剤型別フッ化物配合歯磨剤使用後の唾液中フッ素イオンの経時的変化
フッ化物配合歯磨剤にはペースト状，ジェル状，フォーム状，液状など種々の剤型があり，各々の特徴を生かした用途がある．今回，剤型の違いによる歯磨剤使用後の唾液中フッ素イオン濃度に差が認められるか否かを明らかにするために，11名の健康な成人を対象に，ペースト，ジェル，フォームタイプの950 ppm F，NaF配合歯磨剤を用いて，同量（0.5 g），同用法（スクラッビンク法で2分間磨いた後，15 mLの蒸留水で5秒間洗口）で磨いた場合の唾液中フッ素イオン濃度について，ブラッシング直後から4時間後までの値を測定し比較検討した．その結果，唾液中フッ素イオン濃度に有意差が認められ，フォームタイプが最も高く，...
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| Published in | 口腔衛生学会雑誌 Vol. 71; no. 1; pp. 36 - 45 |
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| Main Authors | , , , , |
| Format | Journal Article |
| Language | Japanese |
| Published |
一般社団法人 口腔衛生学会
01.01.2021
日本口腔衛生学会 |
| Subjects | |
| Online Access | Get full text |
| ISSN | 0023-2831 2189-7379 |
| DOI | 10.5834/jdh.71.1_36 |
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| Abstract | フッ化物配合歯磨剤にはペースト状，ジェル状，フォーム状，液状など種々の剤型があり，各々の特徴を生かした用途がある．今回，剤型の違いによる歯磨剤使用後の唾液中フッ素イオン濃度に差が認められるか否かを明らかにするために，11名の健康な成人を対象に，ペースト，ジェル，フォームタイプの950 ppm F，NaF配合歯磨剤を用いて，同量（0.5 g），同用法（スクラッビンク法で2分間磨いた後，15 mLの蒸留水で5秒間洗口）で磨いた場合の唾液中フッ素イオン濃度について，ブラッシング直後から4時間後までの値を測定し比較検討した．その結果，唾液中フッ素イオン濃度に有意差が認められ，フォームタイプが最も高く，4時間後も歯質の脱灰抑制効果や再石灰化効果があるといわれる0.09 ppm F付近を維持していた．また，唾液中フッ素イオン濃度－時間曲線下面積（AUC）を比較した結果，フォームタイプの総フッ素イオン量（AUC0‒240min）が有意に高い値を示し，発泡剤を含まないジェルタイプが最も低かった．したがって，フォームタイプは他の剤型よりもブラッシング後の唾液中へのフッ素イオンの停滞性が高いことが明らかになった．これは，フォームタイプは発泡剤の他に可溶化剤や発泡補助剤を含むため，泡によりFイオンが短時間に素早く口腔内全体に広がり，それらが粘膜などの口腔組織に吸着もしくは取り込まれた後，徐々に唾液中に遊離するためと考えられた． |
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| AbstractList | 「概要」: フッ化物配合歯磨剤にはペースト状, ジェル状, フォーム状, 液状など種々の剤型があり, 各々の特徴を生かした用途がある. 今回, 剤型の違いによる歯磨剤使用後の唾液中フッ素イオン濃度に差が認められるか否かを明らかにするために, 11名の健康な成人を対象に, ペースト, ジェル, フォームタイプの950ppm F, NaF配合歯磨剤を用いて, 同量(0.5g), 同用法(スクラッビンク法で2分間磨いた後, 15mLの蒸留水で5秒間洗口)で磨いた場合の唾液中フッ素イオン濃度について, ブラッシング直後から4時間後までの値を測定し比較検討した. その結果, 唾液中フッ素イオン濃度に有意差が認められ, フォームタイプが最も高く, 4時間後も歯質の脱灰抑制効果や再石灰化効果があるといわれる0.09ppm F付近を維持していた. また, 唾液中フッ素イオン濃度-時間曲線下面積(AUC)を比較した結果, フォームタイプの総フッ素イオン量(AUC0-240min)が有意に高い値を示し, 発泡剤を含まないジェルタイプが最も低かった. したがって, フォームタイプは他の剤型よりもブラッシング後の唾液中へのフッ素イオンの停滞性が高いことが明らかになった. これは, フォームタイプは発泡剤の他に可溶化剤や発泡補助剤を含むため, 泡によりFイオンが短時間に素早く口腔内全体に広がり, それらが粘膜などの口腔組織に吸着もしくは取り込まれた後, 徐々に唾液中に遊離するためと考えられた. フッ化物配合歯磨剤にはペースト状，ジェル状，フォーム状，液状など種々の剤型があり，各々の特徴を生かした用途がある．今回，剤型の違いによる歯磨剤使用後の唾液中フッ素イオン濃度に差が認められるか否かを明らかにするために，11名の健康な成人を対象に，ペースト，ジェル，フォームタイプの950 ppm F，NaF配合歯磨剤を用いて，同量（0.5 g），同用法（スクラッビンク法で2分間磨いた後，15 mLの蒸留水で5秒間洗口）で磨いた場合の唾液中フッ素イオン濃度について，ブラッシング直後から4時間後までの値を測定し比較検討した．その結果，唾液中フッ素イオン濃度に有意差が認められ，フォームタイプが最も高く，4時間後も歯質の脱灰抑制効果や再石灰化効果があるといわれる0.09 ppm F付近を維持していた．また，唾液中フッ素イオン濃度－時間曲線下面積（AUC）を比較した結果，フォームタイプの総フッ素イオン量（AUC0‒240min）が有意に高い値を示し，発泡剤を含まないジェルタイプが最も低かった．したがって，フォームタイプは他の剤型よりもブラッシング後の唾液中へのフッ素イオンの停滞性が高いことが明らかになった．これは，フォームタイプは発泡剤の他に可溶化剤や発泡補助剤を含むため，泡によりFイオンが短時間に素早く口腔内全体に広がり，それらが粘膜などの口腔組織に吸着もしくは取り込まれた後，徐々に唾液中に遊離するためと考えられた． |
| Author | 八幡, 祥子 福田, 敦史 廣瀬, 弥奈 村田, 幸枝 藤田, 裕介 |
