キトサンオリゴ糖を投与された犬の糞便細菌叢および免疫応答
キトサンオリゴ糖15mg/kg/日を犬に投与したときの糞便細菌叢および免疫応答の変化を調べた。投与2週間後，ビフィズス菌は有意に増加し，クロストリジウムは有意に減少した。CD4陽性リンパ球/CD8陽性リンパ球比は有意に増加した。一方，オリゴ糖投与6週間後，血清中および糞便中IgA濃度はともにオリゴ糖投与群とコントロール群との間に有意差は認められなかったが，ビフィズス菌の増加，クロストリジウム減少などからイヌにおいてキトサンオリゴ糖の有用性が示された。...
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| Published in | Journal of Animal Clinical Medicine Vol. 15; no. 3; pp. 73 - 78 |
|---|---|
| Main Authors | , , , , , |
| Format | Journal Article |
| Language | Japanese |
| Published |
動物臨床医学会
2006
Japanese Society of Clinical Veterinary Medicine |
| Subjects | |
| Online Access | Get full text |
| ISSN | 1344-6991 1881-1574 |
| DOI | 10.11252/dobutsurinshoigaku.15.73 |
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| Abstract | キトサンオリゴ糖15mg/kg/日を犬に投与したときの糞便細菌叢および免疫応答の変化を調べた。投与2週間後，ビフィズス菌は有意に増加し，クロストリジウムは有意に減少した。CD4陽性リンパ球/CD8陽性リンパ球比は有意に増加した。一方，オリゴ糖投与6週間後，血清中および糞便中IgA濃度はともにオリゴ糖投与群とコントロール群との間に有意差は認められなかったが，ビフィズス菌の増加，クロストリジウム減少などからイヌにおいてキトサンオリゴ糖の有用性が示された。 |
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| AbstractList | This study investigated the changes of fecal flora and immune responses in dogs orally given 15 mg/kg/day chitosan-oligosaccharide. Two weeks after inoculation, the preparation had significantly increased number of fecal bifidobacteria and decreased number of fecal clostridia. Then the ratio of CD4-positive lymphocyte/CD8-positive lymphocyte was also significantly higher than those before inoculation. On other investigation, 6 weeks after inoculation, there were no the difference between inoculated groups and non-inoculated ones on serum and fecal IgA.levels There date suggested that chitosan-oligosaccharide is useful on dogs.
キトサンオリゴ糖15mg/kg/日を犬に投与したときの糞便細菌叢および免疫応答の変化を調べた。投与2週間後，ビフィズス菌は有意に増加し，クロストリジウムは有意に減少した。CD4陽性リンパ球/CD8陽性リンパ球比は有意に増加した。一方，オリゴ糖投与6週間後，血清中および糞便中IgA濃度はともにオリゴ糖投与群とコントロール群との間に有意差は認められなかったが，ビフィズス菌の増加，クロストリジウム減少などからイヌにおいてキトサンオリゴ糖の有用性が示された。 キトサンオリゴ糖15mg/kg/日を犬に投与したときの糞便細菌叢および免疫応答の変化を調べた。投与2週間後，ビフィズス菌は有意に増加し，クロストリジウムは有意に減少した。CD4陽性リンパ球/CD8陽性リンパ球比は有意に増加した。一方，オリゴ糖投与6週間後，血清中および糞便中IgA濃度はともにオリゴ糖投与群とコントロール群との間に有意差は認められなかったが，ビフィズス菌の増加，クロストリジウム減少などからイヌにおいてキトサンオリゴ糖の有用性が示された。 |
| Author | 浜川, 弘茂 大谷, 紗智子 深田, 恒夫 道祖, 利幸 柴田, 早苗 大森, 賢吾 |
| Author_FL | FUKATA Tsuneo DOUSO Toshiyuki OTANI Sachiko HAMAKAWA Hiroshige SHIBATA Sanae OMORI Kengo |
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| References | 11) Hong K.N., Na Y.P., Shin H.L., Samuel P.M.: Antibacterial activity of chitosans and chitosan oligomers with different molecular weights. Inter J Food Microbiology, 74, 65-72 (2002 26) Willard M.D., Simpson R.B., Cohen N.D., Clancy J.S.: Effects of dietary fructoologosaccharide in selected bacterial population in feces of dogs. Am J Vet Res, 61, 820-825 (2000 15) 又平芳春：キチン・キトサンオリゴ糖 pp. 272-287 In: オリゴ糖の新知識. 