A pathological complete response after combined chemotherapy of gemcitabine and cisplatin in laterally advanced extrahepatic cholangiocarcinoma: a case report

• Published in: Tando Vol. 36; no. 1; pp. 55 - 59
• Main Author: Yamazoe, Sadaaki
• Format: Journal Article
• Language: Japanese
• Published: Japan Biliary Association 31.03.2022; 一般社団法人 日本胆道学会
• Subjects: bile duct cancer; chemotherapy; complete response; conversion surgery; 化学療法; 完全奏効; 胆管癌
• ISSN: 0914-0077; 1883-6879
• DOI: 10.11210/tando.36.55

The patient was a 71-year-old male with a chief complaint of itching and jaundice. Detailed physical examinations revealed that his condition was diagnosed as laterally advanced extrahepatic cholangiocarcinoma. To obtain the R0 resection, right or left trisectionectomy with pancreatoduodenectomy was needed. We informed him of the treatment strategy such as resection, chemotherapy and second opinion, he selected chemotherapy. Chemotherapy using gemcitabine and cisplatin was initiated and computed tomography after 4 cycles revealed that the tumor had decreased. After 13 cycles, right hepatectomy with caudate lobectomy and extrahepatic bile duct resection was performed as conversion surgery. As a result, a pathological complete response was achieved in the primary tumor. Although he did not receive any further adjuvant chemotherapy, no recurrent lesions have been detected for 28 months after the surgery.