방사선 투과성 담낭결석에 대한 경구 담즙산 제제 ( ursodeoxycholic acid ) 의 용해 효과

• Published in: The Korean journal of gastroenterology Vol. 27; no. 4; pp. 457 - 462
• Main Authors: 김명환, Myung Hwan Kim, 유병무, Byeong Moo Yoo, 박선미, Seon Mee Park, 김석균, Suk Gyun Kim, 송일한, Il Han Song, 최호순, Ho Soon Choi, 이성구, Sung Goo Lee, 서동진, Dong Jin Suh, 민영일, Young Il Min
• Format: Journal Article
• Language: Korean
• Published: 대한소화기학회 01.01.1995
• Subjects: Calculi; Gallbladder; Radiolucent stones; Ursodeoxycholic acid
• ISSN: 1598-9992

Background/Aims: The gallstone composition among Asians is known to be different from that of Caucasians. Thus, we tested the hypothesis that the dissolution rate of radiolucent gallbladder stones by oral bile acid may be different between Koreans and Caucasians. Methods: Sixty patients with radiolucent gallbladder stones were treated with ursodeoxycholic acid(10mg/kg) for 6 months. Abdominal ultrasonogram was measured monthly for evaluation of complete dissolution. Results: Complete dissolution of gallstones occurred in 7 patients(l2%), especially in the patients with gallstone diameter5mm. However, symptoms of biliary colic and dyspepsia were relieved during ursodeoxycholic acid treatment in 30(75%) out of 40 patients, without relationship to complete dissolution. Conclusion: The complete dissolution rate of radiolucent gallbladder stones by ursodeoxycholic acid is lower than that of Caucasians. This may be related to the mixing of' calcium bilirubinate and cholesterol stones in the radiolucent stones. Calcium bilirubinate stones of the gallbladder origin are not rare in Koreans and such stones commonly show radiolucency by simple abdominal x-ray film. (Korean J Gastroenterol 1995;27:457-462)