わが国における肺血栓塞栓症/深部静脈血栓症予防ガイドライン

肺血栓塞栓症および深部静脈血栓症は, 特に手術後や出産後, あるいは急性内科疾患での入院中などに多く発症し不幸な転帰をとることが多い. 欧米では非常に頻度の高い疾患であり, 古くからその予防に力が注がれてきた. 近年, 本症はわが国においても決して少なくない疾患と認識され, 欧米との発生率の差などを考慮したわが国独自の予防ガイドラインが完成した. 本ガイドラインは, エビデンスの少ないなかで作成された発展途上なものであり, 今後の研究発展が期待される....

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Published in日本臨床麻酔学会誌 Vol. 24; no. 9; pp. 480 - 487
Main Author 中村, 真潮
Format Journal Article
LanguageJapanese
Published 日本臨床麻酔学会 15.11.2004
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ISSN0285-4945
1349-9149
DOI10.2199/jjsca.24.480

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Abstract 肺血栓塞栓症および深部静脈血栓症は, 特に手術後や出産後, あるいは急性内科疾患での入院中などに多く発症し不幸な転帰をとることが多い. 欧米では非常に頻度の高い疾患であり, 古くからその予防に力が注がれてきた. 近年, 本症はわが国においても決して少なくない疾患と認識され, 欧米との発生率の差などを考慮したわが国独自の予防ガイドラインが完成した. 本ガイドラインは, エビデンスの少ないなかで作成された発展途上なものであり, 今後の研究発展が期待される.
AbstractList 肺血栓塞栓症および深部静脈血栓症は, 特に手術後や出産後, あるいは急性内科疾患での入院中などに多く発症し不幸な転帰をとることが多い. 欧米では非常に頻度の高い疾患であり, 古くからその予防に力が注がれてきた. 近年, 本症はわが国においても決して少なくない疾患と認識され, 欧米との発生率の差などを考慮したわが国独自の予防ガイドラインが完成した. 本ガイドラインは, エビデンスの少ないなかで作成された発展途上なものであり, 今後の研究発展が期待される.
Author 中村, 真潮
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References 21) Siddiqui AU, Buchman TG, Hotchkiss RS : Pulmonary embolism as a consequence of applying sequential compression device on legs in a patient asymptomatic of deep vein thrombosis. Anesthesiology 92 : 880∼882, 2000
11) Lindblad B, Eriksson A, Bergqvist D : Autopsy-verified pulmonary embolism in a surgical department : analysis of the period from 1951 to 1988. Br J Surg 78 : 849∼852, 1991
20) Warwick D, Harrison J, Glew D, et al. : Comparison of the use of a foot pump with the use of low-molecular-weight heparin for the prevention of deep-vein thrombosis after total hip replacement. A prospective, randomized trial. J Bone Joint Surg Am 80 : 1158∼1166, 1998
3) 中村真潮 : わが国における肺血栓塞栓症の現状. 血栓止血誌 12 : 450~459, 2001
16) 児島正純, 池田聡司, 宮原嘉之ほか : 本邦における肺血栓塞栓症の予後について. Ther Res 23 : 49~51, 2002
18) Anderson FA Jr, Wheeler HB, Goldberg RJ, et al. : The prevalence of risk factors for venous thromboembolism among hospital patients. Arch Intern Med 152 : 1660∼1664, 1992
23) Clagett GP, Reisch JS : Prevention of venous thromboembolism in general surgical patients. Results of meta-analysis. Ann Surg 208 : 227∼240, 1988
22) Collins R, Scrimgeour A, Yusuf S, et al. : Reduction in fatal pulmonary embolism and venous thrombosis by perioperative administration of subcutaneous heparin. Overview of results of randomized trials in general, orthopedic, and urologic surgery. N Engl J Med 318 : 1162∼1173, 1988
4) 中村真潮, 山田典一, 中野赳ほか : 静脈血栓塞栓症の最近の話題. 脈管 43 : 121~126, 2003
26) Leyvraz PF, Richard J, Bachmann F, et al. : Adjusted versus fixed-dose subcutaneous heparin in theprevention of deep-vein thrombosis after total hip replacement. N Engl J Med 309 : 954∼958, 1983
