Effect on Intestinal Flora of Long-term Ingestion of a Novel Supplement Containing Lactic Acid Bacteria Isolated from the Tonewase Persimmon
Human intestinal flora plays an important role in health maintenance, however, in recent years, it has been said that dysbiosis is increasing among Japanese people due to changes in eating habits or greater social stress. In general, sending living lactic acid bacteria to the intestine is thought to...
Saved in:
| Published in | Chōnai saikingaku zasshi Vol. 35; no. 3; pp. 165 - 172 |
|---|---|
| Main Authors | , |
| Format | Journal Article |
| Language | Japanese |
| Published |
Tokyo
The Intestinal Microbiology Society
01.07.2021
Japan Science and Technology Agency |
| Subjects | |
| Online Access | Get full text |
| ISSN | 1343-0882 1349-8363 |
| DOI | 10.11209/jim.35.165 |
Cover
| Abstract | Human intestinal flora plays an important role in health maintenance, however, in recent years, it has been said that dysbiosis is increasing among Japanese people due to changes in eating habits or greater social stress. In general, sending living lactic acid bacteria to the intestine is thought to be an efficient way of improving dysbiosis, and some lactic acid bacteria, commonly known as plant- origin lactic acid bacteria, are expected to withstand the harsh environment of the digestive tract and reach the intestines. In this study, we investigated the effect of long-term intake of the supplement MP-1, which contains lactic acid bacteria isolated from the Tonewase persimmon, on the intestinal flora of mice. The mice were divided into three groups. The MP-1 and control groups were respectively fed tablets with and without MP-1 together with a regular diet, and the remaining group was fed only a regular diet for 28 days. In the fecal flora of the MP-1 group, lactic acid bacteria that were not detected before the experiment were detected on day 28. On the other hand, no significant changes were observed in fecal flora of the control and regular diet groups. Therefore, we concluded that long-term intake of MP-1, a supplement containing lactic acid bacteria isolated from the Tonewase persimmon, had a notable effect on their intestinal flora. |
|---|---|
| AbstractList | Human intestinal flora plays an important role in health maintenance, however, in recent years, it has been said that dysbiosis is increasing among Japanese people due to changes in eating habits or greater social stress. In general, sending living lactic acid bacteria to the intestine is thought to be an efficient way of improving dysbiosis, and some lactic acid bacteria, commonly known as plant- origin lactic acid bacteria, are expected to withstand the harsh environment of the digestive tract and reach the intestines. In this study, we investigated the effect of long-term intake of the supplement MP-1, which contains lactic acid bacteria isolated from the Tonewase persimmon, on the intestinal flora of mice. The mice were divided into three groups. The MP-1 and control groups were respectively fed tablets with and without MP-1 together with a regular diet, and the remaining group was fed only a regular diet for 28 days. In the fecal flora of the MP-1 group, lactic acid bacteria that were not detected before the experiment were detected on day 28. On the other hand, no significant changes were observed in fecal flora of the control and regular diet groups. Therefore, we concluded that long-term intake of MP-1, a supplement containing lactic acid bacteria isolated from the Tonewase persimmon, had a notable effect on their intestinal flora. |
