ABR の振幅変動および cochlear synaptopathy 検出についての検討
要旨: 難聴・耳鳴で来院され, 純音聴力が正常で, 語音弁別能の低下および ABRⅠ波の振幅低下があり cochlear synaptopathy と推定される例があった。 ABR 振幅の個体内変動について正常聴力者と中等度感音難聴者を対象に検討した。 ABR の振幅のばらつきは背景雑音ではなく反応本体に起因すると考えられた。 ABRⅠ波振幅は正規分布をとるとみなせた。 加算回数が増えるとⅠ波振幅の標準偏差は理論通りに小さくなった。Ⅰ波の振幅変動と潜時のばらつきの関連が理論的に予測されたが明確ではなかった。 難聴群 (79dB) と正常群の ABRⅠ波振幅を比較すると, 正常 40dB との比...
Saved in:
| Published in | AUDIOLOGY JAPAN Vol. 61; no. 2; pp. 145 - 153 |
|---|---|
| Main Authors | , , |
| Format | Journal Article |
| Language | Japanese |
| Published |
一般社団法人 日本聴覚医学会
28.04.2018
日本聴覚医学会 |
| Subjects | |
| Online Access | Get full text |
| ISSN | 0303-8106 1883-7301 |
| DOI | 10.4295/audiology.61.145 |
Cover
| Abstract | 要旨: 難聴・耳鳴で来院され, 純音聴力が正常で, 語音弁別能の低下および ABRⅠ波の振幅低下があり cochlear synaptopathy と推定される例があった。 ABR 振幅の個体内変動について正常聴力者と中等度感音難聴者を対象に検討した。 ABR の振幅のばらつきは背景雑音ではなく反応本体に起因すると考えられた。 ABRⅠ波振幅は正規分布をとるとみなせた。 加算回数が増えるとⅠ波振幅の標準偏差は理論通りに小さくなった。Ⅰ波の振幅変動と潜時のばらつきの関連が理論的に予測されたが明確ではなかった。 難聴群 (79dB) と正常群の ABRⅠ波振幅を比較すると, 正常 40dB との比較では難聴群の方が有意に大きく, 正常 80dB との比較では難聴群の方が有意に小さかった。 同じ閾値上レベル (難聴群と正常 40dB) での比較では難聴群の方が有意に CV (標準偏差／平均) が小さかった, いずれも高い音圧レベルでは lower－SR fiberが働き, 難聴者ではその機能が低下しているとして説明可能であった。 |
|---|---|
| AbstractList | 要旨: 難聴・耳鳴で来院され, 純音聴力が正常で, 語音弁別能の低下および ABRⅠ波の振幅低下があり cochlear synaptopathy と推定される例があった。 ABR 振幅の個体内変動について正常聴力者と中等度感音難聴者を対象に検討した。 ABR の振幅のばらつきは背景雑音ではなく反応本体に起因すると考えられた。 ABRⅠ波振幅は正規分布をとるとみなせた。 加算回数が増えるとⅠ波振幅の標準偏差は理論通りに小さくなった。Ⅰ波の振幅変動と潜時のばらつきの関連が理論的に予測されたが明確ではなかった。 難聴群 (79dB) と正常群の ABRⅠ波振幅を比較すると, 正常 40dB との比較では難聴群の方が有意に大きく, 正常 80dB との比較では難聴群の方が有意に小さかった。 同じ閾値上レベル (難聴群と正常 40dB) での比較では難聴群の方が有意に CV (標準偏差／平均) が小さかった, いずれも高い音圧レベルでは lower－SR fiberが働き, 難聴者ではその機能が低下しているとして説明可能であった。 「要旨」:難聴・耳鳴で来院され, 純音聴力が正常で, 語音弁別能の低下およびABR Ｉ波の振幅低下がありcochlear synaptopathyと推定される例があった. ABR振幅の個体内変動について正常聴力者と中等度感音難聴者を対象に検討した. ABRの振幅のばらつきは背景雑音ではなく反応本体に起因すると考えられた. ABR I波振幅は正規分布をとるとみなせた. 加算回数が増えるとI波振幅の標準偏差は理論通りに小さくなった. I波の振幅変動と潜時のばらつきの関連が理論的に予測されたが明確ではなかった. 難聴群(79dB)と正常群のABR I波振幅を比較すると, 正常40dBとの比較では難聴群の方が有意に大きく, 正常80dBとの比較では難聴群の方が有意に小さかった. 同じ閾値上レベル(難聴群と正常40dB)での比較では難聴群の方が有意にCV(標準偏差/平均)が小さかった, いずれも高い音圧レベルではlower-SR fiberが働き, 難聴者ではその機能が低下しているとして説明可能であった. |
| Author | 岡本, 康秀 泰地, 秀信 神崎, 仁 |
| Author_xml | – sequence: 1 fullname: 神崎, 仁 organization: 東京都済生会中央病院耳鼻咽喉科 – sequence: 1 fullname: 泰地, 秀信 organization: 東京都済生会中央病院耳鼻咽喉科 – sequence: 1 fullname: 岡本, 康秀 organization: 東京都済生会中央病院耳鼻咽喉科 |
| BookMark | eNo9kM1Kw0AUhQepYK3du8wLpN75ySSzrEWrUBRE18NkkrYJaVKSdtFlRPEXd-66LCIIunClrxNafAxTq27OWVz4zuXbRJU4iX2EtjE0GBHWjhp7QRIlvUmD4wZm1hqqYsehpk0BV1AVKFDTwcA3UD3LAheAcBsDgyo6au6eGEX-urh_m39czmc387vHIr8tzq-L_N3Qie5HvkqNbBKr4SgZqlF_Yixm0_nVZ5G_FPmsyC-K_GkJmE2_nh-20HpXRZlf_-0aOtvfO20dmJ3j9mGr2TFDii0wic2wA45rCYExuMK2hWbEcgX3mdacUdDle4qC4ykXXA3CYh4lWHQpYbbAtIbaK-7A9wKtoiSOgtiXYTJO43JXegP7x4kkgB0JwDGQsqiE0k4ZFqXALeC0JLVWpDAbqZ4vh2kwUOlEqnQU6MiX_2olx5IsY0n4u-q-SmWo6Df3GoXO |
