Dietary guidance for patients with depressive disorder: A retrospective study focusing on factors associated with discontinuation

  Accumulating evidence has suggested the importance of nutritional approaches in the treatment of depressive disorder. In this study, we tried to identify main nutritional conditions targeted for the guidance of depressed patients and factors associated with continuation/discontinuation of the guid...

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Published inNew diet therapy Vol. 40; no. 1; pp. 3 - 10
Main Authors Kunugi, Hiroshi, Kasahara, Kohei, Miyamoto, Kayoko, Segawa, Kazuhiko
Format Journal Article
LanguageJapanese
Published The Japanese Clinical Nutrition Association 2024
一般社団法人 日本臨床栄養協会
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ISSN0910-7258
2434-7159
DOI10.32270/jcna.40.1_3

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Abstract   Accumulating evidence has suggested the importance of nutritional approaches in the treatment of depressive disorder. In this study, we tried to identify main nutritional conditions targeted for the guidance of depressed patients and factors associated with continuation/discontinuation of the guidance for 6 months. We retrospectively reviewed medical charts of 43 patients with depressive disorder who underwent nutritional guidance by registered dietitians at the National Center of Neurology and Psychiatry Hospital. As a result, most of the requested diseases in the guidance of depressed patients were conditions related to metabolic syndrome. Continuation of the guidance for 6 months was related to a longer history of depression, taking antidepressants, a history of receiving guidance in the past, higher BMI, and type 2 diabetes mellitus. The discontinuation group had a higher rate of missed meals. There was no clear change in BMI of the guidance-continuation group; however, some obese patients showed a substantial reduction of BMI. These results warrant further investigations for the nutrition guidance for depressed patients.
AbstractList   Accumulating evidence has suggested the importance of nutritional approaches in the treatment of depressive disorder. In this study, we tried to identify main nutritional conditions targeted for the guidance of depressed patients and factors associated with continuation/discontinuation of the guidance for 6 months. We retrospectively reviewed medical charts of 43 patients with depressive disorder who underwent nutritional guidance by registered dietitians at the National Center of Neurology and Psychiatry Hospital. As a result, most of the requested diseases in the guidance of depressed patients were conditions related to metabolic syndrome. Continuation of the guidance for 6 months was related to a longer history of depression, taking antidepressants, a history of receiving guidance in the past, higher BMI, and type 2 diabetes mellitus. The discontinuation group had a higher rate of missed meals. There was no clear change in BMI of the guidance-continuation group; however, some obese patients showed a substantial reduction of BMI. These results warrant further investigations for the nutrition guidance for depressed patients.
Author Kunugi, Hiroshi
Miyamoto, Kayoko
Segawa, Kazuhiko
Kasahara, Kohei
Author_FL 笠原 康平
功刀 浩
Segawa Kazuhiko
宮本 佳世子
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  organization: Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry
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  organization: Department of General Internal Medicine, National Center of Psychiatry and Neurology Hospital
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References 19) Serretti A, Mandelli L: Antideptessants and body weight: a comprehensive review and meta-analysis. J Clin Psychiatry 71(10);1259-1272 2010
18) Capuron L, Miller A: Immune System to Brain Signaling: Neuropsychopharmacological Implications. Pharmacol Ther. 130(2);226-238 2011
20) 阿部裕二、今泉博文、瀬川和彦、吉田寿美子. 肥満を合併した外来統合失調症患者に対する栄養食事指導の効果New Diet Therapy 33; 6-8, 2017
22) Prochaska J.O., Velicer W.F. The transtheoretical model of health behavior change. Am J Health Prom 12, 38‐48, 1997.
