維持透析患者におけるrecombinant human erythropoietin投与と血漿分枝鎖アミノ酸濃度の変動
維持透析患者15例 (平均年齢45.8±9.5歳, 平均透析期間38.1±50.5か月) においてrHuEPO投与前後 (平均投与期間8.4±4.4か月) の血漿分枝鎖アミノ酸 (BCAA), 芳香族アミノ酸 (AAA), Fischer比の変動につき検討した. BCAAは平均363.6±70.3nmol/mlから317.3±72.0nmol/ml, valineは平均193.3±36.5nmol/mlから168.4±34.0nmol/ml, leucineは平均109.1±24.5nmol/mlから93.8±26.1nmol/ml, isoleucineは平均61.3±13.7nmol/ml...
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| Published in | 日本透析療法学会雑誌 Vol. 26; no. 10; pp. 1593 - 1597 |
|---|---|
| Main Authors | , , , , , , , , , , , |
| Format | Journal Article |
| Language | Japanese |
| Published |
社団法人 日本透析医学会
28.10.1993
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| Online Access | Get full text |
| ISSN | 0911-5889 1884-6211 |
| DOI | 10.4009/jsdt1985.26.1593 |
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| Abstract | 維持透析患者15例 (平均年齢45.8±9.5歳, 平均透析期間38.1±50.5か月) においてrHuEPO投与前後 (平均投与期間8.4±4.4か月) の血漿分枝鎖アミノ酸 (BCAA), 芳香族アミノ酸 (AAA), Fischer比の変動につき検討した. BCAAは平均363.6±70.3nmol/mlから317.3±72.0nmol/ml, valineは平均193.3±36.5nmol/mlから168.4±34.0nmol/ml, leucineは平均109.1±24.5nmol/mlから93.8±26.1nmol/ml, isoleucineは平均61.3±13.7nmol/mlから55.1±15.8nmol/mlといずれのBCAAとも有意な低下を示した. AAAは平均109.2±27.6nmol/mlから102.2±20.2nmol/mlと有意な変動を示さなかった. Fischer比は平均3.45±0.75から3.18±0.83と低下傾向が認められFischer比低下例ではBCAAの低下がより著明であった. 以上より, 維持透析患者におけるrHuEPO投与時, BCAAの補充の必要性が示唆された. |
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| AbstractList | 維持透析患者15例 (平均年齢45.8±9.5歳, 平均透析期間38.1±50.5か月) においてrHuEPO投与前後 (平均投与期間8.4±4.4か月) の血漿分枝鎖アミノ酸 (BCAA), 芳香族アミノ酸 (AAA), Fischer比の変動につき検討した. BCAAは平均363.6±70.3nmol/mlから317.3±72.0nmol/ml, valineは平均193.3±36.5nmol/mlから168.4±34.0nmol/ml, leucineは平均109.1±24.5nmol/mlから93.8±26.1nmol/ml, isoleucineは平均61.3±13.7nmol/mlから55.1±15.8nmol/mlといずれのBCAAとも有意な低下を示した. AAAは平均109.2±27.6nmol/mlから102.2±20.2nmol/mlと有意な変動を示さなかった. Fischer比は平均3.45±0.75から3.18±0.83と低下傾向が認められFischer比低下例ではBCAAの低下がより著明であった. 以上より, 維持透析患者におけるrHuEPO投与時, BCAAの補充の必要性が示唆された. |
| Author | 金子, 佳照 平尾, 佳彦 吉田, 克法 新井, 邦彦 永吉, 純一 岡島, 英五郎 矢和多, 多姫子 佐々木, 憲二 古川, 佳要子 丘田, 英人 影林, 頼明 本宮, 善恢 |
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| References | 4) 小関萬里, 池田義和, 東島哲也, 真嶋敏光, 中村健司, 岡本公子, 塚本豊久, 前田昌純: 栄養評価方法. 臨牀透析 7: 1689-1693, 1991 8) Bergström J, Alvestrand A, Furst P: Plasma and muscle free amino acids in maintenance hemodialysis patients without protein malnutrition. Kidney Int 38: 108-114, 1990 13) 望月隆弘: 腎不全におけるアミノ酸代謝. 腎と透析 (臨増): 141-145, 1992 7) 吉田 貴, 武藤泰敏: 分枝鎖アミノ酸. 医学のあゆみ 149: 280-282, 1989 2) 小出 輝: 慢性腎不全の代謝異常. 循環器科 3: 272-280, 1978 3) Fischer JE, Rosen HM, Ebeid AM, James JH, Keane JM, Soeters PB: The effect of normalization of plasma amino acids on hepatic encephlopathy in man. Surgery 80: 77-91, 1976 14) May RC, Kelly RA, Mitch WE: Mechanisms for defects in muscle protein metabolism in rats with chronic uremia: influence of metabolic acidosis. J Clin Invest 79: 1099-1103, 1986 15) May RC, Hara Y, Kelly RA, Block KP, Buse M, Mitch WE: Branched-chain amino acid metabolism in rat muscle: abnormal regulation in acidosis. Am J Physiol 252: E712-E718, 1987 6) Tizianello A, Deferrari G, Garibotto G, Robaudo C, Lutman M, Passerone G, Bruzzone M: Branched-chain amino acid metabolism in chronic renal failure. Kidney Int 24 (Suppl 16): 17-22, 1983 1) 水入苑生: 慢性腎不全での蛋白質・アミノ酸代謝異常の特徴. 