下垂体前葉ホルモン分泌調節における dopamine 作働性機構の加齢に伴う変動 (I) dopamine に対する反応性の変動
中枢性 dopamine (DA) neuron の視床下部-下垂体前葉ホルモン分泌調節への関与が注目されているが, その加齢に伴う推移変動を検索するために, 健常若年男子14例及び老年男子23例にDAを持続注入し, 血中LH, FSH, GH, PRLのDAに対する反応性を若年老年両群間で比較検討した. さらに老年群をその血中 testosterone (T) 値から403ng/dl以上をT高値老年群, 403ng/dl以下をT低値老年群に大別し, このT低値老年群に T propionate (TP) 10mg/日, 3日間連続筋注し, 再度DA負荷試験を実施し, TP投与前後で血中LHの...
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| Published in | 日本老年医学会雑誌 Vol. 23; no. 3; pp. 264 - 270 |
|---|---|
| Main Authors | , , , |
| Format | Journal Article |
| Language | Japanese |
| Published |
一般社団法人 日本老年医学会
30.05.1986
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| Subjects | |
| Online Access | Get full text |
| ISSN | 0300-9173 |
| DOI | 10.3143/geriatrics.23.264 |
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| Abstract | 中枢性 dopamine (DA) neuron の視床下部-下垂体前葉ホルモン分泌調節への関与が注目されているが, その加齢に伴う推移変動を検索するために, 健常若年男子14例及び老年男子23例にDAを持続注入し, 血中LH, FSH, GH, PRLのDAに対する反応性を若年老年両群間で比較検討した. さらに老年群をその血中 testosterone (T) 値から403ng/dl以上をT高値老年群, 403ng/dl以下をT低値老年群に大別し, このT低値老年群に T propionate (TP) 10mg/日, 3日間連続筋注し, 再度DA負荷試験を実施し, TP投与前後で血中LHのDAに対する反応性を比較検討した. 1) 若年群ではDA負荷後血中PRLの著明低下, 血中GHの有意上昇を認めたが, 血中LHは有意の変動を示さなかった. 一方, 老年群では血中PRLは若年群と同程度の低下反応を示したが, 血中GHは若年群よりもより強い上昇反応を示した. また血中LHはDA負荷後有意の低下反応を示した. 特にT低値老年群の血中LH及びGHのDAに対する反応性は若年群と比較して有意の高値を示した (p<0.01, p<0.05). 2) T低値老年群においてTP 10mg/日3日間筋注負荷により, 血中LHのDAに対する反応性は有意の低下 (p<0.05) を示した. これらの成績は, 中枢性DA作働機構の視床下部-下垂体前葉ホルモンの分泌調節機能が加齢に伴い低下する可能性を示唆する. またTがDAによる視床下部-下垂体系の調節に関与する可能性が示唆される. |
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| AbstractList | 中枢性 dopamine (DA) neuron の視床下部-下垂体前葉ホルモン分泌調節への関与が注目されているが, その加齢に伴う推移変動を検索するために, 健常若年男子14例及び老年男子23例にDAを持続注入し, 血中LH, FSH, GH, PRLのDAに対する反応性を若年老年両群間で比較検討した. さらに老年群をその血中 testosterone (T) 値から403ng/dl以上をT高値老年群, 403ng/dl以下をT低値老年群に大別し, このT低値老年群に T propionate (TP) 10mg/日, 3日間連続筋注し, 再度DA負荷試験を実施し, TP投与前後で血中LHのDAに対する反応性を比較検討した. 1) 若年群ではDA負荷後血中PRLの著明低下, 血中GHの有意上昇を認めたが, 血中LHは有意の変動を示さなかった. 一方, 老年群では血中PRLは若年群と同程度の低下反応を示したが, 血中GHは若年群よりもより強い上昇反応を示した. また血中LHはDA負荷後有意の低下反応を示した. 特にT低値老年群の血中LH及びGHのDAに対する反応性は若年群と比較して有意の高値を示した (p<0.01, p<0.05). 2) T低値老年群においてTP 10mg/日3日間筋注負荷により, 血中LHのDAに対する反応性は有意の低下 (p<0.05) を示した. これらの成績は, 中枢性DA作働機構の視床下部-下垂体前葉ホルモンの分泌調節機能が加齢に伴い低下する可能性を示唆する. またTがDAによる視床下部-下垂体系の調節に関与する可能性が示唆される. |
| Author | 井林, 博 牟田, 和男 牧, 俊夫 加藤, 堅一 |
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| References | 11) Muta K, Kato K, Akamine Y, Ibayashi H: Age-related changes in the feedback regulation of gonadotrophin secretion by sex steroids in men. Acta Endocrinol 96: 154-162, 1981. 8) Ferrari C, Caldara R, Barbieri C, Testori GP, Benco R, Trezzi R, Crossignani RM, Rampini P: Central nervous system and pituitary mechanisms in dopaminergic stimulation of growth hormone release in women. Neuroendocrinol 32: 213-216, 1981. 21) Sparrow D, Bosse R: The influence of age, alcohol consumption and body fluid on gonadal function in men. J Clin Endocrinol Metab 51: 508-512, 1980. 22) 牟田和男, 牧俊夫, 加藤堅一, 井林博: 男子血中17-Hydroxyprogesterone の加齢に伴う変動. 日内分泌会誌59: 20-30, 1983. 4) Huseman CA, Kugler JA, Schneider IG: Mechanisms in dopaminergic suppression of gonadotropin in men. J Clin Endocrinol Metab 51: 209-214, 1980. 15) Gibbs DM, Neill JD: Dopamine levels in hypophysial stalk blood in the rat are sufficient to inhibit prolactin secretion. Endocrinol 102: 1895-1907, 1978. 9) Santen RJ, Bardin CW: Episodic luteinizing hormone secretion in man; pulse analysis, clinical interpretation, physiologic mechanism. J Clin Invest 52: 2617-2618, 1973. 13) Ohma H, Kato K, Takahashi H, Ibayashi H: The response of serum growth hormone to central and peripheral dopaminergic stimuli in normal subjects and in acromegalic patients. Fukuoka Acta Med 73: 179-188, 1982. 