生体内で働く分子ロボットの実現へ：情報媒体としてのDNA分子とDNAコンピューティング
本稿では，近年，研究が発展している「分子ロボティクス（分子ロボット工学）」について，基礎から最新の動向まで解説する。分子ロボットは，情報分子DNAを利用したナノテクノロジーであるDNAコンピューター・DNAメモリー・DNAナノ構造形成等の生体分子情報技術を基礎にしており，生体内での計算や，診断・治療，人工細胞構築，大容量分子メモリー，脳型コンピューター開発などへの応用が期待されている。DNAにあまり触れたことのない読者を想定し，本分野を理解するために必要なDNAナノテクノロジーやDNAの塩基配列設計の基礎を簡潔に説明した後，最近の注目研究の動向に加え，われわれの研究グループが近年研究を進めてい...
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| Published in | Journal of information processing and management Vol. 60; no. 9; pp. 629 - 640 |
|---|---|
| Main Author | |
| Format | Journal Article |
| Language | Japanese |
| Published |
Tokyo
国立研究開発法人 科学技術振興機構
01.01.2017
Japan Science and Technology Agency |
| Subjects | |
| Online Access | Get full text |
| ISSN | 0021-7298 1347-1597 |
| DOI | 10.1241/johokanri.60.629 |
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| Abstract | 本稿では，近年，研究が発展している「分子ロボティクス（分子ロボット工学）」について，基礎から最新の動向まで解説する。分子ロボットは，情報分子DNAを利用したナノテクノロジーであるDNAコンピューター・DNAメモリー・DNAナノ構造形成等の生体分子情報技術を基礎にしており，生体内での計算や，診断・治療，人工細胞構築，大容量分子メモリー，脳型コンピューター開発などへの応用が期待されている。DNAにあまり触れたことのない読者を想定し，本分野を理解するために必要なDNAナノテクノロジーやDNAの塩基配列設計の基礎を簡潔に説明した後，最近の注目研究の動向に加え，われわれの研究グループが近年研究を進めている，DNA分子とマイクロ水滴を利用した，細胞型分子ロボット（人工細胞）の構築を詳しく解説する。 |
|---|---|
| AbstractList | 本稿では，近年，研究が発展している「分子ロボティクス（分子ロボット工学）」について，基礎から最新の動向まで解説する。分子ロボットは，情報分子DNAを利用したナノテクノロジーであるDNAコンピューター・DNAメモリー・DNAナノ構造形成等の生体分子情報技術を基礎にしており，生体内での計算や，診断・治療，人工細胞構築，大容量分子メモリー，脳型コンピューター開発などへの応用が期待されている。DNAにあまり触れたことのない読者を想定し，本分野を理解するために必要なDNAナノテクノロジーやDNAの塩基配列設計の基礎を簡潔に説明した後，最近の注目研究の動向に加え，われわれの研究グループが近年研究を進めている，DNA分子とマイクロ水滴を利用した，細胞型分子ロボット（人工細胞）の構築を詳しく解説する。 In this paper, we describe "Molecular Robotics" from the fundamental introduction to the recent trends of molecular robotics study. The molecular robots are based on DNA-based biomolecular information nanotechnology such as DNA computers, DNA memories, and DNA nanostructure construction. Therefore, the molecular robots have recently attracted much attention as one of promising technologies to realize in vivo computers, in vivo diagnosis and medical treatment, artificial cells, mass storage molecular memories, brain computers, etc. In this paper, we first briefly explain the basic physics and basic chemistry of DNA required to understand this field for many non-specialists of DNA; then, in addition to the introduction of recent hot topics, we give detailed descriptions of our work in this field, especially, the construction of artificial cell-type molecular robots based on DNA molecules and microdroplet. |
| Author | 瀧ノ上, 正浩 |
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| References | 4) Langecker, M.; Arnaut, V.; Martin, T. G.; List, J.; Renner, S.; Mayer, M.; Dietz, H.; Simmel, F. C. Synthetic lipid membrane channels formed by designed DNA nanostructures. Science. 2012, vol. 338, no. 6109, p. 932-936. 6) 萩谷昌己. 戦略的創造研究推進事業 CREST 研究領域「情報社会を支える新しい高性能情報処理技術」 研究課題「多相的分子インタラクションに基づく大容量メモリの構築」 研究終了報告書. 科学技術振興機構. http://www.jst.go.jp/kisoken/crest/report/sh_heisei13/jyouhou/hagiya.pdf, (accessed 2017-10-01). 9) Rothemund, Paul W. K. Folding DNA to create nanoscale shapes and patterns. Nature. 2006, vol. 440, no. 7082, p. 297-302. 1) Hagiya, Masami; Konagaya, Akihiko; Kobayashi, Satoshi; Saito, Hirohide; Murata, Satoshi. Molecular robots with sensors and intelligence. Acc. Chem. Res. 2014, vol. 47, no. 6, p. 1681-1690. 