皮膚科領域における再生医療の最近の進歩
皮膚領域における再生医療の流れにつき解説し, さらに今後主流となるであろうiPS細胞を用いた新しい展開について解説した. 即ち従来再生医療のターゲットとして考えられてきた表皮細胞 (ケラチノサイト) や真皮線維芽細胞, そしてそれらを組み合わせた3次元培養皮膚の作成とその臨床応用が試みられている.また一方では, 色素細胞 (白斑や白髪の治療) や毛髪 (種々の脱毛症治療) も再生医療のターゲットとして捉えられるようになってきている. 今後これらの知識や技術を基にしたiPS細胞からの皮膚細胞誘導とそれによる治療法の開発が期待される....
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| Published in | 順天堂医学 Vol. 54; no. 4; pp. 464 - 467 |
|---|---|
| Main Author | |
| Format | Journal Article |
| Language | Japanese |
| Published |
順天堂医学会
2008
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| Subjects | |
| Online Access | Get full text |
| ISSN | 0022-6769 2188-2134 |
| DOI | 10.14789/pjmj.54.464 |
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| Abstract | 皮膚領域における再生医療の流れにつき解説し, さらに今後主流となるであろうiPS細胞を用いた新しい展開について解説した. 即ち従来再生医療のターゲットとして考えられてきた表皮細胞 (ケラチノサイト) や真皮線維芽細胞, そしてそれらを組み合わせた3次元培養皮膚の作成とその臨床応用が試みられている.また一方では, 色素細胞 (白斑や白髪の治療) や毛髪 (種々の脱毛症治療) も再生医療のターゲットとして捉えられるようになってきている. 今後これらの知識や技術を基にしたiPS細胞からの皮膚細胞誘導とそれによる治療法の開発が期待される. |
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| AbstractList | 皮膚領域における再生医療の流れにつき解説し, さらに今後主流となるであろうiPS細胞を用いた新しい展開について解説した. 即ち従来再生医療のターゲットとして考えられてきた表皮細胞 (ケラチノサイト) や真皮線維芽細胞, そしてそれらを組み合わせた3次元培養皮膚の作成とその臨床応用が試みられている.また一方では, 色素細胞 (白斑や白髪の治療) や毛髪 (種々の脱毛症治療) も再生医療のターゲットとして捉えられるようになってきている. 今後これらの知識や技術を基にしたiPS細胞からの皮膚細胞誘導とそれによる治療法の開発が期待される. |
| Author | 池田, 志斈 |
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| References | 9) SanmanoB, MizoguchiM, SugaY, et al: Engraftment of umbilical cord epithelial cells in athymic mice: in an attempt to improve reconstructed skin equivalents used as epithelial composite. J Dermatol Sci. 2005 ; 37: 29-39. 3) TrempusCS, DangH, HumbleMM, et al: Comprehensive microarray transcriptome profiling of CD34-enriched mouse keratinocyte stern cells. J Invest Dermatol. 2007 ; 127: 2904-2907. 7) 橋本公二, 白方祐司: 羊膜付き3次元培養皮膚の有用性に関する研究, 厚生労働省研究費補助金難治性疾患克服研究事業, 稀少難治性皮膚疾患に関する調査研究 (班長: 北島康雄), 平成18年度 (2007)総括・分担研究報告書. 120-124. 19) TakahashiK, TanabeK, OhnukiM, et al: Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell. 2007 ; 131: 861-872. 1) NishimuraEK, JordanSA, OshimaH, et al: Dominant role of the niche in melanocyte stem-cell fate determination. Nature. 2002 ; 416: 854-860. 11) HasegawaT, SugaY, MizoguchiM, et al: Intractable venous leg ulcer treated successfully with allogeneic cultured dermal substitute. Scand J Plast Reconstr Surg Hand Surg. 2007 ; 41: 326-328. 8) MizoguchiM, IkedaS, SugaY, et al: Expression of cytokeratins and cornified cell envelope-associated proteins in umbilical cord epithelium: a comparative study of the umbilical cord, amniotic epithelia and fetal skin. J Invest Dermatol. 2000 ; 115: 133-134. 18) ChinoT, TamaiK, YamazakiT, et al: Bone marrow cell transfer into fetal circulation can ameliorate genetic skin diseases by providing fibroblasts to the skin and inducing immune tolerance. Am J Pathol. 2008 ; 173: 803-814. 6) RonfardV, BrolyH, MitchellV, et al: Use of human keratinocytes cultured on fibrin glue in the treatment of burn wounds. Burns. 