 hours, investigation of 100, 100, $100J/cm^2$ laser irradiation. The pulse mode was superior in expirimental data analysis. And it was the Burst pulse mode edge head of a family effect.