食品化学新聞社, 東京 (1998 22) Swanson S., Grieshop M., Flickinger A., Merchen R., Fahey C.: Effect of supplemental fructooligosaccharides and mannanoligosaccharides on colonic microbial populations, immune function and fecal odor components in the canine. J Nutr, 132, 1717-1719 (2002 19) Saavedra J.M., Tschernia A.: Human studies with probiotics and prebiotics: clinical implications. Br J Nutr, 87, Suppl 2, S241-246 (2002 1) Dai D., Nanthkumar N., Newberg D., Walker A.W.: Role of oligosaccharides and glycoconjugates in intestinal host defence. J Pediatr Gastroenterol Nutr, 30, S23-33 (2000 23) Swanson S., Grieshop M., Flickinger A., Bauer L., Healy, Dawson A., Merchen R., Fahey C.: Supplemental fructooligosaccharides and mannanoligosaccharides influence immune function, ileal and total tract nutrient digestibilities, microbial population and concentrations of protein catabolites in the large bowel of dogs. Nutr Immun, 12. 980-989 (2002 9) 早川幸男：オリゴ糖総論, pp. 1-18 In: オリゴ糖の新知識. 食品化学新聞社, 東京 (1998 24) 内田治：すぐわかるEXCELによる統計解析. 東京図書, 東京 (2001 16) 光岡知足：腸内菌の世界. 叢文社, 東京 (1984 7) Greeley E.H., Kealy R.D., Ballam J.M., Lawler D.F., Segre M.: The influence of age on the canine immune system. Vet Immunol Immunopathol. 55, 1-10 (1996 2) Faldyna M., Leva L., Knotigova P., Toman M.: Lymphocyte subsets in peripheral blood of dogs-a flow cytometric study. Vet Immunol Immunopathol, 82, 23-37 (2001 10) 平野茂博：食品添加剤, pp384-400 In: キチン，キトサンハンドブック (キチン・キトサン研究会編). 技報堂出版, 東京 (1995 8) Grieshop C.M., Flickinger E.A., Bruce K.J., Patil A.R., Czarnecki-Maulden G.L., Fahey G.C.: Gastrointestinal and immunological responses of senior dogs to chicory and mannan-oligosaccharides. Arch Anm Nutr, 58, 483-493 (2004 6) Gibson G.R., Roberfroid M.B.: Dietary modulation of the human colonic microbiota: Introducing the concept of prebiotics. J Nutr, 125, 1401-1412 (1995 14) Lim B.O., Yamada K., Nonaka M., Kuramoto Y., Hung P., Sugano M.: Dietary fibers modulate indices of intestinal immune function in rats. J Nutr, 127, 663-667 (1997 27) Willard M.D., Simpson R.B., Delles E.K., Cohen N.D., Fossum T.W., Kolp D., Reinbart G.: Effect of dietary supplementation of fructo-oligosaccharides on small intestinal bacterial overgrowth in dogs. Am J Vet Res, 55, 654-659 (1994 5) Gibson G.R., McCartney A.L., Rastall R.A.: Prebiotics and resistance to gastrointestinal infections. Br J Nutr, 93. Suppl 1, S31-4 (2005 3) 深田恒夫, 青木志保, 吉川陽人, 上林 譲, 鬼頭克也, 北川 均：毛包虫症犬におけるリンパ球CD4/CD8比の意義について. 日本獣医師会雑誌, 58, 113-116 (2005 12) Hosono A., Ozawa A., Kato R., Ohnishi Y., Nakanishi Y., Kimura T., Nakamura R.: Dietary fructooligosaccharides induce immunoregulation of intestinal IgA secretion by Murine Peyer's patch cells. Biosci Biotechnol Biochem, 67, 758-764 (2003 4) Fullar R.: Probiotics in human medicine. Gut, 32, 439-442 (1991 25) Watzl B., Girrbach S., Roller M.: Inulin oligofructose and immunomodulation. Br J Nutr, 93, Suppl 1, S49-55 (2005 13) Lee H.W., Park Y.S., Jung J.S., Shin W.S.: Chitosan oligosaccharides, dp2-8, have prebiotic effect on the Bifidobacterium bifidium and