23) Cong H, Momma H, Nagatomi R, et al.:Independent and combined relationship of habitual unhealthy eating behaviors with depressive Symptoms: A prospective study. J Epidemiol 27; 42-47, 2017
7) Hidese S, Asano S, Saito K, Sasayama D, Kunugi H:Association of depression with body mass index classification, Metabolic disease and lifestyle : A web-based survey involving 11 ,876 Japanese people. J Psychiatr Res 102; 23-28, 2018
12) Culpepper L, Muskin P, Stahl S: Major Depressive Disorder: Understanding the Significance of Residual Symptoms and Balancing Efficacy with Tolerability The American Journal of Medicine Vol128, No9 A 2015
14) 日本うつ病学会 気分障害の治療ガイドライン作成委員会 日本うつ病学会治療ガイドライン Ⅱ.うつ病(DSM-5)/大うつ病性障害 2016(2019年7月24日 序文改定
24) Maki T, Eguchi M, Kuwahara K, Kochi T, Shamima A, Kashino I, Huanhuan H, Kurotani K, Kabe I, Kawakami N, Nanri A.:Breakfast consumption and the risk of depressive symptoms; The Furukawa Nutrition and Health Study. Psychiatry Res273; 551-558, 2019
11) Sarris J, Murphy J, Mischoulon D, Papakostas G, Fava M, Berk Michael B, H Ng C: Adjunctive Nutraceuticals for Depression: A Systematic Review and Meta-Analyses. Am J psychiatry Vol173;575-587 ,2016
8) 功刀浩、古賀賀恵、小川眞太郎「うつ患者における栄養学的異常」日本生物学的精神医学会誌 26;54-58, 2015
21) 功刀浩/阿部裕二(編著):臨床に役立つ精神疾患の栄養食事指導 講談社, 2021
2) 厚生労働省医政局長 医療計画について(通達)医政発0330第28号 平成24年3月30日
17) Esser N, Legrand-Poels S, Piette J, Scheen A, Paquot N: Inflammation as a link Between obesity, metabolic syndrome and type 2 diabetes. Diabetes Research and Clinical Practice 105;141-150 2014
3) Kunugi H. Depression and lifestyle: focusing on nutrition, exercise, and their possible relevance to molecular mechanisms. Psychiatry Clin Neurosci 77: 420-433, 2023
10) 功刀浩 こころに効く精神栄養学. 女子栄養大学出版、東京、2016
1) 厚生労働省政策統括官付参事官付保険統計室 令和2年(2020)患者調査 https://www.mhlw.go.jp/toukei/list/10-20.html
16) Opie R S, Itsiopoulos C, Parletta N, Sanchez-Villegas A, Akbaraly T N, Ruusuen A, Jacka F N.:Dietary recommendations for the prevention of depression. Nutr Neurosci 161-171, 2017
9) 功刀浩 うつ病と栄養・運動療法の効果 臨床心理学 14; 120-125, 2014
6) Luppino FS, de Wit LM, Bouvy PF, Stijnen T, Cuijpers P, Penninx BW, Zitman FG. Overweight, obesity, and depression: a systematic review and meta-analysis of longitudinal studies. Arch Gen Psychiatry 67: 220-229, 2010.
13) 松岡豊、浜崎景. 食からメンタルヘルスを考える ―栄養精神医学の役割と可能性―精神神経学雑誌 118;880-894, 2016
4) 功刀浩: 食生活習慣とうつ病リスク. 医学のあゆみ 284: 33-38, 2023
5) 菅原典夫: 精神疾患とメタボリックシンドローム症候群 臨床栄養 133; 318-324, 2018
15) Firth J, Marx W, Dash S, Carney R, Teasdale S, Solmi M, Stubbs B, Schuch F, Schuch F, Carvalho A, Jacka F, Sarris Jerome S: The effects of dietary improvement on symptoms of depression and anxiety: A meta-analysis of randomized controlled trials. Psychosom Med 81; 265-280, 2019
References_xml – reference: 2) 厚生労働省医政局長 医療計画について(通達)医政発0330第28号 平成24年3月30日
– reference: 20) 阿部裕二、今泉博文、瀬川和彦、吉田寿美子. 肥満を合併した外来統合失調症患者に対する栄養食事指導の効果New Diet Therapy 33; 6-8, 2017
– reference: 9) 功刀浩 うつ病と栄養・運動療法の効果 臨床心理学 14; 120-125, 2014
– reference: 19) Serretti A, Mandelli L: Antideptessants and body weight: a comprehensive review and meta-analysis. J Clin Psychiatry 71(10);1259-1272 2010
