Abdominal Aortic Aneurysm Treatments Requiring Suprarenal Abdominal Aortic Cross-clamping

Introduction: Open repair requiring suprarenal aortic cross-clamping is still the treatment of choice for juxtarenal aortic aneurysms (JAA), despite advances in endovascular aneurysm repair. We assessed rates of mortality and acute kidney injury after open repair for abdominal aortic aneurysm (AAA)...

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Published inJapanese Journal of Vascular Surgery Vol. 21; no. 5; pp. 659 - 662
Main Authors Nishizawa, Masato, Toyohuku, Takahiro, Yonekura, Kouji, Igari, Kimihiro, Uchiyama, Hidetoshi, Kudo, Toshifumi, Jibiki, Masatoshi, Inoue, Yoshinori, Koizumi, Shinya
Format Journal Article
LanguageJapanese
Published JAPANESE SOCIETY FOR VASCULAR SURGERY 25.08.2012
特定非営利活動法人 日本血管外科学会
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ISSN0918-6778
1881-767X
DOI10.11401/jsvs.21.659

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Abstract Introduction: Open repair requiring suprarenal aortic cross-clamping is still the treatment of choice for juxtarenal aortic aneurysms (JAA), despite advances in endovascular aneurysm repair. We assessed rates of mortality and acute kidney injury after open repair for abdominal aortic aneurysm (AAA) requiring suprarenal abdominal aortic cross-clamping in our institution. Materials and Methods: We encountered 56 patients with suprarenal AAA and JAA and infrarenal AAA requiring suprarenal abdominal aortic cross-clamping between 1996 and 2010. We retrospectively reviewed 48 elective patients, excluding 6 who received hemodialysis and 4 cases of rupture. A total of 46 patients, comprising 42 men and 6 women with an average age of 70 ± 8 years were the subjects of this study. Surgically, the suprarenal aorta was exposed after the left renal vein (LRV) was mobilized or divided. Renal preservation was accomplished by the administration of mannitol (0.5 g/kg) before suprarenal aortic cross-clamping and the administration of 4°C cold Ringer solutions in cases of RA cross-clamping of over 30 minutes. A 6-mm ePTFE graft was anastomosed to a Y-graft body prior to end-to-end aorta-to-Y graft anastomosis, and then the RA was reconstructed when necessary. Results: There were 21 patients who had LV division and 14 patients (3 bilateral, 11 one-side) with renal artery reconstruction. The renal artery clamp time was 49 ± 14 and 30 ± 17 min in cases of renal artery reconstruction and no reconstruction, respectively. There were 5 patients with postoperative acute kidney injury (increase in sCr of ≥ 0.3 mg/dl or increase to ≥ 150%-200% from baseline). And there were 2 cases of in-hospital mortality due to cardiac failure and perforation of sigmoid colon cancer. Conclusion: The cause of the renal dysfunction was considered to be embolism, and therefore in future, the possibility of a mural thrombus at the site of the aortic cross-clamp should be determined before cross-clamping. However, open repair of non-ruptured JAA requiring suprarenal abdominal aortic cross-clamping was performed with acceptable results in the current procedures for the preservation of renal function.