Lactobacillus sp. Food microbiology, 8, 319-324 (2002 17) Nicole M., Andreas S., Helga B., Martina M., Erich R.: Influence of fructooligosaccharides on Peyer's patch lymphocyte numbers in healthy and endotoxemic mice. Nutrition, 19, 657-660 (2003 18) Rooler M., Rechkemmer G., Watzl B.: Prebiotic inulin enriched with oligofructose in combination with the probiotics Lactobacillus rhamnosus and Bifidobacterium lactic modulates intestinal immune functions in rats. J Nutr, 134, 153-156 (2004 21) 鈴木茂生, 鈴木益子：キチン・キトサンおよびそのオリゴマーの生理活性 pp162-170 In: キチン，キトサンハンドブック (キチン・キトサン研究会編). 技報堂出版, 東京 (1995 20) Schley P.D., Field C.J.: The immune-enhancing effects of dietary fibres and prebiotics. Br J Nutr, 87, Suppl 2, S221-230 (2002 |
| References_xml | – reference: 11) Hong K.N., Na Y.P., Shin H.L., Samuel P.M.: Antibacterial activity of chitosans and chitosan oligomers with different molecular weights. Inter J Food Microbiology, 74, 65-72 (2002) – reference: 25) Watzl B., Girrbach S., Roller M.: Inulin oligofructose and immunomodulation. Br J Nutr, 93, Suppl 1, S49-55 (2005) – reference: 7) Greeley E.H., Kealy R.D., Ballam J.M., Lawler D.F., Segre M.: The influence of age on the canine immune system. Vet Immunol Immunopathol. 55, 1-10 (1996) – reference: 22) Swanson S., Grieshop M., Flickinger A., Merchen R., Fahey C.: Effect of supplemental fructooligosaccharides and mannanoligosaccharides on colonic microbial populations, immune function and fecal odor components in the canine. J Nutr, 132, 1717-1719 (2002) – reference: 5) Gibson G.R., McCartney A.L., Rastall R.A.: Prebiotics and resistance to gastrointestinal infections. Br J Nutr, 93. Suppl 1, S31-4 (2005) – reference: 21) 鈴木茂生, 鈴木益子：キチン・キトサンおよびそのオリゴマーの生理活性 pp162-170 In: キチン，キトサンハンドブック (キチン・キトサン研究会編). 技報堂出版, 東京 (1995) – reference: 2) Faldyna M., Leva L., Knotigova P., Toman M.: Lymphocyte subsets in peripheral blood of dogs-a flow cytometric study. Vet Immunol Immunopathol, 82, 23-37 (2001) – reference: 27) Willard M.D., Simpson R.B., Delles E.K., Cohen N.D., Fossum T.W., Kolp D., Reinbart G.: Effect of dietary supplementation of fructo-oligosaccharides on small intestinal bacterial overgrowth in dogs. Am J Vet Res, 55, 654-659 (1994) – reference: 13) Lee H.W., Park Y.S., Jung J.S., Shin W.S.: Chitosan oligosaccharides, dp2-8, have prebiotic effect on the Bifidobacterium bifidium and Lactobacillus sp. Food microbiology, 8, 319-324 (2002) – reference: 15) 又平芳春：キチン・キトサンオリゴ糖 pp. 272-287 In: オリゴ糖の新知識. 食品化学新聞社, 東京 (1998) – reference: 19) Saavedra J.M., Tschernia A.: Human studies with probiotics and prebiotics: clinical implications. Br J Nutr, 87, Suppl 2, S241-246 (2002) – reference: 4) Fullar R.: Probiotics in human medicine. Gut, 32, 439-442 (1991) – reference: 14) Lim B.O., Yamada K., Nonaka M., Kuramoto Y., Hung P., Sugano M.: Dietary fibers modulate indices of intestinal immune function in rats. J Nutr, 127, 663-667 (1997) – reference: 12) Hosono A., Ozawa A., Kato R., Ohnishi Y., Nakanishi Y., Kimura T., Nakamura R.: Dietary fructooligosaccharides induce immunoregulation of intestinal IgA secretion by Murine Peyer's patch cells. Biosci Biotechnol Biochem, 67, 758-764 (2003) – reference: 3) 深田恒夫, 青木志保, 吉川陽人, 上林 譲, 鬼頭克也, 北川 均：毛包虫症犬におけるリンパ球CD4/CD8比の意義について. 