初発膠芽腫患者における光線力学療法後の再発形式
初発膠芽腫に対する光線力学療法（photodynamic therapy: PDT）の効果を特に再発部位を中心に後方視的に検証した．PDTは摘出腔底部からの再発を予防しなかったが，摘出腔側壁からの再発は有意に予防した．側壁からの再発は，MGMT非メチル化例でも確認された．一方，開頭術後の有害事象の発生率に変化は無かった．PDTは安全で，摘出腔側壁からの再発を予防し，患者の日常生活維持期間を延長し，生命予後を改善した．...
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| Published in | 日本レーザー医学会誌 Vol. 44; no. 2; pp. 109 - 116 |
|---|---|
| Main Authors | , , , , , , |
| Format | Journal Article |
| Language | Japanese |
| Published |
特定非営利活動法人 日本レーザー医学会
15.07.2023
日本レーザー医学会 |
| Subjects | |
| Online Access | Get full text |
| ISSN | 0288-6200 1881-1639 |
| DOI | 10.2530/jslsm.jslsm-44_0025 |
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| Abstract | 初発膠芽腫に対する光線力学療法（photodynamic therapy: PDT）の効果を特に再発部位を中心に後方視的に検証した．PDTは摘出腔底部からの再発を予防しなかったが，摘出腔側壁からの再発は有意に予防した．側壁からの再発は，MGMT非メチル化例でも確認された．一方，開頭術後の有害事象の発生率に変化は無かった．PDTは安全で，摘出腔側壁からの再発を予防し，患者の日常生活維持期間を延長し，生命予後を改善した． |
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| AbstractList | 初発膠芽腫に対する光線力学療法（photodynamic therapy: PDT）の効果を特に再発部位を中心に後方視的に検証した．PDTは摘出腔底部からの再発を予防しなかったが，摘出腔側壁からの再発は有意に予防した．側壁からの再発は，MGMT非メチル化例でも確認された．一方，開頭術後の有害事象の発生率に変化は無かった．PDTは安全で，摘出腔側壁からの再発を予防し，患者の日常生活維持期間を延長し，生命予後を改善した． 「要旨」初発膠芽腫に対する光線力学療法(photodynamic therapy: PDT)の効果を特に再発部位を中心に後方視的に検証した. PDTは摘出腔底部からの再発を予防しなかったが, 摘出腔側壁からの再発は有意に予防した. 側壁からの再発は, MGMT非メチル化例でも確認された. 一方, 開頭術後の有害事象の発生率に変化は無かった. PDTは安全で, 摘出腔側壁からの再発を予防し, 患者の日常生活維持期間を延長し, 生命予後を改善した. |
| Author | 瀬戸口, 大毅 長谷川, 祐三 井内, 俊彦 杉山, 孝弘 堺田, 司 細野, 純仁 横井, 佐奈 |
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| DOI | 10.2530/jslsm.jslsm-44_0025 |
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| References | 5) Mitra S, Foster TH. In vivo confocal fluorescence imaging of the intratumor distribution of the photosensitizer mono-L-aspartylchlorin-e6. Neoplasia. 2008; 10: 429-438. 2) Iuchi T, Hatano K, Kodama T, Sakaida T, Yokoi S, Kawasaki K, Hasegawa Y, Hara R. Phase 2 trial of hypofractionated high-dose intensity modulated radiation therapy with concurrent and adjuvant temozolomide for newly diagnosed glioblastoma. Int J Radiat Oncol Biol Phys. 2014; 88: 793-800. 14) Nitta M, Muragaki Y, Maruyama T, Iseki H, Komori T, Ikuta S, Saito T, Yasuda T, Hosono J, Okamoto S, Koriyama S, Kawamata T. Role of photodynamic therapy using talaporfin sodium and a semiconductor laser in patients with newly diagnosed glioblastoma. J Neurosurg. 2019; 131: 1361-1368. 4) Hegi ME, Diserens AC, Gorlia T, Hamou MF, de Tribolet N, Weller M, Kros JM, Hainfellner JA, Mason W, Mariani L, Bromberg JEC, Hau P, Mirimanoff RO, Cairncross JG, Janzer RC, Stupp R. MGMT gene silencing and benefit from temozolomide in gliomastoma. N Engl J Med. 2005; 352: 997-1003. 11) Saito K, Mikuniya N, Aizawa K. Effects of photodynamic therapy using mono-L-aspartyl chlorin e6 on vessels and its contribution to the antitumor effect. Jpn J Cancer Res. 2000; 91: 560-565. 6) Saito T, Tsukahara T, Suzuki T, Nojima I, Tadano H, Kawai N, Kubo T, Hirohashi Y, Kanaseki T, Torigoe T, Li L. Spatiotemporal metabolic dynamics of the photosensitizer talaporfin sodium in carcinoma and sarcoma. Cancer Sci. 2021; 112: 550-562. 