A prospective analysis of telomere length and pancreatic cancer in the alpha‐tocopherol beta‐carotene cancer (ATBC) prevention study
Smoking and diabetes, consistent risk factors for pancreatic cancer, are also factors that influence telomere length maintenance. To test whether telomere length is associated with pancreatic cancer risk, we conducted a nested case–control study in the Alpha‐Tocopherol, Beta‐Carotene Cancer Preventi...
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| Published in | International journal of cancer Vol. 133; no. 11; pp. 2672 - 2680 |
|---|---|
| Main Authors | , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Hoboken, NJ
Wiley-Blackwell
01.12.2013
Wiley Subscription Services, Inc |
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| Online Access | Get full text |
| ISSN | 0020-7136 1097-0215 1097-0215 |
| DOI | 10.1002/ijc.28272 |
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| Abstract | Smoking and diabetes, consistent risk factors for pancreatic cancer, are also factors that influence telomere length maintenance. To test whether telomere length is associated with pancreatic cancer risk, we conducted a nested case–control study in the Alpha‐Tocopherol, Beta‐Carotene Cancer Prevention (ATBC) Study cohort of male smokers, aged 50–69 years at baseline. Between 1992 and 2004, 193 incident cases of pancreatic adenocarcinoma occurred (mean follow‐up from blood draw: 6.3 years) among participants with whole blood samples available for telomere length assays. For these cases and 660 controls, we calculated odds ratios (OR) and 95% confidence intervals using unconditional logistic regression, adjusting for age, number of years smoked regularly, and history of diabetes mellitus. Telomere length was categorized into quartiles (shortest to longest) and analyzed as both a categorical and a continuous normal variable (reported per 0.2 unit increase in telomere length). All statistical tests were two‐sided. Longer telomere length was significantly associated with increased pancreatic cancer risk (continuous OR = 1.26 95% CI = 1.09–1.46; highest quartile compared to lowest, OR = 1.57, 95% CI = 1.01–2.43, p‐trend = 0.007). This association remained for subjects diagnosed within the first five years of blood draw (continuous OR = 1.46, 95% CI = 1.19–1.79 highest quartile OR = 2.92, 95% CI = 1.47–5.77, p‐trend = 0.002), but not those diagnosed greater than five years after blood draw (continuous OR = 1.03, 95% CI = 0.85–1.22; highest quartile OR = 1.04, 95% CI = 0.60–1.79). This is the first prospective study to suggest an association between longer blood leukocyte telomere length and increased pancreatic cancer risk.
What's new?
This is the first prospective study to examine the association between blood leukocyte telomere length and pancreatic cancer. In tumor, longer telomeres have been observed in advanced pancreatic cancer and risk factors for pancreatic cancer (cigarette smoke and diabetes) are known to affect telomere length. Based on a nested case‐control study in the Alpha‐Tocopherol, Beta‐Carotene Cancer Prevention (ATBC) Study cohort of male smokers, here the authors found that longer blood leukocyte telomeres were significantly associated with increased pancreatic cancer risk. The results add insight into the role of telomeres in pancreatic cancer, a disease that can benefit from the identification of early detection markers. |
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| AbstractList | Smoking and diabetes, consistent risk factors for pancreatic cancer, are also factors that influence telomere length maintenance. To test whether telomere length is associated with pancreatic cancer risk, we conducted a nested case-control study in the Alpha-Tocopherol, Beta-Carotene Cancer Prevention (ATBC) Study cohort of male smokers, aged 50-69 years at baseline. Between 1992 and 2004, 193 incident cases of pancreatic adenocarcinoma occurred (mean follow-up from blood draw: 6.3 years) among participants with whole blood samples available for telomere length assays. For these cases and 660 controls, we calculated odds ratios (OR) and 95% confidence intervals using unconditional logistic regression, adjusting for age, number of years smoked regularly, and history of diabetes mellitus. Telomere length was categorized into quartiles (shortest to longest) and analyzed as both a categorical and a continuous normal variable (reported per 0.2 unit increase in telomere length). All statistical tests were two-sided. Longer telomere length was significantly associated with increased pancreatic cancer risk (continuous OR = 1.26 95% CI = 1.09-1.46; highest