日本獣医師会雑誌, 58, 113-116 (2005) – reference: 24) 内田治：すぐわかるEXCELによる統計解析. 東京図書, 東京 (2001) – reference: 10) 平野茂博：食品添加剤, pp384-400 In: キチン，キトサンハンドブック (キチン・キトサン研究会編). 技報堂出版, 東京 (1995) – reference: 16) 光岡知足：腸内菌の世界. 叢文社, 東京 (1984) – reference: 23) Swanson S., Grieshop M., Flickinger A., Bauer L., Healy, Dawson A., Merchen R., Fahey C.: Supplemental fructooligosaccharides and mannanoligosaccharides influence immune function, ileal and total tract nutrient digestibilities, microbial population and concentrations of protein catabolites in the large bowel of dogs. Nutr Immun, 12. 980-989 (2002) – reference: 8) Grieshop C.M., Flickinger E.A., Bruce K.J., Patil A.R., Czarnecki-Maulden G.L., Fahey G.C.: Gastrointestinal and immunological responses of senior dogs to chicory and mannan-oligosaccharides. Arch Anm Nutr, 58, 483-493 (2004) – reference: 17) Nicole M., Andreas S., Helga B., Martina M., Erich R.: Influence of fructooligosaccharides on Peyer's patch lymphocyte numbers in healthy and endotoxemic mice. Nutrition, 19, 657-660 (2003) – reference: 26) Willard M.D., Simpson R.B., Cohen N.D., Clancy J.S.: Effects of dietary fructoologosaccharide in selected bacterial population in feces of dogs. Am J Vet Res, 61, 820-825 (2000) – reference: 6) Gibson G.R., Roberfroid M.B.: Dietary modulation of the human colonic microbiota: Introducing the concept of prebiotics. J Nutr, 125, 1401-1412 (1995) – reference: 18) Rooler M., Rechkemmer G., Watzl B.: Prebiotic inulin enriched with oligofructose in combination with the probiotics Lactobacillus rhamnosus and Bifidobacterium lactic modulates intestinal immune functions in rats. J Nutr, 134, 153-156 (2004) – reference: 1) Dai D., Nanthkumar N., Newberg D., Walker A.W.: Role of oligosaccharides and glycoconjugates in intestinal host defence. J Pediatr Gastroenterol Nutr, 30, S23-33 (2000) – reference: 9) 早川幸男：オリゴ糖総論, pp. 1-18 In: オリゴ糖の新知識. 食品化学新聞社, 東京 (1998) – reference: 20) Schley P.D., Field C.J.: The immune-enhancing effects of dietary fibres and prebiotics. Br J Nutr, 87, Suppl 2, S221-230 (2002) |
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| Snippet | キトサンオリゴ糖15mg/kg/日を犬に投与したときの糞便細菌叢および免疫応答の変化を調べた。投与2週間後，ビフィズス菌は有意に増加し，クロストリジウムは有意に減... This study investigated the changes of fecal flora and immune responses in dogs orally given 15 mg/kg/day chitosan-oligosaccharide. Two weeks after... |
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| SubjectTerms | bifidobacteria CD4/CD8 chitosan-oligosaccharide dog IgA キトサンオリゴ糖 ビフィズス菌 犬 |
| Title | キトサンオリゴ糖を投与された犬の糞便細菌叢および免疫応答 |
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