| Author | GOTOH, Akinobu MATSUNAGA, Wataru |
| Author_xml | – sequence: 1 fullname: GOTOH, Akinobu organization: Department of Education for Medical Research Base, Hyogo College of Medicine – sequence: 1 fullname: MATSUNAGA, Wataru organization: Joint-Use Research Facilities, Hyogo College of Medicine |
| BookMark | eNo9UEFOwzAQtBBIlNITH7DEOcWO4zQ5cChVC5UqQKL3yI3XqaPEDrYL4g88GpciLrurmdFoZ67QubEGELqhZEppSsq7VvdTxqc052doRFlWJgXL2fnvzRJSFOklmnivd4TwktCS0hH6XioFdcDW4LUJ4IM2osOrzjqBrcIba5okgOsj2xzZqIuwwM_2Azr8dhiGDnowAS-sCUIbbRq8EXXQNZ7XWuKHeIPTAq-97UQAiZWzPQ57wNv4_qfwgF_Bed331lyjCyU6D5O_PUbb1XK7eEo2L4_rxXyTtEWaJXSX5WWuMk5mkBEmUsZlzrKU8xmRsihkTESYkmUmJJVQC4CUKkilnBHglLAxuj3ZDs6-H2KqqrUHF3P76miSckZ4FlX3J1Xrg2igGpzuhfuqhIvhOqhi2xXjFTuOWPk_Xu-Fq8CwH6ANfrk |
| ContentType | Journal Article |
| Copyright | 2021 The Intestinal Microbiology Society Copyright Japan Science and Technology Agency 2021 |
| Copyright_xml | – notice: 2021 The Intestinal Microbiology Society – notice: Copyright Japan Science and Technology Agency 2021 |
| DBID | 7QL C1K |
| DOI | 10.11209/jim.35.165 |
| DatabaseName | Bacteriology Abstracts (Microbiology B) Environmental Sciences and Pollution Management |
| DatabaseTitle | Bacteriology Abstracts (Microbiology B) Environmental Sciences and Pollution Management |
| DatabaseTitleList | Bacteriology Abstracts (Microbiology B) |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine |
| EISSN | 1349-8363 |
| EndPage | 172 |
| ExternalDocumentID | article_jim_35_3_35_165_article_char_en |
| GroupedDBID | ABJNI ADBBV ALMA_UNASSIGNED_HOLDINGS BAWUL DIK JSF KQ8 MOJWN RJT 7QL C1K |
| ID | FETCH-LOGICAL-j824-1b4696f4507e403a235d63425570dd88dffe03fd94ad1decaee21fe2dd70e5103 |
| ISSN | 1343-0882 |
| IngestDate | Sat Sep 20 15:11:32 EDT 2025 Wed Sep 03 06:31:14 EDT 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | false |
| IsScholarly | true |
| Issue | 3 |
| Language | Japanese |
| LinkModel | OpenURL |
| MergedId | FETCHMERGED-LOGICAL-j824-1b4696f4507e403a235d63425570dd88dffe03fd94ad1decaee21fe2dd70e5103 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 |
| OpenAccessLink | https://www.jstage.jst.go.jp/article/jim/35/3/35_165/_article/-char/en |
| PQID | 2557253054 |
| PQPubID | 2028985 |
| PageCount | 8 |
| ParticipantIDs | proquest_journals_2557253054 jstage_primary_article_jim_35_3_35_165_article_char_en |
| PublicationCentury | 2000 |
| PublicationDate | 20210701 |
| PublicationDateYYYYMMDD | 2021-07-01 |
| PublicationDate_xml | – month: 07 year: 2021 text: 20210701 day: 01 |
| PublicationDecade | 2020 |
| PublicationPlace | Tokyo |
| PublicationPlace_xml | – name: Tokyo |
| PublicationTitle | Chōnai saikingaku zasshi |
| PublicationTitleAlternate | Journal of Intestinal Microbiology |
| PublicationYear | 2021 |
| Publisher | The Intestinal Microbiology Society Japan Science and Technology Agency |
| Publisher_xml | – name: The Intestinal Microbiology Society – name: Japan Science and Technology Agency |