quartile compared to lowest, OR = 1.57, 95% CI = 1.01-2.43, p-trend = 0.007). This association remained for subjects diagnosed within the first five years of blood draw (continuous OR = 1.46, 95% CI = 1.19-1.79 highest quartile OR = 2.92, 95% CI = 1.47-5.77, p-trend = 0.002), but not those diagnosed greater than five years after blood draw (continuous OR = 1.03, 95% CI = 0.85-1.22; highest quartile OR = 1.04, 95% CI = 0.60-1.79). This is the first prospective study to suggest an association between longer blood leukocyte telomere length and increased pancreatic cancer risk. What's new? This is the first prospective study to examine the association between blood leukocyte telomere length and pancreatic cancer. In tumor, longer telomeres have been observed in advanced pancreatic cancer and risk factors for pancreatic cancer (cigarette smoke and diabetes) are known to affect telomere length. Based on a nested case-control study in the Alpha-Tocopherol, Beta-Carotene Cancer Prevention (ATBC) Study cohort of male smokers, here the authors found that longer blood leukocyte telomeres were significantly associated with increased pancreatic cancer risk. The results add insight into the role of telomeres in pancreatic cancer, a disease that can benefit from the identification of early detection markers. [PUBLICATION ABSTRACT] Smoking and diabetes, consistent risk factors for pancreatic cancer, are also factors that influence telomere length maintenance. To test whether telomere length is associated with pancreatic cancer risk, we conducted a nested case-control study in the Alpha-Tocopherol, Beta-Carotene Cancer Prevention (ATBC) Study cohort of male smokers, aged 50–69 years at baseline. Between 1992 and 2004, 193 incident cases of pancreatic adenocarcinoma occurred (mean follow-up from blood draw: 6.3 years) among participants with whole blood samples available for telomere length assays. For these cases and 660 controls, we calculated odds ratios (OR) and 95% confidence intervals using unconditional logistic regression, adjusting for age, number of years smoked regularly, and history of diabetes mellitus. Telomere length was categorized into quartiles (shortest to longest) and analyzed as both a categorical and a continuous normal variable (reported per 0.2 unit increase in telomere length). All statistical tests were two-sided. Longer telomere length was significantly associated with increased pancreatic cancer risk (continuous OR=1.26 95% CI=1.09–1.46; highest quartile compared to lowest, OR=1.57, 95% CI=1.01–2.43, p-trend=0.007). This association remained for subjects diagnosed within the first five years of blood draw (continuous OR=1.46, 95% CI=1.19–1.79 highest quartile OR=2.92, 95%CI=1.47–5.77, p-trend=0.002), but not those diagnosed greater than five years after blood draw (continuous OR=1.03, 95%CI=0.85–1.22; highest quartile OR=1.04, 95%CI=0.60–1.79). This is the first prospective study to suggest an association between longer blood leukocyte telomere length and increased pancreatic cancer risk. Smoking and diabetes, consistent risk factors for pancreatic cancer, are also factors that influence telomere length maintenance. To test whether telomere length is associated with pancreatic cancer risk, we conducted a nested case–control study in the Alpha‐Tocopherol, Beta‐Carotene Cancer Prevention (ATBC) Study cohort of male smokers, aged 50–69 years at baseline. Between 1992 and 2004, 193 incident cases of pancreatic adenocarcinoma occurred (mean follow‐up from blood draw: 6.3 years) among participants with whole blood samples available for telomere length assays. For these cases and 660 controls, we calculated odds ratios (OR) and 95% confidence intervals using unconditional logistic regression, adjusting for age, number of years smoked regularly, and history of diabetes mellitus. Telomere length was categorized into quartiles (shortest to longest) and analyzed as both a categorical and a continuous normal variable (reported per 0.2 unit increase in telomere length). All statistical tests were two‐sided. Longer telomere length was significantly associated with increased pancreatic cancer risk (continuous OR = 1.26 95% CI = 1.09–1.46; highest quartile compared to lowest, OR = 1.57, 95% CI = 1.01–2.43, p‐trend = 0.007). This association remained for subjects diagnosed within the first five years of blood draw (continuous OR = 1.46, 95% CI = 1.19–1.79 highest quartile OR = 2.92, 95% CI = 1.47–5.77, p‐trend = 0.002), but not those diagnosed greater than five years after blood draw (continuous OR = 1.03, 95% CI = 0.85–1.22; highest quartile OR = 1.04, 95% CI = 0.60–1.79). This is the