舌扁平上皮癌におけるラミニンγ2鎖発現とその臨床的意義
舌扁平上皮癌におけるラミニンγ2鎖の発現を免疫組織学的に調べ,臨床的予後との相関について検討した.癌細胞同士が接着し胞巣状に増殖浸潤している場合,ラミニンγ2鎖の発現は胞巣の辺縁細胞のみに観察され,これを辺縁性発現(peripheral expression)とした.癌細胞間の接着性が低下し,癌細胞が分散性に強い浸潤を示す場合,癌細胞一つ一つにラミニンγ2鎖の発現がみられ,これをびまん性発現(diffuse expression)とした.舌癌原発巣組織におけるラミニンγ2鎖の発現パターンがすべて辺縁性発現のものを辺縁性発現型,浸潤の先進部を中心に一部でもびまん性発現がみられるものをびまん性発現...
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| Published in | 日本耳鼻咽喉科学会会報 Vol. 107; no. 6; pp. 653 - 657 |
|---|---|
| Main Authors | , , , , , , , |
| Format | Journal Article |
| Language | English Japanese |
| Published |
一般社団法人 日本耳鼻咽喉科学会
2004
日本耳鼻咽喉科学会 |
| Subjects | |
| Online Access | Get full text |
| ISSN | 0030-6622 1883-0854 |
| DOI | 10.3950/jibiinkoka.107.653 |
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| Abstract | 舌扁平上皮癌におけるラミニンγ2鎖の発現を免疫組織学的に調べ,臨床的予後との相関について検討した.癌細胞同士が接着し胞巣状に増殖浸潤している場合,ラミニンγ2鎖の発現は胞巣の辺縁細胞のみに観察され,これを辺縁性発現(peripheral expression)とした.癌細胞間の接着性が低下し,癌細胞が分散性に強い浸潤を示す場合,癌細胞一つ一つにラミニンγ2鎖の発現がみられ,これをびまん性発現(diffuse expression)とした.舌癌原発巣組織におけるラミニンγ2鎖の発現パターンがすべて辺縁性発現のものを辺縁性発現型,浸潤の先進部を中心に一部でもびまん性発現がみられるものをびまん性発現型に分類したところ,stage II以上の舌癌30例のうち辺縁性発現型が19例(63%),びまん性発現型が11例(37%)であった.辺縁性発現型の3年死因特異的累積生存率が64%であったのに対し,びまん性発現型の3年死因特異的累積生存率は34%であり,びまん性発現型の予後は有意に不良であった.ラミニンγ2鎖は舌癌の増殖•浸潤において重要な働きを有しており,特に細胞分散性の強い浸潤を示す場合にみられるラミニンγ2鎖のびまん性発現は癌細胞に高い悪性度をもたらすものと考えられた.加えて,ラミニンγ2鎖の発現パターンの検討は予後判定に有用であると思われた. |
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| AbstractList | 舌扁平上皮癌におけるラミニンγ2鎖の発現を免疫組織学的に調べ, 臨床的予後との相関について検討した. 癌細胞同士が接着し胞巣状に増殖・浸潤している場合, ラミニンγ2鎖の発現は胞巣の辺縁細胞のみに観察され, これを辺縁性発現（peripheral expression）とした. 癌細胞間の接着性が低下し, 癌細胞が分散性に強い浸潤を示す場合, 癌細胞1つ1つにラミニンγ2鎖の発現がみられ, これをびまん性発現（diffuse expression）とした. 舌癌原発巣組織におけるラミニンγ2鎖の発現パターンがすべて辺縁性発現のものを辺縁性発現型, 浸潤の先進部を中心に一部でもびまん性発現がみられるものをびまん性発現型に分類したところ, stage II以上の舌癌30例のうち辺縁性発現型が19例（63％）, びまん性発現型が11例（37％）であった. 辺縁性発現型の3年死因特異的累積生存率が64％であったのに対し, びまん性発現型の3年死因特異的累積生存率は34％であり, びまん性発現型の予後は有意に不良であった. ラミニンγ2鎖は舌癌の増殖・浸潤において重要な働きを有しており, 特に細胞分散性の強い浸潤を示す場合にみられるラミニンγ2鎖のびまん性発現は癌細胞に高い悪性度をもたらすものと考えられた. 加えて, ラミニンγ2鎖の発現パターンの検討は予後判定に有用であると思われた. 舌扁平上皮癌におけるラミニンγ2鎖の発現を免疫組織学的に調べ,臨床的予後との相関について検討した.癌細胞同士が接着し胞巣状に増殖浸潤している場合,ラミニンγ2鎖の発現は胞巣の辺縁細胞のみに観察され,これを辺縁性発現(peripheral expression)とした.癌細胞間の接着性が低下し,癌細胞が分散性に強い浸潤を示す場合,癌細胞一つ一つにラミニンγ2鎖の発現がみられ,これをびまん性発現(diffuse expression)とした.舌癌原発巣組織におけるラミニンγ2鎖の発現パターンがすべて辺縁性発現のものを辺縁性発現型,浸潤の先進部を中心に一部でもびまん性発現がみられるものをびまん性発現型に分類したところ,stage II以上の舌癌30例のうち辺縁性発現型が19例(63%),びまん性発現型が11例(37%)であった.辺縁性発現型の3年死因特異的累積生存率が64%であったのに対し,びまん性発現型の3年死因特異的累積生存率は34%であり,びまん性発現型の予後は有意に不良であった.ラミニンγ2鎖は舌癌の増殖•浸潤において重要な働きを有しており,特に細胞分散性の強い浸潤を示す場合にみられるラミニンγ2鎖のびまん性発現は癌細胞に高い悪性度をもたらすものと考えられた.加えて,ラミニンγ2鎖の発現パターンの検討は予後判定に有用であると思われた. |
| Author | 益田, 宗幸 山本, 智矢 中島, 寅彦 熊本, 芳彦 倉富, 勇一郎 安松, 隆治 熊本, 真優子 小宮山, 荘太郎 |