AbstractList Introduction: Open repair requiring suprarenal aortic cross-clamping is still the treatment of choice for juxtarenal aortic aneurysms (JAA), despite advances in endovascular aneurysm repair. We assessed rates of mortality and acute kidney injury after open repair for abdominal aortic aneurysm (AAA) requiring suprarenal abdominal aortic cross-clamping in our institution. Materials and Methods: We encountered 56 patients with suprarenal AAA and JAA and infrarenal AAA requiring suprarenal abdominal aortic cross-clamping between 1996 and 2010. We retrospectively reviewed 48 elective patients, excluding 6 who received hemodialysis and 4 cases of rupture. A total of 46 patients, comprising 42 men and 6 women with an average age of 70 ± 8 years were the subjects of this study. Surgically, the suprarenal aorta was exposed after the left renal vein (LRV) was mobilized or divided. Renal preservation was accomplished by the administration of mannitol (0.5 g/kg) before suprarenal aortic cross-clamping and the administration of 4°C cold Ringer solutions in cases of RA cross-clamping of over 30 minutes. A 6-mm ePTFE graft was anastomosed to a Y-graft body prior to end-to-end aorta-to-Y graft anastomosis, and then the RA was reconstructed when necessary. Results: There were 21 patients who had LV division and 14 patients (3 bilateral, 11 one-side) with renal artery reconstruction. The renal artery clamp time was 49 ± 14 and 30 ± 17 min in cases of renal artery reconstruction and no reconstruction, respectively. There were 5 patients with postoperative acute kidney injury (increase in sCr of ≥ 0.3 mg/dl or increase to ≥ 150%–200% from baseline). And there were 2 cases of in-hospital mortality due to cardiac failure and perforation of sigmoid colon cancer. Conclusion: The cause of the renal dysfunction was considered to be embolism, and therefore in future, the possibility of a mural thrombus at the site of the aortic cross-clamp should be determined before cross-clamping. However, open repair of non-ruptured JAA requiring suprarenal abdominal aortic cross-clamping was performed with acceptable results in the current procedures for the preservation of renal function. 要  旨:【はじめに】腎動脈上・傍腎動脈腹部大動脈瘤(PAA・JAA)や腎動脈上腹部大動脈遮断を必要とする腎動脈下腹部大動脈瘤(AAA)症例について検討した.【対象と方法】1996年1月から2010年10月にPAA・JAAや腎動脈上腹部大動脈遮断を必要としたAAA 56例のうち維持透析6例,緊急4例を除く待機例46例(男40例,女6例)(70±8歳)を対象とした.左腎静脈は流入静脈を切離し授動するか左腎静脈を離断し術野を確保し,腎動脈遮断前にマンニトールを0.5 g/kg点滴静注し,30分以上遮断の場合に4°Cリンゲル液40 mlを遮断腎動脈に注入した.腎動脈再建が必要な場合にあらかじめY型人工血管に6 mm ePTFEを側端吻合して中枢側吻合後,腎動脈を端々吻合した.【結果】左腎静脈離断は21例,腎動脈再建14例(両側3例,片側11例)で,腎動脈遮断時間は腎動脈再建例;49±14分,再建なし例;29±16分であった.術前後の腎機能は,各々血清クレアチニン(Cr)値1.0±0.5,1.1±0.5 mg/dl,eGFR値59±22,59±23 ml/min/1.73 m2で,腎動脈再建例でも各々術前後eGFR値56±26,57±31 ml/min/1.73 m2でともに有意差を認めなかった.腎機能増悪(Cr値上昇が0.3 mg/dl以上または術前後Cr比;1.5倍以上)を5例(再建;3例,再建なし;2例)に認め,在院死2例(再建;心不全1例,再建なし;S状結腸癌穿孔1例)だった.【結語】腎動脈上大動脈遮断を必要とするAAAに対して,本術式の方法による腎保護で概ね満足すべき結果が得られた.