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| References_xml | – reference: 1) Whelton HP, Spencer AJ, Do LG et al.: Fluoride revolution and dental caries: Evolution of policies for global use. J Dent Res 98: 837‒846, 2019. – reference: 36) Sotthipoka K, Thanomsuk P, Prasopsuk R et al.: The effects of toothpaste amounts and post-brushing rinsing methods on salivary fluoride retention. J Health Res 32: 421‒431, 2018. – reference: 11) ten Cate JM, Featherstone JD: Mechanistic aspects of the interactions between fluoride and dental enamel. Crit Rev Oral Biol Med 2: 283‒296, 1991. – reference: 51) Vogel GL, Schumacher GE, Chow LC et al.: Oral fluoride levels 1 h after use of a sodium fluoride rinse: Effect of sodium lauryl sulfate. Caries Res 49: 291‒296, 2015. – reference: 6) Bratthall D, Hansel PG, Sundberg H: Reasons for the caries decline: What do experts believe?. Eur J Oral Sci 104: 416‒422, 1996. – reference: 41) Wong MCM, Clarkson J, Glenny AM et al.: Cochrane reviews on the benefits/risks of fluoride toothpaste. J Dent Res 90: 573‒579, 2011. – reference: 52) Herlofson BB, Barkvoll P: Desquamative effect of sodium lauryl sulfate on oral mucosa. A preliminary study. Acta Odont Scand 51: 39‒43, 1993. – reference: 33) Zero DT, Raubertas RF, Pedersen AM et al.: Studies of fluoride retention by oral soft tissues after the application of home-use topical fluorides. J Dent Res 71: 1546‒1552, 1992. – reference: 9) フッ化物応用研究会編：う蝕予防のためのフッ化物配合歯磨剤応用マニュアル，社会保険研究所，東京，2006，9‒26頁． – reference: 10) NPO法人 日本むし歯予防フッ化物協会編：日本におけるフッ化物製剤─フッ化物応用の過去・現在・未来─，口腔保健協会，東京，第10版，2016，2頁． – reference: 26) Featherstone JDB, Glena R, Shariati M et al.: Dependence of in vitro demineralization of apatite and remineralization of dental enamel on fluoride concentration. J Dent Res 69: 620‒625, 1990. – reference: 40) Campus G, Lallai MR, Carboni R: Fluoride concentration in saliva after use of oral hygiene products. Caries Res 37: 66‒70, 2003. – reference: 22) Creeth J, Zero D, Mau M et al.: The effect of dentifrice quantity and toothbrushing behavior on oral delivery and retention of fluoride. Int Dent J 63: 14‒24, 2013. – reference: 24) Featherstone JDB: The science and practice of caries prevention. JADA 131: 887‒899, 2000. – reference: 23) Featherstone JDB: Prevention and reversal of dental caries : Role of low level fluoride. Commun Dent Oral Epidemiol 27: 31‒40, 1999. – reference: 53) Robinson C, Strafford S, Rees G et al.: Plaque biofilms: The effect of chemical environment on natural human plaque biofilm architecture. Arch Oral Biol 51: 1006‒1014, 2006. – reference: 12) Featherstone JDB: Dental caries: A dynamic disease process. Aust Dent J 53: 286‒291, 2008. – reference: 43) Kondo KY, Buzalaf MAR, Manarelli MM et al.: Effects of pH and fluoride concentration of dentifrices on fluoride levels in saliva, biofilm, and biofilm fluid in vivo. 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| Snippet | フッ化物配合歯磨剤にはペースト状，ジェル状，フォーム状，液状など種々の剤型があり，各々の特徴を生かした用途がある．今回，剤型の違いによる歯磨剤使用後の唾液中フッ... 「概要」: フッ化物配合歯磨剤にはペースト状, ジェル状, フォーム状, 液状など種々の剤型があり, 各々の特徴を生かした用途がある. 今回, 剤型の違いによる歯磨剤使用後の唾... |
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| Title | 剤型別フッ化物配合歯磨剤使用後の唾液中フッ素イオンの経時的変化 |
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