8) Kantari C, Walczak H. Caspase-8 and bid: caught in the act between death receptors and mitochonroria. Biochim Biophys Acta. 2011; 1813: 558-563. 9) IuchiT, Hatano K, Kodama T, Tohyama N, Kojima T, Sakaida T, Kawasaki K, Hasegawa Y. Brain deformation after surgery of glioblastoma.—When should we take MRI for planning of irradiation? Radiothel Oncol. 2010; 96: S254. 7) Schmid SL. Reciprocal regulation of signaling and endocytosis: Implications for the evolving cancer cell. J Cell Biol. 2017; 216: 2623-2632. 12) Berghoff A, Rajky O, Winkler F, Bartsch R, Furtner J, Hainfellner JA, Goodman SL, Weller M, Schittenhelm J, Preusser M. Invasion patterns in brain metastases of slid cancers. Neuro Oncol. 2013; 15: 1664-1672. 10) Ogawa E, Akimoto J, Fukami S, Hayashi S, Kohno M, Doi M, Hamada R, Nakazawa H, Miyashita A, Arai T. Diffused light attenuation at 664 nm for PDT in salted cadaber brain. Photodiagnosis Photodyn Ther. 2020; 29: 101593. 3) Qi XS, Shults CJ, Li XA. An estimation of radiobiologic parameters from clinical outcomes for radiation treatment planning of brain tumors. Int J Radiat Oncol Biol Phys. 2006; 64: 1570-1580. 13) Muragaki Y, Akimoto J, Maruyama T, Iseki H, Ikuta S, Nitta M, Maebayashi K, Saito T, Okada Y, Kaneko S, Matumura A, Kuroiwa T, Karasawa K, Nakazato Y, Kayama T. Phase II clinical study on intraoperative photodynamic therapy with talaporfin sodium and semiconductor laser in patients with malignant brain tumors. J Neurosurg. 2013; 119: 845-852. 1) Stupp R, Mason WP, van den Bent MJ, , Weller M, Fisher B, Taphoorn MJB, Belanger K, Brandes AA, Marosi C, Bogdahn U, Curschmann J, Janzer RC, Ludwin SK, Gorlia T, Allgeier A, Lacombe D, Cairncross G, Eisenhauer E, Mirimanoff RO, for the European Organisation for Research and Treatment of Cancer Brain Tumor and Radiotherapy Groups and the National Cancer Institute of Canada Clinical Trials Group. Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. N Engl J Med. 2005; 352: 987-996. |
| References_xml | – reference: 2) Iuchi T, Hatano K, Kodama T, Sakaida T, Yokoi S, Kawasaki K, Hasegawa Y, Hara R. Phase 2 trial of hypofractionated high-dose intensity modulated radiation therapy with concurrent and adjuvant temozolomide for newly diagnosed glioblastoma. Int J Radiat Oncol Biol Phys. 2014; 88: 793-800. – reference: 3) Qi XS, Shults CJ, Li XA. An estimation of radiobiologic parameters from clinical outcomes for radiation treatment planning of brain tumors. Int J Radiat Oncol Biol Phys. 2006; 64: 1570-1580. – reference: 8) Kantari C, Walczak H. Caspase-8 and bid: caught in the act between death receptors and mitochonroria. Biochim Biophys Acta. 2011; 1813: 558-563. – reference: 4) Hegi ME, Diserens AC, Gorlia T, Hamou MF, de Tribolet N, Weller M, Kros JM, Hainfellner JA, Mason W, Mariani L, Bromberg JEC, Hau P, Mirimanoff RO, Cairncross JG, Janzer RC, Stupp R. MGMT gene silencing and benefit from temozolomide in gliomastoma. N Engl J Med. 2005; 352: 997-1003. – reference: 1) Stupp R, Mason WP, van den Bent MJ, , Weller M, Fisher B, Taphoorn MJB, Belanger K, Brandes AA, Marosi C, Bogdahn U, Curschmann J, Janzer RC, Ludwin SK, Gorlia T, Allgeier A, Lacombe D, Cairncross G, Eisenhauer E, Mirimanoff RO, for the European Organisation for Research and Treatment of Cancer Brain Tumor and Radiotherapy Groups and the National Cancer Institute of Canada Clinical Trials Group. Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. N Engl J Med. 2005; 352: 987-996. – reference: 10) Ogawa E, Akimoto J, Fukami S, Hayashi S, Kohno M, Doi M, Hamada R, Nakazawa H, Miyashita A, Arai T. Diffused light attenuation at 664 nm for PDT in salted cadaber brain. Photodiagnosis Photodyn Ther. 2020; 29: 101593. – reference: 7) Schmid SL. Reciprocal regulation of signaling and endocytosis: Implications for the evolving cancer cell. J Cell Biol. 2017; 216: 2623-2632. – reference: 5) Mitra S, Foster TH. In vivo confocal fluorescence imaging of the intratumor distribution of the photosensitizer mono-L-aspartylchlorin-e6. Neoplasia. 2008; 10: 429-438. – reference: 14) Nitta M, Muragaki Y, Maruyama T, Iseki H, Komori T, Ikuta S, Saito T, Yasuda T, Hosono J, Okamoto S, Koriyama S, Kawamata T. Role of photodynamic therapy using talaporfin sodium and a semiconductor laser in patients with newly diagnosed glioblastoma. J Neurosurg. 2019; 131: 1361-1368. – reference: 11) Saito K, Mikuniya N, Aizawa K. Effects of photodynamic therapy using mono-L-aspartyl chlorin e6 on vessels and its contribution to the antitumor effect. Jpn J Cancer Res. 2000; 91: 560-565. – reference: 12) Berghoff A, Rajky O, Winkler F, Bartsch R, Furtner J, Hainfellner JA, Goodman SL, Weller M, Schittenhelm J, Preusser M. Invasion patterns in brain metastases of slid cancers. Neuro Oncol. 2013; 15: 1664-1672. – reference: 13) Muragaki Y, Akimoto J, Maruyama T, Iseki H, Ikuta S, Nitta M, Maebayashi K, Saito T, Okada Y, Kaneko S, Matumura A, Kuroiwa T, Karasawa K, Nakazato Y, Kayama T. Phase II clinical study on intraoperative photodynamic therapy with talaporfin sodium and semiconductor laser in patients with malignant brain tumors. J Neurosurg. 2013; 119: 845-852. – reference: 6) Saito T, Tsukahara T, Suzuki T, Nojima I, Tadano H, Kawai N, Kubo T, Hirohashi Y, Kanaseki T, Torigoe T, Li L. Spatiotemporal metabolic dynamics of the photosensitizer talaporfin sodium in carcinoma and sarcoma. Cancer Sci. 2021; 112: 550-562. – reference: 9) IuchiT, Hatano K, Kodama T, Tohyama N, Kojima T, Sakaida T, Kawasaki K, Hasegawa Y. Brain deformation after surgery of glioblastoma.—When should we take MRI for planning of irradiation? Radiothel Oncol. 2010; 96: S254. |
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| Snippet | 初発膠芽腫に対する光線力学療法（photodynamic therapy: PDT）の効果を特に再発部位を中心に後方視的に検証した．PDTは摘出腔底部からの再発を予防しなかったが，摘出腔... 「要旨」初発膠芽腫に対する光線力学療法(photodynamic therapy: PDT)の効果を特に再発部位を中心に後方視的に検証した. PDTは摘出腔底部からの再発を予防しなかったが, 摘... |
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| SubjectTerms | タラポルフィン 光線力学療法 再発形式 神経膠芽腫 |
| Title | 初発膠芽腫患者における光線力学療法後の再発形式 |
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