1991 ; 17: 181-184. 17) AmohY, LiL, CampilloR, et al: Implanted hair follicle stem cells form Schwann cells that support repair of severed peripheral nerves. Proc Natl Acad Sci USA. 2005 ; 102: 17734-17738. 20) OkitaK, NakagawaM, HyenjongH, et al: Generation of Mouse Induced Pluripotent Stem Cells Without Viral Vectors. Science. 2008. 12) WongT, GammonL, LiuL, et al: Potential offibroblast cell therapy for recessive dystrophic epidermolysis bullosa. J Invest Dermatol. 2008 ; 128: 2179-2189. 13) NielsenHI, DonP: Culture of normal adult human melanocytes. Br J Dermatol. 1984 ; 110: 569-580. 15) HasegawaT, SugaY, IkejimaA, et al: Suction blister grafting with CO (2) laser resurfacing of the graft recipient site for vitiligo. J Dermatol. 2007 ; 34: 490-492. 2) PopovaNV, MorrisRJ: Genetic regulation of mouse stem cells: identification of two keratinocyte stem cell regulatory loci. Curr Top Microbiol Immunol. 2004 ; 280: 111-137. 4) RheinwaldJG, GreenH: Serial cultivation of strains of human epidermal keratinocytes: the formation of keratinizing colonies from single cells. Cell. 1975 ; 6: 331-343. 5) GilchrestBA, MarshallWL, KarassikRL, et al: Characterization and partial purification of keratinocyte growth factor from the hypothalamus. J Cell Physiol. 1984 ; 120: 377-383. 16) AmohY, LiL, KatsuokaK, et al: Multipotent nestin-positive, keratin-negative hair-follicle bulge stem cells can form neurons. Proc Natl Acad Sci USA. 2005 ; 102: 5530-5534. 14) EvesPC, BullettNA, HaddowD, et al: Simplifying the delivery of melanocytes and keratinocytes for the treatment of vitiligo using a chemically defined carrier dressing. J Invest Dermatol. 2008 ; 128: 1554-1564. 10) HasegawaT, SugaY, MizoguchiM, et al: Clinical trial of allogeneic cultured dermal substitute for the treatment of intractable skin ulcers in 3 patients with recessive dystrophic epidermolysis bullosa. J Am Acad Dermatol. 2004 ; 50: 803-804. |
| References_xml | – reference: 3) TrempusCS, DangH, HumbleMM, et al: Comprehensive microarray transcriptome profiling of CD34-enriched mouse keratinocyte stern cells. J Invest Dermatol. 2007 ; 127: 2904-2907. – reference: 15) HasegawaT, SugaY, IkejimaA, et al: Suction blister grafting with CO (2) laser resurfacing of the graft recipient site for vitiligo. J Dermatol. 2007 ; 34: 490-492. – reference: 12) WongT, GammonL, LiuL, et al: Potential offibroblast cell therapy for recessive dystrophic epidermolysis bullosa. J Invest Dermatol. 2008 ; 128: 2179-2189. – reference: 16) AmohY, LiL, KatsuokaK, et al: Multipotent nestin-positive, keratin-negative hair-follicle bulge stem cells can form neurons. Proc Natl Acad Sci USA. 2005 ; 102: 5530-5534. – reference: 14) EvesPC, BullettNA, HaddowD, et al: Simplifying the delivery of melanocytes and keratinocytes for the treatment of vitiligo using a chemically defined carrier dressing. J Invest Dermatol. 2008 ; 128: 1554-1564. – reference: 6) RonfardV, BrolyH, MitchellV, et al: Use of human keratinocytes cultured on fibrin glue in the treatment of burn wounds. Burns. 