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| References | 10) Masuda M. Kuratomi Y, Shiratsuchi H, Nakashima T, Kunitake N, et al: Decreased CD44H expression in early-stage tongue carcinoma associates with late nodal metastases following interstitial brachytherapy. Head Neck 2000; 22: 662-665. 27) Hlubek F, Jung A, Kotzor N, Kirchner T, Brabletz T: Expression of the invasion factor laminin γ2 in colorectalcarcinomas is regulated by β-catenin. Cancer Res 2001; 61: 8089-8093. 25) Perez-Moreno M, Jamora C, Fuchs E: Sticky business: orchestrating cellular signals at adherens junctions, Cell2003; 112: 535-548. 14) Nomizu M. Kuratomi Y. Malinda KM, Song S-Y, Miyoshi K, et al: Cell binding sequences in mouse lamininα1 chain. J Biol Chem 1998; 273: 32491-32499. 9) Chang HW, Chow V, Lam KY, Wei WI, Yuen AP: Loss of E-cadherin expression resulting from promoter hypermethylation in oral tongue carcinoma and its prognostic significance. Cancer 2002; 94: 386-392. 11) Honjo Y, Inohara H, Akahani S, Yoshii T, Takenaka Y, et al: Expression of cytoplasmic galectin-3 as a prognostic marker in tongue carcinoma. Clin Cancer Res 2000; 6: 4635-4640. 28) Liotta LA: Tumor invasion and metastases-role of extracellular matrix: Rhoads memorial award lecture. Can-cer Res 1986; 46: 1-7. 2) Kantola S, Parikka M, Jokinen K, Hyrynkangs K, Soini Y, et al: Prognostic factors in tongue cancer-relative importance of demographic, clinical and histopathological factors. Br J Cancer 2000; 83: 614-619. 13) Nomizu M. Kuratomi Y, Song S-Y, Ponce ML, Hoffman MP, et al: Identification of cell binding sequences inmouse laminin γ1 chain by systematic peptide screening. J Biol Chem 1997; 272: 32198-32205. 8) Yasumatsu R, Nakashima T, Hirakawa N. Kumamoto Y, Kuratomi Y. et al: Maspin expression in stage I and IIoral tongue squamous cell carcinoma. Head Neck 2001: 23: 962-966. 15) Nomizu M. Kuratomi Y, Ponce ML, Song S-Y, Miyoshi K, et al: Cell adhesive sequences in mouse laminin β1chain. Arch Biochem Biophys 2000; 378: 311-320. 18) Giannelli G. Antonaci S: Biologlcal and clinical relevance of laminin-5 in cancer. Clin Exp Metastasis 2000;18: 439-443. 19) 倉富勇一郎:頭頸部扁平上皮癌における基底膜蛋白ラミニンの意義と癌治療への展開.日耳鼻2000;105:721-726. 12) Malinda KM. Kleinman HK: The laminins. Int J Biochem Cell Biol 1996; 28: 957-959. 21) Pyke C, Salo S, Ralfkiaer E, Romer J, Dano K, Tryggvason K: Laminin-5 is a marker of invading cancer cellsin some human carcinomas and is coexpressed with the receptor for urokinase plasminogen activator in buddingcancer cells in colon adenocarcinomas. Cancer Res 1995; 55: 4132-4139. 20) Yamada Y, Kleinman HK: Functional domains of cell adhesion molecules. Curr Opin Cell Biol 1992; 4: 819-823. 