| References | 3) 須藤信行．脳機能と腸内細菌叢．腸内細菌学雑誌．2017; 31: 23–32. 17) Collins MD, Phillips BA, Zanoni P. Deoxyribonucleic Acid Homology Studies of Lactobacillus casei, Lactobacillus paracasei sp. nov., subsp. paracasei and subsp. tolerans, and Lactobacillus rhamnosus sp. nov., comb. nov. Int. J. Syst. Bacterial. 1989; 39: 105–108. 1) Falk PG, Hooper LV, Midtvedt T, Gordon JI. Creating and maintaining the gastrointestinal ecosystem: what we know and need to know from gnotobiology. Microbiol Mol Biol Rev. 1998; 62: 1157–1170. 32) 岡村尚昌，中村 智子．ヤマブシタケから抽出された有効成分をメンタルヘルスに応用する．Journal of Health Psychology Research. 2018; 30: 231–236. 2) Shanahan F. The host–microbe interface within the gut. Best Pract Res Clin Gastroenterol. 2002; 16: 915–931. 27) Yang J, Ren F, Zhang H, Jiang L, Hao Y, Luo X. Induction of Regulatory Dendritic Cells by Lactobacillus paracasei L9 Prevents Allergic Sensitization to Bovine beta-Lactoglobulin in Mice. J Microbiol Biotechnol. 2015; 25: 1687–1696. 4) 河野敦子，石川秀樹，中村富予，河野公一．大腸癌と腸内細菌叢に関する疫学研究の検討～発酵乳製品や乳酸菌製剤による研究を中心に～．日本衛生学雑誌．2010; 65: 422–446. 14) 設楽 修．抗菌性飼料添加物無添加飼料への乳酸菌死菌体製剤添加が肥育豚の発育,血液性状および糞便内細菌数に及ぼす影響．兵庫県立農林水産技術総合センター研究報告：畜産編．2012; 48: p.17–22. 7) 渡邉邦友．自閉症と腸内細菌．腸内細菌学雑誌．2014; 28: 121–128. 30) Hiramoto K, Nishioka J, Suzuki K. Innate immune activation and antitumor effects of Lactobacillus-fermented Sparassis crispa extract in mice. J. Func Foods 2020; 75: 104215. 5) 園山 慶．メタボリックシンドロームと腸内細菌叢．腸内細菌学雑誌．2010; 24: 193–201. 21) テクノスルガ・ラボ：OTU520．https://www.tecsrg.co.jp/t-rflp/tree_html/lactobacillales_520.html（最終閲覧 2020.11.20） 9) 辨野義己．プロバイオティクスとその臨床的展望．日本内科学会雑誌．2015; 104: 86–92. 31) 河岸洋和．きのこが産生する生体機能性物質に関する研究．日本きのこ学会誌．2018; 25: 122–128. 6) Pascal M, Perez-Gordo M, Caballero T, Escribese MM, Lopez Longo MN, Luengo O, Manso L, Matheu V, Seoane E, Zamorano M, Labrador M, Mayorga C. Microbiome and allergic diseases. Front Immunol. 2018; 9: 1584. 28) Pellaton C, Nutten S, Thierry AC, Boudousquié C, Barbier N, Blanchard C, Corthésy B, Mercenier A, Spertini F. Intragastric and Intranasal Administration of Lactobacillus paracasei NCC2461 Modulates Allergic Airway Inflammation in Mice. Int J Inflam. 2012; 2012: 686739. 20) テクノスルガ・ラボ：ヒト腸内細菌分類群（制限酵素BslⅠ）．https://www.tecsrg.co.jp/t-rflp/t_rflp_hito_OTU.html（最終閲覧 2020.11.20） 22) DDBJ：http://getentry.ddbj.nig.ac.jp/getentry/na/D79212/?format=flatfile&filetype=html&trace=true&show_suppressed=false&limit=10（最終閲覧2020.8.25） 16) 岡田早苗．場を浄める乳酸菌．微生物．1988; 4: 151–166. 11) 光岡知足．腸内フローラと生活習慣病．東京：学会出版センター；2011. p.32. 10) 光岡知足．プロバイオティクスの歴史と進化．日本乳酸菌学会誌．2011; 22: 26–37. 15) 河野麻実子，吉野智恵，松浦洋一，浅田雅宣，河原有三．ビフィズス菌および乳酸菌含有腸溶性カプセルの摂取が健常人の排便回数, 便性状に及ぼす影響．腸内細菌学雑誌．2004; 18: 87–92. 12) Abraham BP, Quigley EMM. Probiotics in inflammatory bowel disease. Gastroenterol Clin North Am. 2017; 46: 769–782. 29) Moroi M, Uchi S, Nakamura K, Sato S, Shimizu N, Fujii M, Kumagai T, Saito M, Uchiyama K, Watanabe T, Yamaguchi H, Yamamoto T, Takeuchi S, Furue M. Beneficial effect of a diet containing heat-killed Lactobacillus paracasei K71 on adult type atopic dermatitis. J Dermatol. 2011; 38: 131–139. 25) Tsai YT, Cheng PC, Fan CK, Pan TM. Time-dependent persistence of enhanced immune response by a potential probiotic strain Lactobacillus paracasei subsp. paracasei NTU 101. Int J Food Microbiol. 