first prospective study to suggest an association between longer blood leukocyte telomere length and increased pancreatic cancer risk. What's new? This is the first prospective study to examine the association between blood leukocyte telomere length and pancreatic cancer. In tumor, longer telomeres have been observed in advanced pancreatic cancer and risk factors for pancreatic cancer (cigarette smoke and diabetes) are known to affect telomere length. Based on a nested case‐control study in the Alpha‐Tocopherol, Beta‐Carotene Cancer Prevention (ATBC) Study cohort of male smokers, here the authors found that longer blood leukocyte telomeres were significantly associated with increased pancreatic cancer risk. The results add insight into the role of telomeres in pancreatic cancer, a disease that can benefit from the identification of early detection markers. Smoking and diabetes, consistent risk factors for pancreatic cancer, are also factors that influence telomere length maintenance. To test whether telomere length is associated with pancreatic cancer risk, we conducted a nested case-control study in the Alpha-Tocopherol, Beta-Carotene Cancer Prevention (ATBC) Study cohort of male smokers, aged 50-69 years at baseline. Between 1992 and 2004, 193 incident cases of pancreatic adenocarcinoma occurred (mean follow-up from blood draw: 6.3 years) among participants with whole blood samples available for telomere length assays. For these cases and 660 controls, we calculated odds ratios (OR) and 95% confidence intervals using unconditional logistic regression, adjusting for age, number of years smoked regularly, and history of diabetes mellitus. Telomere length was categorized into quartiles (shortest to longest) and analyzed as both a categorical and a continuous normal variable (reported per 0.2 unit increase in telomere length). All statistical tests were two-sided. Longer telomere length was significantly associated with increased pancreatic cancer risk (continuous OR = 1.26 95% CI = 1.09-1.46; highest quartile compared to lowest, OR = 1.57, 95% CI = 1.01-2.43, p-trend = 0.007). This association remained for subjects diagnosed within the first five years of blood draw (continuous OR = 1.46, 95% CI = 1.19-1.79 highest quartile OR = 2.92, 95% CI = 1.47-5.77, p-trend = 0.002), but not those diagnosed greater than five years after blood draw (continuous OR = 1.03, 95% CI = 0.85-1.22; highest quartile OR = 1.04, 95% CI = 0.60-1.79). This is the first prospective study to suggest an association between longer blood leukocyte telomere length and increased pancreatic cancer risk.Smoking and diabetes, consistent risk factors for pancreatic cancer, are also factors that influence telomere length maintenance. To test whether telomere length is associated with pancreatic cancer risk, we conducted a nested case-control study in the Alpha-Tocopherol, Beta-Carotene Cancer Prevention (ATBC) Study cohort of male smokers, aged 50-69 years at baseline. Between 1992 and 2004, 193 incident cases of pancreatic adenocarcinoma occurred (mean follow-up from blood draw: 6.3 years) among participants with whole blood samples available for telomere length assays. For these cases and 660 controls, we calculated odds ratios (OR) and 95% confidence intervals using unconditional logistic regression, adjusting for age, number of years smoked regularly, and history of diabetes mellitus. Telomere length was categorized into quartiles (shortest to longest) and analyzed as both a categorical and a continuous normal variable (reported per 0.2 unit increase in telomere length). All statistical tests were two-sided. Longer telomere length was significantly associated with increased pancreatic cancer risk (continuous OR = 1.26 95% CI = 1.09-1.46; highest quartile compared to lowest, OR = 1.57, 95% CI = 1.01-2.43, p-trend = 0.007). This association remained for subjects diagnosed within the first five years of blood draw (continuous OR = 1.46, 95% CI = 1.19-1.79 highest quartile OR = 2.92, 95% CI = 1.47-5.77, p-trend = 0.002), but not those diagnosed greater than five years after blood draw (continuous OR = 1.03, 95% CI = 0.85-1.22; highest quartile OR = 1.04, 95% CI = 0.60-1.79). This is the first prospective study to suggest an association between longer blood leukocyte telomere length and increased pancreatic cancer risk. |
| Author | Lan, Qing Cawthon, Richard Lynch, Shannon M. Weinstein, Stephanie J. Major, Jacqueline M. Virtamo, Jarmo Albanes, Demetrius Stolzenberg‐Solomon, Rachael Z. Rothman, Nathaniel |