2) Murata, Satoshi; Konagaya, Akihiko; Kobayashi, Satoshi; Saito, Hirohide; Hagiya, Masami. Molecular robotics: A new paradigm for artifacts. New Generation Computing. 2013, vol. 31, no. 1, p. 27-45. 10) Sato, Yusuke; Hiratsuka, Yuichi; Kawamata, Ibuki; Murata, Satoshi; Nomura, Shin-ichiro M. Micrometer-sized molecular robot changes its shape in response to signal molecules. Science Robotics. 2017, vol. 2, no. 4, p. eaal3735. 12) Kurokawa, Chikako; Fujiwara, Kei; Morita, Masamune; Kawamata, Ibuki; Kawagishi, Yui; Sakai, Atsushi; Murayama, Yoshihiro; Nomura, Shin-ichiro M.; Murata, Satoshi; Takinoue, Masahiro; Yanagisawa, Miho. DNA cytoskeleton for stabilizing artificial cells. Proceedings of the National Academy of Sciences of the United States of America. 2017, vol. 114, no. 28, p. 7228-7233. 3) Douglas, Shawn M.; Bachelet, I.; Church, George M. A logic-gated nanorobot for targeted transport of molecular payloads. Science. 2012, vol. 335, no. 6070, p. 831-834. 14) Ohara, Masayuki; Takinoue, Masahiro; Kawano, Ryuji. Nanopore Logic Operation with DNA to RNA Transcription in a Droplet System. ACS Synthetic Biology. 2017, vol. 6, no. 7, p. 1427-1432. 13) Takinoue, Masahiro; Kiga, Daisuke; Shohda, Koh-ichiroh; Suyama, Akira. Experiments and simulation models of a basic computation element of an autonomous molecular computing system. Physical Review E. 2008, vol. 78, no. 4, p. 41921. 7) Takinoue, Masahiro; Suyama, Akira. Hairpin-DNA memory using molecular addressing. Small. 2006, vol. 2, no. 11, p. 1244-1247. 5) Erlich, Yaniv; Zielinski, Dina. DNA fountain enables a robust and efficient storage architecture. Science. 2017, vol. 355, no. 6328, p. 950-954. 15) Sugiura, Haruka; Ito, Manami; Okuaki, Tomoya; Mori, Yoshihito; Kitahata, Hiroyuki; Takinoue, Masahiro. Pulse-density modulation control of chemical oscillation far from equilibrium in a droplet open-reactor system. Nature Communications. 2016, vol. 7, p. 10212. 8) Sander, Jeffry D.; Joung, J. K. CRISPR-Cas systems for editing, regulating and targeting genomes. Nature biotechnology. 2014, vol. 32, no. 4, p. 347-355. 11) Ishikawa, Daisuke; Suzuki, Yuki; Kurokawa, Chikako; Ohara, Masayuki; Morita, Masamune; Yanagisawa, Miho; Kawano, Ryuji; Endo, Masayuki; Takinoue, Masahiro. "Self-Assembled Microcapsule of Amphiphilic Janus DNA Nanoplates at the Water-Oil Interface". Proceedings of the 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences (microTAS 2016). Dublin, Ireland, 2016-10-09/13. 2017, pp.116-117. |
| References_xml | – reference: 14) Ohara, Masayuki; Takinoue, Masahiro; Kawano, Ryuji. Nanopore Logic Operation with DNA to RNA Transcription in a Droplet System. ACS Synthetic Biology. 2017, vol. 6, no. 7, p. 1427-1432. – reference: 6) 萩谷昌己. 戦略的創造研究推進事業 CREST 研究領域「情報社会を支える新しい高性能情報処理技術」 研究課題「多相的分子インタラクションに基づく大容量メモリの構築」 研究終了報告書. 科学技術振興機構. http://www.jst.go.jp/kisoken/crest/report/sh_heisei13/jyouhou/hagiya.pdf, (accessed 2017-10-01). – reference: 11) Ishikawa, Daisuke; Suzuki, Yuki; Kurokawa, Chikako; Ohara, Masayuki; Morita, Masamune; Yanagisawa, Miho; Kawano, Ryuji; Endo, Masayuki; Takinoue, Masahiro. "Self-Assembled Microcapsule of Amphiphilic Janus DNA Nanoplates at the Water-Oil Interface". Proceedings of the 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences (microTAS 2016). Dublin, Ireland, 2016-10-09/13. 