2008; 128: 219–225. 23) Wang J, Tang H, Zhang C, Zhao Y, Derrien M, Rocher E, van-Hylckama Vlieg JE, Strissel K, Zhao L, Obin M, Shen J. Modulation of gut microbiota during probiotic-mediated attenuation of metabolic syndrome in high fat diet-fed mice. ISME J. 2015; 9: 1–15. 8) 功刀 浩．うつ病・自閉症と腸内細菌叢．腸内細菌学雑誌．2018; 32: 7–13. 24) Nishida S, Michinaka A, Nakashima K, Iino H, Fujii T. Evaluation of the probiotic potential of Lactobacillus paracasei KW3110 based on in vitro tests and oral administration tests in healthy adults. J Gen Appl Microbiol. 2008; 54: 267–276. 19) Nagashima K, Mochizuki J, Hisada T, Suzuki S, Shimomura K. Phylogenetic analysis of 16S ribosomal RNA gene sequences from Human fecal microbiota and improved utility of terminal restriction fragment length polymorphism profiling. Bioscience and Microflora. 2006; 25: 99–107. 13) 本雄宇，鈴木 司，石毛太一郎, 熊谷武久，藤田信之，山本 祐司，田中尚人．肥満モデルマウスにおけるLactobacillus paracasei K71加熱死菌体摂取による腸内細菌叢および脂質代謝への影響．日本乳酸菌学会誌．2018; 29: 152–157. 18) Nagashima K, Hisada T, Sato M, Mochizuki J. Application of new primer-enzyme combinations to terminal restriction fragment length polymorphism profiling of bacterial populations in human feces. Appl Environ Microbiol. 2003; 69: 1251–1262. 26) 上野 豊, 石黒貴寛．大豆の凍結変性による難消化性たん白質のプレバイオティック機能性強化．大豆たん白質研究．2016; 19: 50–54. |
| References_xml | – reference: 12) Abraham BP, Quigley EMM. Probiotics in inflammatory bowel disease. Gastroenterol Clin North Am. 2017; 46: 769–782. – reference: 1) Falk PG, Hooper LV, Midtvedt T, Gordon JI. Creating and maintaining the gastrointestinal ecosystem: what we know and need to know from gnotobiology. Microbiol Mol Biol Rev. 1998; 62: 1157–1170. – reference: 14) 設楽 修．抗菌性飼料添加物無添加飼料への乳酸菌死菌体製剤添加が肥育豚の発育,血液性状および糞便内細菌数に及ぼす影響．兵庫県立農林水産技術総合センター研究報告：畜産編．2012; 48: p.17–22. – reference: 17) Collins MD, Phillips BA, Zanoni P. Deoxyribonucleic Acid Homology Studies of Lactobacillus casei, Lactobacillus paracasei sp. nov., subsp. paracasei and subsp. tolerans, and Lactobacillus rhamnosus sp. nov., comb. nov. Int. J. Syst. Bacterial. 1989; 39: 105–108. – reference: 27) Yang J, Ren F, Zhang H, Jiang L, Hao Y, Luo X. Induction of Regulatory Dendritic Cells by Lactobacillus paracasei L9 Prevents Allergic Sensitization to Bovine beta-Lactoglobulin in Mice. J Microbiol Biotechnol. 2015; 25: 1687–1696. – reference: 4) 河野敦子，石川秀樹，中村富予，河野公一．大腸癌と腸内細菌叢に関する疫学研究の検討～発酵乳製品や乳酸菌製剤による研究を中心に～．日本衛生学雑誌．2010; 65: 422–446. – reference: 8) 功刀 浩．うつ病・自閉症と腸内細菌叢．腸内細菌学雑誌．2018; 32: 7–13. – reference: 15) 河野麻実子，吉野智恵，松浦洋一，浅田雅宣，河原有三．ビフィズス菌および乳酸菌含有腸溶性カプセルの摂取が健常人の排便回数, 便性状に及ぼす影響．腸内細菌学雑誌．2004; 18: 87–92. – reference: 20) テクノスルガ・ラボ：ヒト腸内細菌分類群（制限酵素BslⅠ）．https://www.tecsrg.co.jp/t-rflp/t_rflp_hito_OTU.html（最終閲覧 2020.11.20）． – reference: 29) Moroi M, Uchi S, Nakamura K, Sato S, Shimizu N, Fujii M, Kumagai T, Saito M, Uchiyama K, Watanabe T, Yamaguchi H, Yamamoto T, Takeuchi S, Furue M. Beneficial effect of a diet containing heat-killed Lactobacillus paracasei K71 on adult type atopic dermatitis. J Dermatol. 2011; 38: 131–139. – reference: 19) Nagashima K, Mochizuki J, Hisada T, Suzuki S, Shimomura K. Phylogenetic analysis of 16S ribosomal RNA gene sequences from Human fecal microbiota and improved utility of terminal restriction fragment length polymorphism profiling. Bioscience and Microflora. 