Glomus Tumor of the Palate Report of a Case and Review of the Literatures
A Glomus tumour is a benign neoplasm arising from the glomus cells which are located arteriovenous anastomosis in vascular plexus of skin and nail bed. In this paper, we report a case of glomus tumor arising in the palate and review of the literatures. A 21-year-old man presented with swelling measu...
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| Published in | The Journal of Showa University Dental Society Vol. 25; no. 1; pp. 6 - 10 |
|---|---|
| Main Authors | , , , , , , , , |
| Format | Journal Article |
| Language | Japanese |
| Published |
Showa University Dental Society
31.03.2005
昭和大学・昭和歯学会 |
| Subjects | |
| Online Access | Get full text |
| ISSN | 0285-922X 2186-5396 |
| DOI | 10.11516/dentalmedres1981.25.6 |
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| Abstract | A Glomus tumour is a benign neoplasm arising from the glomus cells which are located arteriovenous anastomosis in vascular plexus of skin and nail bed. In this paper, we report a case of glomus tumor arising in the palate and review of the literatures. A 21-year-old man presented with swelling measuring 3 cm in diameter in the hard and soft palate. Histopathological examination showed a well-circumscribed nodule formation in submucosa. Tumor cells were uniform shape and composed of solid proliferation with showed the pattern of nonepithelial neoplasm where the individual cells are surrounded by reteticulin fibers. Immunohistochemical staining, vimentin, alpha smooth muscle actin and HHF-35 were positive and keratin, desmin, S-100 protein and factor VIII were negative in tumor cells. Our review of the literature revealed 24 reported cases of glomus tumor and appeared that a predilection of the palate (34.7%), male predominance (1.6 : 1) and slow growth. |
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| AbstractList | A Glomus tumour is a benign neoplasm arising from the glomus cells which are located arteriovenous anastomosis in vascular plexus of skin and nail bed. In this paper, we report a case of glomus tumor arising in the palate and review of the literatures. A 21-year-old man presented with swelling measuring 3 cm in diameter in the hard and soft palate. Histopathological examination showed a well-circumscribed nodule formation in submucosa. Tumor cells were uniform shape and composed of solid proliferation with showed the pattern of nonepithelial neoplasm where the individual cells are surrounded by reteticulin fibers. Immunohistochemical staining, vimentin, alpha smooth muscle actin and HHF-35 were positive and keratin, desmin, S-100 protein and factor VIII were negative in tumor cells. Our review of the literature revealed 24 reported cases of glomus tumor and appeared that a predilection of the palate (34.7%), male predominance (1.6 : 1) and slow growth. A Glomus tumour is a benign neoplasm arising from the glomus cells which are located arteriovenous anastomosis in vascular plexus of skin and nail bed. In this paper, we report a case of glomus tumor arising in the palate and review of the literatures. A 21-year-old man presented with swelling measuring 3 cm in diameter in the hard and soft palate. Histopathological