16) Schneider HPG, McCann SM: Possible role of dopamine as transmitter to promote discharge of LH-releasing factor. Endocrinol 85: 121-132, 1969. 17) MacLeod RM, Fontham EM, Lehmeyer JE: Prolactin and growth hormone production as influenced by catecholamines and agents that affect brain catecholamines. Neuroendocrinol 6: 283-294, 1970. 14) Sasahara K, Nitanai T, Habara T, Ninomiya A, Morioka T, Nakajima E: Dosage from design for improvement of bioavailability of levodopa. I. The determination of levodopa and its metabolites in plasma and urine for the bioavailability study of levodopa. Ann Rep Sankyo Res Lab 30: 65-83, 1978. 1) Leebaw WF, Lee LA, Woolf PD: Dopamine effects basal and augumented pituitary hormone secretion. J Clin Endocrinol Metab 47: 480-487, 1978. 5) Kaptein EM, Kletzky OA, Spencer CA, Nicoloff JT: Effects of prolonged dopamine infusion on anterior pituitary function in normal males. J Clin Endocrinol Metab 51: 488-491, 1980. 12) Wasada T: The changes in serum levels of FSH, LH, LH and -subunit, and prolactin and pituitary responsiveness to synthetic LH-RH and TRH in normal subjects with aging. Fukuoka Acta Med 69: 506-518, 1978. 2) Judd SJ, Rakoff JS, Yen SSC: Inhibition of gonadotropin and prolactin release by dopamine: Effect of endogenous estradiol levels. J Clin Endocrinol Metab 47: 494-498, 1978. 19) McNeill TH, Sladek JR: Fluorescence-immunocytochemistry: Stimultaneous localization of catecholamines and gonadotropin-releasing hormone. Science 200: 72-74, 1978. 6) Langer G, Sachar EJ, Halpern FS: Effect of dopamine and neuroleptics on plasma growth hormone and prolactin in normal men. Psychoneuroendocrinol 3: 165-169, 1977. 20) Martin JB: Neural regulation of growth hormone secretion. N Eng J Med 288: 1384-1393, 1973. 10) 牟田和男, 赤嶺康夫, 加藤堅一, 井林博: 老化と内分泌腺 (第11報). 老年者視床下部-下垂体-性腺機能の推移変動について. 日内分泌会誌56: 534, 1981. 3) Judd SJ, Rigg LA, Yen SSC: The effects of ovariectomy and estrogen treatment on the dopamine inhibition of gonadotropin and prolactin release. J Clin Endocrinol Metab 49: 182-184, 1979. 23) Carlsson A, Winblad B: Influence of age and time interval between death and autopsy on dopamine and 3-methoxytyramine levels in human basal ganglia. J Neurol Transmission 38: 271-276, 1976. 7) Bansel A, Lee LA, Woolf PD: Dopaminergic regulation of growth hormone (GH) secretion in normal man: Correlation of l-dopa and dopamine levels with the GH response. J Clin Endocrinol Metab 33: 301-306, 1981. 18) Rotszejn WH, Charli JL, Pattou E, Kordon C: Stimulation by dopamine of luteinizing hormone-releaseing hormone (LH-RH) release from the mediobasal hypothalamus in male rats. Endocrinol 101: 1475-1483, 1977. |
| References_xml | – reference: 5) Kaptein EM, Kletzky OA, Spencer CA, Nicoloff JT: Effects of prolonged dopamine infusion on anterior pituitary function in normal males. J Clin Endocrinol Metab 51: 488-491, 1980. – reference: 16) Schneider HPG, McCann SM: Possible role of dopamine as transmitter to promote discharge of LH-releasing factor. Endocrinol 85: 121-132, 1969. – reference: 19) McNeill TH, Sladek JR: Fluorescence-immunocytochemistry: Stimultaneous localization of catecholamines and gonadotropin-releasing hormone. Science 200: 72-74, 1978. – reference: 3) Judd SJ, Rigg LA, Yen SSC: The effects of ovariectomy and estrogen treatment on the dopamine inhibition of gonadotropin and prolactin release. J Clin Endocrinol Metab 49: 182-184, 1979. – reference: 8) Ferrari C, Caldara R, Barbieri C, Testori GP, Benco R, Trezzi R, Crossignani RM, Rampini P: Central nervous system and pituitary mechanisms in dopaminergic stimulation of growth hormone release in women. Neuroendocrinol 32: 213-216, 1981. – reference: 