| ContentType | Journal Article |
| Copyright | 2018 日本聴覚医学会 |
| Copyright_xml | – notice: 2018 日本聴覚医学会 |
| CorporateAuthor | 東京都済生会中央病院耳鼻咽喉科 読売クリニック耳鼻咽喉科 |
| CorporateAuthor_xml | – name: 東京都済生会中央病院耳鼻咽喉科 – name: 読売クリニック耳鼻咽喉科 |
| DOI | 10.4295/audiology.61.145 |
| DatabaseTitleList | |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine |
| EISSN | 1883-7301 |
| EndPage | 153 |
| ExternalDocumentID | dm7audio_2018_006102_003_0145_01533065063 article_audiology_61_2_61_145_article_char_ja |
| GroupedDBID | 53G ADBBV ALMA_UNASSIGNED_HOLDINGS BAWUL DIK JMI JSF JSH KQ8 MOJWN OK1 RJT RZJ |
| ID | FETCH-LOGICAL-j3150-2741808b599110b9779c425b96e4cc6430c104a308dab0bc0954d3219f3247913 |
| ISSN | 0303-8106 |
| IngestDate | Thu Jul 10 16:10:37 EDT 2025 Wed Sep 03 05:51:06 EDT 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 2 |
| Language | Japanese |
| LinkModel | OpenURL |
| MergedId | FETCHMERGED-LOGICAL-j3150-2741808b599110b9779c425b96e4cc6430c104a308dab0bc0954d3219f3247913 |
| OpenAccessLink | https://www.jstage.jst.go.jp/article/audiology/61/2/61_145/_article/-char/ja |
| PageCount | 9 |
| ParticipantIDs | medicalonline_journals_dm7audio_2018_006102_003_0145_01533065063 jstage_primary_article_audiology_61_2_61_145_article_char_ja |
| PublicationCentury | 2000 |
| PublicationDate | 20180428 |
| PublicationDateYYYYMMDD | 2018-04-28 |
| PublicationDate_xml | – month: 04 year: 2018 text: 20180428 day: 28 |
| PublicationDecade | 2010 |
| PublicationTitle | AUDIOLOGY JAPAN |
| PublicationTitleAlternate | AUDIOLOGY JAPAN |
| PublicationYear | 2018 |
| Publisher | 一般社団法人 日本聴覚医学会 日本聴覚医学会 |
| Publisher_xml | – name: 一般社団法人 日本聴覚医学会 – name: 日本聴覚医学会 |
| References | 17) Sato K, Mimura K, Sata H, et al: On random fluctuations in EEG and evoked potentials. Japanese J Physiol 21: 167-185, 1970 3) Furman AC, Kujawa SC, Liberman MC: Noise-induced cochlear neuropathy in selective for fibers with low spontaneous rates. J Neurophysiol 110: 577-586, 2013 24) Psatta DM, Matei M: Age-dependent amplitude variation of brain-stem auditory evoked potentials. Electroenceph Clin Neurophysiol 44: 459-470, 1978 5) Chiappa KH, Gladstone KJ, Young RR: Brain stem auditory evoked responses: Studies of waveform variations in 50 normal hearing subjects. Arch Neurol 36: 81-87, 1979 4) Rowe Ⅲ MJ: Normal variability of the brain stem auditory evoked response in young and adult subjects. Electroenceph Clin Neurophysiol 44: 459-470, 1978 14) Shim HJ, An YH, Kim DH, et al: Comparisons of auditory brainstem response and sound level tolerance in tinnitus ears and non-tinnitus