examination showed a well-circumscribed nodule formation in submucosa. Tumor cells were uniform shape and composed of solid proliferation with showed the pattern of nonepithelial neoplasm where the individual cells are surrounded by reteticulin fibers.Immunohistochemical staining, vimentin, alpha smooth muscle actin and HHF-35 were positive and keratin, desmin, S-100 protein and factor VIII were negative in tumor cells. Our review of the literature revealed 24 reported cases of glomus tumor and appeared that a predilection of the palate (34.7%), male predominance (1.6 : 1) and slow growth. グロームス腫瘍は皮膚や爪床にある血管叢内の動静脈吻合部にみられる糸球細胞 (glomus cells) 由来の腫瘍である.今回, 我々は若年者の口蓋に発生したグロームス腫瘍の一例を経験したので, 文献的考察と合わせて報告する.患者は21歳, 男性.左側硬口蓋から軟口蓋にかけて直径約3cm大の粘膜下腫瘤を認めた.病理組織学的には粘膜上皮下に線維性被膜構造を有する結節性病変がみられた.腫瘍細胞は比較的均一な大きさの円形もしくは類円形を呈し, 充実性に増殖していた.また, 内皮細胞を有する血管腔を認めた.銀染色では個々の腫瘍細胞が好銀線維に取り囲まれる非上皮性腫瘍の染色patternを示した.免疫染色では, 腫瘍細胞はVimentin, α-Smooth muscleactin, HHF-35に陽性であり, Keratin, Desmin, S-100蛋白, FactorVIIIに陰性であった.文献的には, 口腔領域に生じたグロームス腫瘍の報告例は渉猟し得た限りにおいて23例であった.口腔ではグロームス腫瘍は口蓋に生じることが多く (34.7%), 男女比は1.6 : 1であり, 発育は緩慢である.グロームス腫瘍は皮膚や爪床にある血管叢内の動静脈吻合部にみられる糸球細胞 (glomus cells) 由来の腫瘍である.口腔領域における本腫瘍の発生は稀である. |
| Author | TACHIKAWA, Tetsuhiko TAKARADA, Mie MAEDA, Yukiko NAGUMO, Masao NAGOSHI, Yuki AIDA, Tadateru IRIE, Tarou MATSUI, Yoshirou YAMAMOTO, Gou |
| Author_FL | 松井 義郎 前田 由紀子 立川 哲彦 宝田 三恵 名越 有紀 相田 忠輝 入江 太朗 南雲 正男 山本 剛 |
| Author_FL_xml | – sequence: 1 fullname: 前田 由紀子 – sequence: 2 fullname: 入江 太朗 – sequence: 3 fullname: 山本 剛 – sequence: 4 fullname: 名越 有紀 – sequence: 5 fullname: 相田 忠輝 – sequence: 6 fullname: 宝田 三恵 – sequence: 7 fullname: 松井 義郎 – sequence: 8 fullname: 南雲 正男 – sequence: 9 fullname: 立川 哲彦 |
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| References | 8) Herbst WM, Nakayama K, Hornstein OP : Glomus tumors of the skin. Br J Dermatol, 124 : 172-176, 1991 14) Saku T, Okabe H, Matsutani K, Sasaki M : Glomus tumor of the cheek : An immunohistochemical demonstration of actin and myosin. Oral Surg Oral Med Oral Pathol, 60 : 65-71, 1985 13) Moody GH, Myskow M, Musgrove C : Glomus tumor of the lip. A case report and immunohistochemical study. Oral Surg Oral Med Oral Pathol, 62 : 312-318, 1986 1) Masson P : Le glomus neuromyoarterial des regions tctiles et ses tumeurs. Lyon Chir, 21 : 257, 1924 16) Geraghty JM, Thomas RWN, Robertson JM, Blundell JW : Glomus tumor of the palate : Case report and review of the literature. Br J Oral Maxillofac Surg, 30 : 398-400, 1992 7) Gould EW, Manivel JC, Albores-Saavedra J, Monforte H : Locally infiltrative glomus tumors and glomangiosarcomas. Cancer, 65 : 310-318, 1990 9) 徐 信夫, 草壁秀成, 伊木まり子, 清金公裕, 安原稔 : グロムス腫瘍-その3症例と免疫組織化学的検討-.耳鼻咽喉, 35 : 361-367, 1993 10) Stajcic Z, Bojic P : Intraoral glomus tumour. A case report. J Craniomaxillofac Surg, 15 : 376-378, 1987 12) Sakashita H, Miyata M, Nagao K : Glomus tumor in the upper lip. A case report. Int J Oral Maxillofac Surg, 26 : 301-302, 1997 5) Hegyi L, Cormack GC, Grant W : Histochemical investigation into the molecular mechanisms of transformation in a benign glomus tumor. J Clin Pathol, 51 : 872-874, 1998 6) Schüirch W, Skalli 0, Lagace R, Seemayer TA, Gabbiani G : Intermediate filament proteins and actin isoforms as markers