塩酸サルポグレラートによる血小板凝集抑制作用の速度論的解析とその処方設計への応用 : 未変化体及び活性代謝物(M-1)の血小板膜上5-HT2受容体への可逆的阻害を考慮したPK/PDモデルの構築

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Published inYAKUGAKU ZASSHI Vol. 119; no. 11; pp. 850 - 860
Main Authors 清水, 孝子, 小瀧, 一, 伊賀, 立二, 山田, 安彦, 澤田, 康文, 田下, 明子, 山本, 康次郎
Format Journal Article
LanguageJapanese
Published 公益社団法人 日本薬学会 01.11.1999
Online AccessGet full text
ISSN0031-6903
1347-5231
DOI10.1248/yakushi1947.119.11_850

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Author 山本, 康次郎
伊賀, 立二
清水, 孝子
小瀧, 一
澤田, 康文
山田, 安彦
田下, 明子
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8) 磯貝行秀, 横瀬琢男, 池本卓, 前田俊彦, 秋山雅昭, 臨床医薬, 7, 1227-1233 (1991).
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17) 丹羽卓朗, 山本美奈子, 小松貞子, 飯田成宇, 薬理と治療, 19, 161-168 (1991).
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22) 山口寛, 古川欽一, 臨床医薬, 7, 1235-1241 (1991).
References_xml – reference: 11) Qi R., Ozaki Y., Satoh K., Kurota K., Asazuma N., Yatomi Y., Thromb. Res., 81, 43-54 (1996).
– reference: 7) Nishio H., Inoue A., Nakata Y., Arch. Int. Pharmacodyn., 331, 189-202 (1996).
– reference: 10) Maruyama K., Kinami J., Sugita Y., Takada Y., Sugiyama E., Tsutcihashi H., Nagatomo T., J.Pharmacobio-Dyn., 14, 177-181 (1991).
– reference: 8) 磯貝行秀, 横瀬琢男, 池本卓, 前田俊彦, 秋山雅昭, 臨床医薬, 7, 1227-1233 (1991).
– reference: 17) 丹羽卓朗, 山本美奈子, 小松貞子, 飯田成宇, 薬理と治療, 19, 161-168 (1991).
– reference: 12) 清水孝子, 山田安彦, 片島正貴, 田下明子, 山本康次郎, 小瀧, 一, 澤田康文, 伊賀立二, 病院薬学, 24, 333-339 (1998).
– reference: 4) Geaney P.D., Schachter M., Elliot M.J., Grahame-Smith G.D., Eur. J. Pharmacol., 97, 87-93 (1984).
– reference: 16) Maclntyre E.D., Pollock K.W., Shaw M.A., Bushfield M., Macmillan J.L., Mcnicol A., Adv. Exp. Med. Biol., 192, 127-144 (1985).
– reference: 18) Yamaoka K., Tanigawara Y., Nakagawa T., Uno T., J. Pharmacobio-Dyn., 4, 879-885 (1981).
– reference: 19) 磯貝行秀, 横瀬琢男, 池本卓, 前田俊彦, 秋山雅昭, 原啓人, 北島安喜子, 井沢修, 臨床医薬, 7, 1177-1192 (1991).
– reference: 20) Yamaoka K., Nakagawa T., J. Pharmacobio-Dyn., 6, 595-606 (1983).
– reference: 9) Hara H., Osakabe M., Kitajima A., Tamao Y., Kikumoto R., Thromb. Haemostas., 65, 415-420 (1991).
– reference: 14) Affolter H., Erne P., Burgisser E., Pletscher A., Naunyn-Schmiedeberg's Arch. Pharmacol., 325, 337-342 (1984).
– reference: 3) Leysen E.J., Gommeren W., Clerck de F., Eur. J. Pharmacol., 88, 125-130 (1983).
– reference: 13) 島田浩志, 原啓人, 玉尾嘉邦, 薬理と治療, 19, S599-S603 (1991).
– reference: 15) Erne P., Pletscher A., Br. J. Pharmacol., 84, 545-549 (1985).
– reference: 21) Tsuchihashi H., Yagi N., Kimura M., Shirota K., Kinami J., Nagatomo T., J. Pharmacobio-Dyn., 14, 461-466 (1991).
– reference: 22) 山口寛, 古川欽一, 臨床医薬, 7, 1235-1241 (1991).
– reference: 5) Van Nueten M.J., Janssen J.A.P., van Beek J., Xhonneux R., Verbeuren T.J., Vanhoutte M.P., J. Pharmacol. Exp. Ther., 218, 217-230 (1981).
– reference: 6) Kikumoto R., Hara H., Ninomiya K., Osakabe M., Sugano M., Fukami H., Tamao Y., J. Med. Chem., 33, 1818-1823 (1990).
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Title 塩酸サルポグレラートによる血小板凝集抑制作用の速度論的解析とその処方設計への応用 : 未変化体及び活性代謝物(M-1)の血小板膜上5-HT2受容体への可逆的阻害を考慮したPK/PDモデルの構築
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