Scanning Electron Microscopic Studies on the Influence of Drug Spray on the Nasal Mucosa
The morphological changes of nasal mucosa after nasal spray with drugs such as decongestants, anesthetics, lysozyme chloride, beclomethasone dipropionate and physiolosical saline solution were examined with scanning electron microscopy in human subjects and in guinea pigs. In a clinical study, 18 ca...
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| Published in | OTOLOGIA FUKUOKA Vol. 29; no. 6; pp. 909 - 928 |
|---|---|
| Main Author | |
| Format | Journal Article |
| Language | Japanese |
| Published |
JIBI TO RINSHO KAI
20.11.1983
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| Online Access | Get full text |
| ISSN | 0447-7227 2185-1034 |
| DOI | 10.11334/jibi1954.29.6_909 |
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| Abstract | The morphological changes of nasal mucosa after nasal spray with drugs such as decongestants, anesthetics, lysozyme chloride, beclomethasone dipropionate and physiolosical saline solution were examined with scanning electron microscopy in human subjects and in guinea pigs. In a clinical study, 18 cases were investigated. The first group of cases composed of 11 with hypertrophic rhinitis and 5 with nasal allergy, were sprayed with a decongestant and anesthetic solution on one side of the nasal cavity for three to fourteen days before nasal operation undertaken. As a control, the other side was sprayed with only physiolosical saline solution. In two additional cases with nasal allergy, the nasal cavities were sprayed bilaterally with beclomethasone dipropionate for three days in one case and for over a month in the other. The specimens which were taken bilaterally by turbinectomies were observed by means of scanning electron microscopy. The characteristic changes of mucosal surface, such as squamous cell metaplasia, bulging of the, cell surface, swelling of microvilli, acceleration of secretion and cell destruction, were more marked in the drug-sprayed specimens compared with the control specimens. In an experimental study, 25 guinea pigs were divided into 5 groups and sprayed intranasally for fourteen days with decongestant, anesthetic, lysozyme chloride, beclomethasone dipropionate and physiological saline solution, respectively. The morphological characteristics of the nasal mucosa were indistinctness of the cell border, swelling of the cell surface and destruction of cell membrane with some ciliary damage. These morphological changes were most marked in the decongestant group followed by the anesthetic group. Little change was found in either the lysozyme group or the beclomethasone group. Topical treatments of the nose were evaluated and their clinical significance was discussed briefly. |
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| AbstractList | The morphological changes of nasal mucosa after nasal spray with drugs such as decongestants, anesthetics, lysozyme chloride, beclomethasone dipropionate and physiolosical saline solution were examined with scanning electron microscopy in human subjects and in guinea pigs. In a clinical study, 18 cases were investigated. The first group of cases composed of 11 with hypertrophic rhinitis and 5 with nasal allergy, were sprayed with a decongestant and anesthetic solution on one side of the nasal cavity for three to fourteen