ANALYSIS OF ACUTE MYELOID LEUKEMIA IN SHOWA UNIVERSITY HOSPITAL IN PAST TEN YEARS

We retrospectively analyzed the pathology and prognosis of 111 pts with acute myeloid leukemia （AML） in the past 10 years in the Showa University Hospital; 52.2％ of the patients was over 65 years old and 28.8％ had a diagnosis of AML with MRC. Overall survival （OS） was 34.5％ and median survival time...

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Published inJournal of The Showa University Society Vol. 79; no. 6; pp. 725 - 733
Main Authors FUJIWARA, Shun, TSUKAMOTO, Hiroyuki, SAITO, Bungo, HATTORI, Norimichi, ARAI, Nana, NAKAMAKI, Tsuyoshi, WATANUKI, Megumi, YANAGISAWA, Kouji
Format Journal Article
LanguageJapanese
Published The Showa University Society 2020
昭和大学学士会
Subjects
acute myeloid leukemia （AML）
aging
AML with MRC
targeted therapy
層別化治療
急性骨髄性白血病
高年齢化
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ISSN2187-719X
2188-529X
DOI10.14930/jshowaunivsoc.79.725

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Summary:We retrospectively analyzed the pathology and prognosis of 111 pts with acute myeloid leukemia （AML） in the past 10 years in the Showa University Hospital; 52.2％ of the patients was over 65 years old and 28.8％ had a diagnosis of AML with MRC. Overall survival （OS） was 34.5％ and median survival time was 22 months. Multivariate analysis showed that age and gender significantly influenced OS of patients. Except for t（15；17）, the significance of karyotype was limited. SCT did not significantly improve OS of AML. Introduction of a further targeted therapy based on the molecular pathology and a decrease non-relapse mortality in SCT appeared to be important to improve survival of AML of high age elderly.
ISSN:2187-719X
2188-529X
DOI:10.14930/jshowaunivsoc.79.725