A Case of Tenosynovial Giant Cell Tumor, Localized Type of the Temporomandibular Joint
A diffuse-type tenosynovial giant cell tumor is a benign bone and soft tissue tumor arising from the joint synovium or tendon sheath, and is a subclass of tenosynovial giant cell tumors. It occurs mainly in large joints such as the knee joint, and occurs rarely in the temporomandibular joint. In thi...
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| Published in | JIBI INKOKA TEMBO Vol. 66; no. 5; pp. 217 - 223 |
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| Main Authors | , , , , |
| Format | Journal Article |
| Language | Japanese |
| Published |
Society of Oto-rhino-laryngology Tokyo
15.10.2023
耳鼻咽喉科展望会 |
| Subjects | |
| Online Access | Get full text |
| ISSN | 0386-9687 1883-6429 |
| DOI | 10.11453/orltokyo.66.5_217 |
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| Abstract | A diffuse-type tenosynovial giant cell tumor is a benign bone and soft tissue tumor arising from the joint synovium or tendon sheath, and is a subclass of tenosynovial giant cell tumors. It occurs mainly in large joints such as the knee joint, and occurs rarely in the temporomandibular joint. In this case, a patient visited a previous doctor with the chief complaints of left temporomandibular joint pain, trismus, and headache. Giant cell reparative granuloma was suspected based upon CT-guided biopsy, and she was referred to our hospital for treatment. Imaging tests were also performed at our hospital, but no definitive diagnosis was made. An initial surgical resection was performed for the purpose of diagnosis and treatment, and the pathological results and site of origin led to the diagnosis of diffuse-type tenosynovial giant cell tumor. Recurrence of the headache was subsequently observed, and it was thought to be due to residual lesions. Although there was a possibility that postoperative functional impairment remained, from the viewpoint of local control, a second surgical excision was performed using wide excision. The recurrence rate of giant cell reparative granuloma is 10–17% after sufficient curettage and resection of the lesion, but diffuse-type tenosynovial giant cell tumor has a high recurrence rate of 25–46%. Wide excision is preferable from the perspective of local control, although there remains the possibility that later functional impairment may occur. |
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| AbstractList | A diffuse-type tenosynovial giant cell tumor is a benign bone and soft tissue tumor arising from the joint synovium or tendon sheath, and is a subclass of tenosynovial giant cell tumors. It occurs mainly in large joints such as the knee joint, and occurs rarely in the temporomandibular joint. In this case, a patient visited a previous doctor with the chief complaints of left temporomandibular joint pain, trismus, and headache. Giant cell reparative granuloma was suspected based upon CT-guided biopsy, and she was referred to our hospital for treatment. Imaging tests were also performed at our hospital, but no definitive diagnosis was made. An initial surgical resection was performed for the purpose of diagnosis and treatment, and the pathological results and site of origin led to the diagnosis of diffuse-type tenosynovial giant cell tumor. Recurrence of the headache was subsequently observed, and it was thought to be due to residual lesions. Although there was a possibility that postoperative functional impairment remained, from the viewpoint of local control, a second surgical excision was performed using wide excision. The recurrence rate of giant cell reparative granuloma is 10–17% after sufficient curettage and resection of the lesion, but diffuse-type tenosynovial giant cell tumor has a high recurrence rate of 25–46%. Wide excision is preferable from the perspective of local control, although there remains the possibility that later functional impairment may occur. A diffuse-type tenosynovial