4) Yuen AP, Lam KY, Wei WI, Lam KY, Ho CM, et al: A comparison of the prognostic significance of tumor diameter, length, width, thickness, area, volume, and clinicopathological features of oral tongue carcinoma. Am J Surg 2000; 180: 139-143. 5) Shintani S, Nakayama B, Matsuura H, Hasegawa Y: Intraoral ultrasonography is useful to evaluate tumor thickness in tongue carcinoma. Am J Surg 1997; 173: 345-347. 24) Takahashi S. Hasebe T, Oda T, Sasaki S, Kinoshita T, et al: Cytoplasmic expression of laminin γ2 chain corre-lates with postoperative hepatic metastasis and poor prognosis in patients with pancreatic ductal adenocarcinoma. Cancer 2002; 94: 1894-1901. 26) Polakis P: Wnt signaling and cancer. Genes Dev 2000; 14: 1837-1851. 29) Danen EH, Yamada KM: Fibronectin, integrins, and growth control. J Cell Physiol 2001; 189: 1-13. 17) Kuratomi Y, Nomizu M, Tanaka K, Ponce ML, Komiyama S, et a1: Laminin γ1 chain peptide, C-16 (KAFDITYVRLKF), promotes migration, MMP-9 secretion, and pulmonary metastasis of B16-F10 mouse melanoma cells. Br J Cancer 2002; 86: 1169-1173. 1) 小宮山荘太郎:頭頸部癌の放射線化学療法とその効果増強に関する研究.XV口腔癌の治療成績.耳鼻と臨床会2000;162-174. 22) Koshikawa N, Moriyama K, Takamura H, Mizushima H, Nagashima Y, et al: Overexpression of laminin γ2 chainmonomer in invading gastric carcinoma cells. Cancer Res 1999; 59: 5596-5601. 16) Kuratomi Y, Nomizu M, Nielsen PK, Tanaka K, Song S Y, et al: ldentification of metastasis-promoting sequences in the mouse laminin α1 chain.Exp Cell Res 1999; 249: 386-395. 6) Iwai H, Kyomoto R, Ha-Kawa SK. Lee S, Yamashita T: Magnetic resonance determination of tumor thickness aspredictive factor of cervical metastasis in oral tongue carcinoma. Laryngoscope 2002; 112: 457-461. 23) Yamamoto H, Itoh F, Iku S, Hosokawa M, Imai K: Expression of the γ(2) chain of laminin-5 at the invasivefront is associated with recurrence and poor prognosis in human esophageal squamous cell carcinoma. Clin Can-cer Res 2001; 7: 896-900. 3) Asakage T, Yokose T, Mukai K, Tsugane S, Tsubono Y, et al: Tumor thickness predicts cervical metastasis inpatients with stage I/II carcinoma of the tongue. Cancer 1998; 82: 1443-1448. 7) Yoshizaki T. Maruyama Y. Sato H, Furukawa M: Expression of tissue inhibitor of matrix metalloproteinase-2correlates with activation of matrix metalloproteinase-2 and predicts poor prognosis in tongue squamous cellcarcinoma, Int J Cancer 2001; 95: 44-50. |
| References_xml | – reference: 6) Iwai H, Kyomoto R, Ha-Kawa SK. Lee S, Yamashita T: Magnetic resonance determination of tumor thickness aspredictive factor of cervical metastasis in oral tongue carcinoma. Laryngoscope 2002; 112: 457-461. – reference: 29) Danen EH, Yamada KM: Fibronectin, integrins, and growth control. J Cell Physiol 2001; 189: 1-13. – reference: 26) Polakis P: Wnt signaling and cancer. Genes Dev 2000; 14: 1837-1851. – reference: 