ears in unilateral tinnitus patients with normal audiograms. PLoS ONE 12 (12) : e0189157, 2017 13) Liberman MC, Epstein MJ, Cleveland SS, et al: Toward a differential diagnosis of hidden hearing loss in humans. PLoS ONE 11 (9) : e0162726, 2016 19) Don M, Elbering C, Waring M: Objective detection of averaged auditory brainstem responses. Sacnd Audiol 13: 219-228, 1984 7) Liberman MC, Kujawa SC: Cochlear synaptopathy in acquired hearing loss: Manifestations and mechanism. Hear Res doi: 10.1016/j.heares.2017.01.003 22) Stockard JE, Stockard JJ, Coen RW: Auditory brain stem response variability in infants. Ear Hear 4: 11-23, 1983 2) Lin HW, Furman AC, Kujawa SC, et al: Primary neural degeneration in the Guinea pig cochlea after reversible noise-induced threshold shift. J Assoc Res Otolaryngol 12: 605-616, 2011 11) Callaway E, Jones RT, Donchin E: Auditory evoked potential variability in schizophrenia. Electroenceph Clin Neurophysiol 29: 421-428,1970 20) Thornton ARD: The measurement of surfacerecorded electrocochleograhic responses. Scan Audiol 4: 51-58, 1975 6) Van Dijk P: Characteristics and mechanisms of spontaneous optoacoustic emissions. Thesis, University of Groningen, the Netherlands, 1990 10) Stamper GC, Johnson TA: Auditory function in normal-hearing, noise-exposed human ears. Ear Hear 36: 172-184, 2014 23) Thornton ARD: Statistical properties of surface-recorded electrocochleograhic responses. Scan Audiol 4: 91-102, 1975 18) Don M, Ponton CW, Eggermont JJ, et al: Auditory brainstem response (ABR) peak amplitude variability reflects individual differences in cochlear response times. J Acoust Soc Am 96: 3476-3491, 1994 25) Lauter JL, Oyler RF, Lord-Maes J: Amplitude stability of auditory brainstem responses in two groups of children compared with adults. Br J Audiol 27: 263-271, 1993 8) Florentine M, Buus S, Mason CR: Level discrimination as a function of level for tones from 0.25 to 16 kHz. J Acoust Soc Am 81: 1528-1541, 1987 21) Salamy A, Mendelsohn T, Tooley WH: Developmental profiles for the brainstem auditory evoked potentials. Early Hum Dev 331-339, 1982 16) Beattie RC, Zipp JA, Schaffer CA, et al: Effects of sample size on the latency and amplitude of the auditory evoked response. Am J Otolaryngol 13: 55-67, 1992 9) Bharadwaj HM, Verhulst S, Shaheen L, et al:Cochlear neuropathy and the coding of suprathreshold sound. Front Syst Neurosci 8: 26, 2014 15) Bramhall NF, Konrad-Martin D, McMillan GP, et al: Auditory brainstem response altered in humans with noise exposure despite normal outer hair cell function. Ear Hear 38: e1-e12, 2017 1) Kujawa SC, Liberman MC: Adding insult to injury : cochlear nerve degeneration after “temporary” noise-inducing hearing loss. J Neurosci 29: 14077-14085, 2009 12) Lauter JL, Loomis RL: Individual differences in auditory electric responses: comparison of between-subject and within-subject variability II: Amplitude and brainstem vertex-positive peaks. Scand Audiol 17: 87-92, 1988 |