– reference: 3) Kunugi H. Depression and lifestyle: focusing on nutrition, exercise, and their possible relevance to molecular mechanisms. Psychiatry Clin Neurosci 77: 420-433, 2023
– reference: 12) Culpepper L, Muskin P, Stahl S: Major Depressive Disorder: Understanding the Significance of Residual Symptoms and Balancing Efficacy with Tolerability The American Journal of Medicine Vol128, No9 A 2015
– reference: 16) Opie R S, Itsiopoulos C, Parletta N, Sanchez-Villegas A, Akbaraly T N, Ruusuen A, Jacka F N.:Dietary recommendations for the prevention of depression. Nutr Neurosci 161-171, 2017
– reference: 21) 功刀浩/阿部裕二(編著):臨床に役立つ精神疾患の栄養食事指導 講談社, 2021
– reference: 5) 菅原典夫: 精神疾患とメタボリックシンドローム症候群 臨床栄養 133; 318-324, 2018
– reference: 23) Cong H, Momma H, Nagatomi R, et al.:Independent and combined relationship of habitual unhealthy eating behaviors with depressive Symptoms: A prospective study. J Epidemiol 27; 42-47, 2017
– reference: 13) 松岡豊、浜崎景. 食からメンタルヘルスを考える ―栄養精神医学の役割と可能性―精神神経学雑誌 118;880-894, 2016
– reference: 6) Luppino FS, de Wit LM, Bouvy PF, Stijnen T, Cuijpers P, Penninx BW, Zitman FG. Overweight, obesity, and depression: a systematic review and meta-analysis of longitudinal studies. Arch Gen Psychiatry 67: 220-229, 2010.
– reference: 4) 功刀浩: 食生活習慣とうつ病リスク. 医学のあゆみ 284: 33-38, 2023
– reference: 1) 厚生労働省政策統括官付参事官付保険統計室 令和2年(2020)患者調査 https://www.mhlw.go.jp/toukei/list/10-20.html
– reference: 10) 功刀浩 こころに効く精神栄養学. 女子栄養大学出版、東京、2016
– reference: 7) Hidese S, Asano S, Saito K, Sasayama D, Kunugi H:Association of depression with body mass index classification, Metabolic disease and lifestyle : A web-based survey involving 11 ,876 Japanese people. J Psychiatr Res 102; 23-28, 2018
– reference: 14) 日本うつ病学会 気分障害の治療ガイドライン作成委員会 日本うつ病学会治療ガイドライン Ⅱ.うつ病(DSM-5)/大うつ病性障害 2016(2019年7月24日 序文改定)
– reference: 15) Firth J, Marx W, Dash S, Carney R, Teasdale S, Solmi M, Stubbs B, Schuch F, Schuch F, Carvalho A, Jacka F, Sarris Jerome S: The effects of dietary improvement on symptoms of depression and anxiety: A meta-analysis of randomized controlled trials. Psychosom Med 81; 265-280, 2019
– reference: 24) Maki T, Eguchi M, Kuwahara K, Kochi T, Shamima A, Kashino I, Huanhuan H, Kurotani K, Kabe I, Kawakami N, Nanri A.:Breakfast consumption and the risk of depressive symptoms; The Furukawa Nutrition and Health Study. Psychiatry Res273; 551-558, 2019
– reference: 8) 功刀浩、古賀賀恵、小川眞太郎「うつ患者における栄養学的異常」日本生物学的精神医学会誌 26;54-58, 2015
– reference: 18) Capuron L, Miller A: Immune System to Brain Signaling: Neuropsychopharmacological Implications. Pharmacol Ther. 130(2);226-238 2011
– reference: 22) Prochaska J.O., Velicer W.F. The transtheoretical model of health behavior change. Am J Health Prom 12, 38‐48, 1997.
– reference: 11) Sarris J, Murphy J, Mischoulon D, Papakostas G, Fava M, Berk Michael B, H Ng C: Adjunctive Nutraceuticals for Depression: A Systematic Review and Meta-Analyses. Am J psychiatry Vol173;575-587 ,2016
– reference: 17) Esser N, Legrand-Poels S, Piette J, Scheen A, Paquot N: Inflammation as a link Between obesity, metabolic syndrome and type 2 diabetes. Diabetes Research and Clinical Practice 105;141-150 2014
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