| AuthorAffiliation | 4 Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland 3 Department of Human Genetics, University of Utah, Salt Lake City, UT 84112 United States 5 Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 2 Center for Clinical Epidemiology and Biostatistics, Center for Genetics and Complex Traits, University of Pennsylvania, Philadelphia, PA 1 Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD |
| AuthorAffiliation_xml | – name: 4 Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland – name: 3 Department of Human Genetics, University of Utah, Salt Lake City, UT 84112 United States – name: 1 Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD – name: 2 Center for Clinical Epidemiology and Biostatistics, Center for Genetics and Complex Traits, University of Pennsylvania, Philadelphia, PA – name: 5 Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD |
| Author_xml | – sequence: 1 givenname: Shannon M. surname: Lynch fullname: Lynch, Shannon M. organization: Center for Genetics and Complex Traits, University of Pennsylvania – sequence: 2 givenname: Jacqueline M. surname: Major fullname: Major, Jacqueline M. organization: Division of Cancer Epidemiology and Genetics, National Cancer Institute – sequence: 3 givenname: Richard surname: Cawthon fullname: Cawthon, Richard organization: University of Utah – sequence: 4 givenname: Stephanie J. surname: Weinstein fullname: Weinstein, Stephanie J. organization: Division of Cancer Epidemiology and Genetics, National Cancer Institute – sequence: 5 givenname: Jarmo surname: Virtamo fullname: Virtamo, Jarmo organization: National Institute for Health and Welfare – sequence: 6 givenname: Qing surname: Lan fullname: Lan, Qing organization: Division of Cancer Epidemiology and Genetics, National Cancer Institute – sequence: 7 givenname: Nathaniel surname: Rothman fullname: Rothman, Nathaniel organization: Division of Cancer Epidemiology and Genetics, National Cancer Institute – sequence: 8 givenname: Demetrius surname: Albanes fullname: Albanes, Demetrius organization: Division of Cancer Epidemiology and Genetics, National Cancer Institute – sequence: 9 givenname: Rachael Z. surname: Stolzenberg‐Solomon fullname: Stolzenberg‐Solomon, Rachael Z. organization: Division of Cancer Epidemiology and Genetics, National Cancer Institute |
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| Keywords | Biological marker Malignant tumor biomarker Epidemiology Telomere Prospective Prevention pancreatic cancer Cancerology Length Pancreas cancer Tocopherols Digestive diseases Betacarotene telomere length Cancer Pancreatic disease epidemiology |
| Language | English |
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| References_xml | – volume: 41 start-page: 381 year: 2002 end-page: 388 article-title: The Finnish Cancer Registry as follow‐up source of a large trial cohort—accuracy and delay publication-title: Acta Oncol – volume: 127 start-page: 1421 year: 2010 end-page: 8 article-title: Family history of cancer and risk of pancreatic cancer: a pooled analysis from the Pancreatic Cancer Cohort Consortium (PanScan) publication-title: Int J Cancer – volume: 15 start-page: 54 year: 2012 end-page: 8 article-title: Telomere length and type 2 diabetes in males, a premature aging syndrome publication-title: Aging Male – volume: 73 start-page: 133 year: 2011 end-page: 37 article-title: A prospective study of telomere length measured by monochrome multiplex quantitative PCR and risk of lung cancer publication-title: Lung Cancer – volume: 35 start-page: 1424 year: 2006 end-page: 29 article-title: Human telomere biology: pitfalls of moving from the laboratory to epidemiology publication-title: Int J Epidemiol – volume: 155 start-page: 783 year: 2002 end-page: 92 article-title: Prospective study of diet and pancreatic cancer in male smokers publication-title: Am J Epidemiol – volume: 28 start-page: 968 year: 2008 end-page: 74 article-title: Telomere gap between granulocytes and lymphocytes is a determinant for hematopoetic progenitor cell impairment in patients with previous myocardial infarction publication-title: Arterioscler Thrombo Vasc Biol – volume: 9 start-page: 653 year: 2010 end-page: 66 article-title: Role of shelterin in cancer and aging publication-title: Aging Cell – volume: 16 start-page: 815 year: 2007 end-page: 9 article-title: Telomere length, cigarette smoking, and bladder cancer risk in men and women publication-title: Cancer Epidemiol Biomarkers Prev – volume: 57 start-page: 485 year: 2003 end-page: 92 article-title: T‐cell receptor excisional circles, telomere length, proliferation and apoptosis in peripheral blood mononuclear cells of human immunodeficiency virus‐infected individuals after 18 months of treatment induced viral