The influence of aging on spinal motoneuron excitability in healthy subjects
This study aimed to assess the relationship between the physiological loss of motor units and spinal excitability in aging process of healthy person. Multiple point stimulation technique was used to calculate MUNE and 100 F-wave were analyzed to determine the spinal excitability by F-wave persistenc...
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| Published in | Japanese Journal of Clinical Neurophysiology Vol. 48; no. 1; pp. 1 - 7 |
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| Main Authors | , , , , , |
| Format | Journal Article |
| Language | Japanese |
| Published |
Japanese Society of Clinical Neurophysiology
01.02.2020
一般社団法人 日本臨床神経生理学会 |
| Subjects | |
| Online Access | Get full text |
| ISSN | 1345-7101 2188-031X |
| DOI | 10.11422/jscn.48.1 |
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| Abstract | This study aimed to assess the relationship between the physiological loss of motor units and spinal excitability in aging process of healthy person. Multiple point stimulation technique was used to calculate MUNE and 100 F-wave were analyzed to determine the spinal excitability by F-wave persistence (FP) and the amplitude ratio between F-wave and CMAP (F%M) at right median nerve of sixty-four healthy volunteers (mean age, 43.1 years). We divided the subjects into four groups, young adult (18 to 30 years), adulthood (31 to 45 years), middle-aged (46 to 59 years), and older group (above 60 years). MUNE decreased in elder group compared with young and middle age groups. Whereas, FP and F%M increased in high-middle and elder groups compared with young group. Multiple regression analysis showed significant relation between the MUNE decrease with FP increase and aging. We concluded the aging process, which was known as motor neuron loss, was compensated with excessive spinal motoneuron excitability which was the result of dysregulation of inhibitory process from central nervous system. |
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| AbstractList | This study aimed to assess the relationship between the physiological loss of motor units and spinal excitability in aging process of healthy person. Multiple point stimulation technique was used to calculate MUNE and 100 F-wave were analyzed to determine the spinal excitability by F-wave persistence (FP) and the amplitude ratio between F-wave and CMAP (F%M) at right median nerve of sixty-four healthy volunteers (mean age, 43.1 years). We divided the subjects into four groups, young adult (18 to 30 years), adulthood (31 to 45 years), middle-aged (46 to 59 years), and older group (above 60 years). MUNE decreased in elder group compared with young and middle age groups. Whereas, FP and F%M increased in high-middle and elder groups compared with young group. Multiple regression analysis showed significant relation between the MUNE decrease with FP increase and aging. We concluded the aging process, which was known as motor neuron loss, was compensated with excessive spinal motoneuron excitability which was the result of dysregulation of inhibitory process from central nervous system.
痙縮などの脊髄興奮性の増大に伴って, F波出現頻度 (F-wave persistence: FP) や振幅が増加することが知られているが, F波研究における生理的加齢の脊髄興奮性変化の知見は少ない。18〜93歳の健常対象者64名を若年群, 壮年群, 中年群, 高年群の4群に分け, 運動単位数推定 (motor unit number estimation: MUNE) とF波検査を行った。運動単位数, 単一運動単位電位の平均振幅, FP, CMAPに対するF波平均振幅の比 (F%M) を比較し, 年齢と各指標との相関を単回帰分析で検討した。さらに年齢に対するFPとMUNEの関連性を重回帰分析で検討した。MUNEは高年群で低下し, FPおよびF%Mは高値であった。MUNEは年齢と負の相関を認め, FPとF%Mは年齢と正の相関を認めた。また重相関の検討にてFPとMUNEはそれぞれ年齢との間に有意な相関を認めた。以上, 脊髄興奮性に生理的加齢性が影響している可能性が確認された。 This study aimed to assess the relationship between the physiological loss of motor units and spinal excitability in aging process of healthy person. Multiple point stimulation technique was used to calculate MUNE and 100 F-wave were analyzed to determine the spinal excitability by F-wave persistence (FP) and the amplitude ratio between F-wave and CMAP (F%M) at right median nerve of sixty-four healthy volunteers (mean age, 43.1 years). We divided the subjects into four groups, young adult (18 to 30 years), adulthood (31 to 45 years), middle-aged (46 to 59 years), and older group (above 60 years). MUNE decreased in elder group compared with young and middle age groups. Whereas, FP and F%M increased in high-middle and elder groups compared with young group. Multiple regression analysis showed significant relation between the MUNE decrease with FP increase and aging. We concluded the aging process, which was known as motor neuron loss, was compensated with excessive spinal motoneuron excitability which was the result of dysregulation of inhibitory process from central nervous system. |
| Author | Hirashima, Fumiko Kitao, Ruriko Abe, Tatsuya Ohkuma, Aya Kimura, Toshinori Komori, Tetsuo |
| Author_FL | 小森 哲夫 阿部 達哉 北尾 るり子 平島 富美子 大熊 彩 木村 俊紀 |
| Author_FL_xml | – sequence: 1 fullname: 阿部 達哉 – sequence: 2 fullname: 大熊 彩 – sequence: 3 fullname: 北尾 るり子 – sequence: 4 fullname: 平島 富美子 – sequence: 5 fullname: 木村 俊紀 – sequence: 6 fullname: 小森 哲夫 |