2017, pp.116-117. – reference: 4) Langecker, M.; Arnaut, V.; Martin, T. G.; List, J.; Renner, S.; Mayer, M.; Dietz, H.; Simmel, F. C. Synthetic lipid membrane channels formed by designed DNA nanostructures. Science. 2012, vol. 338, no. 6109, p. 932-936. – reference: 9) Rothemund, Paul W. K. Folding DNA to create nanoscale shapes and patterns. Nature. 2006, vol. 440, no. 7082, p. 297-302. – reference: 2) Murata, Satoshi; Konagaya, Akihiko; Kobayashi, Satoshi; Saito, Hirohide; Hagiya, Masami. Molecular robotics: A new paradigm for artifacts. New Generation Computing. 2013, vol. 31, no. 1, p. 27-45. – reference: 12) Kurokawa, Chikako; Fujiwara, Kei; Morita, Masamune; Kawamata, Ibuki; Kawagishi, Yui; Sakai, Atsushi; Murayama, Yoshihiro; Nomura, Shin-ichiro M.; Murata, Satoshi; Takinoue, Masahiro; Yanagisawa, Miho. DNA cytoskeleton for stabilizing artificial cells. Proceedings of the National Academy of Sciences of the United States of America. 2017, vol. 114, no. 28, p. 7228-7233. – reference: 3) Douglas, Shawn M.; Bachelet, I.; Church, George M. A logic-gated nanorobot for targeted transport of molecular payloads. Science. 2012, vol. 335, no. 6070, p. 831-834. – reference: 15) Sugiura, Haruka; Ito, Manami; Okuaki, Tomoya; Mori, Yoshihito; Kitahata, Hiroyuki; Takinoue, Masahiro. Pulse-density modulation control of chemical oscillation far from equilibrium in a droplet open-reactor system. Nature Communications. 2016, vol. 7, p. 10212. – reference: 10) Sato, Yusuke; Hiratsuka, Yuichi; Kawamata, Ibuki; Murata, Satoshi; Nomura, Shin-ichiro M. Micrometer-sized molecular robot changes its shape in response to signal molecules. Science Robotics. 2017, vol. 2, no. 4, p. eaal3735. – reference: 1) Hagiya, Masami; Konagaya, Akihiko; Kobayashi, Satoshi; Saito, Hirohide; Murata, Satoshi. Molecular robots with sensors and intelligence. Acc. Chem. Res. 2014, vol. 47, no. 6, p. 1681-1690. – reference: 7) Takinoue, Masahiro; Suyama, Akira. Hairpin-DNA memory using molecular addressing. Small. 2006, vol. 2, no. 11, p. 1244-1247. – reference: 13) Takinoue, Masahiro; Kiga, Daisuke; Shohda, Koh-ichiroh; Suyama, Akira. Experiments and simulation models of a basic computation element of an autonomous molecular computing system. Physical Review E. 2008, vol. 78, no. 4, p. 41921. – reference: 8) Sander, Jeffry D.; Joung, J. K. CRISPR-Cas systems for editing, regulating and targeting genomes. Nature biotechnology. 2014, vol. 32, no. 4, p. 347-355. – reference: 5) Erlich, Yaniv; Zielinski, Dina. DNA fountain enables a robust and efficient storage architecture. Science. 2017, vol. 355, no. 6328, p. 950-954. |
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| Snippet | 本稿では，近年，研究が発展している「分子ロボティクス（分子ロボット工学）」について，基礎から最新の動向まで解説する。分子ロボットは，情報分子DNAを利... In this paper, we describe "Molecular Robotics" from the fundamental introduction to the recent trends of molecular robotics study. The molecular robots are... |
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| SubjectTerms | Brain Deoxyribonucleic acid DNA DNAコンピューター DNAメモリー Health services Nanotechnology Robotics Robots ソフトマター マイクロ水滴 人工細胞 分子ロボット 分子ロボティクス 生物物理学 自己組織化 |
| Title | 生体内で働く分子ロボットの実現へ：情報媒体としてのDNA分子とDNAコンピューティング |
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