15) Nomizu M. Kuratomi Y, Ponce ML, Song S-Y, Miyoshi K, et al: Cell adhesive sequences in mouse laminin β1chain. Arch Biochem Biophys 2000; 378: 311-320. – reference: 5) Shintani S, Nakayama B, Matsuura H, Hasegawa Y: Intraoral ultrasonography is useful to evaluate tumor thickness in tongue carcinoma. Am J Surg 1997; 173: 345-347. – reference: 22) Koshikawa N, Moriyama K, Takamura H, Mizushima H, Nagashima Y, et al: Overexpression of laminin γ2 chainmonomer in invading gastric carcinoma cells. Cancer Res 1999; 59: 5596-5601. – reference: 23) Yamamoto H, Itoh F, Iku S, Hosokawa M, Imai K: Expression of the γ(2) chain of laminin-5 at the invasivefront is associated with recurrence and poor prognosis in human esophageal squamous cell carcinoma. Clin Can-cer Res 2001; 7: 896-900. – reference: 3) Asakage T, Yokose T, Mukai K, Tsugane S, Tsubono Y, et al: Tumor thickness predicts cervical metastasis inpatients with stage I/II carcinoma of the tongue. Cancer 1998; 82: 1443-1448. – reference: 19) 倉富勇一郎:頭頸部扁平上皮癌における基底膜蛋白ラミニンの意義と癌治療への展開.日耳鼻2000;105:721-726. – reference: 21) Pyke C, Salo S, Ralfkiaer E, Romer J, Dano K, Tryggvason K: Laminin-5 is a marker of invading cancer cellsin some human carcinomas and is coexpressed with the receptor for urokinase plasminogen activator in buddingcancer cells in colon adenocarcinomas. Cancer Res 1995; 55: 4132-4139. – reference: 14) Nomizu M. Kuratomi Y. Malinda KM, Song S-Y, Miyoshi K, et al: Cell binding sequences in mouse lamininα1 chain. J Biol Chem 1998; 273: 32491-32499. – reference: 24) Takahashi S. Hasebe T, Oda T, Sasaki S, Kinoshita T, et al: Cytoplasmic expression of laminin γ2 chain corre-lates with postoperative hepatic metastasis and poor prognosis in patients with pancreatic ductal adenocarcinoma. Cancer 2002; 94: 1894-1901. – reference: 20) Yamada Y, Kleinman HK: Functional domains of cell adhesion molecules. Curr Opin Cell Biol 1992; 4: 819-823. – reference: 7) Yoshizaki T. Maruyama Y. Sato H, Furukawa M: Expression of tissue inhibitor of matrix metalloproteinase-2correlates with activation of matrix metalloproteinase-2 and predicts poor prognosis in tongue squamous cellcarcinoma, Int J Cancer 2001; 95: 44-50. – reference: 18) Giannelli G. Antonaci S: Biologlcal and clinical relevance of laminin-5 in cancer. Clin Exp Metastasis 2000;18: 439-443. – reference: 28) Liotta LA: Tumor invasion and metastases-role of extracellular matrix: Rhoads memorial award lecture. Can-cer Res 1986; 46: 1-7. – reference: 25) Perez-Moreno M, Jamora C, Fuchs E: Sticky business: orchestrating cellular signals at adherens junctions, Cell2003; 112: 535-548. – reference: 27) Hlubek F, Jung A, Kotzor N, Kirchner T, Brabletz T: Expression of the invasion factor laminin γ2 