1991 ; 17: 181-184. – reference: 4) RheinwaldJG, GreenH: Serial cultivation of strains of human epidermal keratinocytes: the formation of keratinizing colonies from single cells. Cell. 1975 ; 6: 331-343. – reference: 19) TakahashiK, TanabeK, OhnukiM, et al: Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell. 2007 ; 131: 861-872. – reference: 20) OkitaK, NakagawaM, HyenjongH, et al: Generation of Mouse Induced Pluripotent Stem Cells Without Viral Vectors. Science. 2008. – reference: 1) NishimuraEK, JordanSA, OshimaH, et al: Dominant role of the niche in melanocyte stem-cell fate determination. Nature. 2002 ; 416: 854-860. – reference: 5) GilchrestBA, MarshallWL, KarassikRL, et al: Characterization and partial purification of keratinocyte growth factor from the hypothalamus. J Cell Physiol. 1984 ; 120: 377-383. – reference: 8) MizoguchiM, IkedaS, SugaY, et al: Expression of cytokeratins and cornified cell envelope-associated proteins in umbilical cord epithelium: a comparative study of the umbilical cord, amniotic epithelia and fetal skin. J Invest Dermatol. 2000 ; 115: 133-134. – reference: 9) SanmanoB, MizoguchiM, SugaY, et al: Engraftment of umbilical cord epithelial cells in athymic mice: in an attempt to improve reconstructed skin equivalents used as epithelial composite. J Dermatol Sci. 2005 ; 37: 29-39. – reference: 18) ChinoT, TamaiK, YamazakiT, et al: Bone marrow cell transfer into fetal circulation can ameliorate genetic skin diseases by providing fibroblasts to the skin and inducing immune tolerance. Am J Pathol. 2008 ; 173: 803-814. – reference: 2) PopovaNV, MorrisRJ: Genetic regulation of mouse stem cells: identification of two keratinocyte stem cell regulatory loci. Curr Top Microbiol Immunol. 2004 ; 280: 111-137. – reference: 13) NielsenHI, DonP: Culture of normal adult human melanocytes. Br J Dermatol. 1984 ; 110: 569-580. – reference: 10) HasegawaT, SugaY, MizoguchiM, et al: Clinical trial of allogeneic cultured dermal substitute for the treatment of intractable skin ulcers in 3 patients with recessive dystrophic epidermolysis bullosa. J Am Acad Dermatol. 2004 ; 50: 803-804. – reference: 11) HasegawaT, SugaY, MizoguchiM, et al: Intractable venous leg ulcer treated successfully with allogeneic cultured dermal substitute. Scand J Plast Reconstr Surg Hand Surg. 2007 ; 41: 326-328. – reference: 17) AmohY, LiL, CampilloR, et al: Implanted hair follicle stem cells form Schwann cells that support repair of severed peripheral nerves. Proc Natl Acad Sci USA. 2005 ; 102: 17734-17738. – reference: 7) 橋本公二, 白方祐司: 羊膜付き3次元培養皮膚の有用性に関する研究, 厚生労働省研究費補助金難治性疾患克服研究事業, 稀少難治性皮膚疾患に関する調査研究 (班長: 北島康雄), 平成18年度 (2007)総括・分担研究報告書. 120-124. |
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| Snippet | 皮膚領域における再生医療の流れにつき解説し, さらに今後主流となるであろうiPS細胞を用いた新しい展開について解説した. 即ち従来再生医療のターゲットとして... |
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| SubjectTerms | iPS細胞 再生医療 皮膚 |
| Title | 皮膚科領域における再生医療の最近の進歩 |
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