Effects of Lip Closure Training on Lip Functions and Brain Hemodynamic Responses in Healthy Female Subjects
In the present study, the effects of lip closure training were examined in terms of brain activity and oral functions. Nineteen healthy women (22.1±2.9 years old) were randomly assigned to two groups: the training group in which lip closure training was performed for 4 weeks using a mouth rehabilita...
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| Published in | The Japanese Journal of Dysphagia Rehabilitation Vol. 17; no. 2; pp. 117 - 125 |
|---|---|
| Main Authors | , , , , , , , |
| Format | Journal Article |
| Language | Japanese |
| Published |
The Japanese Society of Dysphagia Rehabilitation
31.08.2013
一般社団法人 日本摂食嚥下リハビリテーション学会 |
| Subjects | |
| Online Access | Get full text |
| ISSN | 1343-8441 2434-2254 |
| DOI | 10.32136/jsdr.17.2_117 |
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| Abstract | In the present study, the effects of lip closure training were examined in terms of brain activity and oral functions. Nineteen healthy women (22.1±2.9 years old) were randomly assigned to two groups: the training group in which lip closure training was performed for 4 weeks using a mouth rehabilitation apparatus, and the control group in which the training was not performed. Maximum lip closure pressure was measured before and after the training. Furthermore, brain hemodynamic responses (Oxy-Hb concentration) in the whole brain were measured during a lip closure task using this mouth rehabilitation apparatus and during a task in which the subjects were required to keep 50% of the maximum lip closure pressure (50%-pressure task). The results indicated that the maximum lip closure pressure and performance in the 50%-pressure task were improved after the training in the training group. Before the training, mean cortical hemodynamic responses (Oxy-Hb concentration) increased in the prefrontal pole, right and left dorsolateral prefrontal cortex, supplementary motor area, and presupplementary motor area during the lip closure task in both the control and training groups. Furthermore, 4 weeks after the training intervention, the mean cortical Oxy-Hb concentrations in the various prefrontal regions including the prefrontal pole similarly increased during the lip closure task in the training group. However, in the control group, the mean cortical Oxy-Hb concentrations in the prefrontal pole did not increase during the lip closure task 4 weeks after the first measurement. These results suggest that continuous lip closure training improves not only lip closure functions but also higher brain functions by persistent activation of the prefrontal pole. |
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| AbstractList | In the present study, the effects of lip closure training were examined in terms of brain activity and oral functions. Nineteen healthy women (22.1±2.9 years old) were randomly assigned to two groups: the training group in which lip closure training was performed for 4 weeks using a mouth rehabilitation apparatus, and the control group in which the training was not performed. Maximum lip closure pressure was measured before and after the training. Furthermore, brain hemodynamic responses (Oxy-Hb concentration) in the whole brain were measured during a lip closure task using this mouth rehabilitation apparatus and during a task in which the subjects were required to keep 50% of the maximum lip closure pressure (50%-pressure task). The results indicated that the maximum lip closure pressure and performance in the 50%-pressure task were improved after the training in the training group. Before the training, mean cortical hemodynamic responses (Oxy-Hb concentration) increased in the prefrontal pole, right and left dorsolateral prefrontal cortex, supplementary motor area, and presupplementary motor area during the lip closure task in both the control and training groups. Furthermore, 4 weeks after the training intervention, the mean cortical Oxy-Hb concentrations in the various prefrontal regions including the prefrontal pole similarly increased during the lip closure task in the training group. However, in the control group, the mean cortical Oxy-Hb concentrations in the prefrontal pole did not increase during the lip closure task 4 weeks after the first measurement. These results suggest that continuous lip closure training improves not only lip closure functions but also higher brain functions by persistent activation of the prefrontal pole.