for soft-tissue tumor differentiation and origin. Am J Pathol, 136 : 771-786, 1990 3) Shugart RR, Soule EH, Johnson EW : Glomus tumor. Surg Gynecol Obstet, 117 : 334, 1963 11) Ficarra G, Merrell PW, Johnson WH, Hansen LS : Intraoral solitary glomus tumor (glomangioma) : Case report and literature review. Oral Surg Oral Med Oral Pathol, 62 : 306-311, 1986 4) 飯島宗一, 石川栄世, 影山圭三, 島峰徹郎, 吉利和 : 病理学大系神経・血管・リンパ管・結合組織・脂肪組織・筋・骨格系腫瘍, 19C : 120-121, 1992 15) Kessaris P, Klimis T, Zanakis S : Glomus tumors of the hard palate : Case report and reviews. Br J Oral Maxillofac Surg, 39 : 478-479, 2001 2) Enzinger FM, Weiss WW : Glomus tumor. In Soft tissue tumors, 2nd Ed., pp 581-595 |
| References_xml | – reference: 2) Enzinger FM, Weiss WW : Glomus tumor. In Soft tissue tumors, 2nd Ed., pp 581-595 – reference: 7) Gould EW, Manivel JC, Albores-Saavedra J, Monforte H : Locally infiltrative glomus tumors and glomangiosarcomas. Cancer, 65 : 310-318, 1990 – reference: 10) Stajcic Z, Bojic P : Intraoral glomus tumour. A case report. J Craniomaxillofac Surg, 15 : 376-378, 1987 – reference: 16) Geraghty JM, Thomas RWN, Robertson JM, Blundell JW : Glomus tumor of the palate : Case report and review of the literature. Br J Oral Maxillofac Surg, 30 : 398-400, 1992 – reference: 13) Moody GH, Myskow M, Musgrove C : Glomus tumor of the lip. A case report and immunohistochemical study. Oral Surg Oral Med Oral Pathol, 62 : 312-318, 1986 – reference: 15) Kessaris P, Klimis T, Zanakis S : Glomus tumors of the hard palate : Case report and reviews. Br J Oral Maxillofac Surg, 39 : 478-479, 2001 – reference: 5) Hegyi L, Cormack GC, Grant W : Histochemical investigation into the molecular mechanisms of transformation in a benign glomus tumor. J Clin Pathol, 51 : 872-874, 1998 – reference: 8) Herbst WM, Nakayama K, Hornstein OP : Glomus tumors of the skin. Br J Dermatol, 124 : 172-176, 1991 – reference: 4) 飯島宗一, 石川栄世, 影山圭三, 島峰徹郎, 吉利和 : 病理学大系神経・血管・リンパ管・結合組織・脂肪組織・筋・骨格系腫瘍, 19C : 120-121, 1992 – reference: 1) Masson P : Le glomus neuromyoarterial des regions tctiles et ses tumeurs. Lyon Chir, 21 : 257, 1924 – reference: 9) 徐 信夫, 草壁秀成, 伊木まり子, 清金公裕, 安原稔 : グロムス腫瘍-その3症例と免疫組織化学的検討-.耳鼻咽喉, 35 : 361-367, 1993 – reference: 11) Ficarra G, Merrell PW, Johnson WH, Hansen LS : Intraoral solitary glomus tumor (glomangioma) : Case report and literature review. Oral Surg Oral Med Oral Pathol, 62 : 306-311, 1986 – reference: 14) Saku T, Okabe H, Matsutani K, Sasaki M : Glomus tumor of the cheek : An immunohistochemical demonstration of actin and myosin. Oral Surg Oral Med Oral Pathol, 60 : 65-71, 1985 – reference: 6) Schüirch W, Skalli 0, Lagace R, Seemayer TA, Gabbiani G : Intermediate filament proteins and actin isoforms as markers for soft-tissue tumor differentiation and origin. Am J Pathol, 136 : 771-786, 1990 – reference: 3) Shugart RR, Soule EH, Johnson EW : Glomus tumor. Surg Gynecol Obstet, 117 : 334, 1963 – reference: 12) Sakashita H, Miyata M, Nagao K : Glomus tumor in the upper lip. A case report. Int J Oral Maxillofac Surg, 26 : 301-302, 1997 |
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| Title | Glomus Tumor of the Palate Report of a Case and Review of the Literatures |
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