장피부 누공을 동반한 베체트 장염 환자를 Adalimumab으로 치료한 1예

• Published in: Journal of rheumatic diseases Vol. 19; no. 3; pp. 147 - 151
• Main Authors: 오일환, Il Hwan Oh, 김진옥, Jin Ok Kim, 변영재, Young Jae Byun, 성윤경, Yoon Kyoung Sung, 최찬범, Chan Bum Choi, 김태환, Tae Hwan Kim, 전재범, Jae Bum Jun, 엄완식, Wan Sik Uhm
• Format: Journal Article
• Language: Korean
• Published: 대한류마티스학회 30.06.2012
• Subjects: Adalimumab; Behcet`s disease; Intestine; TNF-α; 내과학
• ISSN: 2093-940X; 2233-4718

Behcet`s disease (BD) is a multisystemic disorder, which is characterized by recurrent oral aphthous ulcers, genital ulcers, uveitis, and skin lesion. Although intestinal involvement is an uncommon manifestation of the BD, it leads to a poor prognosis, as a result of a high complication, such as intestinal perforation, fistula formation, and massive hemorrhage. Intestinal BD has the tendency for the resistance to conventional medical treatment, and it often requires a surgical intervention because of severe complication. Although the causes of intestinal BD are unknown, some studies show that tumor necrosis factor Alpha (TNF-α) plays a key role in the pathogenesis of BD. Therefore, anti- TNF-α monoclonal antibody, such as adalimumab, is one of the useful treatment for refractory and relapsed intestinal BD. We describe a patient who had intestinal BD complicated enterocutanous fistula with a good response to adalimumab.