本研究では，口唇閉鎖訓練の効果を，脳活動・口唇機能の観点から検討した．健常女性19 名（22.1±2.9 歳）を対象に，口腔リハビリ器具を用いて，口唇閉鎖訓練を4 週間続けて行う（Training）群と同訓練を行わない（Control）群に無作為に分けた．同訓練前後で最大口唇閉鎖力を測定するとともに，口腔リハビリ器具を用いた口唇閉鎖課題および最大口唇閉鎖力50% 保持課題遂行中の脳酸素化ヘモグロビン（Oxy-Hb）変化量を，全頭型NIRS（近赤外分光法）測定装置を用いて記録した．最大口唇閉鎖力50% 保持課題では，各被験者の最大口唇閉鎖力の50% の力を維持させた．その結果，Training 群では，最大口唇閉鎖力が増加し最大口唇閉鎖力50% 保持課題における誤差値が有意に縮小した．脳活動では，訓練前においてControl 群およびTraining 群ともに，口唇閉鎖課題時に前頭極，左右背外側前頭前野，補足運動野，および前補足運動野におけるOxy-Hb 変化量が増大した．しかし，同訓練後は，前頭極におけるOxy-Hb変化量がControl 群では増加しなかったのに対し，Training 群では増加した．以上から，口唇閉鎖訓練を継続して行うことにより，口唇閉鎖機能の向上だけでなく，前頭前野の持続的な脳賦活効果が認められた． In the present study, the effects of lip closure training were examined in terms of brain activity and oral functions. Nineteen healthy women (22.1±2.9 years old) were randomly assigned to two groups: the training group in which lip closure training was performed for 4 weeks using a mouth rehabilitation apparatus, and the control group in which the training was not performed. Maximum lip closure pressure was measured before and after the training. Furthermore, brain hemodynamic responses (Oxy-Hb concentration) in the whole brain were measured during a lip closure task using this mouth rehabilitation apparatus and during a task in which the subjects were required to keep 50% of the maximum lip closure pressure (50%-pressure task). The results indicated that the maximum lip closure pressure and performance in the 50%-pressure task were improved after the training in the training group. Before the training, mean cortical hemodynamic responses (Oxy-Hb concentration) increased in the prefrontal pole, right and left dorsolateral prefrontal cortex, supplementary motor area, and presupplementary motor area during the lip closure task in both the control and training groups. Furthermore, 4 weeks after the training intervention, the mean cortical Oxy-Hb concentrations in the various prefrontal regions including the prefrontal pole similarly increased during the lip closure task in the training group. However, in the control group, the mean cortical Oxy-Hb concentrations in the prefrontal pole did not increase during the lip closure task 4 weeks after the first measurement. These results suggest that continuous lip closure training improves not only lip closure functions but also higher brain functions by persistent activation of the prefrontal pole. |
| Author | ONO, Taketoshi URAKAWA, Susumu HORI, Etsuro ISHIKAWA, Akihiro NAKADA, Takeshi NISHIJO, Hisao TAKAMOTO, Kouichi KONISHI, Hideo |
| Author_FL | 西条 寿夫 小西 秀男 高本 考一 小野 武年 石川 亮宏 浦川 将 中田 健史 HORI Etsuro |
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| References_xml | – reference: 26） Grefkes C, Fink GR: Reorganization of cerebral networks after stroke: New insights from neuroimaging with connectivity approaches, Brain, 134: 1264–1276, 2011. – reference: 3） 坂東智子：口唇閉鎖機能と口呼吸の関連性，九州歯会誌，60：9–23，2006． – reference: 13） 石川健太郎，村田尚道，弘中祥司，他：要介護高齢者に対する簡便な器具を用いた口腔機能向上の効果，老年歯医，21194–21201，2006． – reference: 18） Adachi K, Hasegawa M, Ikeda H, et al: The superior colliculus contains a discrete region involved in the control of jaw movements: Role of GABAA receptors, Eur J Pharmacol, 464: 147–154, 2003. – reference: 25） Robertson IH, Murre JM: Rehabilitation of brain damage: Brain plasticity and principles of guided recovery, Psychol Bull, 125: 544–575, 