in colorectalcarcinomas is regulated by β-catenin. Cancer Res 2001; 61: 8089-8093. – reference: 2) Kantola S, Parikka M, Jokinen K, Hyrynkangs K, Soini Y, et al: Prognostic factors in tongue cancer-relative importance of demographic, clinical and histopathological factors. Br J Cancer 2000; 83: 614-619. – reference: 8) Yasumatsu R, Nakashima T, Hirakawa N. Kumamoto Y, Kuratomi Y. et al: Maspin expression in stage I and IIoral tongue squamous cell carcinoma. Head Neck 2001: 23: 962-966. – reference: 11) Honjo Y, Inohara H, Akahani S, Yoshii T, Takenaka Y, et al: Expression of cytoplasmic galectin-3 as a prognostic marker in tongue carcinoma. Clin Cancer Res 2000; 6: 4635-4640. – reference: 17) Kuratomi Y, Nomizu M, Tanaka K, Ponce ML, Komiyama S, et a1: Laminin γ1 chain peptide, C-16 (KAFDITYVRLKF), promotes migration, MMP-9 secretion, and pulmonary metastasis of B16-F10 mouse melanoma cells. Br J Cancer 2002; 86: 1169-1173. – reference: 12) Malinda KM. Kleinman HK: The laminins. Int J Biochem Cell Biol 1996; 28: 957-959. – reference: 13) Nomizu M. Kuratomi Y, Song S-Y, Ponce ML, Hoffman MP, et al: Identification of cell binding sequences inmouse laminin γ1 chain by systematic peptide screening. J Biol Chem 1997; 272: 32198-32205. – reference: 9) Chang HW, Chow V, Lam KY, Wei WI, Yuen AP: Loss of E-cadherin expression resulting from promoter hypermethylation in oral tongue carcinoma and its prognostic significance. Cancer 2002; 94: 386-392. – reference: 10) Masuda M. Kuratomi Y, Shiratsuchi H, Nakashima T, Kunitake N, et al: Decreased CD44H expression in early-stage tongue carcinoma associates with late nodal metastases following interstitial brachytherapy. Head Neck 2000; 22: 662-665. – reference: 1) 小宮山荘太郎:頭頸部癌の放射線化学療法とその効果増強に関する研究.XV口腔癌の治療成績.耳鼻と臨床会2000;162-174. – reference: 4) Yuen AP, Lam KY, Wei WI, Lam KY, Ho CM, et al: A comparison of the prognostic significance of tumor diameter, length, width, thickness, area, volume, and clinicopathological features of oral tongue carcinoma. Am J Surg 2000; 180: 139-143. – reference: 16) Kuratomi Y, Nomizu M, Nielsen PK, Tanaka K, Song S Y, et al: ldentification of metastasis-promoting sequences in the mouse laminin α1 chain.Exp Cell Res 1999; 249: 386-395. |
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| Snippet | 舌扁平上皮癌におけるラミニンγ2鎖の発現を免疫組織学的に調べ,臨床的予後との相関について検討した.癌細胞同士が接着し胞巣状に増殖浸潤している場合,ラミニンγ2鎖の発... 舌扁平上皮癌におけるラミニンγ2鎖の発現を免疫組織学的に調べ, 臨床的予後との相関について検討した. 癌細胞同士が接着し胞巣状に増殖・浸潤している場合, ラミニンγ2... |
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| Title | 舌扁平上皮癌におけるラミニンγ2鎖発現とその臨床的意義 |
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| ispartofPNX | 日本耳鼻咽喉科学会会報, 2004/07/20, Vol.107(6), pp.653-657 |
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