| Author_xml | – sequence: 1 fullname: Ohkuma, Aya organization: Department of Neurology, Center for Neuromuscular and Intractable Diseases, National Hospital Organization Hakone Hospital – sequence: 1 fullname: Komori, Tetsuo organization: Department of Neurology, Center for Neuromuscular and Intractable Diseases, National Hospital Organization Hakone Hospital – sequence: 1 fullname: Kitao, Ruriko organization: Department of Neurology, Center for Neuromuscular and Intractable Diseases, National Hospital Organization Hakone Hospital – sequence: 1 fullname: Abe, Tatsuya organization: Department of Neurology, Center for Neuromuscular and Intractable Diseases, National Hospital Organization Hakone Hospital – sequence: 1 fullname: Hirashima, Fumiko organization: Department of Rehabilitation Medicine, Flower and Forest Tokyo Hospital – sequence: 1 fullname: Kimura, Toshinori organization: Department of Neurology, Center for Neuromuscular and Intractable Diseases, National Hospital Organization Hakone Hospital |
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| References | 8) Guiloff RJ, Modarres-Sadeghi H: Preferential generation of recruit responses by groups of motor neurons in man. Conventional and single unit F wave study. Brain 114: 1771–1801, 1991. 5) Mesrati F, Vecchierini MF: F-waves: neurophysiology and clinical value. Neurophysiol Clin 34: 217–243, 2004. 7) Peioglou-Harmoussi S, Howel D, Fawcett PRW, et al: F-response behavior in a control population. J Neurol Neurosurg Psychiatry 48: 1152–1158, 1985. 2) Gawel M, Kostera-Pruszczyk A: Effect of age and gender on the number of motor units in healthy subjects estimated by the multiple point incremental MUNE method. J Clin Neurophysiol 31: 272–278, 2014. 11) Taniguch S, Kimura J, Yamada T, et al: Effect of motion imagery to counter rest-induced suppression of F-wave as a measure of anterior horn cell excitability. Clin Neurophysiol 119: 1346–1352, 2008. 12) Hara M, Kimura J, Walker DD, et al: Effect of motor imagery and voluntary muscle contraction on the F-wave. Muscle Nerve 42: 208–212, 2010. 9) Doherty TJ, Komori T, Stashuk DW, et al: Physiological properties of single thenar motor unit in the F-response of younger and older adults. Muscle Nerve 17: 860–872, 1994. 10) Ichikawa T, Yokota T: F wave change by decreased motoneuronal excitability: a sleep study. Bull Tokyo Med Dent Univ 41: 15–22, 1994. 6) Kimura J: Electrodiagnosis in Diagnosis of Nerve and Muscle: Principles and Practice. Ed4, Oxford University Press, New York, pp 439–465, 2013. 3) McNeil CJ, Doherty TJ, Stashuk DW, et al: Motor unit number estimation in the tibialis anterior muscle of young, old, and very old men. Muscle Nerve 31: 461–467, 2005. 13) Bhandari A, Radhu N, Farzan F, et al: A meta-analysis of the efficacy of aging on motor cortex neurophysiology assessed by transcranial magnetic stimulation. Clin Neurophysiol 127: 2834–2854, 2016. 1) Doherty TJ, Brown WF: The estimated number and relative size of thenar motor units as selected by multiple point stimulation in young and older adults. Muscle Nerve 16: 355–366, 1993. 4) Brown WF: A method for estimating the number of motor units in thenar muscles and the changes in motor unit count with ageing. J Neurol Neurosurg Psychiatry 35: 845–852, 1972. |
| References_xml | – reference: 4) Brown WF: A method for estimating the number of motor units in thenar muscles and the changes in motor unit count with ageing. J Neurol Neurosurg Psychiatry 35: 845–852, 1972. – reference: 7) Peioglou-Harmoussi S, Howel D, Fawcett PRW, et al: F-response behavior in a control population. J Neurol Neurosurg Psychiatry 48: 1152–1158, 1985. – reference: 10) Ichikawa T, Yokota T: F wave change by decreased motoneuronal excitability: a sleep study. Bull Tokyo Med Dent Univ 41: 15–22, 1994. – reference: 2) Gawel M, Kostera-Pruszczyk A: Effect of age and gender on the number of motor units in healthy subjects estimated by the multiple point incremental MUNE method. J Clin Neurophysiol 31: 272–278, 2014. – reference: 6) Kimura J: Electrodiagnosis in Diagnosis of Nerve and Muscle: Principles and Practice. Ed4, Oxford University Press, New York, pp 439–465, 2013. – reference: 13) Bhandari A, Radhu N, Farzan F, et al: A meta-analysis of the efficacy of aging on motor cortex neurophysiology assessed by transcranial magnetic stimulation. Clin Neurophysiol 127: 2834–2854, 2016. – reference: 5) Mesrati F, Vecchierini MF: F-waves: neurophysiology and clinical value. Neurophysiol Clin 34: 217–243, 2004. – reference: 8) Guiloff RJ, Modarres-Sadeghi H: Preferential generation of recruit responses by groups of motor neurons in man. Conventional and single unit F wave study. Brain 114: 1771–1801, 1991. – reference: 12) Hara M, Kimura J, Walker DD, et al: Effect of motor imagery and voluntary muscle contraction on the F-wave. Muscle Nerve 42: 208–212, 2010. – reference: 3) McNeil CJ, Doherty TJ, Stashuk DW, et al: Motor unit number estimation in the tibialis anterior muscle of young, old, and very old men. Muscle Nerve 31: 461–467, 2005. – reference: 11) Taniguch S, Kimura J, Yamada T, et al: Effect of motion imagery to counter rest-induced suppression of F-wave as a measure of anterior horn cell excitability. Clin Neurophysiol 119: 1346–1352, 2008. – reference: 1) Doherty TJ, Brown WF: The estimated number and relative size of thenar motor units as selected by multiple point stimulation in young and older adults. Muscle Nerve 16: 355–366, 1993. – reference: 9) Doherty TJ, Komori T, Stashuk DW, et al: Physiological properties of single thenar motor unit in the F-response of younger and older adults. Muscle Nerve 17: 860–872, 1994. |
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| Title | The influence of aging on spinal motoneuron excitability in healthy subjects |
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