2006; 25: 99–107. – reference: 7) 渡邉邦友．自閉症と腸内細菌．腸内細菌学雑誌．2014; 28: 121–128. – reference: 26) 上野 豊, 石黒貴寛．大豆の凍結変性による難消化性たん白質のプレバイオティック機能性強化．大豆たん白質研究．2016; 19: 50–54. – reference: 24) Nishida S, Michinaka A, Nakashima K, Iino H, Fujii T. Evaluation of the probiotic potential of Lactobacillus paracasei KW3110 based on in vitro tests and oral administration tests in healthy adults. J Gen Appl Microbiol. 2008; 54: 267–276. – reference: 30) Hiramoto K, Nishioka J, Suzuki K. Innate immune activation and antitumor effects of Lactobacillus-fermented Sparassis crispa extract in mice. J. Func Foods 2020; 75: 104215. – reference: 16) 岡田早苗．場を浄める乳酸菌．微生物．1988; 4: 151–166. – reference: 9) 辨野義己．プロバイオティクスとその臨床的展望．日本内科学会雑誌．2015; 104: 86–92. – reference: 22) DDBJ：http://getentry.ddbj.nig.ac.jp/getentry/na/D79212/?format=flatfile&filetype=html&trace=true&show_suppressed=false&limit=10（最終閲覧2020.8.25）． – reference: 3) 須藤信行．脳機能と腸内細菌叢．腸内細菌学雑誌．2017; 31: 23–32. – reference: 6) Pascal M, Perez-Gordo M, Caballero T, Escribese MM, Lopez Longo MN, Luengo O, Manso L, Matheu V, Seoane E, Zamorano M, Labrador M, Mayorga C. Microbiome and allergic diseases. Front Immunol. 2018; 9: 1584. – reference: 2) Shanahan F. The host–microbe interface within the gut. Best Pract Res Clin Gastroenterol. 2002; 16: 915–931. – reference: 11) 光岡知足．腸内フローラと生活習慣病．東京：学会出版センター；2011. p.32. – reference: 13) 本雄宇，鈴木 司，石毛太一郎, 熊谷武久，藤田信之，山本 祐司，田中尚人．肥満モデルマウスにおけるLactobacillus paracasei K71加熱死菌体摂取による腸内細菌叢および脂質代謝への影響．日本乳酸菌学会誌．2018; 29: 152–157. – reference: 18) Nagashima K, Hisada T, Sato M, Mochizuki J. Application of new primer-enzyme combinations to terminal restriction fragment length polymorphism profiling of bacterial populations in human feces. Appl Environ Microbiol. 2003; 69: 1251–1262. – reference: 25) Tsai YT, Cheng PC, Fan CK, Pan TM. Time-dependent persistence of enhanced immune response by a potential probiotic strain Lactobacillus paracasei subsp. paracasei NTU 101. Int J Food Microbiol. 2008; 128: 219–225. – reference: 21) テクノスルガ・ラボ：OTU520．https://www.tecsrg.co.jp/t-rflp/tree_html/lactobacillales_520.html（最終閲覧 2020.11.20）． – reference: 10) 光岡知足．プロバイオティクスの歴史と進化．日本乳酸菌学会誌．2011; 22: 26–37. – reference: 28) Pellaton C, Nutten S, Thierry AC, Boudousquié C, Barbier N, Blanchard C, Corthésy B, Mercenier A, Spertini F. Intragastric and Intranasal Administration of Lactobacillus paracasei NCC2461 Modulates Allergic Airway Inflammation in Mice. Int J Inflam. 2012; 2012: 686739. – reference: 23) Wang J, Tang H, Zhang C, Zhao Y, Derrien M, Rocher E, van-Hylckama Vlieg JE, Strissel K, Zhao L, Obin M, Shen J. Modulation of gut microbiota during probiotic-mediated attenuation of metabolic syndrome in high fat diet-fed mice. ISME J. 2015; 9: 1–15. – reference: 31) 河岸洋和．きのこが産生する生体機能性物質に関する研究．日本きのこ学会誌．2018; 25: 122–128. – reference: 32) 岡村尚昌，中村 智子．ヤマブシタケから抽出された有効成分をメンタルヘルスに応用する．Journal of Health Psychology Research. 2018; 30: 231–236. – reference: 5) 園山 慶．メタボリックシンドロームと腸内細菌叢．腸内細菌学雑誌．2010; 24: 193–201. |
| SSID | ssib005901911 ssib000961636 ssib002484391 ssj0036821 |
| Score | 2.270728 |
| Snippet | Human intestinal flora plays an important role in health maintenance, however, in recent years, it has been said that dysbiosis is increasing among Japanese... |
| SourceID | proquest jstage |
