脳静脈血栓症を契機にバセドウ病と診断された1例
症例は71歳男性．主訴は突然発症の右上肢麻痺，頭部MRI画像で両側頭頂部に異常信号を認め，脳血管障害が疑われ入院した．頭部CT venography（CTV）で上矢状静脈洞内に血栓を認め，脳静脈血栓症（cerebral venous thrombosis; CVT）と診断した．血栓性素因として凝固活性第8因子の亢進と甲状腺機能の亢進が明らかとなり，甲状腺刺激ホルモン受容体抗体が陽性であったため，CVTの発症にバセドウ病が関与したと考えられた．...
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| Published in | 臨床神経学 Vol. 58; no. 11; pp. 696 - 699 |
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| Main Authors | , , |
| Format | Journal Article |
| Language | Japanese |
| Published |
日本神経学会
2018
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| Subjects | |
| Online Access | Get full text |
| ISSN | 0009-918X 1882-0654 |
| DOI | 10.5692/clinicalneurol.cn-001212 |
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| Abstract | 症例は71歳男性．主訴は突然発症の右上肢麻痺，頭部MRI画像で両側頭頂部に異常信号を認め，脳血管障害が疑われ入院した．頭部CT venography（CTV）で上矢状静脈洞内に血栓を認め，脳静脈血栓症（cerebral venous thrombosis; CVT）と診断した．血栓性素因として凝固活性第8因子の亢進と甲状腺機能の亢進が明らかとなり，甲状腺刺激ホルモン受容体抗体が陽性であったため，CVTの発症にバセドウ病が関与したと考えられた． |
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| AbstractList | 症例は71歳男性．主訴は突然発症の右上肢麻痺，頭部MRI画像で両側頭頂部に異常信号を認め，脳血管障害が疑われ入院した．頭部CT venography（CTV）で上矢状静脈洞内に血栓を認め，脳静脈血栓症（cerebral venous thrombosis; CVT）と診断した．血栓性素因として凝固活性第8因子の亢進と甲状腺機能の亢進が明らかとなり，甲状腺刺激ホルモン受容体抗体が陽性であったため，CVTの発症にバセドウ病が関与したと考えられた． |
| Author | 大島, 淳 長谷川, 泰弘 今井, 健 |
| Author_xml | – sequence: 1 fullname: 長谷川, 泰弘 organization: 聖マリアンナ医科大学神経内科 – sequence: 1 fullname: 大島, 淳 organization: 聖マリアンナ医科大学横浜市西部病院神経内科 – sequence: 1 fullname: 今井, 健 organization: 聖マリアンナ医科大学横浜市西部病院神経内科 |
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| References | 2) 塚田剛史，増岡 徹，濱田秀雄ら．甲状腺機能亢進症に併発した脳静脈洞血栓症の1例．脳卒中 2017;39:273-276. 1) Saposnik G, Barinagarrementeria F, Brown RD Jr, et al. Diagnosis and management of cerebral venous thrombosis: a statement for healthcare professionals from the American Heart Association/American Stroke Association. Stroke 2011;42:1158-1192. 8) Kellett HA, Sawers JS, Boulton FE, et al. Problems of anticoagulation with warfarin in hyperthyroidism. Q J Md 1986;58:43-51. 9) Chute JP, Ryan CP, Sladek G, et al. Exacerbation of warfarin-induced anticoagulation by hyperthyroidism. Endocr Pract 1997;3:77-79. 7) 川原一郎，豊田啓介，広瀬 誠ら．潜在性Basedow病に合併した脳静脈洞血栓症の1症例．Neurol Surg 2017;45:805-810. 4) Ferro JM, Canhão P, Stam J, et al. Prognosis of cerebral vein and dural sinus thrombosis: results of the International Study on Cerebral Vein and Dural Sinus Thrombosis (ISCVT). Stroke 2004;35:664-670. 6) Horacek J, Maly J, Svilias I, et al. Prothrombotic changes due to an increase in thyroid hormone levels. Eur J Endocrinol 2015;172:537-542. 10) Geisbüsch C, Richter D, Herweh C, et al. Novel factor xa inhibitor for the treatment of cerebral venous and sinus thrombosis: first experience in 7 patients. Stroke 2014;45:2469-2471. 5) Stuijver DJ, van Zaane B, Romualdi E, et al. The effect of hyperthyroidism on procoagulant, anticoagulant and fibrinolytic factors: a systematic review and meta-analysis. Thromb Haemost 2012;108:1077-1088. 3) 亀田知明，林 夢夏，直井為任ら．Xa阻害薬を治療に用いた甲状腺機能亢進症を伴う脳静脈血栓症の1例．脳卒中 2017;39:361-364. |
| References_xml | – reference: 8) Kellett HA, Sawers JS, Boulton FE, et al. Problems of anticoagulation with warfarin in hyperthyroidism. Q J Md 1986;58:43-51. – reference: 4) Ferro JM, Canhão P, Stam J, et al. Prognosis of cerebral vein and dural sinus thrombosis: results of the International Study on Cerebral Vein and Dural Sinus Thrombosis (ISCVT). Stroke 2004;35:664-670. – reference: 7) 川原一郎，豊田啓介，広瀬 誠ら．潜在性Basedow病に合併した脳静脈洞血栓症の1症例．Neurol Surg 2017;45:805-810. – reference: 10) Geisbüsch C, Richter D, Herweh C, et al. Novel factor xa inhibitor for the treatment of cerebral venous and sinus thrombosis: first experience in 7 patients. Stroke 2014;45:2469-2471. – reference: 1) Saposnik G, Barinagarrementeria F, Brown RD Jr, et al. Diagnosis and management of cerebral venous thrombosis: a statement for healthcare professionals from the American Heart Association/American Stroke Association. Stroke 2011;42:1158-1192. – reference: 2) 塚田剛史，増岡 徹，濱田秀雄ら．甲状腺機能亢進症に併発した脳静脈洞血栓症の1例．脳卒中 2017;39:273-276. – reference: 3) 亀田知明，林 夢夏，直井為任ら．Xa阻害薬を治療に用いた甲状腺機能亢進症を伴う脳静脈血栓症の1例．脳卒中 2017;39:361-364. – reference: 6) Horacek J, Maly J, Svilias I, et al. Prothrombotic changes due to an increase in thyroid hormone levels. Eur J Endocrinol 2015;172:537-542. – reference: 5) Stuijver DJ, van Zaane B, Romualdi E, et al. The effect of hyperthyroidism on procoagulant, anticoagulant and fibrinolytic factors: a systematic review and meta-analysis. Thromb Haemost 2012;108:1077-1088. – reference: 9) Chute JP, Ryan CP, Sladek G, et al. Exacerbation of warfarin-induced anticoagulation by hyperthyroidism. Endocr Pract 1997;3:77-79. |
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| Snippet | 症例は71歳男性．主訴は突然発症の右上肢麻痺，頭部MRI画像で両側頭頂部に異常信号を認め，脳血管障害が疑われ入院した．頭部CT venography（CTV）で上矢状静脈洞内に血... |
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| SubjectTerms | バセドウ病 凝固活性第8因子 甲状腺機能亢進症 脳静脈血栓症 |
| Title | 脳静脈血栓症を契機にバセドウ病と診断された1例 |
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