days before nasal operation undertaken. As a control, the other side was sprayed with only physiolosical saline solution. In two additional cases with nasal allergy, the nasal cavities were sprayed bilaterally with beclomethasone dipropionate for three days in one case and for over a month in the other. The specimens which were taken bilaterally by turbinectomies were observed by means of scanning electron microscopy. The characteristic changes of mucosal surface, such as squamous cell metaplasia, bulging of the, cell surface, swelling of microvilli, acceleration of secretion and cell destruction, were more marked in the drug-sprayed specimens compared with the control specimens. In an experimental study, 25 guinea pigs were divided into 5 groups and sprayed intranasally for fourteen days with decongestant, anesthetic, lysozyme chloride, beclomethasone dipropionate and physiological saline solution, respectively. The morphological characteristics of the nasal mucosa were indistinctness of the cell border, swelling of the cell surface and destruction of cell membrane with some ciliary damage. These morphological changes were most marked in the decongestant group followed by the anesthetic group. Little change was found in either the lysozyme group or the beclomethasone group. Topical treatments of the nose were evaluated and their clinical significance was discussed briefly. |
| Author | OHNO, Ikuo |
| Author_FL | 大野 郁夫 |
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| Author_xml | – sequence: 1 fullname: OHNO, Ikuo organization: Department of Otorhinolaryngology, School of Medicine, Kagoshima University |
| BackLink | https://cir.nii.ac.jp/crid/1390001205500954496$$DView record in CiNii |
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| DocumentTitleAlternate | 局所薬物療法の鼻粘膜上皮細胞におよぼす影響に関する走査電顕的研究 |
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| References | 40) 飯沼寿孝他: 点鼻薬乱用の病理組織所見. 耳展17: 73-79, 1974. 2) 三吉康郎: シンポジウム: 上部気道と下部気道の相関. 4. 上部気道の立場から. 気食29: 107-115, 1978. 49) 坂倉康夫・谷口強: ネブユライザー療法にともなう副作用について-アンケート調査による研究-. 耳喉52: 99-104, 1980. 15) 神田敬他: モルモット及び人間の嗅上皮の走査型電子顕微鏡による観察. 日耳鼻76: 739-743, 1973. 46) SACKNER M A: Mucociliary transport. Ann Otol 87: 474-483, 1978. 42) 三吉康郎他: 気管線毛上皮の薬物吸収に関する実験的研究. 耳鼻臨床65: 1119-1130, 1972. 16) OHNo I et al: Comparative anatomy of olfactory epithelium. Biomedical Research 2: 455-458, 1981. 18) 沢木修二他編: 臨床耳鼻咽喉科学 I. 中外医学社, 1976. 17) 檜学編: 現代の耳鼻咽喉科学. 金原出版, 1979. 9) TAKAGI S F: EOG Problems. Olfaction and Taste III 71 C Pfaffmann (ed) Rockefeller Univ Press New York, 1969. 21) YAMAMOTO M et al: Regeneration of olfactory bipolar neurons in the normal olfactory epithelium of the adult bat. Okajimas Fol Anat Jap 53: 291-304, 1976. 4) 三吉康郎: 喉頭全別出術の鼻粘膜変化におよぼす影響の形態学的研究. 耳鼻臨床49: 890-900, 1956. 3) 高坂知節他: 鼻副鼻腔粘膜病態の電子顕微鏡的研究. 耳鼻23: 623-645, 1977. 10) TAKAGI S F et al: The electropositive potential in the normal and degenerating olfactory epithelium. Olfaction and Taste III 92 C Pfaffmann (ed) Rockefeller Univ Press New York, 1969. 43) 坂倉康夫他: 鼻粘膜からの抗生物質の吸収について. 耳鼻臨床71: 467-472, 1978. 34) DUDLEY J P and CHERRY J D: Efect of topical anesthetics on ciliary activity of chicken embryo tracheal organ cultures. Ann Otol 87: 533-537, 1978. 27) 殿塚慎一郎・高橋誠: 急性鼻炎に対するviruseen Sprayの臨床使用経験. 耳喉38: 1119-1122, 1966. 41) MYGIND N et al: The nasal mucosa during long-term treatment with Beclomethasone dipropionate aerosol. Acta Otolaryngol 85: 437-443, 1978. 