진단 전 흡연과 음주 행태와 위암 환자의 생존율: 전향적 환자 코호트 연구

• Published in: The Korean journal of gastroenterology Vol. 73; no. 3; pp. 141 - 151
• Main Authors: 김신아, Shin Ah Kim, 최보율, Bo Youl Choi, 송규상, Kyu Sang Song, 박찬혁, Chan Hyuk Park, 은창수, Chang Soo Eun, 한동수, Dong Soo Han, 김용성, Yong Sung Kim, 김현자, Hyun Ja Kim
• Format: Journal Article
• Language: Korean
• Published: 대한소화기학회 31.03.2019
• Subjects: Drinking; Prospective studies; Smoking; Stomach neoplasms; Survival; 내과학
• ISSN: 1598-9992; 2233-6869

Background/Aims: Behavioral factors, such as smoking and heavy alcohol consumption, increase the risk of gastric cancer (GC), but their effects on survival are not clear. We examined associations between prediagnostic smoking and alcohol drinking behavior and GC death by long-term follow-up. Methods: The participants were 508 GC patients enrolled at Chungnam University Hospital and Hanyang University Guri Hospital from 2001 to 2006. Information on clinicopathologic and behavioral risk factors was collected, and patient survival was prospectively followed until 2016 by medical chart review and telephone survey. Results: During above 10 years follow-up period, overall death was 46.2% (n=226) and GC deaths was 38.2% (n=187) among the 489 GC patients included in the analysis. No significant association was found between smoking habits and overall or GC survival. However, after stratification by histological type, the hazard ratio (HR) of GC death for current smokers tended to be higher for the diffuse type (HR 1.61, 95% CI 0.57-4.59 for current vs. never) rather than for the intestinal type (HR 0.78, 95% CI 0.28-2.19 for current vs. never). Light alcohol consumption was found to be associated with a significantly lower risk of GC death (HR 0.52, 95% CI 0.36-0.75 for <20 g/day for women or <40 g/day for men vs. never and past), and the effects of alcohol drinking habits had similar effects on GC death for the intestinal and diffuse types. Conclusions: These results suggest smoking and alcohol drinking behaviors before a diagnosis of GC are weakly associated with GC survival. Nevertheless, the effect of smoking behavior on prognosis appears to depend on the histological type of GC. (Korean J Gastroenterol 2019;73:141-151)