suppression publication-title: Scand J Immunol – volume: 8 start-page: 110 year: 2008 end-page: 25 article-title: Pancreatic carcinogenesis publication-title: Pancreatology – volume: 170 start-page: 791 year: 2010 end-page: 802 article-title: Anthropometric measures, body mass Index, and pancreatic cancer: A pooled analysis from the pancreatic Cancer Cohort Consortium (PanScan) publication-title: Arch Intern Med – volume: 90 start-page: 73 year: 2008 end-page: 82 article-title: Telomere instability and cancer publication-title: Biochimie – volume: 20 start-page: 1238 year: 2011 end-page: 50 article-title: The association of telomere length and cancer: a meta‐analysis publication-title: Cancer Epidemiol Biomarkers Prev – volume: 23 start-page: 149 year: 2011 end-page: 67 article-title: An evolutionary review of human telomere biology: the thrifty telomere hypothesis and notes on potential adaptive paternal effects publication-title: Am J Hum Biol – volume: 12 start-page: 17 year: 2008 end-page: 29 article-title: Telomere shortening and telomerase expression during multistage carcinogenesis of intraductal papillary mucinous neoplasms of the pancreas publication-title: J Gastrointest Surg – volume: 124 start-page: 17 year: 1986 end-page: 27 article-title: Total energy intake: implications for epidemiologic analyses publication-title: Am J Epidemiol – volume: 3 start-page: 991 year: 2002 end-page: 98 article-title: Cancer immunoediting: from immunosurveillance to tumor escape publication-title: Nat Immunol – volume: 24 start-page: 256 year: 2011 end-page: 66 article-title: Telomeres are shortened in acinar‐to‐ductal metaplasia lesions associated with pancreatic intraepithelial neoplasia but not in isolated acinar‐to‐ductal metaplasias publication-title: Mod Pathol – volume: 70 start-page: 7365 year: 2010 end-page: 71 article-title: The role of telomeres and telomerase in cancer research publication-title: Cancer Res – volume: 5 start-page: 718 year: 2006 end-page: 21 article-title: Role of the TRF2 telomeric protein in cancer and aging publication-title: Cell Cycle – volume: 97 start-page: 952 year: 2008 end-page: 4 article-title: Telomere length and obesity publication-title: Acta Paediatr – volume: 21 start-page: 1213 year: 2010 end-page: 25 article-title: Alcohol intake and pancreatic cancer: a pooled analysis from the pancreatic cancer cohort consortium (PanScan) publication-title: Cancer Causes Control – volume: 5 start-page: 1173 year: 2012 end-page: 82 article-title: Longitudinal change in telomere length and the chronic stress response in a randomized pilot biobehavioral clinical study: implications for cancer prevention publication-title: Cancer Prev Res – volume: 21 start-page: 2095 year: 2012 end-page: 100 article-title: Telomere length and pancreatic cancer: a case–control study publication-title: Cancer Epidemiol Biomarkers Prev – volume: 341 start-page: 128 year: 2006 end-page: 31 article-title: Telomere length of normal leukocytes is affected by a functional polymorphism of hTERT publication-title: Biochem Biophys Res Commun – volume: 12 start-page: e16 year: 2010 article-title: Variation at the TERT locus and predisposition for cancer publication-title: Exp Rev Mol Med – volume: 41 start-page: 882 year: 2006 end-page: 86 article-title: Telomere shortening with aging in the human pancreas publication-title: Exp Gerontol – volume: 319 start-page: 130 year: 2012 end-page: 35 article-title: Surrogate tissue telomere length and cancer risk: shorter or longer? publication-title: Cancer Lett – volume: 42 start-page: 301 year: 2008 end-page: 34 article-title: How shelterin protects mammalian telomeres publication-title: Annu Rev Genet – volume: 19 start-page: 1864 year: 1999 end-page: 70 article-title: Telomerase activity is sufficient to allow transformed cells to escape from crisis publication-title: Mol Cell Biol – volume: 15 start-page: 7429 year: 2009 end-page: 33 article-title: A prospective study of telomere length measured by monochrome multiplex quantitative PCR and risk of Non‐Hodgkin lymphoma publication-title: Clin Cancer Res – volume: 467 start-page: 1114 year: 2010 end-page: 17 article-title: Distant metastasis occurs late during the genetic evolution of pancreatic cancer publication-title: Nature – volume: 168 start-page: 154 year: 2008 end-page: 8 article-title: The association between physical activity in leisure time and leukocyte telomere length publication-title: Arch Intern Med – year: 2003 – volume: 54 start-page: 3037 year: 2011 end-page: 46 article-title: Diabetes mellitus, glycated haemoglobin and C‐peptide levels in relation to pancreatic cancer risk: a study