28) 中島礼士他: 耳鼻咽喉科領域におけるコールタイジン使用経験. 耳鼻臨床57: 186-189, 1964. 12) LENZ H: Die Oberfläche der regio olfactoria des Menschen im Rasteleaktronenmikroskop. Acta Otolaryngol 84: 145-154, 1977. 1) 武村民子: 鼻, 口腔粘膜の形態的基礎. 耳鼻25: 123-124, 1979. 48) 福島淑子他: 副腎皮質ホルモン点鼻療法-鼻疾患に対する使用限界の検討-. 耳喉51: 719-722, 1979. 31) BLOOM F L et al: Flunisolide aerosol in the treatment of perennial allergic rhinitis. Ann Allerg 38: 408-412, 1977. 14) 山田清治他: ヒト嗅上皮の走査電子顕微鏡的観察, J Clin Electron Microscop 13: 63-68, 1980. 20) YAMAMOTO M: An Electron Microscopic Study of the Olfactory Mucosa in the Bat and Rabbit. Arch Histol Jap 38: 359-412, 1976. 30) 長谷川誠: 鼻アレルギーの保存療法-DSCG療法-. 耳鼻臨床70: 562-564, 1977. 11) TAKAGI S F and YAJIMA T: Electrical activity and histological change of the degenerating olfactory epithelium. J G Physiol 48: 559, 1965. 35) 坂本邦彦他: 気管粘液繊毛運動の光電変換法によるin vivoの測定-薬物効果の判定への応用-. 気食33: 180, 1982. 38) 飯泉修他: NO2曝露マウスの鼻副鼻腔の病理組織学的研究. 日耳鼻80: 27-30, 1977. 13) 大野聖: 嗅上皮に関する研究. 耳鼻25: 677-697, 1979. 45) 大山勝: 局所処置と鼻粘膜の病態生理. 耳鼻26: 754-760, 1980. 5) 星野知之・児玉章: 有毒性および薬用エアロゾルによる気道粘膜の変化. 耳鼻25: 545-554, 1979. 47) 平野一弥・深町正雄: 乳幼児と点鼻薬-特に点鼻薬の副作用について-. 耳喉32: 1073-1078, 1960. 6) HOLOPAINEN E et al: Nasal polyposis. Acta Otolaryngol 87: 330-334, 1979. 37) 三吉康郎: 公害 (大気汚染による) と上気道疾患, 日耳鼻72: 649-652, 1969. 32) RAMON K Sy: Flunisolide intranasal spray in the treatment of perennial rhinitis. Arch Otolaryngol 105: 649-653, 1979. 25) 態沢忠躬他: 鼻閉に対する薬物の効果判定 (KB-227“Towk”について). 耳展8, 409-416, 1965. 23) 高須照男他: 慢性副鼻腔炎に対する各種新抗生剤の局所応用. 日耳鼻65: 1182-1192, 1962. 26) 井出靖夫・市川瑞雄: 血管収縮剤トークの鼻閉に対する効果. 耳喉37: 769-772, 1965. 36) 菊池恭三・久松建一: 鼻アレルギーに対するエアロゾル療法. 耳鼻25: 585-589, 1979. 7) 大山勝他: 気管呼吸の気道粘膜表面微細構造におよぼす影響に関する実験的研究-走査電顕的映画の新しい試みによる解析-. 耳鼻23: 666-686, 1977. 19) 石井哲夫・鳥山稔: ヒト嗅粘膜の加令による組織学的変化. 耳鼻臨床66: 779-787, 1973. 29) 大迫茂人: 鼻アレルギーに対する副腎皮質ステロイド剤の局所療法. 耳鼻臨床70: 559-561, 1977. 33) 斎藤等: 鼻粘膜およびその上下層にたいするエアロゾルの作用. 耳鼻25: 599-604, 1979. 44) RYANRE: The histologic effect of repeated application of certain nose drops to the nasal mucous membrane of rabbits. Ann Otol 56: 46-57, 1947. 24) 久保村雅夫: 鼻粘膜腫脹に対する新薬剤Towk (KB-227) 使用成果について. 耳鼻10: 256-260, 1964. 39) 高山乙彦: 気道系における感染と汚染との関連性. 気食26: 68-73, 1975. 8) 井土ふさ他: 喉頭摘出患者鼻粘膜の走査電子顕微鏡的観察. 耳展19 (補4): 555-562, 1976. 22) 藤田恒夫: パラニューロン. 耳鼻25: 629-633, 1979. |
| References_xml | – reference: 31) BLOOM F L et al: Flunisolide aerosol in the treatment of perennial allergic rhinitis. Ann Allerg 38: 408-412, 1977. – reference: 9) TAKAGI S F: EOG Problems. Olfaction and Taste III 71 C Pfaffmann (ed) Rockefeller Univ Press New York, 1969. – reference: 33) 斎藤等: 鼻粘膜およびその上下層にたいするエアロゾルの作用. 耳鼻25: 599-604, 1979. – reference: 12) LENZ H: Die Oberfläche der regio olfactoria des Menschen im Rasteleaktronenmikroskop. Acta Otolaryngol 84: 145-154, 1977. – reference: 28) 中島礼士他: 耳鼻咽喉科領域におけるコールタイジン使用経験. 耳鼻臨床57: 186-189, 1964. – reference: 32) RAMON K Sy: Flunisolide intranasal spray in the treatment of perennial rhinitis. Arch Otolaryngol 105: 649-653, 1979. – reference: 16) OHNo I et al: Comparative anatomy of olfactory epithelium. Biomedical Research 2: 455-458, 1981. – reference: 15) 神田敬他: モルモット及び人間の嗅上皮の走査型電子顕微鏡による観察. 日耳鼻76: 739-743, 1973. – reference: 17) 檜学編: 現代の耳鼻咽喉科学. 金原出版, 1979. – reference: 37) 三吉康郎: 公害 (大気汚染による) と上気道疾患, 日耳鼻72: 649-652, 1969. – reference: 43) 坂倉康夫他: 鼻粘膜からの抗生物質の吸収について. 