giant cell tumor is a benign bone and soft tissue tumor arising from the joint synovium or tendon sheath, and is a subclass of tenosynovial giant cell tumors. It occurs mainly in large joints such as the knee joint, and occurs rarely in the temporomandibular joint. In this case, a patient visited a previous doctor with the chief complaints of left temporomandibular joint pain, trismus, and headache. Giant cell reparative granuloma was suspected based upon CT-guided biopsy, and she was referred to our hospital for treatment. Imaging tests were also performed at our hospital, but no definitive diagnosis was made. An initial surgical resection was performed for the purpose of diagnosis and treatment, and the pathological results and site of origin led to the diagnosis of diffuse-type tenosynovial giant cell tumor. Recurrence of the headache was subsequently observed, and it was thought to be due to residual lesions. Although there was a possibility that postoperative functional impairment remained, from the viewpoint of local control, a second surgical excision was performed using wide excision. The recurrence rate of giant cell reparative granuloma is 10–17% after sufficient curettage and resection of the lesion, but diffuse-type tenosynovial giant cell tumor has a high recurrence rate of 25–46%. Wide excision is preferable from the perspective of local control, although there remains the possibility that later functional impairment may occur. びまん型腱滑膜巨細胞腫は,関節滑膜や腱鞘から発生する良性骨軟部腫瘍であり,腱滑膜巨細胞腫の亜分類である.主に膝関節などの大関節に発生し,顎関節に発生することは極めて稀とされている.今回経験した症例は,左顎関節痛,開口障害,頭痛を主訴に前医を受診し,頭頸部CT検査において左顎関節部腫瘤を指摘された.CTガイド下生検において巨細胞修復性肉芽腫が疑われ,治療目的で当院に紹介となった.当院においても画像検査を行ったが,確定診断には至らなかった.診断および治療目的に初回の外科的切除を行い,病理結果と発生部位よりびまん型腱滑膜巨細胞腫の診断となった.その後,頭痛の再燃を認め,残存病変によるものと考え,術後の機能障害が残存する可能性はあるものの局所制御の観点から広範切除術を用いた2回目の外科的切除を行なった.巨細胞修復性肉芽腫は病変の十分な掻爬術や摘出術によって再発率は10~17%とされているが,びまん型腱滑膜巨細胞腫は再発率が25~46%と高く,術後の機能障害が残存する可能性はあるものの局所制御の観点から広範切除が望ましいと考えた. |
| Author | Yui, Ryosuke Nagaoka, Masato Shiraki, Yuichiro Kobayashi, Toshiki Kawasaki, Takeshi |
| Author_FL | 小林 俊樹 由井 亮輔 長岡 真人 MD Shiraki Yuichiro 川崎 健史 |
| Author_FL_xml | – sequence: 1 fullname: 川崎 健史 – sequence: 2 fullname: MD Shiraki Yuichiro – sequence: 3 fullname: 由井 亮輔 – sequence: 4 fullname: 長岡 真人 – sequence: 5 fullname: 小林 俊樹 |
| Author_xml | – sequence: 1 fullname: Shiraki, Yuichiro organization: Department of Otolaryngology, The Jikei University School of Medicine – sequence: 1 fullname: Nagaoka, Masato organization: Department of Otolaryngology, The Jikei University School of Medicine – sequence: 1 fullname: Kawasaki, Takeshi organization: Department of Otolaryngology, The Jikei University School of Medicine – sequence: 1 fullname: Kobayashi, Toshiki organization: Department of Otolaryngology, Head and Neck Surgery, The Jikei University Kashiwa Hospital – sequence: 1 fullname: Yui, Ryosuke organization: Department of Otolaryngology, The Jikei University School of Medicine |
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| References | 3) 梅林芳弘:皮膚科セミナリウム第32回分かりやすい皮膚良性腫瘍.日皮誌 117: 2461–2469, 2007. 5) John SC, Melinda AM, Kelli DM, et al: Translocation and expression of CSF1 inpigmentedvillonodular synovitis, tenosynovial giant cell tumor, rheumatoid arthritis and other reactive synovitides. Am J Surg Pathol 31: 970–976, 2007. 1) De Saint Aubain N, Van Rijin M: Tenosynovial giant cell tumour, localized type. WHO Classification of Tumours of Soft Tissue and Bone Tumours (5 th ed.), Fletcher CDM, Bridge JA, Hogendoorn PCW, et al (eds): WHO, IARC Press, Lyon, 2013, 133–138. 6) Mastboom MJL, Verspoor FGM, Verschoor AJ, et al: Higher incidence rates than previously known in tenosynovial giant cell tumors. Acta Orthop 88: 688–694, 2017. 11) John RG, Sharon WW: Tenosynovial giant cell tumor diffuse type. Soft Tissue Tumors 5th ed., Weiss SW, Goldblum JR (eds): Mosby Press, Saint Louis, 2001, 1047–1054. 7) 甲斐裕基,岡元信和,佐藤広生,他:痛風結節を伴った膝関節内の限局型腱滑膜巨細胞腫の1例.整外と災外 66: 529–533, 2017. 