14) Gulba DC, Schmid C, Borst HG, et al. : Medical compared with surgical treatment for massive pulmonary embolism. Lancet 343 : 576∼577, 1994
17) Virchow R : Gesammelte Abhandlungen zur Wissenschaftlichen Medizin. Meidinger Sohn, Frankfurt, 1856
6) 肺血栓塞栓症/深部静脈血栓症 (静脈血栓塞栓症) 予防ガイドライン作成委員会. 肺血栓塞栓症/深部静脈血栓症 (静脈血栓塞栓症) 予防ガイドライン : Medical Front International Limited, 東京, 2004
7) Hirst AE, Gore I, Tanaka K, et al. : Myocardial infarction and pulmonary embolism. Arch Pathol 80 : 365∼370, 1965
1) Geerts WH, Heit JA, Clagett GP, et al. : Prevention of venous thromboembolism. Chest 119 (1 Suppl) : 132S∼175S, 2001
25) 砂川浩, 二神信夫, 崎尾浩由, 他 : 当センターにおける術後肺血栓塞栓症に対する予防措置と施行前後での術後肺血栓塞栓症の発症例数の変化と発症例の検討 (1996~2002). J Anesthesia 17 (suppl) : 359, 2003
30) Magnani HN : Heparin-induced thrombocytopenia (HIT) : an overview of 230 patients treated with orgaran (Org 10172). Thromb Haemost 70 : 554∼561, 1993
13) 中村陽一, 由谷親夫, 今北正美ほか : 肺梗塞発生に至る静脈血栓症および肺血栓塞栓症の病理組織学的研究. 静脈学 7 : 17~22, 1996
28) Hull R, Raskob G, Pineo G, et al. : A comparison of subcutaneous low-molecular-weight heparin with warfarin sodium for prophylaxis against deep-vein thrombosis after hip or knee implantation. N Engl J Med 329 : 1370∼1376, 1993
5) 肺血栓塞栓症/深部静脈血栓症 (静脈血栓塞栓症) 予防ガイドライン作成委員会. 肺血栓塞栓症/深部静脈血栓症 (静脈血栓塞栓症) 予防ガイドライン. ダイジェスト版 : Medical Front International Limited, 東京, 2004
15) Ota M, Nakamura M, Yamada N, et al. : Prognostic significance of early diagnosis in acute pulmonary thromboembolism with circulatory failure. Heart Vessels 17 : 7∼11, 2002
19) Wells PS, Lensing AW, Hirsh J : Graduated compression stockings in the prevention of postoperative venous thromboembolism. A meta-analysis. Arch Intern Med 154 : 67∼72, 1994
29) Wells PS, Kovacs MJ, Bormanis J, et al. : Expanding eligibility for outpatient treatment of deep venous thrombosis and pulmonary embolism with low-molecular-weight heparin : a comparison of patient self-injection with homecare injection. Arch Intern Med 158 : 1809∼1812, 1998
10) Diebold J, Lohrs U : Venous thrombosis and pulmonary embolism. A study of 5039 autopsies. Pathol Res Pract 187 : 260∼266, 1991
8) Kumasaka N, Sakuma M, Shirato K : Incidence of pulmonary thromboembolism in Japan. Jpn Circ J 63 : 439∼441, 1999
9) Kitamukai O, Sakuma M, Takahashi T, et al. : Incidence and characteristics of pulmonary thromboembolism in Japan 2000. Intern Med 42 : 1090∼1094, 2003
24) Campbell NR, Hull RD, Brant R, et al. : Aging and heparin-related bleeding. Arch Intern Med 156 : 857∼860, 1996
27) Hull RD, Pineo GF, Francis CW, et al. : Low-molecular-weight heparin prophylaxis using dalteparin in close proximity to surgery versus warfarin in hip arthroplasty patients : a double-blind, randomized comparison. Arch Intern Med 160 : 2199∼2207, 2000
12) 中野赳, 伊藤早苗, 竹沢英郎 : 肺塞栓症の疫学. 日本医事新報 2949 : 43~47, 1980