臨牀透析 3: 191-195, 1987 12) Kokot F, Wiecek A, Grzeszczak W, Klin M, Zukowska-Szczechowska E: Influence of Erythropoietin Treatment on Glucose Tolerance, Insulin, Glucagon, Gastrin and Pancreatic Polypeptide Secretion in Haemodialyzed Patients with End-Stage Renal Failure. Erythropoietin in the 90s. Contrib Nephrol 87: 42-51, 1990 11) 山本正博, 篠原幸人: Hemodilution療法-急性期脳血管障害における有効性. CLINICAL NEUROSCIENCE 10: 194-197, 1992 5) Evans WJ, Fisher EC, Hoerr RA, Young VR: Protein metabolism and endurance exercise. The Physician And Sportsmedicine 11: 63-72, 1983 10) Barany P, Pettersson E, Ahlberg M, Hultman E, Bergström J: Nutritional assessment in anemic hemodialysis patients treated with recombinant human erythropoietin. Clinical Nephrol 35: 270-279, 1991 9) Riedel E, Hampl H, Scigalla P, Nundel M, Kessel M: Correction of amino acid metabolism by recombinant human erythropoietin therapy in hemodialysis patients. Kidney Int 36 (Suppl 27): 216-221, 1989 |
| References_xml | – reference: 5) Evans WJ, Fisher EC, Hoerr RA, Young VR: Protein metabolism and endurance exercise. The Physician And Sportsmedicine 11: 63-72, 1983 – reference: 8) Bergström J, Alvestrand A, Furst P: Plasma and muscle free amino acids in maintenance hemodialysis patients without protein malnutrition. Kidney Int 38: 108-114, 1990 – reference: 11) 山本正博, 篠原幸人: Hemodilution療法-急性期脳血管障害における有効性. CLINICAL NEUROSCIENCE 10: 194-197, 1992 – reference: 1) 水入苑生: 慢性腎不全での蛋白質・アミノ酸代謝異常の特徴. 臨牀透析 3: 191-195, 1987 – reference: 14) May RC, Kelly RA, Mitch WE: Mechanisms for defects in muscle protein metabolism in rats with chronic uremia: influence of metabolic acidosis. J Clin Invest 79: 1099-1103, 1986 – reference: 6) Tizianello A, Deferrari G, Garibotto G, Robaudo C, Lutman M, Passerone G, Bruzzone M: Branched-chain amino acid metabolism in chronic renal failure. Kidney Int 24 (Suppl 16): 17-22, 1983 – reference: 15) May RC, Hara Y, Kelly RA, Block KP, Buse M, Mitch WE: Branched-chain amino acid metabolism in rat muscle: abnormal regulation in acidosis. Am J Physiol 252: E712-E718, 1987 – reference: 4) 小関萬里, 池田義和, 東島哲也, 真嶋敏光, 中村健司, 岡本公子, 塚本豊久, 前田昌純: 栄養評価方法. 臨牀透析 7: 1689-1693, 1991 – reference: 2) 小出 輝: 慢性腎不全の代謝異常. 循環器科 3: 272-280, 1978 – reference: 9) Riedel E, Hampl H, Scigalla P, Nundel M, Kessel M: Correction of amino acid metabolism by recombinant human erythropoietin therapy in hemodialysis patients. Kidney Int 36 (Suppl 27): 216-221, 1989 – reference: 3) Fischer JE, Rosen HM, Ebeid AM, James JH, Keane JM, Soeters PB: The effect of normalization of plasma amino acids on hepatic encephlopathy in man. Surgery 80: 77-91, 1976 – reference: 10) Barany P, Pettersson E, Ahlberg M, Hultman E, Bergström J: Nutritional assessment in anemic hemodialysis patients treated with recombinant human erythropoietin. Clinical Nephrol 35: 270-279, 1991 – reference: 12) Kokot F, Wiecek A, Grzeszczak W, Klin M, Zukowska-Szczechowska E: Influence of Erythropoietin Treatment on Glucose Tolerance, Insulin, Glucagon, Gastrin and Pancreatic Polypeptide Secretion in Haemodialyzed Patients with End-Stage Renal Failure. Erythropoietin in the 90s. Contrib Nephrol 87: 42-51, 1990 – reference: 13) 望月隆弘: 腎不全におけるアミノ酸代謝. 腎と透析 (臨増): 141-145, 1992 – reference: 7) 吉田 貴, 武藤泰敏: 分枝鎖アミノ酸. 医学のあゆみ 149: 280-282, 1989 |
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| Title | 維持透析患者におけるrecombinant human erythropoietin投与と血漿分枝鎖アミノ酸濃度の変動 |
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