Current status and future of subnormothermic machine perfusion preservation

• Published in: Organ Biology Vol. 29; no. 1; pp. 13 - 20
• Main Authors: Takahashi, Hiroyuki, Ishii, Daisuke, Toriumi, Asuka, Matsuno, Naoto, Yokoo, Hideki, Iwata, Hiroyoshi, Teraguchi, Hiroyuki, Otani, Masahide, Imai, KoJi, Hagiwara, Masahiro, Obara, Hiromichi
• Format: Journal Article
• Language: Japanese
• Published: The Japan Society for Organ Preservation and Biology 2022; 一般社団法人 日本臓器保存生物医学会
• Subjects: extracorporeal membrane oxygenation; hemoglobin vesicles; liver; rewarming machine perfusion; subnormothermic machine perfusion; 人工赤血球; 体外式膜型人工肺; 室温機械灌流法; 復温機械灌流法; 臓器保存法
• ISSN: 1340-5152; 2188-0204
• DOI: 10.11378/organbio.29.13

Recently, it has become clear that machine perfusion preservation is a more beneficial than cold storage. Cold-induced preservation injury causes inadequate cellular metabolic function, the depletion of energy stores or the deleterious direct effects of cooling. Normothermic machine perfusion (NMP) can help maintain and recover graft function, and evaluate the viability. However, because it requires high level of oxygen, blood-based perfusates those may increase the risk of microvascular failure and bacterial growth, are used. Therefore, NMP remains a challenging problem. On the other hand, subnormothermic machine perfusion (SNMP) at around 20℃-25℃ needs lower level of oxygen compared to NMP. Herein, we demonstrate the current status and future of SNMP.