| SourceType | Aggregation Database Publisher |
| StartPage | 165 |
| SubjectTerms | Acids Bacteria Diet Dysbacteriosis Eating behavior Gastrointestinal tract Ingestion intestinal flora Intestinal microflora Intestine Lactic acid Lactic acid bacteria Lacticaseibacillus paracasei Persimmons Social interactions |
| Title | Effect on Intestinal Flora of Long-term Ingestion of a Novel Supplement Containing Lactic Acid Bacteria Isolated from the Tonewase Persimmon |
| URI | https://www.jstage.jst.go.jp/article/jim/35/3/35_165/_article/-char/en https://www.proquest.com/docview/2557253054 |
| Volume | 35 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| ispartofPNX | Journal of Intestinal Microbiology, 2021, Vol.35(3), pp.165-172 |
| journalDatabaseRights | – providerCode: PRVAFT databaseName: Open Access Digital Library customDbUrl: eissn: 1349-8363 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0036821 issn: 1343-0882 databaseCode: KQ8 dateStart: 19970101 isFulltext: true titleUrlDefault: http://grweb.coalliance.org/oadl/oadl.html providerName: Colorado Alliance of Research Libraries – providerCode: PRVBFR databaseName: Free Medical Journals customDbUrl: eissn: 1349-8363 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0036821 issn: 1343-0882 databaseCode: DIK dateStart: 19970101 isFulltext: true titleUrlDefault: http://www.freemedicaljournals.com providerName: Flying Publisher |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lj9MwELbKIiEuiKdYWJAPmEuUksRJ6hzTbkqBbitEKvUWOY_upgvNstty2N_An-UfMOO4SdAiBFyiyHGe82XmG3vGQ8irILOt1M-EmQbpynRlzk1ZOLkZFDiPhpWSVIbcycyfLNz3S2_Z6_3oRC3ttmk_u_5tXsn_SBXaQK6YJfsPkm0uCg2wD_KFLUgYtn8lY730cFUP7MHPitRyDB64VEP_1ebURM0LR3EWSVNDacyqb8VnQ9XzVIODmPa3rStFGFOVNGWEWZkbw3olZ2m8g9eQSE2bZJS4AjoOBlBF0JdqIK3DckdnbOQxcbyRpXElSxyNl-c74xqI-lnZiDiMPy1m4dtQhfnJrbzcNcFA83g-UVoLTq3Spp1FPguO2TDCnaHFhsJQe4KJoO0zYOGQhZbqHLLQwQuxyMPTxIhFggXQw-0Odzh2ExqrTRFQiFbv4dxCOwVhhCpdtaPNuctN9CFqY7dvC0zBtVbVJqBeMUVDnXf0uV0XsrhpZxy1Tuu6_NLnXl_3-nU179k8GS-m0ySOlvHri68mFjrDgABd9eUWue2AIcJqIx8-dhhx4AND7nh8rsDc6FZlAn8L7CaKiftCpxbqN9UpqPh8b9qnA3q1Bmfj9CbjUDQqvk_uaf-HhjWYH5DeWj4kd050hMcj8r3GNK02tMU0VZim1Yo2mKYNprFZUoVp2mKatpimNaYpYpruMU33mKaIaQqYpntM0wbTj0k8juLRxNQVQ8y1cFzTTl0_8Fcu-DiFa3HpcC_3OVglb2DluRA5vIHFV3kAOsnOi0wWhWOvQDXlA6vApSWfkIMN3OspoX6WOuBLFTYX0vWzAfBg0FtuYKWOn9k5PyR-_UWTi3pVmERrgQS-esK9hOMGPn3TjlmUoLQOydFeAolWJVcJPqHjgel1n_358HNyt_0pjsjB9nJXvABWvE1fKhz9BJaEsXs |
| linkProvider | Colorado Alliance of Research Libraries |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Effect+on+Intestinal+Flora+of+Long-term+Ingestion+of+a+Novel+Supplement+Containing+Lactic+Acid+Bacteria+Isolated+from+the+Tonewase+Persimmon&rft.jtitle=Ch%C5%8Dnai+saikingaku+zasshi&rft.au=MATSUNAGA%2C+Wataru&rft.au=GOTOH%2C+Akinobu&rft.au=%E6%9D%BE%E6%B0%B8+%E6%B8%89&rft.au=%E7%AB%A0%E6%9A%A2%2C+%E5%BE%8C%E8%97%A4&rft.date=2021-07-01&rft.pub=Japan+Science+and+Technology+Agency&rft.issn=1343-0882&rft.eissn=1349-8363&rft.volume=35&rft.issue=3&rft.spage=165&rft_id=info:doi/10.11209%2Fjim.35.165&rft.externalDBID=NO_FULL_TEXT |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1343-0882&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1343-0882&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1343-0882&client=summon |