15) Gelderblom H, Wagner AJ, Tap WD, et al: Long-term outcomes of pexidartinib in tenosynovial giant cell tumors. Cancer 127: 884–893, 2021. 9) 石橋 利,清水正嗣,石橋克禮,他:顎関節突起部に発生した骨腫および骨軟骨腫.日口腔科会誌 33: 607–620, 1984. 10) 野島孝之,角田優子:腫瘍病理鑑別診断アトラス 骨腫瘍 第2版,小田義直,吉田朗彦 編:文光堂,東京,2021, 99–101, 165–169. 12) Anwar B, Taiseer A, Ma’amon AR: The surgical treatment of giant cell granuloma of the mandible. J Oral Maxillofac Surg 60: 756–761, 2002. 8) 佐々 航,三又義訓,多田広志,他:臀部に発生した腱滑膜巨細胞腫の1例.東日整災外会誌 32: 546–549, 2020. 14) Tap WD, Gelderblom H, Palmerini E, et al: Pexidartinib versus placebo for advanced tenosynovial giant cell tumour (ENLIVEN): a randomised phase 3 trial. Lancet 394: 478–487, 2019. 4) West RB, Rubin BP, Melinda AM, et al: A landscape effect in tenosynovial giant-cell tumor from activation of CSF1 expression by a translocation in a minority of tumorcells. Proc Natl Acad Sci USA 103: 690–695, 2006. 13) Minić A, Stajcić Z: Prognostic significance of cortical perforation in the recurence of central giant cell granulomas of the jaws. J Craniomaxillofac Surg 24: 104–108, 1996. 2) Bredell M, Schucknecht B, Bode-Lesniewska B: Tenosynovial, diffuse type giant cell tumor of the temporomandibular joint, diagnosis and management of a rare tumor. J Clin Med Res 7: 262–266, 2015. |
| References_xml | – reference: 3) 梅林芳弘:皮膚科セミナリウム第32回分かりやすい皮膚良性腫瘍.日皮誌 117: 2461–2469, 2007. – reference: 12) Anwar B, Taiseer A, Ma’amon AR: The surgical treatment of giant cell granuloma of the mandible. J Oral Maxillofac Surg 60: 756–761, 2002. – reference: 4) West RB, Rubin BP, Melinda AM, et al: A landscape effect in tenosynovial giant-cell tumor from activation of CSF1 expression by a translocation in a minority of tumorcells. Proc Natl Acad Sci USA 103: 690–695, 2006. – reference: 11) John RG, Sharon WW: Tenosynovial giant cell tumor diffuse type. Soft Tissue Tumors 5th ed., Weiss SW, Goldblum JR (eds): Mosby Press, Saint Louis, 2001, 1047–1054. – reference: 13) Minić A, Stajcić Z: Prognostic significance of cortical perforation in the recurence of central giant cell granulomas of the jaws. J Craniomaxillofac Surg 24: 104–108, 1996. – reference: 6) Mastboom MJL, Verspoor FGM, Verschoor AJ, et al: Higher incidence rates than previously known in tenosynovial giant cell tumors. Acta Orthop 88: 688–694, 2017. – reference: 14) Tap WD, Gelderblom H, Palmerini E, et al: Pexidartinib versus placebo for advanced tenosynovial giant cell tumour (ENLIVEN): a randomised phase 3 trial. Lancet 394: 478–487, 2019. – reference: 5) John SC, Melinda AM, Kelli DM, et al: Translocation and expression of CSF1 inpigmentedvillonodular synovitis, tenosynovial giant cell tumor, rheumatoid arthritis and other reactive synovitides. Am J Surg Pathol 31: 970–976, 2007. – reference: 10) 野島孝之,角田優子:腫瘍病理鑑別診断アトラス 骨腫瘍 第2版,小田義直,吉田朗彦 編:文光堂,東京,2021, 99–101, 165–169. – reference: 15) Gelderblom H, Wagner AJ, Tap WD, et al: Long-term outcomes of pexidartinib in tenosynovial giant cell tumors. Cancer 127: 884–893, 2021. – reference: 9) 石橋 利,清水正嗣,石橋克禮,他:顎関節突起部に発生した骨腫および骨軟骨腫.日口腔科会誌 33: 607–620, 1984. – reference: 2) Bredell M, Schucknecht B, Bode-Lesniewska B: Tenosynovial, diffuse type giant cell tumor of the temporomandibular joint, diagnosis and management of a rare tumor. J Clin Med Res 7: 262–266, 2015. – reference: 8) 佐々 航,三又義訓,多田広志,他:臀部に発生した腱滑膜巨細胞腫の1例.東日整災外会誌 32: 546–549, 2020. – reference: 1) De Saint Aubain N, Van Rijin M: Tenosynovial giant cell tumour, localized type. WHO Classification of Tumours of Soft Tissue and Bone Tumours (5 th ed.), Fletcher CDM, Bridge JA, Hogendoorn PCW, et al (eds): WHO, IARC Press, Lyon, 2013, 133–138. – reference: 7) 甲斐裕基,岡元信和,佐藤広生,他:痛風結節を伴った膝関節内の限局型腱滑膜巨細胞腫の1例.整外と災外 66: 529–533, 2017. |
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| SubjectTerms | temporomandibular joint tumor tenosynovial giant cell tumour wide excision びまん型腱滑膜巨細胞腫 広範切除 顎関節腫瘍 |
| Title | A Case of Tenosynovial Giant Cell Tumor, Localized Type of the Temporomandibular Joint |
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