耳鼻臨床71: 467-472, 1978. – reference: 34) DUDLEY J P and CHERRY J D: Efect of topical anesthetics on ciliary activity of chicken embryo tracheal organ cultures. Ann Otol 87: 533-537, 1978. – reference: 5) 星野知之・児玉章: 有毒性および薬用エアロゾルによる気道粘膜の変化. 耳鼻25: 545-554, 1979. – reference: 48) 福島淑子他: 副腎皮質ホルモン点鼻療法-鼻疾患に対する使用限界の検討-. 耳喉51: 719-722, 1979. – reference: 30) 長谷川誠: 鼻アレルギーの保存療法-DSCG療法-. 耳鼻臨床70: 562-564, 1977. – reference: 3) 高坂知節他: 鼻副鼻腔粘膜病態の電子顕微鏡的研究. 耳鼻23: 623-645, 1977. – reference: 4) 三吉康郎: 喉頭全別出術の鼻粘膜変化におよぼす影響の形態学的研究. 耳鼻臨床49: 890-900, 1956. – reference: 41) MYGIND N et al: The nasal mucosa during long-term treatment with Beclomethasone dipropionate aerosol. Acta Otolaryngol 85: 437-443, 1978. – reference: 24) 久保村雅夫: 鼻粘膜腫脹に対する新薬剤Towk (KB-227) 使用成果について. 耳鼻10: 256-260, 1964. – reference: 44) RYANRE: The histologic effect of repeated application of certain nose drops to the nasal mucous membrane of rabbits. Ann Otol 56: 46-57, 1947. – reference: 46) SACKNER M A: Mucociliary transport. Ann Otol 87: 474-483, 1978. – reference: 36) 菊池恭三・久松建一: 鼻アレルギーに対するエアロゾル療法. 耳鼻25: 585-589, 1979. – reference: 11) TAKAGI S F and YAJIMA T: Electrical activity and histological change of the degenerating olfactory epithelium. J G Physiol 48: 559, 1965. – reference: 22) 藤田恒夫: パラニューロン. 耳鼻25: 629-633, 1979. – reference: 10) TAKAGI S F et al: The electropositive potential in the normal and degenerating olfactory epithelium. Olfaction and Taste III 92 C Pfaffmann (ed) Rockefeller Univ Press New York, 1969. – reference: 1) 武村民子: 鼻, 口腔粘膜の形態的基礎. 耳鼻25: 123-124, 1979. – reference: 27) 殿塚慎一郎・高橋誠: 急性鼻炎に対するviruseen Sprayの臨床使用経験. 耳喉38: 1119-1122, 1966. – reference: 35) 坂本邦彦他: 気管粘液繊毛運動の光電変換法によるin vivoの測定-薬物効果の判定への応用-. 気食33: 180, 1982. – reference: 38) 飯泉修他: NO2曝露マウスの鼻副鼻腔の病理組織学的研究. 日耳鼻80: 27-30, 1977. – reference: 14) 山田清治他: ヒト嗅上皮の走査電子顕微鏡的観察, J Clin Electron Microscop 13: 63-68, 1980. – reference: 47) 平野一弥・深町正雄: 乳幼児と点鼻薬-特に点鼻薬の副作用について-. 耳喉32: 1073-1078, 1960. – reference: 45) 大山勝: 局所処置と鼻粘膜の病態生理. 耳鼻26: 754-760, 1980. – reference: 20) YAMAMOTO M: An Electron Microscopic Study of the Olfactory Mucosa in the Bat and Rabbit. Arch Histol Jap 38: 359-412, 1976. – reference: 6) HOLOPAINEN E et al: Nasal polyposis. Acta Otolaryngol 87: 330-334, 1979. – reference: 18) 沢木修二他編: 臨床耳鼻咽喉科学 I. 中外医学社, 1976. – reference: 21) YAMAMOTO M et al: Regeneration of olfactory bipolar neurons in the normal olfactory epithelium of the adult bat. Okajimas Fol Anat Jap 53: 291-304, 1976. – reference: 29) 大迫茂人: 鼻アレルギーに対する副腎皮質ステロイド剤の局所療法. 耳鼻臨床70: 559-561, 1977. – reference: 13) 大野聖: 嗅上皮に関する研究. 耳鼻25: 677-697, 1979. – reference: 2) 三吉康郎: シンポジウム: 上部気道と下部気道の相関. 4. 上部気道の立場から. 気食29: 107-115, 1978. – reference: 8) 井土ふさ他: 喉頭摘出患者鼻粘膜の走査電子顕微鏡的観察. 耳展19 (補4): 555-562, 1976. – reference: 40) 飯沼寿孝他: 点鼻薬乱用の病理組織所見. 耳展17: 73-79, 1974. – reference: 7) 大山勝他: 気管呼吸の気道粘膜表面微細構造におよぼす影響に関する実験的研究-走査電顕的映画の新しい試みによる解析-. 耳鼻23: 666-686, 1977. – reference: 49) 坂倉康夫・谷口強: ネブユライザー療法にともなう副作用について-アンケート調査による研究-. 耳喉52: 99-104, 1980. – reference: 26) 井出靖夫・市川瑞雄: 血管収縮剤トークの鼻閉に対する効果. 耳喉37: 769-772, 1965. – reference: 42) 三吉康郎他: 気管線毛上皮の薬物吸収に関する実験的研究. 耳鼻臨床65: 1119-1130, 1972. – reference: 23) 高須照男他: 慢性副鼻腔炎に対する各種新抗生剤の局所応用. 日耳鼻65: 1182-1192, 1962. – reference: 25) 態沢忠躬他: 鼻閉に対する薬物の効果判定 (KB-227“Towk”について). 耳展8, 409-416, 1965. – reference: 39) 高山乙彦: 気道系における感染と汚染との関連性. 気食26: 68-73, 1975. – reference: 19) 石井哲夫・鳥山稔: ヒト嗅粘膜の加令による組織学的変化. 耳鼻臨床66: 779-787, 1973. |
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