2) Nicolaides AN, Breddin HK, Fareed J, et al. : Prevention of venous thromboembolism. International Consensus Statement. Guidelines compiled in accordance with the scientific evidence. Int Angiol 20 : 1∼37, 2001
References_xml – reference: 7) Hirst AE, Gore I, Tanaka K, et al. : Myocardial infarction and pulmonary embolism. Arch Pathol 80 : 365∼370, 1965
– reference: 3) 中村真潮 : わが国における肺血栓塞栓症の現状. 血栓止血誌 12 : 450~459, 2001
– reference: 14) Gulba DC, Schmid C, Borst HG, et al. : Medical compared with surgical treatment for massive pulmonary embolism. Lancet 343 : 576∼577, 1994
– reference: 23) Clagett GP, Reisch JS : Prevention of venous thromboembolism in general surgical patients. Results of meta-analysis. Ann Surg 208 : 227∼240, 1988
– reference: 2) Nicolaides AN, Breddin HK, Fareed J, et al. : Prevention of venous thromboembolism. International Consensus Statement. Guidelines compiled in accordance with the scientific evidence. Int Angiol 20 : 1∼37, 2001
– reference: 8) Kumasaka N, Sakuma M, Shirato K : Incidence of pulmonary thromboembolism in Japan. Jpn Circ J 63 : 439∼441, 1999
– reference: 18) Anderson FA Jr, Wheeler HB, Goldberg RJ, et al. : The prevalence of risk factors for venous thromboembolism among hospital patients. Arch Intern Med 152 : 1660∼1664, 1992
– reference: 13) 中村陽一, 由谷親夫, 今北正美ほか : 肺梗塞発生に至る静脈血栓症および肺血栓塞栓症の病理組織学的研究. 静脈学 7 : 17~22, 1996
– reference: 19) Wells PS, Lensing AW, Hirsh J : Graduated compression stockings in the prevention of postoperative venous thromboembolism. A meta-analysis. Arch Intern Med 154 : 67∼72, 1994
– reference: 28) Hull R, Raskob G, Pineo G, et al. : A comparison of subcutaneous low-molecular-weight heparin with warfarin sodium for prophylaxis against deep-vein thrombosis after hip or knee implantation. N Engl J Med 329 : 1370∼1376, 1993
– reference: 1) Geerts WH, Heit JA, Clagett GP, et al. : Prevention of venous thromboembolism. Chest 119 (1 Suppl) : 132S∼175S, 2001
– reference: 25) 砂川浩, 二神信夫, 崎尾浩由, 他 : 当センターにおける術後肺血栓塞栓症に対する予防措置と施行前後での術後肺血栓塞栓症の発症例数の変化と発症例の検討 (1996~2002). J Anesthesia 17 (suppl) : 359, 2003
– reference: 6) 肺血栓塞栓症/深部静脈血栓症 (静脈血栓塞栓症) 予防ガイドライン作成委員会. 肺血栓塞栓症/深部静脈血栓症 (静脈血栓塞栓症) 予防ガイドライン : Medical Front International Limited, 東京, 2004
– reference: 30) Magnani HN : Heparin-induced thrombocytopenia (HIT) : an overview of 230 patients treated with orgaran (Org 10172). Thromb Haemost 70 : 554∼561, 1993
– reference: 5) 肺血栓塞栓症/深部静脈血栓症 (静脈血栓塞栓症) 予防ガイドライン作成委員会. 肺血栓塞栓症/深部静脈血栓症 (静脈血栓塞栓症) 予防ガイドライン. ダイジェスト版 : Medical Front International Limited, 東京, 2004
– reference: 10) Diebold J, Lohrs U : Venous thrombosis and pulmonary embolism. A study of 5039 autopsies. Pathol Res Pract 187 : 260∼266, 1991
– reference: 22) Collins R, Scrimgeour A, Yusuf S, et al. : Reduction in fatal pulmonary embolism and venous thrombosis by perioperative administration of subcutaneous heparin. Overview of results of randomized trials in general, orthopedic, and urologic surgery. N Engl J Med 318 : 1162∼1173, 1988