Introduction: Open repair requiring suprarenal aortic cross-clamping is still the treatment of choice for juxtarenal aortic aneurysms (JAA), despite advances in endovascular aneurysm repair. We assessed rates of mortality and acute kidney injury after open repair for abdominal aortic aneurysm (AAA) requiring suprarenal abdominal aortic cross-clamping in our institution. Materials and Methods: We encountered 56 patients with suprarenal AAA and JAA and infrarenal AAA requiring suprarenal abdominal aortic cross-clamping between 1996 and 2010. We retrospectively reviewed 48 elective patients, excluding 6 who received hemodialysis and 4 cases of rupture. A total of 46 patients, comprising 42 men and 6 women with an average age of 70 ± 8 years were the subjects of this study. Surgically, the suprarenal aorta was exposed after the left renal vein (LRV) was mobilized or divided. Renal preservation was accomplished by the administration of mannitol (0.5 g/kg) before suprarenal aortic cross-clamping and the administration of 4°C cold Ringer solutions in cases of RA cross-clamping of over 30 minutes. A 6-mm ePTFE graft was anastomosed to a Y-graft body prior to end-to-end aorta-to-Y graft anastomosis, and then the RA was reconstructed when necessary. Results: There were 21 patients who had LV division and 14 patients (3 bilateral, 11 one-side) with renal artery reconstruction. The renal artery clamp time was 49 ± 14 and 30 ± 17 min in cases of renal artery reconstruction and no reconstruction, respectively. There were 5 patients with postoperative acute kidney injury (increase in sCr of ≥ 0.3 mg/dl or increase to ≥ 150%-200% from baseline). And there were 2 cases of in-hospital mortality due to cardiac failure and perforation of sigmoid colon cancer. Conclusion: The cause of the renal dysfunction was considered to be embolism, and therefore in future, the possibility of a mural thrombus at the site of the aortic cross-clamp should be determined before cross-clamping. However, open repair of non-ruptured JAA requiring suprarenal abdominal aortic cross-clamping was performed with acceptable results in the current procedures for the preservation of renal function.
Author Kudo, Toshifumi
Inoue, Yoshinori
Nishizawa, Masato
Uchiyama, Hidetoshi
Toyohuku, Takahiro
Yonekura, Kouji
Jibiki, Masatoshi
Igari, Kimihiro
Koizumi, Shinya
Author_FL 猪狩 公宏
地引 政利
内山 英俊
工藤 敏文
豊福 崇浩
西澤 真人
米倉 孝治
井上 芳徳
小泉 伸也
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特定非営利活動法人 日本血管外科学会
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References 12)Calligaro KD, Savarese RP, McCombs PR, et al. Division of the left renal vein during aortic surgery. Am J Surg 1990;160:192-196.
5)Jongkind V, Yeung KK, Akkersdijk GJ, et al. Juxtarenal aortic aneurysm repair. J Vasc Surg 2010;52:760-767.
13)Jibiki M, Inoue Y, Kurihara N, et al. The proximal form of mural thrombus in aortoiliac occlusive disease using computed tomography. Int Angiol 2002;21:123-127.
4)Greenberg RK, Sternbergh WC 3rd, Makaroun M, et al. Intermediate results of a United States multicenter trial of fenestrated endograft repair for juxtarenal abdominal aorticaneurysms. J Vasc Surg 2009;50:730-737.
10)Mitaka C, Kudo T, Jibiki M, et al. Effects of human atrial natriuretic peptide on renal function in patients undergoing abdominal aortic aneurysm repair. Crit Care Med 2008;36:745-751.
11)Gupta SK, Veith FJ. Management of juxtarenal aortic occlusions: technique for suprarenal clamp placement. Ann Vasc Surg 1992;6: 306-312.
1)Parodi JC, Palmaz JC, Barone HD. Transfemoral intraluminal graft implantation for abdominal aortic aneurysms. Ann Vasc Surg 1991;5:491-499.
9)Henke PK, Cardneau JD, Welling TH 3rd, et al. Renal artery aneurysms: a 35-year clinical experience with 252 aneurysms in 168 patients. Ann Surg 2001;234:454-462; discussion 462-463.
8)Miller DC, Myers BD. Pathophysiology and prevention of acute renal failure associated with thoracoabdominal or abdominal aortic surgery. J Vasc Surg 1987;5:518-523.
6)Mehta RL, Kellum JA, Shah SV, et al. Acute Kidney Injury Network: report of an initiative to improve outcomes in acute kidney injury. Crit Care 2007;11:R31.