1999. – reference: 8） Syrjala AM, Ylostalo P, Sulkava R, et al: Relationship between cognitive impairment and oral health: Results of the health 2000 health examination survey in Finland, Acta Odontol Scand, 65: 103–108, 2007. – reference: 24） Johansson BB: Brain plasticity and stroke rehabilitation. The Willis lecture, Stroke, 31: 223–230, 2000. – reference: 4） 黛真奈美：廃用性症候群を防ぐために 栄養管理の視点から，月刊 総合ケア，14：30–33，2008． – reference: 6） Bergdahl M, Habib R, Bergdahl J, et al: Natural teeth and cognitive function in humans. Scand J Psychol, 48: 557–565, 2007. – reference: 16） Floyer-Lea A, Matthews PM: Changing brain networks for visuomotor control with increased movement automaticity, J Neurophysiol, 92: 2405–2412, 2004. – reference: 2） 野呂明夫：口腔リハビリ器具「パタカラ」を使用した口腔筋機能療法，日歯東洋医会誌，20：6–24，2001． – reference: 21） Baars BJ, Ramsøy TZ, Laureys S: Brain, conscious experience and the observing self, TRENDS Neurosci, 26: 671–675, 2003. – reference: 19） Leh SE, Johansen-Berg H, Ptito A, et al: Unconscious vision: New insights into the neuronal correlate of blindsight using diffusion tractography, Brain, 129: 1822–1832, 2006. – reference: 10） 小坂 健，伊藤 奏，相田 潤：介護老人福祉施設における口腔衛生に関する調査．平成23 年度厚生労働省 老人保健健康増進等事業 施設入所者に対する経口移行の提供体制のあり方に関する調査研究事業報告書 2011． – reference: 15） Jenkins IH, Brooks DJ, Nixon PD, et al: Motor sequence learning: A study with positron emission tomography, J Neurosci, 14: 3775–3790, 1994. – reference: 20） Baddeley AD: Working Memory, Oxford Univ Press, Oxford, 1986. – reference: 9） Yamamoto T, Hirayama A: Effects of soft-diet feeding on synaptic density in the hippocampus and parietal cortex of senescence-accelerated mice, Brain Res, 902: 255–263, 2001. – reference: 5） 岡田澄子，才藤栄一，重田律子：脳卒中慢性期高齢者の諸特徴と摂食・嚥下リハビリテーションの帰結，日摂食嚥下リハ会誌，12：240–246，2008． – reference: 11） 灰田宗孝：NIRS（近赤外分光法），脳と循環，10：207–212，2005． – reference: 23） Grady CL, McIntosh AR, Beig S, et al: An examination of the effects of stimulus type encoding task, and functional connectivity on the role of right prefrontal cortex in recognition memory, Neuroimage, 14: 556–571, 2001. – reference: 1） 大岡貴史，拝野俊之，弘中祥司，他：日常的に行う口腔機能訓練による高齢者の口腔機能向上への効果，口腔衛生会誌，58：88–93，2008． – reference: 14） Onozuka M, Fujita M, Watanabe K, et al: Age-related changes in brain regional activity during chewing: A functional magnetic resonance imaging study, J Dent Res, 82: 657–660, 2003. – reference: 22） Phillips CI, Smith VM, Antle MC, et al: Neonatal medial frontal cortex lesions disrupt circadian activity patterns, Dev Neurosci, 31: 412–419, 2009. – reference: 7） Kim JM, Stewart R, Prince M, et al: Dental health, nutritional status and recent-onset dementia in a Korean community population, Int J Geriatr Psychiatry, 22: 850–855, 2007. – reference: 12） 秋廣良昭：口閉じトレーニング，日抗加齢医会誌，2：113–120，2006． – reference: 17） Ndiaye A, Pinganauda G, VanderWerfb F, et al: Connections between the trigeminal mesencephalic nucleus and the superior colliculus in the rat, Neurosci Lett, 294: 17–20, 2000. |
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| SubjectTerms | lip closure training near-infrared spectroscopy (NIRS) oral cavity prefrontal cortex 前頭前野 口唇閉鎖訓練 近赤外分光法（NIRS） |
| Title | Effects of Lip Closure Training on Lip Functions and Brain Hemodynamic Responses in Healthy Female Subjects |
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