– reference: 12) 中野赳, 伊藤早苗, 竹沢英郎 : 肺塞栓症の疫学. 日本医事新報 2949 : 43~47, 1980
– reference: 20) Warwick D, Harrison J, Glew D, et al. : Comparison of the use of a foot pump with the use of low-molecular-weight heparin for the prevention of deep-vein thrombosis after total hip replacement. A prospective, randomized trial. J Bone Joint Surg Am 80 : 1158∼1166, 1998
– reference: 26) Leyvraz PF, Richard J, Bachmann F, et al. : Adjusted versus fixed-dose subcutaneous heparin in theprevention of deep-vein thrombosis after total hip replacement. N Engl J Med 309 : 954∼958, 1983
– reference: 29) Wells PS, Kovacs MJ, Bormanis J, et al. : Expanding eligibility for outpatient treatment of deep venous thrombosis and pulmonary embolism with low-molecular-weight heparin : a comparison of patient self-injection with homecare injection. Arch Intern Med 158 : 1809∼1812, 1998
– reference: 11) Lindblad B, Eriksson A, Bergqvist D : Autopsy-verified pulmonary embolism in a surgical department : analysis of the period from 1951 to 1988. Br J Surg 78 : 849∼852, 1991
– reference: 17) Virchow R : Gesammelte Abhandlungen zur Wissenschaftlichen Medizin. Meidinger Sohn, Frankfurt, 1856
– reference: 21) Siddiqui AU, Buchman TG, Hotchkiss RS : Pulmonary embolism as a consequence of applying sequential compression device on legs in a patient asymptomatic of deep vein thrombosis. Anesthesiology 92 : 880∼882, 2000
– reference: 15) Ota M, Nakamura M, Yamada N, et al. : Prognostic significance of early diagnosis in acute pulmonary thromboembolism with circulatory failure. Heart Vessels 17 : 7∼11, 2002
– reference: 16) 児島正純, 池田聡司, 宮原嘉之ほか : 本邦における肺血栓塞栓症の予後について. Ther Res 23 : 49~51, 2002
– reference: 27) Hull RD, Pineo GF, Francis CW, et al. : Low-molecular-weight heparin prophylaxis using dalteparin in close proximity to surgery versus warfarin in hip arthroplasty patients : a double-blind, randomized comparison. Arch Intern Med 160 : 2199∼2207, 2000
– reference: 4) 中村真潮, 山田典一, 中野赳ほか : 静脈血栓塞栓症の最近の話題. 脈管 43 : 121~126, 2003
– reference: 9) Kitamukai O, Sakuma M, Takahashi T, et al. : Incidence and characteristics of pulmonary thromboembolism in Japan 2000. Intern Med 42 : 1090∼1094, 2003
– reference: 24) Campbell NR, Hull RD, Brant R, et al. : Aging and heparin-related bleeding. Arch Intern Med 156 : 857∼860, 1996
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Snippet 肺血栓塞栓症および深部静脈血栓症は, 特に手術後や出産後, あるいは急性内科疾患での入院中などに多く発症し不幸な転帰をとることが多い. 欧米では非常に頻度の高い疾...
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SubjectTerms Anticoagulation
Deep vein thrombosis
Pulmonary thromboembolism
抗凝固療法
深部静脈血栓症
肺血栓塞栓症
Title わが国における肺血栓塞栓症/深部静脈血栓症予防ガイドライン
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