| References_xml | – reference: 7) Liberman MC, Kujawa SC: Cochlear synaptopathy in acquired hearing loss: Manifestations and mechanism. Hear Res doi: 10.1016/j.heares.2017.01.003 – reference: 16) Beattie RC, Zipp JA, Schaffer CA, et al: Effects of sample size on the latency and amplitude of the auditory evoked response. Am J Otolaryngol 13: 55-67, 1992 – reference: 19) Don M, Elbering C, Waring M: Objective detection of averaged auditory brainstem responses. Sacnd Audiol 13: 219-228, 1984 – reference: 5) Chiappa KH, Gladstone KJ, Young RR: Brain stem auditory evoked responses: Studies of waveform variations in 50 normal hearing subjects. Arch Neurol 36: 81-87, 1979 – reference: 14) Shim HJ, An YH, Kim DH, et al: Comparisons of auditory brainstem response and sound level tolerance in tinnitus ears and non-tinnitus ears in unilateral tinnitus patients with normal audiograms. PLoS ONE 12 (12) : e0189157, 2017 – reference: 4) Rowe Ⅲ MJ: Normal variability of the brain stem auditory evoked response in young and adult subjects. Electroenceph Clin Neurophysiol 44: 459-470, 1978 – reference: 15) Bramhall NF, Konrad-Martin D, McMillan GP, et al: Auditory brainstem response altered in humans with noise exposure despite normal outer hair cell function. Ear Hear 38: e1-e12, 2017 – reference: 23) Thornton ARD: Statistical properties of surface-recorded electrocochleograhic responses. Scan Audiol 4: 91-102, 1975 – reference: 3) Furman AC, Kujawa SC, Liberman MC: Noise-induced cochlear neuropathy in selective for fibers with low spontaneous rates. J Neurophysiol 110: 577-586, 2013 – reference: 1) Kujawa SC, Liberman MC: Adding insult to injury : cochlear nerve degeneration after “temporary” noise-inducing hearing loss. J Neurosci 29: 14077-14085, 2009 – reference: 11) Callaway E, Jones RT, Donchin E: Auditory evoked potential variability in schizophrenia. Electroenceph Clin Neurophysiol 29: 421-428,1970 – reference: 21) Salamy A, Mendelsohn T, Tooley WH: Developmental profiles for the brainstem auditory evoked potentials. Early Hum Dev 331-339, 1982 – reference: 2) Lin HW, Furman AC, Kujawa SC, et al: Primary neural degeneration in the Guinea pig cochlea after reversible noise-induced threshold shift. J Assoc Res Otolaryngol 12: 605-616, 2011 – reference: 6) Van Dijk P: Characteristics and mechanisms of spontaneous optoacoustic emissions. Thesis, University of Groningen, the Netherlands, 1990 – reference: 17) Sato K, Mimura K, Sata H, et al: On random fluctuations in EEG and evoked potentials. Japanese J Physiol 21: 167-185, 1970 – reference: 24) Psatta DM, Matei M: Age-dependent amplitude variation of brain-stem auditory evoked potentials. Electroenceph Clin Neurophysiol 44: 459-470, 1978 – reference: 13) Liberman MC, Epstein MJ, Cleveland SS, et al: Toward a differential diagnosis of hidden hearing loss in humans. PLoS ONE 11 (9) : e0162726, 2016 – reference: 10) Stamper GC, Johnson TA: Auditory function in normal-hearing, noise-exposed human ears. Ear Hear 36: 172-184, 2014 – reference: 12) Lauter JL, Loomis RL: Individual differences in auditory electric responses: comparison of between-subject and within-subject variability II: Amplitude and brainstem vertex-positive peaks. Scand Audiol 17: 87-92, 1988 – reference: 8) Florentine M, Buus S, Mason CR: Level discrimination as a function of level for tones from 0.25 to 16 kHz. J Acoust Soc Am 81: 1528-1541, 1987 – reference: 20) Thornton ARD: The measurement of surfacerecorded electrocochleograhic responses. Scan Audiol 4: 51-58, 1975 – reference: 9) Bharadwaj HM, Verhulst S, Shaheen L, et al:Cochlear neuropathy and the coding of suprathreshold sound. Front Syst Neurosci 8: 26, 2014 – reference: 25) Lauter JL, Oyler RF, Lord-Maes J: Amplitude stability of auditory brainstem responses in two groups of children compared with adults. Br J Audiol 27: 263-271, 1993 – reference: 18) Don M, Ponton CW, Eggermont JJ, et al: Auditory brainstem response (ABR) peak amplitude variability reflects individual differences in cochlear response times. J Acoust Soc Am 96: 3476-3491, 1994 – reference: 22) Stockard JE, Stockard JJ, Coen RW: Auditory brain stem response variability in infants. Ear Hear 4: 11-23, 1983 |
| SSID | ssib002671040 ssib002670262 ssj0060397 ssib058492327 |
| Score | 2.1435711 |
| Snippet | 要旨: 難聴・耳鳴で来院され, 純音聴力が正常で, 語音弁別能の低下および ABRⅠ波の振幅低下があり cochlear synaptopathy と推定される例があった。 ABR 振幅の個体内変... 「要旨」:難聴・耳鳴で来院され, 純音聴力が正常で, 語音弁別能の低下およびABR Ｉ波の振幅低下がありcochlear synaptopathyと推定される例があった. ABR振幅の個体内変... |
| SourceID | medicalonline jstage |
| SourceType | Publisher |
| StartPage | 145 |
| SubjectTerms | ABR cochlear synaptopathy lower－SR fiber 個体内変動 振幅 |
| Title | ABR の振幅変動および cochlear synaptopathy 検出についての検討 |
| URI | https://www.jstage.jst.go.jp/article/audiology/61/2/61_145/_article/-char/ja http://mol.medicalonline.jp/en/journal/download?GoodsID=dm7audio/2018/006102/003&name=0145-0153j |
| Volume | 61 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| ispartofPNX | AUDIOLOGY JAPAN, 2018/04/28, Vol.61(2), pp.145-153 |