18) Rotszejn WH, Charli JL, Pattou E, Kordon C: Stimulation by dopamine of luteinizing hormone-releaseing hormone (LH-RH) release from the mediobasal hypothalamus in male rats. Endocrinol 101: 1475-1483, 1977. – reference: 7) Bansel A, Lee LA, Woolf PD: Dopaminergic regulation of growth hormone (GH) secretion in normal man: Correlation of l-dopa and dopamine levels with the GH response. J Clin Endocrinol Metab 33: 301-306, 1981. – reference: 1) Leebaw WF, Lee LA, Woolf PD: Dopamine effects basal and augumented pituitary hormone secretion. J Clin Endocrinol Metab 47: 480-487, 1978. – reference: 20) Martin JB: Neural regulation of growth hormone secretion. N Eng J Med 288: 1384-1393, 1973. – reference: 21) Sparrow D, Bosse R: The influence of age, alcohol consumption and body fluid on gonadal function in men. J Clin Endocrinol Metab 51: 508-512, 1980. – reference: 9) Santen RJ, Bardin CW: Episodic luteinizing hormone secretion in man; pulse analysis, clinical interpretation, physiologic mechanism. J Clin Invest 52: 2617-2618, 1973. – reference: 23) Carlsson A, Winblad B: Influence of age and time interval between death and autopsy on dopamine and 3-methoxytyramine levels in human basal ganglia. J Neurol Transmission 38: 271-276, 1976. – reference: 4) Huseman CA, Kugler JA, Schneider IG: Mechanisms in dopaminergic suppression of gonadotropin in men. J Clin Endocrinol Metab 51: 209-214, 1980. – reference: 13) Ohma H, Kato K, Takahashi H, Ibayashi H: The response of serum growth hormone to central and peripheral dopaminergic stimuli in normal subjects and in acromegalic patients. Fukuoka Acta Med 73: 179-188, 1982. – reference: 2) Judd SJ, Rakoff JS, Yen SSC: Inhibition of gonadotropin and prolactin release by dopamine: Effect of endogenous estradiol levels. J Clin Endocrinol Metab 47: 494-498, 1978. – reference: 10) 牟田和男, 赤嶺康夫, 加藤堅一, 井林博: 老化と内分泌腺 (第11報). 老年者視床下部-下垂体-性腺機能の推移変動について. 日内分泌会誌56: 534, 1981. – reference: 14) Sasahara K, Nitanai T, Habara T, Ninomiya A, Morioka T, Nakajima E: Dosage from design for improvement of bioavailability of levodopa. I. The determination of levodopa and its metabolites in plasma and urine for the bioavailability study of levodopa. Ann Rep Sankyo Res Lab 30: 65-83, 1978. – reference: 12) Wasada T: The changes in serum levels of FSH, LH, LH and -subunit, and prolactin and pituitary responsiveness to synthetic LH-RH and TRH in normal subjects with aging. Fukuoka Acta Med 69: 506-518, 1978. – reference: 15) Gibbs DM, Neill JD: Dopamine levels in hypophysial stalk blood in the rat are sufficient to inhibit prolactin secretion. Endocrinol 102: 1895-1907, 1978. – reference: 11) Muta K, Kato K, Akamine Y, Ibayashi H: Age-related changes in the feedback regulation of gonadotrophin secretion by sex steroids in men. Acta Endocrinol 96: 154-162, 1981. – reference: 6) Langer G, Sachar EJ, Halpern FS: Effect of dopamine and neuroleptics on plasma growth hormone and prolactin in normal men. Psychoneuroendocrinol 3: 165-169, 1977. – reference: 17) MacLeod RM, Fontham EM, Lehmeyer JE: Prolactin and growth hormone production as influenced by catecholamines and agents that affect brain catecholamines. Neuroendocrinol 6: 283-294, 1970. – reference: 22) 牟田和男, 牧俊夫, 加藤堅一, 井林博: 男子血中17-Hydroxyprogesterone の加齢に伴う変動. 日内分泌会誌59: 20-30, 1983. |
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| Snippet | 中枢性 dopamine (DA) neuron の視床下部-下垂体前葉ホルモン分泌調節への関与が注目されているが, その加齢に伴う推移変動を検索するために, 健常若年男子14例及び老年男... |
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| SubjectTerms | テストステロン ドパミン ドパミン作動機構 下垂体前葉ホルモン |
| Subtitle | (I) dopamine に対する反応性の変動 |
| Title | 下垂体前葉ホルモン分泌調節における dopamine 作働性機構の加齢に伴う変動 |
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