사용 전 베타락탐 항생제 피부시험의 유용성에 대한 전문가 의견

• Published in: Allergy asthma & respiratory disease pp. 3 - 8
• Main Authors: 김성렬, 김수정, 김세훈, 박종숙, 박혜정, 서동인, 심다운, 양민석, 이재현, 이화영, 정재우, 최미라, 강혜련
• Format: Journal Article
• Language: Korean
• Published: 대한 소아알레르기 호흡기학회 30.01.2022
• Subjects: 소아과학
• ISSN: 2288-0402; 2288-0410
• DOI: 10.4168/aard.2022.10.1.3

An allergy skin test is used to diagnose certain allergies by identifying sensitized allergens. In other words, it is a test for patients who are already sensitized to certain allergens. Because of the prevailing perception that beta-lactam allergy can be dangerous and potentially lethal, the intradermal test has long been routinely performed before use to screen beta-lactam allergy in Korea. The prevalence of penicillin allergy is estimated to be 1% to 2%. However, only 14% of the subjects with perceived penicillin allergy is considered to have true penicillin allergy. Moreover, it is difficult to justify performing a skin test on subjects who are very unlikely to be sensitized to beta-lactam, such as those who never used beta-lactam or never experienced allergy after previous use of beta-lactam. Therefore, allergists recommend beta-lactam skin testing in those who have allergy after the use of beta-lactam. Nevertheless, many hospitals in Korea are conducting routine skin tests on patients regardless of a history of beta-lactam allergy, which are not clinically validated but consume considerable human and material resources. False-positive results can consequently result in inappropriate labeling of beta-lactam allergy, leading to the unnecessary restriction of medication prescriptions and the increase in medical expenses. Herein, the drug allergy working group affiliated with the Korean Academy of Asthma, Allergy, and Clinical Immunology announces an expert opinion on the preuse beta-lactam skin test for subjects without a history of beta-lactam allergy based on the objective evidence from the literature and clinical relevance. KCI Citation Count: 0