| journalDatabaseRights | – providerCode: PRVAFT databaseName: Open Access Digital Library customDbUrl: eissn: 1883-7301 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0060397 issn: 0303-8106 databaseCode: KQ8 dateStart: 19680101 isFulltext: true titleUrlDefault: http://grweb.coalliance.org/oadl/oadl.html providerName: Colorado Alliance of Research Libraries – providerCode: PRVBFR databaseName: Free Medical Journals customDbUrl: eissn: 1883-7301 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0060397 issn: 0303-8106 databaseCode: DIK dateStart: 19680101 isFulltext: true titleUrlDefault: http://www.freemedicaljournals.com providerName: Flying Publisher |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1LaxRBEB5iBBFEfGJ8sQf7FCZOz6OnBzzYs04ISoJKArkN89glLOSB7h705IjiE2_eclxEEPTgSf_OsMGf4Vc9s5NJ8GD0MvT2VtVUV_Wjarq62jBu2JnMHD_xTJEngenCwKeL3D2T9-DhWn3oPaEd3eUVsbTm3l331meOPWtFLY2G6UL29I_nSv5Fq6iDXumU7BE02xBFBcrQL57QMJ5_pWMVPpxnkQNrkKmIRYLJLlOLLPJYGDDpUUHBVgyoIEMWeDWwVLpgMynrmtCZx8y4QXdIUBKDZGe4TXcVP5knqqARdDUNn4Vq-sJwWnCnVKcFJQ4wVaNLpiSTUdsaVrBG9UYWOtJ91WwKschnymNBpFuCBuiITRa5LAyZ5PtgAnyz0CIwvAEFDQZknwI4CH6RqRY8qNmoIETAq24F71GjQr9BbH8I4ZL2dOqD5dR1NVWpyUsSH4gQHio1t0HIlFMzRuJ2NW2lxRjoVjXvJnxOzSPJoFJpCXepjaS3O1qMwO_ir9Z0DWPAlNyqE3tXy4mUjklzaHu9qZLP1-PKbi0evEqsWdshvEqifHiJg_1A2UCSUV4dZ1oQfKFBPJA4vO6WcQMaCx7b9AB8PP2XDvfFA3gYx21fCLoD5N6DlgMqfKudUBK_4b83MzysVzgIdvOJQ1iOvs6okUUVGEA83zzMMUy-ARwgymxxarPalKySw7Tsu9UzxunaMeuoiuGzxswgOWecWK5DT84bKxhsnbL4uvf-2-THy8n4zeTdx7J4Wz5_XRbfO9PB02kPns7eeHfy6mdZfCmLcVm8KItPRGC8--vzhwvG2mK02l0y68tIzIEDp8nUaZ4smXpwqLiVwm0KMqx3aSB6bpbBrrcySCZxLJknqZVmcF3c3IE90IfL4gfcuWjMbm1v9S4ZnUDkGUVrpb0kcXnaT3LHtfxekKc272eZP2fcqiQT71QZZ-IjqXLOuH1AnnE9Yz2O801fU4hp-MTkvVg2JQeOKbYAD4o0h8cmnMv_x8EV4-T-AL1qzA4fjXrXYLsP0-u6e_0GmGjLCw |
| linkProvider | Colorado Alliance of Research Libraries |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=ABR+%E3%81%AE%E6%8C%AF%E5%B9%85%E5%A4%89%E5%8B%95%E3%81%8A%E3%82%88%E3%81%B3+cochlear+synaptopathy+%E6%A4%9C%E5%87%BA%E3%81%AB%E3%81%A4%E3%81%84%E3%81%A6%E3%81%AE%E6%A4%9C%E8%A8%8E&rft.jtitle=AUDIOLOGY+JAPAN&rft.au=%E7%A5%9E%E5%B4%8E%2C+%E4%BB%81&rft.au=%E6%B3%B0%E5%9C%B0%2C+%E7%A7%80%E4%BF%A1&rft.au=%E5%B2%A1%E6%9C%AC%2C+%E5%BA%B7%E7%A7%80&rft.date=2018-04-28&rft.pub=%E4%B8%80%E8%88%AC%E7%A4%BE%E5%9B%A3%E6%B3%95%E4%BA%BA+%E6%97%A5%E6%9C%AC%E8%81%B4%E8%A6%9A%E5%8C%BB%E5%AD%A6%E4%BC%9A&rft.issn=0303-8106&rft.eissn=1883-7301&rft.volume=61&rft.issue=2&rft.spage=145&rft.epage=153&rft_id=info:doi/10.4295%2Faudiology.61.145&rft.externalDocID=article_audiology_61_2_61_145_article_char_ja |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0303-8106&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0303-8106&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0303-8106&client=summon |