Anti-PL-12 Antibody-positive Interstitial Pneumonia Diagnosed During Treatment for Rheumatoid Arthritis

• Published in: The Journal of the Japan Society for Respiratory Endoscopy Vol. 44; no. 1; pp. 64 - 68
• Main Authors: Sano, Go, Homma, Sakae, Shibuya, Kazutoshi, Uekusa, Toshimasa, Shimizu, Hiroshige, Sugino, Keishi
• Format: Journal Article
• Language: Japanese
• Published: The Japan Society for Respiratory Endoscopy 25.01.2022; 特定非営利活動法人 日本呼吸器内視鏡学会
• Subjects: Anti PL-12 antibody; Anti-aminoacyl tRNA synthetase syndrome; Interstitial pneumonia; Rheumatoid arthritis; 抗ARS抗体症候群; 抗PL-12抗体; 間質性肺炎; 関節リウマチ（rheumatoid arthritis：RA）
• ISSN: 0287-2137; 2186-0149
• DOI: 10.18907/jjsre.44.1_64

Backgroud. The onset of interstitial pneumonia during treatment of rheumatoid arthritis (RA) rarely leads to the diagnosis of anti-aminoacyl tRNA synthetase (ARS) syndrome. Case. A 66-year-old man was admitted to our hospital complaining of a 1-month history of persistent cough and dyspnea on exertion with the onset of interstitial pneumonia during treatment, such as sodium aurothiomalate for RA. Chest high-resolution computed tomography (HRCT) revealed diffuse reticular lesions, interlobular septal thickening, and traction bronchiectasis, admixed with consolidation predominantly in the bilateral lower lobes. The histopathological findings of video-assisted thoracic surgery (VATS) specimens showed fibro-cellular non-specific interstitial pneumonia. Consequently, we diagnosed him with anti-ARS syndrome due to positive serum findings for anti-PL-12 antibody. Conclusion. Anti-ARS antibodies should be measured in patients with suspected connective tissue disease-interstitial lung disease showing the above findings on HRCT.