within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort publication-title: Diabetologia – volume: 2 start-page: 459 year: 2009 end-page: 65 article-title: Constitutive short telomere length of chromosome 17p and 12q but not 11q and 2p is associated with an increased risk for esophageal cancer publication-title: Cancer Prev Res – volume: 584 start-page: 3800 end-page: 11 article-title: Assaying and investigating alternative lengthening of telomeres activity in human cells and cancers publication-title: FEBS Lett – volume: 21 start-page: 1305 year: 2010 end-page: 14 article-title: Body mass index, effect modifiers, and risk of pancreatic cancer: a pooled study of seven prospective cohorts publication-title: Cancer Causes Control – year: 2012 – volume: 13 start-page: 2075 year: 2008 end-page: 90 article-title: Telomere dysfunction, genome instability and cancer publication-title: Front Biosci – volume: 467 start-page: 1109 year: 2010 end-page: 13 article-title: The patterns and dynamics of genomic instability in metastatic pancreatic cancer publication-title: Nature – volume: 4 start-page: 1 year: 1994 end-page: 10 article-title: The alpha‐tocopherol, beta‐carotene lung cancer prevention study: design, methods, participant characteristics, and compliance publication-title: Ann Epidemiol – volume: 165 start-page: 14 year: 2007 end-page: 21 article-title: Leukocyte telomere length and cardiovascular disease in the cardiovascular health study publication-title: Am J Epidemiol – volume: 59 start-page: 169 year: 2008 end-page: 86 article-title: Telomere shortening and ageing of the immune system publication-title: J Physiol Pharmacol – volume: 88 start-page: 1405 year: 2008 end-page: 12 article-title: Dietary patterns, food groups, and telomere length in the Multi‐Ethnic Study of Atherosclerosis (MESA) publication-title: Am J Clin Nutr – volume: 6 start-page: e20466 year: 2011 article-title: Shortened telomere length is associated with increased risk of cancer: a meta‐analysis publication-title: PLoS ONE – volume: 170 start-page: 403 year: 2009 end-page: 13 article-title: Cigarette smoking and pancreatic cancer: a pooled analysis from the pancreatic Cancer Cohort Consortium publication-title: Am J Epidemiol – volume: 18 start-page: 765 year: 2009 end-page: 76 article-title: Alcohol intake and pancreatic cancer risk: a pooled analysis of fourteen cohort studies publication-title: Cancer Epidemiol Biomarkers Prev – volume: 44 start-page: 363 year: 2009 end-page: 66 article-title: Telomere length‐heterogeneity among myeloid cells is a predictor for chronological ageing publication-title: Exp Gerontol – volume: 37 start-page: e21 year: 2009 article-title: Telomere length measurement by a novel monochrome multiplex quantitative PCR method publication-title: Nucl Acids Res – volume: 153 start-page: 680 year: 2001 end-page: 7 article-title: Dietary and other methyl‐group availability factors and pancreatic cancer risk in a cohort of male smokers publication-title: Am J Epidemiol – volume: 161 start-page: 1541 year: 2002 end-page: 47 article-title: Telomere shortening is nearly universal in pancreatic intraepithelial neoplasia publication-title: Am J Pathol – volume: 7 start-page: 651 year: 2011 end-page: 58 article-title: Dual roles of immune cells and their factors in cancer development and progression publication-title: Int J Biol Sci |
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| Snippet | Smoking and diabetes, consistent risk factors for pancreatic cancer, are also factors that influence telomere length maintenance. To test whether telomere... |
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| SubjectTerms | Aged alpha-Tocopherol - administration & dosage beta Carotene - administration & dosage Biological and medical sciences biomarker Cancer Case-Control Studies Confidence intervals Disease prevention epidemiology Gastroenterology. Liver. Pancreas. Abdomen Humans Liver. Biliary tract. Portal circulation. Exocrine pancreas Logistic Models Male Medical research Medical sciences Middle Aged Multiple tumors. Solid tumors. Tumors in childhood (general aspects) Pancreatic cancer Pancreatic Neoplasms - epidemiology Pancreatic Neoplasms - etiology Pancreatic Neoplasms - genetics Pancreatic Neoplasms - pathology Prospective Studies Risk Factors Smoking - adverse effects Telomerase Telomere Homeostasis - drug effects Telomere Homeostasis - genetics telomere length Tumors Vitamin A |
| Title | A prospective analysis of telomere length and pancreatic cancer in the alpha‐tocopherol beta‐carotene cancer (ATBC) prevention study |
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