3)Greenberg RK, Haulon S, Lyden SP, et al. Endovascular management of juxtarenal aneurysms with fenestrated endovascular grafting. J Vasc Surg 2004;39:279-287.
7)Minion DJ, Yancey A, Patterson DE, et al. The endowedge and kilt techniques to achieve additional juxtarenal seal during deployment of the Gore Excluder endoprosthesis. Ann Vasc Surg 2006;20:472-477.
2)Ohrlander T, Sonesson B, Ivancev K, et al. The chimney graft: a technique for preserving or rescuing aortic branch vessels in stent-graft sealing zones. J Endovasc Ther 2008;15:427-432.
References_xml – reference: 6)Mehta RL, Kellum JA, Shah SV, et al. Acute Kidney Injury Network: report of an initiative to improve outcomes in acute kidney injury. Crit Care 2007;11:R31.
– reference: 7)Minion DJ, Yancey A, Patterson DE, et al. The endowedge and kilt techniques to achieve additional juxtarenal seal during deployment of the Gore Excluder endoprosthesis. Ann Vasc Surg 2006;20:472-477.
– reference: 1)Parodi JC, Palmaz JC, Barone HD. Transfemoral intraluminal graft implantation for abdominal aortic aneurysms. Ann Vasc Surg 1991;5:491-499.
– reference: 12)Calligaro KD, Savarese RP, McCombs PR, et al. Division of the left renal vein during aortic surgery. Am J Surg 1990;160:192-196.
– reference: 3)Greenberg RK, Haulon S, Lyden SP, et al. Endovascular management of juxtarenal aneurysms with fenestrated endovascular grafting. J Vasc Surg 2004;39:279-287.
– reference: 5)Jongkind V, Yeung KK, Akkersdijk GJ, et al. Juxtarenal aortic aneurysm repair. J Vasc Surg 2010;52:760-767.
– reference: 10)Mitaka C, Kudo T, Jibiki M, et al. Effects of human atrial natriuretic peptide on renal function in patients undergoing abdominal aortic aneurysm repair. Crit Care Med 2008;36:745-751.
– reference: 2)Ohrlander T, Sonesson B, Ivancev K, et al. The chimney graft: a technique for preserving or rescuing aortic branch vessels in stent-graft sealing zones. J Endovasc Ther 2008;15:427-432.
– reference: 9)Henke PK, Cardneau JD, Welling TH 3rd, et al. Renal artery aneurysms: a 35-year clinical experience with 252 aneurysms in 168 patients. Ann Surg 2001;234:454-462; discussion 462-463.
– reference: 4)Greenberg RK, Sternbergh WC 3rd, Makaroun M, et al. Intermediate results of a United States multicenter trial of fenestrated endograft repair for juxtarenal abdominal aorticaneurysms. J Vasc Surg 2009;50:730-737.
– reference: 8)Miller DC, Myers BD. Pathophysiology and prevention of acute renal failure associated with thoracoabdominal or abdominal aortic surgery. J Vasc Surg 1987;5:518-523.
– reference: 13)Jibiki M, Inoue Y, Kurihara N, et al. The proximal form of mural thrombus in aortoiliac occlusive disease using computed tomography. Int Angiol 2002;21:123-127.
– reference: 11)Gupta SK, Veith FJ. Management of juxtarenal aortic occlusions: technique for suprarenal clamp placement. Ann Vasc Surg 1992;6: 306-312.
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Snippet Introduction: Open repair requiring suprarenal aortic cross-clamping is still the treatment of choice for juxtarenal aortic aneurysms (JAA), despite advances...
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SubjectTerms Abdominal aortic aneurysm
Juxtarenal abdominal aortic aneurysm
Suprarenal abdominal aortic cross-clamping
傍腎動脈腹部大動脈瘤
腎動脈上腹部大動脈遮断
腹部大動脈瘤
Title Abdominal Aortic Aneurysm Treatments Requiring Suprarenal Abdominal Aortic Cross-clamping
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